SEATTLE CHILDREN'S RESEARCH INSTITUTE
SEATTLE CHILDREN'S RESEARCH INSTITUTE Patent applications | ||
Patent application number | Title | Published |
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20140275279 | CYSTEAMINE IN THE TREATMENT OF FIBROTIC DISEASE - Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ECM) deposition, interstitial fibroblasts, interstitial volume, expression of Collagen I mRNA and protein, expression of profibrotic cytokines and macrophage infiltration by Cysteamine treatment. | 09-18-2014 |
20120276074 | COUPLING ENDONUCLEASES WITH END-PROCESSING ENZYMES DRIVES HIGH EFFICIENCY GENE DISRUPTION - The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage. | 11-01-2012 |