20140120108 | MUTANT PTP ALPHA GENE GROUP IN MALIGNANT TUMORS AND PRODUCTION METHOD - A group of mutant PTPαgenes in malignant tumor are provided, which are ΔPTPα245, ΔPTPα652 and ΔPTPα445 respectively. The mutation includes insertion of 95 new nucleotides after nucleotide at position 711, deletion of nucleotides at position 1015-1437, and deletion of nucleotides at position 1015-1437 accompanied by insertion of 340 nucleotides after coding exon at position 1681 and fusion of 26 new amino acids at C-terminal. The group of mutant PTPαgenes in different types of malignant tumor disclosed in the present application have not been reported all over the world so far. The detection method of using PTPαmutant genes is useful in exactly diagnosing malignant tumor, developing new anti-tumor drugs, and targeted treatment at molecular pathologic level. | 05-01-2014 |