| STICHTING HET NEDERLANDS KANKER INSTITUUT Patent applications |
| Patent application number | Title | Published |
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| 20120322677 | PREDICTING BENEFIT OF ANTI-CANCER THERAPY VIA ARRAY COMPARATIVE GENOMIC HYBRIDIZATION - Array comparative genomic hybridization classifiers, arrays comprising the classifiers, and related methods of using the same for predicting the therapeutic efficacy of anti-cancer therapy by detecting phenotypic genetic traits using comparative genomic hybridization are disclosed. | 12-20-2012 |
| 20120232381 | METHOD FOR NON-INVASIVE QUANTITATIVE ASSESSMENT OF RADIOACTIVE TRACER LEVELS IN THE BLOOD STREAM - A method and system for non-invasive quantitative assessment of radionuclide tracer levels in the blood stream. The method relies on the finding that the gamma-radiation signal acquired using a gamma scintillation probe, is the resultant from a wave-component with changing amplitude, resulting from the radiotracer in the bloodstream and a non-wave background component resulting from radiotracer distributed throughout the tissue surrounding the arterial vessel. The method involves phase-sensitive conversion of the ‘input signal’, extracting there from an output signal representing the signal component originating from the bloodstream, using the changes in arterial blood volume as the reference wave-form. A particular aspect of the invention concerns methods of quantitative PET or SPECT imaging wherein the concentration of radionuclides in the blood stream as a function of time after injection is assessed using the method of the invention. | 09-13-2012 |
| 20120225076 | FRA-1 TARGET GENES AS DRUG TARGETS FOR TREATING CANCER - The invention relates to the use of an inhibitor of one of the following polypeptides, wherein the polypeptide is represented by the following sequences selected from the following group SEQ ID NO:1-32, each of the polypeptide being preferably as identified in claim | 09-06-2012 |
| 20110269155 | Detecting Antigen Responsive Cells in a Sample - The present invention relates to methods for detecting antigen responsive cells in a sample using multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (NHC). Further, the present invention relates to the use of the present multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (MHC), for detecting antigen responsive cells in a sample, preferably a single sample, such as a blood sample. The present method allows high-throughput analysis of specific antigen responsive cells, such as T- and B-cells, thereby providing, for example, high-throughput methods for monitoring of diseases or conditions and the development of immunotherapeutics, vaccines, or the identification epitopes or immunogenic amino acid sequences. | 11-03-2011 |
| 20110097706 | MICRO-REACTOR FOR OBSERVING PARTICLES IN A FLUID - The invention relates to a micro-reactor for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor shows a first channel formed between two layers for containing the fluid, with an inlet and an outlet, the two layers separated by a first distance. A likewise second channel with an inlet and an outlet is placed adjacent to the first channel. A gap connects the first channel and the second channel, at the gap at least one layer showing a window transparent to the method of inspection and at the window the two layers being separated by a very small distance of, for example, 1 μm or less. | 04-28-2011 |
| 20100297624 | Involvement of Lipid Kinase, and Signal Transduction Pathway Comprising Said Lipid Kinase, in Resistance to HER2-Targeting Therapy - The invention is related to a method for determining whether an individual suffering from cancer is at risk of exhibiting or acquiring a reduced response towards HER2-targeting therapy. In one aspect, the invention utilizes the activity of a signal transduction pathway modulated by a lipid kinase for determining said risk. | 11-25-2010 |
