| SANOFI-AVENTIS DEUTSCHLAND GMBH Patent applications |
| Patent application number | Title | Published |
|---|
| 20120136334 | Delivery of Two or More Medicaments Through a Single Dose Selection and Dispense Interface - An injection system for co-delivery of two medicaments ( | 05-31-2012 |
| 20120136318 | Drug Delivery Device with Retractable Needle - Drug delivery device, comprising a needle, which a distal end and a proximal end comprises an inner surface forming a channel, an outer surface, a first salient located on the outer surface. | 05-31-2012 |
| 20120136317 | DRUG DELIVERY DEVICE - The invention provides a drug delivery device for dispensing of a dose of a medicinal product, comprising:
| 05-31-2012 |
| 20120136316 | Medicated Module With User Selection - A medicated module ( | 05-31-2012 |
| 20120132201 | Medical Device Comprising Mechanical-Electrical Transducing Means - The present invention relates to a medical device for administering a dose of a medicament to a user, comprising:
| 05-31-2012 |
| 20120130316 | Drug Delivery Device - The present invention relates to a drug delivery comprising a housing ( | 05-24-2012 |
| 20120125951 | Delivery of Two or More Medicaments Through a Single Dose Selection and Single Dispense Interface - A injection system for co-delivery of two medicaments ( | 05-24-2012 |
| 20120123351 | Needle Assembly - A needle assembly ( | 05-17-2012 |
| 20120123347 | Medication Delivery Device - A medication delivery device comprises a housing ( | 05-17-2012 |
| 20120123346 | MEDICATED MODULE WITH NEEDLE GUARD - A medicated module comprising a connecting body configured for attachment to a drug delivery device. A first needle is fixed within the connecting body and an outer body operatively coupled to the connecting body. A needle guard operatively coupled to the outer body and a biasing member positioned between the outer body and needle guard. A second needle fixed within the outer body and a recess within the connecting body defines a reservoir. The reservoir contains at least one dose of a medicament and is configured for fluid communication with the first and second needle. | 05-17-2012 |
| 20120118139 | DUAL-CHAMBER CARPULE - The invention relates to a dual-chamber carpule having a first partial cylinder comprising a sealing cap, a bypass, and an intermediate stopper, an optional sealing element, and a second partial cylinder comprising an end stopper and, optionally, a stop, an axial groove, and an additional intermediate stopper; the invention further relates to a method for producing and filling said dual-chamber carpule. | 05-17-2012 |
| 20120116349 | Medicated Module with Premix Medicament - A medicated module ( | 05-10-2012 |
| 20120116320 | Drug Delivery Device - Drug delivery device, comprising a body unit having a first opening and a second opening, a plunger arranged such that its distal end is positioned inside the body unit, wherein the plunger is moveable in the distal direction with respect to the body unit, a needle assembly, with a proximal end and a distal end comprising a needle, wherein the proximal end of the needle assembly and the distal end of the plunger are configured such that they can get into a vacuum connection. | 05-10-2012 |
| 20120116311 | Medical Injection Device with Electric Motor Drive Control - This invention relates to an injection device for delivering a medicament to the human or animal body, in particular, but not exclusively, to a device having a replaceable medicament cartridge, including an auto-injector,
| 05-10-2012 |
| 20120116306 | NEEDLE UNIT - A needle unit for a drug delivery device, wherein the needle unit comprises a needle which is retractable into the drug delivery device from a starting position to an end position and a needle retainer having a stop member. The stop member is configured to prevent a re-exposure of the needle when the needle has been retracted into the drug delivery device. | 05-10-2012 |
| 20120116196 | Medical Device and Method for Glycemic Control - A medical device and method for determining a dose of insulin to be administered for glycemic control is provided, wherein the dose is stepwise adapted, comprising determining a blood glucose value, receiving glycemic event information in respect to a predetermined glycemic event, wherein the predetermined glycemic event occurred within a predetermined time interval, receiving a previously adapted dose value stored in a storage unit, and setting an alert based on at least the blood glucose value, the glycemic event information and the previously adapted dose, wherein the alert indicates that the blood glucose value and the predetermined glycemic event are not in a specified relation to the previously adapted dose value. | 05-10-2012 |
| 20120109687 | Medical System and Method for Providing Information for Glycemic Control - A medical device and a method for configuring a process for determining a dose of insulin to be administered for glycemic control is provided, wherein the dose is stepwise adapted, comprising defining different dose adjustment profiles for stepwise adapting the dose, wherein each of the different dose adjustment profiles is based at least on a specific initial dose value, a specific time interval for increasing the dose, a specific dose increase step and a specific low blood glucose threshold value, storing the different dose adjustment profiles, selecting one of the stored different dose adjustment profiles based on specific requirements for stepwise adapting the dose, and personalising the selected dose adjustment profile by defining at least a specific target blood glucose value for a specific user. | 05-03-2012 |
| 20120109075 | MEDICAL DEVICE - The medical device comprises a wave spring or wave washer in a mechanism to engage or disengage a first element and a second element. The invention also discloses the use of a multiple wave spring or wave washer comprising at least two waved spring layers in a medical device. | 05-03-2012 |
| 20120109074 | DRUG DELIVERY DEVICE WITH AN IMPROVED PISTON ROD - An improved drug delivery device is provided having a piston rod that incorporates on its proximal end at least one guidepost that is configured for transmitting axial and rotational forces from a drive mechanism. The device comprises a drug delivery device housing and a medicament contained in the drug delivery device housing. | 05-03-2012 |
