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SECRETARY OF THE DEPTARTMENT OF HEALTH AND HUMAN SERVICES

ROCKVILLE, MD US

SECRETARY OF THE DEPTARTMENT OF HEALTH AND HUMAN SERVICES Patent applications
Patent application numberTitlePublished
20090247457NEUROTROPHIC COMPONENTS OF THE ADNF I COMPLEX - This invention relates to Activity Dependent Neurotrophic Factor I complex (ADNF I complex) and polypeptides of this complex, which produce their neurotrophic effects through multiple proteases intrinsic to the ADNF I complex. The invention also relates to pharmaceutical compositions comprising ADNF I complex polypeptides, as well as methods for reducing neuronal cell death in vitro and in vivo, methods for treating oxidative stress in a patient, methods for reducing a condition associated with fetal alcohol syndrome in a subject, and methods of enhancing learning and memory both pre- and post-natally, all of which methods use the ADNF I complex polypeptides of the invention.10-01-2009