| SIGMA-ALDRICH CO. Patent applications |
| Patent application number | Title | Published |
|---|
| 20120041222 | PROCESS THE SYNTHESIS OF BETA GLYCEROL PHOSPHATE - The present invention provides methods for the preparation of beta glycerol phosphate and its salts. In particular, the invention provides efficient methods for the synthesis of beta glycerol phosphate of high purity. | 02-16-2012 |
| 20120023599 | GENOME EDITING OF CYTOCHROME P450 IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence encoding CYP proteins, as well as methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-26-2012 |
| 20120010404 | OXAZINE DYES WITH IMPROVED AQUEOUS SOLUBILITY - The present invention provides oxazine dyes, processes for preparing the oxazine dyes, intermediates that may be utilized in the processes for preparing the oxazine dyes, and methods for using the oxazine dyes. | 01-12-2012 |
| 20110312035 | STABILIZED COMPOSITIONS OF THERMOSTABLE DNA POLYMERASE AND ANIONIC OR ZWITTERIONIC DETERGENT - The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to greater than 100° C. The composition comprises a thermostable DNA polymerase and an anionic detergent or zwitterionic detergent. | 12-22-2011 |
| 20110184156 | PRECURSORS FOR DEPOSITION OF METAL OXIDE LAYERS OR FILMS - Rare earth metal precursors, for use in MOCVD techniques have a ligand of the general formula OCR | 07-28-2011 |
| 20110174416 | VALVE ASSEMBLIES - A valve assembly is provided that can operate to fill and/or 100 refill a container with, for example, a liquid while venting excess vapor from the container associated with the liquid to relieve pressure in the container created by the liquid, and that can operate to introduce a carrier gas into the container for use in retrieving vapor products from the liquid within the container. The valve assembly includes a housing defining two bores and multiple ports extending through the housing in communication with the bores. A valve spool is located within each bore to selectively control movement through the housing of the liquid, the excess vapor associated with the liquid, the carrier gas, and the vapor products retrieved from the liquid by the carrier gas. | 07-21-2011 |
| 20110165780 | METHODS OF FORMING RUTHENIUM-CONTAINING FILMS BY ATOMIC LAYER DEPOSITION - A method of forming ruthenium-containing films by atomic layer deposition is provided. The method comprises delivering at least one precursor to a substrate, the at least one precursor corresponding in structure to Formula I: (L)Ru(CO) | 07-07-2011 |
| 20110165401 | HIGH-K DIELECTRIC FILMS AND METHODS OF PRODUCING USING CERIUM-BASED BETA-DIKETONATE PRECURSORS - Methods are provided to form and stabilize high-κ dielectric films by chemical phase deposition processes using metal-source precursors and cerium-based β-diketonate precursors according to Formula I: Ce(L) | 07-07-2011 |
| 20110151227 | HIGH-K DIELECTRIC FILMS AND METHODS OF PRODUCING USING TITANIUM-BASED B-DIKETONATE PRECURSORS - Methods are provided to form and stabilize high-κ dielectric films by vapor deposition processes using metal-source precursors and titanium-based β-diketonate precursors according to Formula I: Ti(L) | 06-23-2011 |
| 20110136118 | REAL TIME POLYMERASE CHAIN REACTION PROCESS USING A UNIVERSAL DETECTION SYSTEM - Provided are methods and kits for detecting amplification of a target nucleic acid during a real time quantitative polymerase chain reaction process using a universal detection system. The detection system uses an unlabeled probe that detects the amplified target nucleic acid and interacts with a universal detection module. | 06-09-2011 |
| 20110086429 | METHODS AND DEVICES FOR DETECTING OZONE AND CARBONYL-CONTAINING COMPOUNDS - Methods and devices are provided for detecting the presence of both ozone and carbonyl-containing compounds in air samples. Method and device for detecting the presence of ozone and carbonyl-containing compounds in an air sample, the method comprising: (a) contacting an air sample with an ozone-reactive adsorbent wherein if ozone is present in the air sample, the ozone reacts with the ozone-reactive adsorbent to form an aldehyde product; (b) contacting the air sample from Step (a) further with a carbonyl-reactive adsorbent wherein if a carbonyl-containing compound is present in the air sample, the carbonyl-containing compound reacts with the carbonyl-reactive adsorbent to form a first hydrazone product; (c) eluting with a solvent from the carbonyl-reactive adsorbent into the ozone-reactive adsorbent, wherein any aldehyde product of step (a) forms a second hydrazone product; and (d) analyzing eluate from Step (c) for presence of hydrazone products formed in Step (b) and Step (c). | 04-14-2011 |
| 20110054146 | Preparation of Low Molecular Weight Polylysine and Polyornithine in High Yield - The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons. In preferred embodiments, the polymer is a homopolymer of poly-L-lysine. | 03-03-2011 |