| 20120103329 | Trigger Mechanism for a Drug Delivery Device - The invention relates to a trigger mechanism for a drug delivery device comprising at least one energy storing element, an actuation element and a series of cascaded trigger elements. The trigger elements are pre-stressed with increasing pre-stressing and coupled to the at least one energy storing element such that the trigger elements, upon exerting a sufficient actuation force (Fa, U) on the actuation element, cause a cascaded release of increasing portions of energy stored in the at least one energy storing device. At least one of the trigger elements is equipped with a latch element directly coupling at least two trigger elements such that the latch element restrains at least one of these trigger elements to its pre-stressed state before exerting the actuation force (Fa, U). | 05-03-2012 |
| 20120103328 | Dose Setting Element for a Drug Delivery Device and Drug Delivery Device with Dose Setting Element - The invention relates to a dose setting mechanism ( | 05-03-2012 |
| 20120101452 | DRUG DELIVERY DEVICE - A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. The device is constructed in such a manner that a reset of the piston rod is facilitated. | 04-26-2012 |
| 20120101446 | SYRINGE, AUTO-INJECTOR DEVICE AND SET OF AUTO-INJECTOR DEVICES AND SYRINGES - A syringe comprising a first coding feature for mechanical interaction with a second coding feature of an auto-injector device is provided. The first coding feature is designed such that the syringe is only mountable in an auto-injector device having a second coding feature mating the first coding feature. Furthermore, an auto-injector device having a housing, wherein a syringe can be mounted, and a set of at least two auto-injector devices and syringes are provided. | 04-26-2012 |
| 20120101445 | Medicament Identification System for Multi-Dose Injection Devices - An identification system for a multi-dose pen-type injection device includes an elastic band that is associated with a specific medicament can be placed around the outside of the device to allow a user to readily identify the medicament contained within the device. Alternatively, a pocket clip with a unique structural design is used as the medicament identifier. | 04-26-2012 |
| 20120101444 | Medical Delivery Device - A medication delivery device comprises display means ( | 04-26-2012 |
| 20120095438 | MEDICATION DELIVERY DEVICE WITH FOLDABLE FINGER PAD - A medication delivery device is configured to deliver medication when a button element is moved, the medication delivery device having a folding finger pad. | 04-19-2012 |
| 20120095414 | DRUG DELIVERY DEVICE - Drug delivery device, comprising a body unit having a first opening and a second opening, a plunger arranged such that its distal end is positioned inside the body unit, wherein the plunger is moveable in the distal direction with respect to the body unit, a needle assembly, with a proximal end and a distal end comprising a needle, wherein the proximal end of the needle assembly and the distal end of the plunger are configured such that they can get into an adhesion connection. | 04-19-2012 |
| 20120095413 | Drive Mechanism for a Medication Delivery Device and Medication Delivery Device - A drive mechanism for a medication delivery device ( | 04-19-2012 |
| 20120095412 | INJECTION DEVICE WITH HOLDING MEANS TO PREVENT UNINTENTIONAL MOVEMENTS OF PISTON ROD - The invention relates to a injection device, comprising a housing being adapted to receive in its proximal housing portion a container with an injection fluid and to receive in its distal housing portion a dose setting and injection mechanism, wherein the mechanism includes a piston rod being axially displaceable with respect to the housing for dispensing injection fluid from the container, wherein the piston rod has an outer thread and is arranged torque proof with respect to the housing, dose setting means comprising a threaded element, which threaded element has an inner thread being in engagement with the outer thread of the piston rod, is designed so that its axial position relative to the housing is changeable and is rotatable relative to the piston rod and relative to the housing during setting of an injection dose, wherein the dose setting means are designed such that the threaded element is held in torque proof manner relative to the piston rod and to the housing during the injection of the beforehand set injection dose in such a manner that the threaded element and the piston rod are axially displaceable together with respect to the housing, wherein the mechanism further comprises holding means being in contact with the piston rod and being designed such that the axial displacement of the piston rod can be substantially immobilized during use of the device except for the dispensing of the injection dose. It is proposed according to the invention that the holding means are axially fixed with respect to the housing. | 04-19-2012 |
| 20120095411 | DRUG DELIVERY DEVICE - A drug delivery device comprises an outer housing rollable around a rotation axis and at least one stop member. The stop member protrudes radially from the outer housing of the drug delivery device and is configured to prevent rolling movement of the drug delivery device along a predetermined surface. The outer housing comprises a main housing and a dose member. The dose member is movable with respect to the main housing when setting and/or delivering a dose of a drug. The stop member comprises a first part and a second part, wherein the first part is arranged on the main housing and the second part is arranged on the dose member. | 04-19-2012 |
| 20120095409 | SEAL MEMBER - A seal member is configured to seal a chamber of a drug delivery device which is suitable to contain a drug, wherein the seal member comprises a diaphragm. | 04-19-2012 |
| 20120089099 | SPRING ELEMENT FOR A DRUG DELIVERY DEVICE, USE THEREOF AND DRUG DELIVERY DEVICE - A spring element for a drug delivery device is proposed, the spring element comprising multiple windings with two windings being mechanically coupled to each other by a rigid transverse connection. Furthermore, a drug delivery device comprising such a spring element and using such a spring element in a drug delivery device are proposed. | 04-12-2012 |
| 20120089097 | MOUNTING ARRANGEMENT AND COUPLING ASSEMBLY FOR A DRUG-DELIVERY DEVICE - A mounting arrangement for a drug-delivery device is proposed, the mounting arrangement comprising: a plug element with a longitudinal axis (L) and a housing part having a recess with a side wall which is adapted to receive the plug element. At least one of the plug element or the side wall of the recess are provided with a protrusion for fixing the plug element in a given position relative to the housing part by a force-fit engagement. Furthermore, a coupling assembly is proposed, the coupling assembly comprising the plug element and the housing part being mechanically coupled to each other. | 04-12-2012 |
