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Seattle Genectics, Inc.

Seattle Genectics, Inc. Patent applications
Patent application numberTitlePublished
20090111756Monomethylvaline Compounds Having Phenylalanine Carboxy Modifications at the C-Terminus - Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.04-30-2009