| 20110036975 | IMIDAZOLIUM-BASED LIQUID SALTS AND METHODS OF USE THEREOF - Imidazolium-based dicationic liquid salts and methods of using such imidazolium-based dicationic liquid salts in techniques such as ESI-MS are provided. | 02-17-2011 |
| 20110030072 | GENOME EDITING OF IMMUNODEFICIENCY GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding immunodeficiency proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding immunodeficiency proteins. | 02-03-2011 |
| 20110023159 | OVINE GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified ovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the ovine genome. | 01-27-2011 |
| 20110023158 | BOVINE GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified bovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the bovine genome. | 01-27-2011 |
| 20110023157 | EQUINE GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified equine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the equine genome. | 01-27-2011 |
| 20110023156 | FELINE GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified feline or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the feline genome. | 01-27-2011 |
| 20110023154 | SILKWORM GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified silkworm or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the silkworm genome. | 01-27-2011 |
| 20110023153 | GENOMIC EDITING OF GENES INVOLVED IN ALZHEIMER'S DISEASE - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with AD. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to study AD development and methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with AD. | 01-27-2011 |
| 20110023152 | GENOME EDITING OF COGNITION RELATED GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences associated with cognitive disorders. | 01-27-2011 |
| 20110023151 | GENOME EDITING OF ABC TRANSPORTERS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding ABC transporter proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding ABC transporter proteins. | 01-27-2011 |
| 20110023150 | GENOME EDITING OF GENES ASSOCIATED WITH SCHIZOPHRENIA IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences associated with schizophrenia. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence associated with schizophrenia and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences associated with schizophrenia. | 01-27-2011 |
| 20110023149 | GENOMIC EDITING OF GENES INVOLVED IN TUMOR SUPPRESSION IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence involved in tumor suppression and the nucleic acids encoding the zinc finger nucleases. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences involved in tumor suppression. | 01-27-2011 |
| 20110023148 | GENOME EDITING OF ADDICTION-RELATED GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with addiction disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequence encoding addiction-related proteins and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for addiction and withdrawal side effects and other effects. | 01-27-2011 |
| 20110023147 | GENOMIC EDITING OF PRION DISORDER-RELATED GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-27-2011 |
| 20110023146 | GENOMIC EDITING OF GENES INVOLVED IN SECRETASE-ASSOCIATED DISORDERS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with a secretase disorder. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-27-2011 |
| 20110023145 | GENOMIC EDITING OF GENES INVOLVED IN AUTISM SPECTRUM DISORDERS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with ASD. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to study ASD development and screen agents for assessing their effect on progression or symptoms of an ASD. | 01-27-2011 |
| 20110023144 | GENOMIC EDITING OF GENES INVOLVED IN AMYOTROPHYIC LATERAL SCLEROSIS DISEASE - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated ALS. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-27-2011 |
| 20110023143 | GENOMIC EDITING OF NEURODEVELOPMENTAL GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurodevelopmental disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-27-2011 |
| 20110023141 | GENOMIC EDITING OF GENES INVOLVED WITH PARKINSON'S DISEASE - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with Parkinson's disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to study PD development and screen agents for assessing their effect on progression or symptoms of PD. | 01-27-2011 |
| 20110023140 | RABBIT GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified rabbit or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the rabbit genome. | 01-27-2011 |
| 20110023139 | GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE - The present invention provides genetically modified animals and cells comprising edited chromosomal involved in cardiovascular disease. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. The invention also provides zinc finger nucleases that target chromosomal sequences involved in cardiovascular disease and the nucleic acids encoding said zinc finger nucleases. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-27-2011 |