| 20120083748 | DRUG DELIVERY DEVICE - A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. The device is constructed in such a manner that a reset of the piston rod is facilitated by a stop element inhibiting a reversal of the movement of the piston rod when being reset. | 04-05-2012 |
| 20120083745 | DRIVE ASSEMBLY SUITABLE FOR USE IN A MEDICATION DELIVERY DEVICE AND MEDICATION DELIVERY DEVICE - A drive assembly for use in a medication delivery device is provided for, which comprises a housing having a proximal end and a distal end, a drive member moveable in the proximal direction with respect to the housing for setting a dose of the medication to be delivered and in the distal direction with respect to the housing for delivering the dose, a piston rod adapted to be driven by the drive member in the distal direction with respect to the housing during movement of the drive member in the distal direction for delivering the dose and a restriction member for restricting proximal movement of the piston rod with respect to the housing during proximal movement of the drive member by mechanical interaction of the restriction member with a stop feature of the piston rod, wherein the restriction member and the stop feature are arranged for the piston rod to be moved proximally a first distance during a first proximal movement of the drive member before the restriction member and the stop feature interact mechanically, wherein the first distance which the piston rod moves proximally during the first proximal movement of the drive member is larger than a subsequent distance which the piston rod moves proximally during a subsequent proximal movement of the drive member. | 04-05-2012 |
| 20120078195 | DRUG DELIVERY DEVICE BODY - The body of a portable drug delivery device, especially an injection pen, is provided on its outer surface with a recess, in which directly accessible information is displayed. The information is protected against damages during everyday use by the recessed location. | 03-29-2012 |
| 20120078171 | DUAL-CHAMBER CARPULE WITH ATTACHMENT - The invention relates to a dual-chamber carpule comprising a cylinder comprising a bypass, a central plug and an end plug, and an attachment; the invention further relates to a method for producing and filling said dual-chamber carpule. | 03-29-2012 |
| 20120071836 | DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE - The present invention relates to a drive mechanism for a drug delivery device as well as to a drug delivery device for dispensing of a dose of a medicinal product, wherein the drive mechanism comprises: | 03-22-2012 |
| 20120071834 | METHOD OF MANUFACTURING A DRUG DELIVERY DEVICE BODY - The invention relates to a method for manufacturing a drug delivery device body comprising the following steps:
| 03-22-2012 |
| 20120071819 | MEDICAMENT DELIVERY DEVICES - A medicament delivery device comprises a housing, a holder within the housing for receiving a medicament cartridge, a piston rod for driving a bung of the medicament cartridge, a drive mechanism including a motor for providing an output drive to the piston rod for delivering the medicament and control means for controlling operation of the device. The device is additionally provided with a bung sensor for sensing when the piston rod is in contact with the bung and the control means is operative for advancing the drive of the piston rod towards the bung. | 03-22-2012 |
| 20120071520 | CRYSTALLINE PHASES OF 2'--BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE - The present invention relates to polymorphic forms and solvates of 2′-{[2-(4-methoxy-phenyl)-acetylamino]-methyl]}-biphenyl-2-carboxylic acid (2-pyhdin-3-yl-ethyl)-amide, processes for their preparation and their use, in particular for the preparation of medicaments. | 03-22-2012 |
| 20120066042 | METHOD OF COLLECTION OF INFORMATION ON AWARENESS OF CONSUMERS AND/OR USERS WITH RESPECT TO A GOOD OR SERVICE - The utility model relates to methods of marketing and social researches, while informing consumers and/or users in respect of a specific product or service with using telecommunications devices of communication. | 03-15-2012 |
| 20120066027 | METHOD OF DISSEMINATION OF INFORMATION ABOUT A PRODUCT OR SERVICE TO IMPROVE AWARENESS OF CONSUMERS AND/OR USERS - The utility model relates to methods of marketing and social researches, while informing consumers and/or users in respect of a specific product or service with using telecommunications devices of communication. | 03-15-2012 |
| 20120065894 | MEDICAL SYSTEM AND METHOD FOR PROVIDING GLYCEMIC CONTROL BASED ON GLYCEMIC RESPONSE INFORMATION - A medical device for providing information for glycemic control is provided, wherein the device comprises a storage unit arranged to store information on an initial dose of insulin and to store information on a blood glucose level measured after the initial dose of insulin was administered and after specific food was consumed, and a determining unit arranged to determine a subsequent dose of insulin to be administered before the specific food is consumed based at least on said information on the initial dose of insulin and said information on the blood glucose level. | 03-15-2012 |
| 20120046643 | INJECTION DEVICE - An injection device ( | 02-23-2012 |
| 20120046613 | Drug Delivery Device with Piston Rod Carrying Dose Markings - The present invention relates to a drug delivery ( | 02-23-2012 |
| 20120041387 | Medicament Delivery Devices - A medicament delivery device ( | 02-16-2012 |
| 20120041379 | Cartridge and Medication Delivery Device - A single-use cartridge for a medication delivery device, comprises a body element ( | 02-16-2012 |
| 20120041364 | INTERLOCK MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE - The invention refers to an interlock mechanism for restricting a rotational movement of a rotatable component ( | 02-16-2012 |
| 20120029442 | DRUG DELIVERY DEVICE - The present invention relates to drug delivery devices. The drug delivery device according to the invention includes a housing with a needle holder suitable for attaching a needle unit to the housing at the distal end, and a cap being capable of covering the distal end of the drug delivery device and comprising a retaining member capable of securing the cap by engaging with the housing, the retaining member is prevented from engaging with the housing with the needle unit being attached to the needle holder. Furthermore, using a cap for covering the distal end of the drug delivery device is disclosed. | 02-02-2012 |
