| 20110065208 | DETERMINATION AND ESTIMATION OF ABSORPTION AND DISTRIBUTION OF SUBSTANCES IN BRAIN TISSUE - A method determines or estimates the absorption and partition of substances into brain tissue and parameters derivable therefrom, such as the permeability of substances through the blood-brain barrier and also, more particularly, the proportion of substances freely available in the brain. The partition coefficient of the corresponding substance between an aqueous phase and the lipid phase is determined with the help of lipid membranes which are preferably contained in a test kit and immobilized on a solid body as a carrier material. The partition coefficient can be subsequently used as a parameter in a QSAR model to determine the blood-brain partition coefficient. | 03-17-2011 |
