Silicon Biosystems S.P.A. Patent applications |
Patent application number | Title | Published |
20150031040 | Devices, Apparatus, Kit and Method for Treating a Biological Sample - Method for the treatment of a biological sample comprising at least one cell and a liquid component; according to the method, a force is applied to the sample inserted in an inner chamber of a hollow device towards a filter which has pores with diameters from 2 nm to 1 μm, so that at least part of the liquid component passes through the filter and the cell remains in the inner chamber, thus obtaining a concentrated sample; the filter has a surface facing the inner chamber of less than 12.6 mm | 01-29-2015 |
20140315236 | Method and Apparatus for the Processing and/or Analysis and/or Selection of Particles, in Particular, Biological Particles - Methods and apparatus are described for the processing (for example washing, incubation, etc.) of particles in which the particles suspended in a first fluid are introduced under laminar flow conditions into at least one first microchamber or first region of the same, in which a second fluid is introduced under laminar flow conditions into at least one second region of the microchamber or of a second microchamber, in such a way as not to mix with the first fluid, and in which at least one field of force acting on the particles is activated in the microchamber(s), to provoke a shift of the particles alone in a predetermined direction and to transfer the same in suspension into the second fluid; an apparatus is preferably used including at least three microchambers n microchambers arranged in sequence with each other in one direction and each connected with the microchamber immediately before it and after it with two orifices offset from each other in a direction perpendicular to the direction of sequence of the microchambers. | 10-23-2014 |
20140302490 | METHOD AND DEVICE FOR OPTICAL ANALYSIS OF PARTICLES AT LOW TEMPERATURES - Method and device ( | 10-09-2014 |
20140246320 | Method and Apparatus for the Characterizing and Counting Particles, in Particular, Biological Particles - The present invention relates to a method and an apparatus for the characterization and/or the counting of particles by means of non uniform, time variable force fields and integrated optical or impedance meter sensors. The force fields can be of positive or negative dielectrophoresis, electrophoresis or electro-hydrodynamic motions, characterized by a set of stable equilibrium points for the particles (solid, liquid or gaseous); the same method is suitable for the manipulation of droplets (liquid particles) by exploiting effects known to the international scientific community with the name of Electro-wetting on dielectric. The aim of the present invention is to act on the control of the position of each particle which is present in the sample, for the purpose of displacing such particles in a deterministic or statistical way, in order to detect their presence with the integrated optical or impedance meter sensors and/or characterize their type, for the purpose of counting or manipulating them in an efficient way. | 09-04-2014 |
20140131207 | Method and Apparatus for the Manipulation and/or the Detection of Particles - Method and apparatus for the manipulation and/or control of the position of particles using time-variable fields of force; the fields of force can be of dielectrophoresis (positive or negative), electrophoresis, electrohydrodynamic or electrowetting on dielectric, possessing a set of stable points of equilibrium for the particles. | 05-15-2014 |
20130343966 | Microfluidic Device for the Manipulation of Particles - A microfluidic device for isolating particles of at least one given type of a sample; the device is designed to be connected to an apparatus through a plurality of electrical connectors and comprises a system of microfluidic channels and a flash memory, which contains information on the structure (arrangement and geometry of the various components) of the system of microfluidic channels, a map of non-functioning parts of the device, the maximum number of uses and the maximum time of use of the device; the memory has portions allocated for storing the number of times and the time of use of the device. | 12-26-2013 |
20130045144 | Micro-Fluidic System - A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole, within which a closing portion of a closing element extends; when the closing portion is arranged within the micro-fluidic channel, the passage of the liquid along the channel is interrupted; by deforming the closing element by suction the closing portion may be lifted and therefore allow the passage of liquid along the micro-fluidic channel. | 02-21-2013 |
20130043133 | METHOD AND DEVICE FOR THE MANIPULATION OF PARTICLES BY OVERLAPPING FIELDS OF FORCE - Methods and related devices are illustrated for generating time-variable electric fields suitable for determining the creation of closed dielectrophoretic cages able to trap inside even single particles without the cages being necessarily positioned at relative minimum points of the electric field. | 02-21-2013 |
20130042936 | Micro-Fluidic System - A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; and a closing element, which is adapted to cooperate with a partition arranged within the micro-fluidic channel in the area of the hole to isolate or connect two segments of the channel; the closing element is made of a photoresist material, in particular a material obtained by the polymerisation of a photopolymerable material. | 02-21-2013 |
20130037139 | Micro-Fluidic System - A micro-fluidic system comprising a micro-fluidic channel, which has a wall provided with a hole; a closing element, which is partially housed within the hole and has a membrane portion adapted to deform and a side portion sealingly connected with the above mentioned wall; and a partition arranged within the micro-fluidic channel between a first and a second segment; the closing element is deformable between a locked configuration in contact with the partition and an open configuration spaced from the partition; the closing element may be deformed by suction or by a rod or a piston. | 02-14-2013 |