| 20120029440 | APPARATUS FOR HOLDING A COVER OF A NEEDLE UNIT AND METHOD - An apparatus comprises a recess configured to hold an outer cover of a needle packaging for providing a needle unit. The outer cover is suitable to cover at least a part of a needle unit for a medication delivery device. | 02-02-2012 |
| 20120022462 | DRUG DELIVERY DEVICE - A drug delivery device ( | 01-26-2012 |
| 20120021978 | COMBINATION OF AN INSULIN AND A GLP-1-AGONIST - The invention relates to a drug comprising at least one insulin and at least one GLP-1 receptor agonist. | 01-26-2012 |
| 20120015335 | DEVICE FOR SIMULATING THE OPERATION OF A MEDICATION DELIVERY DEVICE - A simulation device for simulating the operation of a medication delivery device comprises a housing ( | 01-19-2012 |
| 20120010576 | DRIVE ASSEMBLY AND MEDICATION DELIVERY DEVICE - A drive assembly suitable for a medication delivery device comprises a housing, a drive member, a piston rod, a rotation sleeve, a guide member and a biasing member. The rotation sleeve is arranged to be displaced in a distal direction when the drive member is displaced in the distal direction by mechanical interaction of the drive member and the rotation sleeve with the rotation sleeve and the drive member both being guided axially by the at guide member. The biasing member exerts a force on the rotation sleeve acting in the proximal direction, said force being transformed into a rotational movement of the rotation sleeve. The rotational movement of the rotation sleeve being transformed into a rotational movement of the piston rod. | 01-12-2012 |
| 20120010575 | DRIVE ASSEMBLY SUITABLE FOR USE IN A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE - A drive assembly for use in a drug delivery device is proposed, the drive assembly comprising: a housing having a proximal end and a distal end; an axis extending between the proximal end and the distal end; at least one drive member; a piston rod adapted to be driven along the axis by the drive member; an indicator adapted to provide positional information about a position of the piston rod relative to the proximal end, wherein the indicator and the piston rod are configured to convert a movement of the piston rod with respect to the housing into a rotational movement of the indicator. Additionally, a drug delivery device comprising the drive assembly is provided for. | 01-12-2012 |
| 20120010568 | MOTOR MECHANISM FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE - The invention refers to a motor mechanism ( | 01-12-2012 |
| 20110319831 | PROTECTION ASSEMBLY - A protection assembly is disclosed that combines a cover to preserve sterility of a sharp instrument with a trap to prevent accidental sticks where in one embodiment the cover is detached from the protection assembly and disposed and in another embodiment the cover is permanently attached to the protection assembly. | 12-29-2011 |
| 20110306947 | MEDICATION DELIVERY DEVICE AND METHOD FOR OPERATING A MEDICATION DELIVERY DEVICE - A medication delivery device comprises a housing having a proximal end (P) and a distal end (D), a cartridge for holding a medication (M), the cartridge having an outlet, a moveable piston being retained within the cartridge, a drive member moveable in a proximal direction with respect to the housing for setting a dose of medication (M) to be delivered and in the distal direction with respect to the housing for delivering the dose and a piston rod adapted to drive the piston in a distal direction with respect to the cartridge for delivering the dose. The drive member is releasably coupled to the piston rod. The medication delivery device further comprises a resilient member which is arranged to move the drive member in the proximal direction with respect to the housing after dose delivery, thereby reducing pressure of the piston rod on the piston. | 12-15-2011 |
| 20110306939 | DRUG DELIVERY DEVICE AND METHOD OF MANUFACTURING A DRUG DELIVERY DEVICE - The present invention relates to drug delivery device and a and method of manufacturing a drug delivery device with a housing having a proximal end and a distal end, a cartridge adapted to accommodate a drug, a cartridge retaining member adapted to retain the cartridge, the cartridge retaining member being secured to the housing, and a spring washer being arranged within the housing so as to exerting a force on the cartridge and securing the cartridge against movement with respect to the cartridge retaining member and against movement with respect to the housing. | 12-15-2011 |
| 20110306670 | PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS OR DIAGNOSTIC AIDS, AND MEDICAMENTS COMPRISING THEM - Pentafluorosulfanylbenzoylguanidines of the formula I and II | 12-15-2011 |
| 20110306656 | Biologically tolerated low molecular weight polyethylenimines - The invention relates to low molecular weight polyethylenimines, to vectors for inserting nucleic acids into cells which contain low molecular weight polyethylenimines, and to the preparation and use of the low molecular weight polyethylenimine and the vector. | 12-15-2011 |
| 20110276009 | Drive Mechanisms Suitable for Use in Drug Delivery Devices - A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. The drive mechanism may include a housing, a dose dial sleeve, and a drive sleeve. A clutch is configured to permit rotation of the drive sleeve and the dose dial sleeve with respect to the housing when the dose dial sleeve and drive sleeve are coupled through the clutch. Conversely, when the dose dial sleeve and drive sleeve are in a de-coupled state, rotation of the dose dial sleeve with respect to the housing is permitted and rotation of the drive sleeve with respect to the housing is prevented. In the de-coupled state, axial movement of the drive sleeve transfers force in a longitudinal direction for actuation of a drug delivery device. | 11-10-2011 |
| 20110276008 | NEEDLE ASSEMBLY AND MEDICATION DELIVERY SYSTEM - A needle assembly has distal and proximal ends. The needle assembly comprises a body element having distal and proximal ends, an attachment means configured to be attached to a medication delivery device, a button element which is movable from a first position to a second position, and a needle configured to move to the distal direction, when the button element is moved from the first position to the second position. | 11-10-2011 |
| 20110276006 | Medication Delivery Device and Method of Assembling a Medication Delivery Device - A medication delivery device ( | 11-10-2011 |
| 20110245486 | METHOD FOR THE PRODUCTION OF 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES - The invention relates to a method for producing 1,4-benzothiepin-1,1-dioxide derivatives substituted with benzyl groups. | 10-06-2011 |
