Seattle Genectics, Inc.
|Seattle Genectics, Inc. Patent applications|
|Patent application number||Title||Published|
|20090111756||Monomethylvaline Compounds Having Phenylalanine Carboxy Modifications at the C-Terminus - Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.||04-30-2009|