20120184010 | Microfluidic Device for Isolation of Cells - A microfluidic system ( | 07-19-2012 |
20120071335 | Method for Identification, Selection and Analysis of Tumour Cells - The present invention relates to a method for the diagnosis of tumoural conditions and/or of the corresponding state of advance, wherein a specimen of an organic fluid taken from the patient and having a high probability of containing at least one circulating tumour cell (CTC) or a disseminated tumour cell (CTD) is enriched in a population of CTCs or CTDs. According to the invention, at least one type of CTCs or CTDs is isolated by selecting individually single cells in a microfluidic device so to constitute a diagnostic specimen having a purity of at least 90%. On the specimen thus obtained there is subsequently performed a molecular analysis such as to highlight a characteristic thereof suited to enabling diagnosis. | 03-22-2012 |
20120028349 | Sorting Chamber - A sorting chamber ( | 02-02-2012 |
20110050200 | Apparatus and Method for Counting and Identifying Particles of Interest in a Fluid - The invention relates to an apparatus for counting particles in a fluid comprising a substrate having a first surface; a lid having a second surface facing the first; at least one spacer element interposed between the substrate and the lid so as to maintain the first and second surface spaced from one another; a partition with a plurality of through-openings having nanometric size, the partition being interposed between the spacer element and the lid so as to define at least one first chamber between the partition and the lid and at least one second chamber between the partition and the substrate, the chambers being fluidically connected with one another through at least one of the openings. According to the invention, the substrate has at least one first electrode on the first surface and the lid has a second electrode, each first electrode being configured so as to detect an electric signal associated to the passage of one of said particles through one of the through-openings of the partition. The invention further relates to a corresponding method for counting particles in a fluid. | 03-03-2011 |
20100331205 | Method and Apparatus for the Identification and Handling of Particles - The present invention refers to the optimised selection and isolation, within a respective population, of elements of interest and/or utility for a series of subsequent operations. The invention concerns a method comprising the phases of: a) identifying, for each particle, at least one of a plurality of characteristic parameters; b) selecting the particles of interest, comparing for each of these the at least one parameter with a respective reference parameter. It furthermore comprises the phases of c) storing, for each of said particles, the at least one parameter identified; d) processing the value of a function of said stored parameter, associating the function with a criterion for selection of the particles of interest chosen from a group of possible selection criteria; e) establishing for each particle a threshold criterion to be used as reference parameter. The threshold criterion is established on a time by time basis according to the result of the above processing. | 12-30-2010 |
20100200404 | METHOD AND DEVICE FOR THE MANIPULATION OF PARTICLES BY OVERLAPPING FIELDS OF FORCE - Methods and relative devices are illustrated for generating time-variable electric fields suitable for determining the creation of closed dielectrophoretic cages able to trap inside even single particles without the cages being necessarily positioned at relative minimum points of the electric field. | 08-12-2010 |
20100196897 | Method and Device for Non-Invasive Prenatal Diagnosis - Method for non-invasive prenatal diagnosis comprising the following steps: a. obtain a sample of an organic fluid having a high probability of containing foetal cells from a pregnant woman; b. enrich said sample of organic fluid in at least one population of cells comprising at least one type of foetal nucleated cells; c. isolate at least one cell from among said at least one type of foetal nucleated cells; d. perform a genetic analysis on said at least one cell isolated from among said at least one type of foetal nucleated cells in order to highlight at least one genetic characteristic of said at least one foetal nucleated cell suitable for permitting said diagnosis; wherein the step of isolating at least one cell from among said at least one type of foetal nucleated cells is performed by individually selecting single cells in a microfluidic device designed for said purpose. | 08-05-2010 |
20100068780 | METHOD FOR THE SELECTION AND/OR THE PROCESSING OF PARTICLES, IN PARTICULAR CELLS - Method for the selection or the processing of first particles sensitive to the application of an external stimulus including the step of producing, through the application of the external stimulus, the permeabilization of at least a selected first particle, consisting in the organization of the first particles through a first force field, to generate a second force field substantially placed in proximity of at least a selected first particle to be permeabilized. | 03-18-2010 |
20090220974 | METHODS AND APPARATUS FOR THE SELECTION AND/OR PROCESSING OF PARTICLES, IN PARTICULAR FOR THE SELECTIVE AND/OR OPTIMISED LYSIS OF CELLS - Methods and apparatus for the selection or processing of particles sensitive to the application of an external stimulus, in which is produced, by applying the external stimulus, the rupture/lysis of at least one selected particle or the fusion of first and second selected particles, by means of the organisation of the particles using a first field of force by selectively energising electrodes of an array of selectable electrodes having dimensions comparable to or smaller than those of the particles, applying to the electrodes a first configuration of stresses; and by applying to the electrodes a second configuration of stresses, so as to create a second field of force, located substantially close to at least one selected particle to be lysated or to a pair of first and second particles to be fused and such as to produce the application of a stimulus suited to produce their lysis or fusion. | 09-03-2009 |