| 20110224640 | CARTRIDGE AND NEEDLE SYSTEM THEREFOR - The invention refers to a cartridge ( | 09-15-2011 |
| 20110223628 | METHOD FOR THE IDENTIFICATION OF A RISK FOR A THROMBOGENIC DISORDER BY DETERMINING THE TAFl-lle347 POLYMORPHISM - The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism. | 09-15-2011 |
| 20110184177 | CXCR2 INHIBITORS - The invention relates to compounds of the formula I: | 07-28-2011 |
| 20110173722 | NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE - The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof. | 07-14-2011 |
| 20110118180 | METHOD OF TREATMENT OF DIABETES TYPE 2 COMPRISING ADD-ON THERAPY TO METFORMIN - A method for the treatment of diabetes mellitus type 2 comprising administering
| 05-19-2011 |
| 20110118178 | METHOD OF TREATMENT OF DIABETES TYPE 2 COMPRISING ADD-ON THERAPY TO INSULIN GLARGINE AND METFORMIN - A method for the treatment of diabetes mellitus type 2 comprising administering
| 05-19-2011 |
| 20110117569 | POLYMIDE NUCLEIC ACID DERIVATIVES, AND AGENTS AND PROCESSES FOR PREPARING THEM - The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents. | 05-19-2011 |
| 20110105405 | METHOD FOR ALLEVIATING PAIN USING PROTEIN ASSOCIATED WITH MYC AND RELATED COMPOUNDS, AND ASSAYS FOR IDENTIFYING SUCH COMPOUNDS - Use of PAM or functional fragments or derivatives thereof for the preparation of pharmaceutical compounds. | 05-05-2011 |
| 20110104704 | ASSOCIATION OF EDG5 POLYMORPHISM V286A WITH TYPE II DIABETES MELLITUS AND VENOUS THROMBOSIS/PULMONARY EMBOLISM AND THE USE THEREOF - The present invention relates to a method of identifying an increase in risk for type II Diabetes mellitus, venous thrombosis, or pulmonary embolism in a subject, wherein the presence of an amino acid exchange at position 286 from valine (Val) to alanine (Ala) in the EDG5 protein in a biological sample taken from the subject. | 05-05-2011 |
| 20110077197 | NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE - The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4. | 03-31-2011 |
| 20110060274 | TWO-CHAMBER INJECTION DEVICE HAVING GAS-PERMEABLE MEMBRANE - The invention relates to a two-chamber syringe device comprising a cylinder element ( | 03-10-2011 |
| 20110021505 | Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain - The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, | 01-27-2011 |
| 20110021462 | SUBSTITUTED TETRAHYDRO-2H-ISOQUINOLIN-1-ONE DERIVATIVES, AND METHODS FOR THE PRODUCTION AND USE THEREOF - This invention relates to compounds according to the general formula (I), where the definitions of the substituents R1, R2, Ar and X are as specified in the description, and to their physiologically tolerated salts, methods for the preparation of these compounds and their use as medicaments. | 01-27-2011 |
| 20110015576 | MEDICAMENT IDENTIFICATION SYSTEM FOR MULTI-DOSE INJECTION DEVICES - A dynamic identification system for a multi-dose injection device includes a dose dial sleeve containing indicia of the medicament contained within the device becomes visible or available to the olfactory or gustation senses only during dose setting as the dial sleeve is translated proximally out of the outer housing of the device. A user can readily identify the medicament contained within the device as the dose is being set. A static identifier located on the device that matches the dynamic identifier on the dial sleeve can also be used as a medicament identifier. | 01-20-2011 |
| 20110015400 | PROCESS FOR THE PREPARATION OF TRYPTASE INHIBITORS - This invention is directed to processes for the preparation of a compound of the formula I or salt thereof, | 01-20-2011 |
| 20110004191 | DOSING MECHANISM FOR A DRUG DELIVER DEVICE - A maximum settable dose feature is disclosed that is set by a user or health care professional one time that prevents future injections from exceeding the desired maximum dose. The feature includes a locking band initially in an unlocked configuration, which transforms to a locked configuration when activated after setting a desired maximum dose. The feature can include a trigger mechanism to transform the locking band to the locked configuration. | 01-06-2011 |
| 20100331806 | DRIVE MECHANISM FOR A DRUG DELIVERY DEVICE - A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove. The inner housing guides a driver having either a blocking or locking member disposed inside the driver that can lock a flexible tab to an internal groove during dose delivery in the inner housing such that the driver follows the path of the groove and to advance a spindle to move a cartridge bung. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. | 12-30-2010 |
| 20100331792 | DRUG DELIVERY DEVICE INNER HOUSING HAVING HELICAL SPLINE - A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing. | 12-30-2010 |
| 20100331791 | DRUG DELIVERY DEVICE WITH DOSE DIAL SLEEVE ROTATIONAL STOP - A method and system for a dose setting mechanism of a drug delivery device. The dose setting mechanism includes an inner housing having a helical groove along an external surface of the housing. The inner housing includes a rotational stop feature near one end of the helical groove. The dose setting mechanism also includes a dial sleeve rotatably engaged with the helical groove of the inner housing. When a user rotates the dial sleeve to select a dose, the rotational stop member prevents the user from selecting a dose greater than a pre-defined maximum selectable dose. | 12-30-2010 |
| 20100331790 | SPINDLE FOR A DRUG DELIVERY DEVICE - A spindle for driving a bung of a cartridge. The spindle includes a generally circular shaft having an outer surface. The generally circular shaft extends from a distal end to a proximal end of said circular shaft. A first helical groove is provided along a first portion of the outer surface. The first helical groove having a first pitch. A second helical groove provided along a second portion of the outer surface of the generally circular shaft. The second helical groove overlapping the first helical groove. The second helical groove having a second pitch. | 12-30-2010 |
| 20100331789 | DOSE SETTING MECHANISM FOR PRIMING A DRUG DELIVERY DEVICE - A method and system for priming a drug delivery device. The drug delivery device includes a forced priming feature that requires the user to move the dose dial sleeve axially to cause the spindle to pre-load a cartridge bung before a first dose can be dialed. | 12-30-2010 |
| 20100331788 | RESETTABLE DRUG DELIVERY DEVICE - A resetting mechanism for a reusable drug delivery device. The device comprises a spindle and a spindle guide engaging the spindle. During a resetting step of the resetting mechanism, the spindle rotates while the spindle guide does not rotate. | 12-30-2010 |
