| STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN Patent applications |
| Patent application number | Title | Published |
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| 20130071428 | PEPTIDES, CONJUGATES AND METHOD FOR INCREASING IMMUNOGENICITY OF A VACCINE - The present invention relates to conjugates comprising a peptide of at least 10 amino acid residues comprising the amino acid sequence GITELKKL for induction of potent humoral and cellular immune responses when administered to subjects having antibodies against tetanus toxoid. In one embodiment the invention relates to a prophylactic and therapeutic vaccine and in a further embodiment the invention relates to the treatment or prevention of cancer or an infectious disease. | 03-21-2013 |
| 20120295321 | Pentose Transporters and Uses Thereof - The invention relates to the production of biofuels, proteins, peptides and other value-added compounds from crude carbon sources. The inventors identified genes encoding novel pentose transporters, in particular transporters of L-arabinose and/or D-xylose. Regulation of the | 11-22-2012 |
| 20110276003 | INTEGRATED MICRONEEDLE ARRAY AND A METHOD FOR MANUFACTURING THEREOF - The invention relates to a method of manufacturing of a microneedle array comprising the steps of selecting a soft production mold comprising a set of microscopic incisions defining geometry of the microneedles, said soft production mold being capable of providing the microneedle array integrated into a base plate; using a filler material for abundantly filling the microscopic incisions of the soft production mold thereby producing the microneedle array with pre-defined geometry integrated into the base plate; wherein for the filler material a water or alcohol based ceramic or polymer-ceramic slurry is selected. The invention further relates to a microneedle array, a composition comprising a microneedle array, a system for enabling transport of a substance through a barrier and a system for measuring an electric signal using an electrode. | 11-10-2011 |
| 20110203945 | method of preserving a sensor in a container and a container containing a sensor and a storage solution - The invention relates to a method of preserving a sensor in a container, said sensor comprising a sensing area of metallic or a semi-conducting material covered with molecules having a MW>100 Dalton, said molecules being bound to the material wherein at least the sensing area of the layer is kept submerged in a storage solution, said storage solution having a composition that consists for at least 80% by volume of at least one compound chosen from water, ethanol, triethylene glycol and isopropanol, with the provisios that | 08-25-2011 |
| 20110195861 | METHOD OF DETECTING AUTO-ANTIBODIES FROM PATIENTS SUFFERING FROM RHEUMATOID ARTHRITIS, A PEPTIDE AND AN ASSAY KIT - A liposomal composition, preferably a vaccine, comprising liposomes formed of liposome forming compounds, containing coentrapped polysaccharide antigen and T-cell dependent protein carrier, such as tetanus toxoid or diphtheria toxin modified to render it non-toxic. The invention is of use in the production of vaccines against | 08-11-2011 |
| 20110050283 | SYNCHRONOUS PHASE DETECTION CIRCUIT - A phase detection circuit arranged as sigma-delta modulator for determining a phase difference between a periodic signal and a reference signal, the periodic signal and the reference signal having a substantially equal frequency, includes: a source input configured to receive the periodic signal whose phase relationship with respect to the reference signal is to be determined; a feedback signal generator configured to provide a feedback signal, the feedback signal and reference signal having substantially the same frequency; a phase difference circuit coupled to the source input node and a second signal input node coupled to the feedback signal generator, and configured to determine an error signal as a function of the phase difference between the periodic signal and the feedback signal; an integrator circuit coupled to the phase difference circuit, configured to receive the error signal and to integrate the error signal to provide an integration signal; a digitizing circuit coupled to the integration circuit, configured to digitize the integration signal; wherein the feedback signal generator is coupled to the digitizing circuit, configured to provide the feedback signal based on the digitized integration signal from the digitizing circuit; and configured to select the phase of the feedback signal from a number of fixed phases, wherein the phase detection circuit is arranged for generating a time-average of the phase of the feedback signal as selected from the plurality of fixed phases. | 03-03-2011 |
| 20100224798 | SCINTILLATOR BASED ON LANTHANUM IODIDE AND LANTHANUM BROMIDE - A scintillator material has a formula La | 09-09-2010 |
| 20100191116 | Method, A Computer Program And An Apparatus For Quantification Of A Degree Of Obstruction In A Liquid Passageway - The invention relates to a method for quantification of a degree of obstruction in a liquid passageway, notably a male urethra. Data related to sonic waves generated by a liquid passing the obstruction may be accessed from a suitable file, or, alternatively may be directly obtained as a result of a measuring step | 07-29-2010 |