| 20110017908 | DICATIONIC LIQUID SALTS AND METHODS OF USE THEREOF - Dicationic liquid salts and methods of using such dicationic liquid salts in techniques such as ESI-MS are provided. | 01-27-2011 |
| 20110016546 | PORCINE GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified porcine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the porcine genome. | 01-20-2011 |
| 20110016543 | GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. | 01-20-2011 |
| 20110016542 | CANINE GENOME EDITING WITH ZINC FINGER NUCLEASES - The present invention provides a genetically modified canine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger nuclease-mediated editing process. The disclosure also provides zinc finger nucleases that target specific chromosomal sequences in the canine genome. | 01-20-2011 |
| 20110016541 | GENOME EDITING OF SENSORY-RELATED GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with nociception or taste disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-20-2011 |
| 20110016540 | GENOME EDITING OF GENES ASSOCIATED WITH TRINUCLEOTIDE REPEAT EXPANSION DISORDERS IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with trinucleotide repeat expansion disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-20-2011 |
| 20110016539 | GENOME EDITING OF NEUROTRANSMISSION-RELATED GENES IN ANIMALS - The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurotransmission disorders. In particular, the animals or cells are generated using a zinc finger nuclease-mediated editing process. Also provided are methods of using the genetically modified animals or cells disclosed herein to screen agents for toxicity and other effects. | 01-20-2011 |
| 20100291688 | COMPOSITIONS AND METHODS FOR SOLID PHASE EXTRACTION OF LIPIDS - A composition, method and device for the preparation of biological samples for subsequent instrumental analyses, such as GC, GC-MS, LC and LC-MS analysis, using a solid phase extraction (SPE) process is described. Through SPE process alone or an integrated combination of protein precipitation, filtration, and SPE using a hydrophobic zirconia-coated chromatographic media, interfering compounds, such as proteins, glycerides and phosphate-containing compounds, are eliminated from the biological, food, environmental and biotechnology samples, affording an enhanced analyte response during the instrumental analysis. | 11-18-2010 |
| 20100291624 | COMPOSITIONS AND METHODS FOR IMPROVED GLYCOPROTEIN SIALYLATION - The present invention provides compositions and methods for the production of glycoproteins with enhanced sialylation. In particular, the invention provides cell lines comprising disrupted sialidase expression and methods of using the cell lines to produce glycoproteins with enhanced sialylation. | 11-18-2010 |
| 20100261350 | METHODS OF FORMING THIN METAL-CONTAINING FILMS BY CHEMICAL PHASE DEPOSITION - Methods of forming thin metal-containing films by chemical phase deposition, particularly atomic layer deposition (ALD) and chemical vapor deposition (CVD), are provided. The methods comprise delivering at least one organometallic precursor to a substrate, wherein the at least one precursor corresponds in structure to Formula (II); wherein: M is Ru, Fe or Os; R is Q-C | 10-14-2010 |
| 20100041045 | NUCLEIC ACID FLUORESCENT STAINS - The present invention provides fluorescent dye compounds and methods of using the compounds for the staining of nucleic acids including qPCR applications. In particular, the dye compounds comprise heterocyclic molecules with hydroxy alkyl and aromatic substituents, and the dye compounds form highly fluorescent complexes upon nucleic acid binding. | 02-18-2010 |
| 20090263871 | Methods and Compositions for Amplification of DNA - The invention provides an Enzyme Blend comprising a DNA polymerase and a DNA repair enzyme. Methods and kits for amplification of DNA that is damaged, undamaged, or suspected of being damaged are also provided. | 10-22-2009 |
| 20090092776 | Polysilazane Thermosetting Polymers for Use in Chromatographic Systems and Applications - This invention relates to an amorphous non-glassy ceramic composition that may be prepared by curing, calcining and/or pyrolyzing a precursor material comprising silicon, a Group III metal, a Group IVA metal, and/or a Group IVB metal. | 04-09-2009 |
| 20090023000 | Polysilazane Thermosetting Polymers for Use in Chromatographic Systems and Applications - This invention relates to an amorphous non-glassy ceramic composition that may be prepared by curing, calcining and/or pyrolyzing a precursor material comprising silicon, a Group III metal, a Group IVA metal, and/or a Group IVB metal. | 01-22-2009 |
| 20080275255 | Stabilized Borane-Tetrahydrofuran Complex - A stabilized borane-tetrahydrofuran complex is disclosed. Also disclosed are processes for the preparation of the borane-tetrahydrofuran complex and methods of storing and transporting the prepared complex. The borane-tetrahydrofuran complexes exhibit enhanced shelf life and increased self-accelerated decomposition temperatures. | 11-06-2008 |