| 20100331786 | SPINDLE AND BEARING COMBINATION AND DRUG DELIVERY DEVICE - An improved spindle and bearing combination for a drug delivery device is provided that has a first connection between the spindle and bearing comprising a web and a second connection that replaces the first connection when the web is severed that allows the spindle to rotate relative to the bearing. | 12-30-2010 |
| 20100324528 | DOSE SETTING MECHANISM FOR PRIMING A DRUG DELIVERY DEVICE - A method and system for priming a drug delivery device. The drug delivery device includes a dose dial sleeve and an internal housing portion. The dose dial sleeve is coupled to the internal housing. The dose dial sleeve rotates on a substantially circumferential rotational path during priming of the drug delivery device. Further, the dose dial sleeve rotates on a helical path during dose setting of the drug delivery device. | 12-23-2010 |
| 20100324527 | DRUG DELIVERY DOSE SETTING MECHANISM WITH VARIABLE MAXIMUM DOSE - A method and system for proving a drug delivery device having a variable dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first and second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device. | 12-23-2010 |
| 20100324497 | BIASING MECHANISM FOR A DRUG DELIVERY DEVICE - A method and system for biasing a cartridge in a drug delivery device. An element for biasing a cartridge in a cartridge housing of a drug delivery device is provided. This non-plastic element does not comprise a coil spring. A self retained element for providing a spring bias to a cartridge in a cartridge holder of a drug delivery device comprises a first member having a shape that allows passage of a spindle of the drug delivery device. A portion of the first member is self retained by an internal surface of the drug delivery device. The self retained element biases the cartridge against an inner surface of the cartridge holder. This cartridge could be a removable cartridge. | 12-23-2010 |
| 20100324496 | DOSE SETTING MECHANISM FOR PRIMING A DRUG DELIVERY DEVICE - A method and system for providing a drug delivery device. The drug delivery device comprises a dose setting mechanism comprising a spindle and a cartridge holder coupled to the dose setting mechanism. The cartridge holder comprising a cartridge having a movable bung at one end of the cartridge. The cartridge holder must be rotated before a dose may set with the dose setting mechanism. | 12-23-2010 |
| 20100324495 | RESETTABLE DRUG DELIVERY DEVICE - A resettable dosing mechanism comprises a dose button and a dial grip operatively coupled to the dose button. A spindle acts on a bung of a cartridge and a driver is operatively coupled between the dose button and the spindle. During an injection of the dose, the dose button moves in an axial direction to cause the spindle to administer the dose. During resetting of the dose setting mechanism, the spindle is retracted back into the dose setting mechanism. | 12-23-2010 |
| 20100324494 | DRUG DELIVERY DEVICE LAST DOSE LOCK-OUT MECHANISM - A method and system for limiting a maximum dose that may be set in a drug delivery device. A dose setting mechanism, which is operable to be coupled to a medication cartridge, comprises a lock-out mechanism that prevents one from setting a dose greater than the medication in the cartridge. The lock-out mechanism comprises a rotatable shaft. A helical groove having a first pitch is provided along a first portion of the rotatable shaft and a second pitch provided along a second portion of the rotatable shaft. The first pitch is different from the second pitch. A third pitch may be provided on a third portion of the shaft. This third pitch is provided at the end of the second pitch and is preferably different than the second pitch. The lock-out mechanism further comprises a non-rotating member disposed on the helical groove of said shaft. During dose setting, the shaft is rotated relative to the non-rotating member while the non-rotating member traverses along the groove from a proximal end of the shaft towards a distal end of the shaft. | 12-23-2010 |
| 20100324493 | Inner housing for a drug delivery device - A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove. The inner housing guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing. | 12-23-2010 |
| 20100311112 | METHOD FOR AMIDATING POLYPEPTIDES WITH BASIC AMINO ACID C-TERMINALS BY MEANS OF SPECIFIC ENDOPROTEASES - The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry. | 12-09-2010 |
| 20100298378 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT - The invention relates to aryl-substituted polycyclic amines of formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; | 11-25-2010 |
| 20100274186 | DUAL-CHAMBER CARPULE WITH ATTACHMENT - The invention relates to a dual-chamber carpule comprising a cylinder ( | 10-28-2010 |
| 20100262074 | DUAL-CHAMBER CARPULE - The invention relates to a dual-chamber carpule having ( | 10-14-2010 |
| 20100261664 | Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof - Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof | 10-14-2010 |
| 20100221738 | METHOD OF DIAGNOSIS OF A PREDISPOSITION TO DEVELOP THROMBOTIC DISEASE AND ITS USES - The present invention refers to a method of diagnosis of a predisposition to develop thrombotic disease, to test systems and their use for the diagnosis of a predisposition to develop thrombotic disease, to a P | 09-02-2010 |
| 20100221714 | ANALYSIS AND USE OF PAR1 POLYMORPHISMS FOR EVALUATING THE RISK OF CARDIOVASCULAR DISEASE - The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis. | 09-02-2010 |
| 20100216692 | Acidic Insulin Preparations Having Improved Stability - The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and combinations thereof; a surfactant or combinations of two or more surfactants; optionally a preservative or combinations of two or more preservatives; and optionally an isotonicizing agent, buffers or further excipients or combinations thereof, the pharmaceutical formulation having a pH in the acidic range. | 08-26-2010 |
| 20100203617 | USE OF SACCHAROMYCES CEREVISIAE ERG4 MUTANTS FOR EXPRESSING MAMMALIAN GLUCOSE TRANSPORTERS - The invention relates to yeast strains in which a human GLUT4 transport or a human GLUT1 transporter can be functionally expressed and to particular GLUT4 transport proteins which can be functionally expressed particularly readily in yeast strains. | 08-12-2010 |