| 20100041987 | Imaging Apparatus And Method - A thermoacoustic imaging apparatus comprises an electromagnetic radiation source configured to irradiate a sample area and an acoustic signal detection probe arrangement for detecting acoustic signals. A radiation responsive acoustic signal generator is added outside the sample area. The detection probe arrangement detects both signals generated in a sample area in response to the irradiation and an acoustic signal from the radiation responsive acoustic signal generator that has traveled through the sample area. A computing system distinguishes first acoustic signal detections attributed to the acoustic signal generated by the radiation responsive acoustic signal generator and second acoustic signal detections attributed to the acoustic signals generated by the sample area. The computing system performs a tomographic computation of an acoustic transmission parameter as a function of a position in the sample area from the first acoustic signal detections. The acoustic transmission parameter may be a speed of sound or absorption. The acoustic transmission parameter may be used to correct the computation of a thermoacoustic image. | 02-18-2010 |
| 20090297612 | HOMOGENEOUS, INTRINSIC RADIOPAQUE EMBOLIC PARTICLES - The invention is directed to embolic material comprising spherical, homogeneous and substantially non-porous radiopaque polymer particles based on at least one hydrophilic monomer and at least one radiopaque monomer according to general formula | 12-03-2009 |
| 20090281390 | Optical Triggering System For Stroboscopy, And A Stroboscopic System - A triggering system for a stroboscope system, comprising: a light source for projecting light on a vibratory object, such as vocal folds, an optical sensor for sensing light reflected or transmitted from said vibratory object in response to the projected light, in order to obtain vibratory information from the vibratory object; and a control arrangement connected to the optical sensor, for converting the vibratory information into triggering signals for the stroboscope system, said electronic control arrangement including a control output connectable to said stroboscope system, for outputting said triggering signals to said stroboscope system. | 11-12-2009 |
| 20090264492 | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF A FUNGAL SKIN DISORDER AND A METHOD FOR THE PREPARATION THEREOF - The present invention relates to a pharmaceutical composition for photodynamic treatment of a fungal skin disorder, said pharmaceutical composition comprising a photosensitizer and an enhancer, wherein the photosensitizer is a cationic photosensitizer and the enhancer is chosen from the group of i) an acid, and ii) a metal chelating agent. Such a composition is capable of eliminating both conidiae and hy-phae. The invention also relates to a method for the preparation of the pharmaceutical composition. | 10-22-2009 |
| 20090212875 | Oscillator based on thermal diffusion - An oscillator device for generating an oscillator signal, includes a heater arrangement, a first switching element, a temperature sensor, signal process means, and voltage controlled oscillator; an output of the temperature sensor being connected to an input of the signal processing means, and an output of the signal processing means being connected to an input of the voltage controlled oscillator. The first switching element is arranged for receiving the oscillator signal from the voltage controlled oscillator and for providing a heater drive signal to either a first heater element or a second heater element of the heater arrangement based on the oscillator signal. The signal processing means comprise a synchronous demodulator. | 08-27-2009 |
| 20090039269 | High Light Yield Fast Scintillator - The invention concerns a material comprising a compound of formula Pr | 02-12-2009 |
| 20080267877 | Peptide-based carrier devices for stellate cells - A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recognizing peptide (RRP) and with the proviso that the compound is not a naturally occurring receptor agonist or antagonist. Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGBβ, INFα and interleukinβ. The cyclic portion of the peptide can contain at least one amino acid sequence RGD or KPT. The compounds can be used as an active targeting ingredient for manufacturing a pharmaceutical composition for therapy, prophylaxis or diagnosis of a disease chosen from fibrotic disease, sclerotic disease, and chronic or acute inflammatory processes including glomeruloscherosis, interstitial fibrosis, lung fibrosis, atherosclerosis, rheumatoid arthritis, Crohns disease, colitis ulcerosa, glomerulonephritis and sepsis, and particularly for targeting HSC. Pharmaceutical compositions contain the above-compound(s). | 10-30-2008 |
| 20080200815 | Intravascular Ultrasound Techniques - Intravascular ultrasound techniques provide for intravascular imaging using contrast agents and nonlinear techniques. An ultrasound imaging device for detecting internal properties of a target body comprises an ultrasound transducer positioned at a distal end portion of a catheter, for transmitting excitation pulses and for receiving echo signals. A signal processor analyses echo signals at harmonics and/or subharmonics of the transmit frequency. The catheter may include a contrast agent delivery conduit extending along the catheter, the delivery conduit having an exit orifice proximal to the ultrasound transducer. The device may discriminate between echo signals respectively arising from interaction with tissue and from the interaction with contrast agent. The device may generate an image of the site of interest using non-linear components of the received ultrasound echo signals. | 08-21-2008 |