| 20100196953 | CLEAVAGE OF PRECURSORS OF INSULINS BY A VARIANT OF TRYPSIN - The present invention relates to the production of a variant of recombinant trypsin with increased substrate specificity for arginine versus lysine in non-animal host organisms. Moreover, the present invention relates to a variant of recombinant trypsin and their production. Also provided are use of recombinant porcine pancreatic trypsin variants for cleavage of precursors of insulins, and kits containing the variant of trypsin. | 08-05-2010 |
| 20100183712 | ACYLATED INDANYL AMINES AND THEIR USE AS PHARMACEUTICALS - The present invention relates to acylated indanyl amines according to the general formula (I) | 07-22-2010 |
| 20100168196 | N-Substituted (Benzoimidazol-2-yl)phenylamines, Processes for Their Preparation, Their Use as a Medicament or Diagnostic Aid, and a Medicament Comprising Them - This invention is directed to the compound of formula (I), compositions containing said compounds to inhibit the sodium-proton exchanger of subtype 3 (NHE3) which are useful in the prevention or treatment of various disorders in a patient suffering from a disease state, such as, renal disorders including acute or chronic renal failure, disorders of biliary function and for respiratory disorders such as snoring or sleep apnea or for stroke. | 07-01-2010 |
| 20100160282 | NOVEL DIPHENYLAZETIDINONES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS AND THEIR USE - Compounds of the formula I, | 06-24-2010 |
| 20100152672 | RESETTABLE DRIVE MECHANISM FOR A MEDICATION DELIVERY DEVICE AND MEDICATION DELIVERY DEVICE - A resettable drive mechanism for a medication delivery device is proposed, said mechanism comprising a housing ( | 06-17-2010 |
| 20100152671 | DRIVE MECHANISM FOR A MEDICATION DELIVERY DEVICE AND MEDICATION DELIVERY DEVICE - A drive mechanism for a medication delivery device ( | 06-17-2010 |
| 20100137792 | MEDICATION DELIVERY DEVICE AND METHOD FOR OPERATING A MEDICATION DELIVERY DEVICE - A medication delivery device ( | 06-03-2010 |
| 20100137791 | DRIVE ASSEMBLY SUITABLE FOR USE IN A MEDICATION DELIVERY DEVICE AN MEDICATION DELIVERY DEVICE - A drive assembly for use in a medication delivery device is provided for, which comprises a housing having a proximal end and a distal end, a drive member moveable in the proximal direction with respect to the housing for setting a dose of the medication to be delivered and in the distal direction with respect to the housing for delivering the dose, a piston rod adapted to be driven by the drive member in the distal direction with respect to the housing during movement of the drive member in the distal direction for delivering the dose and a restriction member for restricting proximal movement of the piston rod with respect to the housing during proximal movement of the drive member by mechanical interaction of the restriction member with a stop feature of the piston rod, wherein the restriction member and the stop feature are arranged for the piston rod to be moved proximally a first distance during a first proximal movement of the drive member before the restriction member and the stop feature interact mechanically, wherein the first distance which the piston rod moves proximally during the first proximal movement of the drive member is larger than a subsequent distance which the piston rod moves proximally during a subsequent proximal movement of the drive member. | 06-03-2010 |
| 20100137257 | METHOD FOR ALLEVIATING PAIN USING SPHINGOSINE-1-PHOSPHATE AND RELATED COMPOUNDS, AND ASSAYS FOR IDENTIFYING SUCH COMPOUNDS - Methods for alleviating pain comprising administering to a subject sphingosine-1-phosphate, functional fragments and derivatives thereof, and other compounds, and assays for identifying such compounds. | 06-03-2010 |
| 20100099663 | 4-TRIFLUOROMETHOXYPHENOXYBENZOL-4'-SULFONIC ACIDS, METHOD FOR THE PRODUCTION AND USE THEREOF IN MEDICAMENTS - The present invention is directed to a compound of formula I, | 04-22-2010 |
| 20100094253 | Drive mechanisms suitable for use in drug delivery devices - The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device. | 04-15-2010 |
| 20100094207 | Drive mechanisms suitable for use in drug delivery devices - The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device. | 04-15-2010 |
| 20100094206 | Drive mechanisms suitable for use in drug delivery devices - The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device. | 04-15-2010 |
| 20100094205 | Dosing and Drive Mechanism for Drug Delivery Device - The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device. | 04-15-2010 |
| 20100069661 | PROCESS FOR CARBONYLATING PHENYLALKYL DERIVATIVES BY MEANS OF CARBON MONOXIDE - The invention is directed a process of preparing a compound of formula (I), | 03-18-2010 |
| 20100041058 | PIM-3 KINASE AS A TARGET FOR TYPE 2 DIABETES MELLITUS - The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus. | 02-18-2010 |
| 20100035962 | NOVEL 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH CYCLOHEXYL GROUPS, METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF - This Invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof. | 02-11-2010 |
| 20100035961 | Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof - This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof. | 02-11-2010 |
| 20100022016 | POLYAMIDE NUCLEIC ACID DERIVATIVES AND AGENTS, AND PROCESSES FOR PREPARING THEM - The present invention relates to PNA derivatives which carry, at the C terminus, or at both the C and N termini of the PNA backbone, one or more phosphoryl radicals. The phosphoryl radicals carry, where appropriate, one or more labeling groups, groups for crosslinking, groups which promote intracellular uptake, or groups which increase the binding affinity of the PNA derivative for nucleic acids. The invention furthermore relates to a process for preparing the above-mentioned PNA derivatives and to their use as pharmaceuticals or diagnostic agents. | 01-28-2010 |
| 20100010045 | PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS - The present invention is directed to a compound of formula I, | 01-14-2010 |
| 20090299279 | OPTICAL DETERMINATION OF THE POSITION OF THE STOPPER IN GLASS AMPOULES - This invention relates to a method for determining the stopper position of a medicament cartridge in a medical apparatus by means of a light source and photosensitive sensor surface. | 12-03-2009 |
| 20090292247 | PERISTALTIC MICROPUMP WITH EXCHANGEABLE PUMP HEAD - The present invention relates to a device for injecting a pharmaceutical into the human or animal body by means of a simply and quickly exchangeable motorized pump head. | 11-26-2009 |
| 20090292245 | MICROPUMP-OPERATED DRUG DOSING SYSTEM - The present invention relates to a device for injecting a substance into the human or animal body, where the medicament to be injected is removed from a reservoir by generating a subatmospheric pressure. | 11-26-2009 |
| 20090286988 | METHOD FOR THE PRODUCTION OF OXAZOLES BY CONDENSING AROMATIC ALDEHYDES WITH a-KETOXIMES TO N-OXIDES AND THEN REACTING THE SAME WITH ACTIVATED ACID DERIVATIVES - The invention is related to a process for preparing compounds of the formula IV by means of conversion of aromatic aldehydes of the formula I using α-ketoximes of the formula II via N-oxides of the formula III to halomethyloxazoles of the formula IV, | 11-19-2009 |
| 20090275916 | Medication Delivery Device - The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in such medication delivery device, in particular in pen-type injectors, preferably having a dose setting member and a drive device enabling the dose setting and the administration of a medicinal product from a multi-dose medication cartridge, to methods using such device, and to methods of manufacturing and assembly of such device. | 11-05-2009 |
| 20090275915 | Medication Delivery Device - The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device. | 11-05-2009 |
| 20090275914 | Medication Delivery Device - The present invention relates to a medication delivery device, to dosing mechanisms suitable for use in medication delivery devices, in particular in pen-type injectors, preferably having dose setting means and a drive device enabling the administration of a medicinal product from a single- or multi-dose medication cartridge, to a use of such device, and to a method of manufacturing or assembling such device. | 11-05-2009 |
| 20090275621 | 1, 3, 4-OXADIAZOL-2-ONES AS PPAR DELTA MODULATORS AND THEIR USE THEREOF - The present invention is directed to 1,3,4-oxadiazalones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein. | 11-05-2009 |
| 20090264402 | NOVEL DIPHENYLAZETIDINONE SUBSTITUTED BY PIPERAZINE-1-SULFONIC ACID AND HAVING IMPROVED PHARMACOLOGICAL PROPERTIES - The invention therefore relates to the compound of the formula I | 10-22-2009 |
| 20090258881 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT - The invention relates to aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; | 10-15-2009 |
| 20090258872 | USE OF ARYL-SUBSTITUTED POLYCYCLIC AMINES AS MEDICAMENTS - The invention relates to therapeutic use of aryl-substituted polycyclic amines of the formula I, especially bicyclic amines, and to the physiologically tolerated salts and physiologically functional derivatives thereof; | 10-15-2009 |
| 20090239237 | METHOD FOR THE IDENTIFICATION OF A RISK FOR A THROMBOGENIC DISORDER BY DETERMINING THE TAFl-lle347 POLYMORPHISM - The present invention is directed to a method identifying a risk for a thrombogenic disorder including, without limitation, atrial fibrillation, stroke, prolonged intermitted neurological deficit (PRIND), transitory ischemic attack (TIA), atherosclerotic cerebrovascular disease (CVD) and/or coronary heart disease, as well as to a method for selecting patients with a risk for a thrombogenic disorder, to a method for identifying a pharmaceutical for the therapy or prophylaxis of a thrombogenic disorder as well as to a method for producing a medicament and a diagnostic by employing the TAFI-Ile347 polymorphism. | 09-24-2009 |
| 20090215824 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE SENSITIVE LIPASE - The present invention relates to indazole derivatives of the general formulae I or II having the meanings indicated in the description, to the pharmaceutically useful salts thereof and the use thereof as drugs. | 08-27-2009 |
| 20090209767 | 2-(Butyl-1-sulfonylamino)-n-[1(R)-(6-methoxy-pyridin-3-yl)-propyl]-benzami- d, the use thereof in the form of drug an pharmaceutical preparations containing said compound - The invention relates to 2-(butyl-1-sulfonylamino)-N-[1(R)-(6-methoxy-pyridin-3-yl)propyl]benzamide of the formula I | 08-20-2009 |
| 20090203918 | METHOD FOR PRODUCING ENANTIOMERIC FORM OF 2,3-DIAMINOPROPIONIC ACID DERIVATIVES - The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II). | 08-13-2009 |
| 20090203761 | PROCESS FOR PREPARING (3-OXO-2,3-DIHYDRO-1H-ISOINDOL-1-YL) ACETYLGUANIDINE DERIVATIVES - The present invention relates to processes for preparing (3-oxo-2,3-dihydro-1H-isoindol-1-yl)acetylguanidine derivatives of the formula I | 08-13-2009 |
| 20090192096 | 2'-Substituted 1,1'-Biphenyl-2-Carboxamides, Processes For Their Preparation, Their Use As Medicaments, And Pharmaceutical Preparations Comprising Them - Compounds of the formula I, | 07-30-2009 |
| 20090192073 | METHOD FOR PRODUCING INSULIN ANALOGS HAVING A DIBASIC B CHAIN TERMINUS - The invention relates to a method for producing a type of insulin by genetically engineering a precursor thereof and converting said precursor to the respective insulin in an enzyme-catalyzed ligation reaction with lysine amide or arginine amide, or by lysine or arginine which is modified by protective groups, and optionally subsequent hydrolysis. | 07-30-2009 |
| 20090176692 | AMIDATED INSULIN GLARGINE - The invention relates to insulin glargine which is modified by amidation, especially Gly (A21), Arg (B31), Arg amide (B32) human insulin (insulin glargine amide). | 07-09-2009 |
| 20090149496 | INHIBITORS OF THE TASK-1 AND TASK-3 ION CHANNEL - The invention relates to the use of Kv1.5 inhibitors for the therapy or prophylaxis of respiratory disorders, sleep-related respiratory disorders, central and obstructive sleep apneas, upper airway resistance syndrome, Cheyne-Stokes respiration, snoring, disrupted central respiratory drive, sudden child death, postoperative hypoxia and apnea, muscle-related respiratory disorders, respiratory disorders after long-term ventilation, respiratory disorders during adaptation in high mountains, acute and chronic lung disorders with hypoxia and hypercapnia, neurodegenerative disorders, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, cancer disorders, breast cancer, lung cancer, colon cancer and prostate cancer. | 06-11-2009 |
| 20090149332 | METHODS FOR DETERMINING THE ACTIVITY OF ADAM-TS PROTEASES USING THIOPEPTOLIDES - The invention concerns the use of thiopeptolides of formula R-(Xaa) | 06-11-2009 |
| 20090143473 | USE OF INHIBITORS OF THE CELLULAR NA+/H+ EXCHANGER (NHE) FOR PREPARING A MEDICAMENT FOR NORMALIZING SERUM LIPIDS - Use of inhibitors of the cellular Na | 06-04-2009 |
| 20090137630 | SUBSTITUTED THIOPHENES: COMPOSITIONS, PROCESSES OF MAKING, AND USES IN DISEASE TREATMENT AND DIAGNOSIS - The present invention comprises compounds and compositions comprising substituted thiophene derivatives with the following backbone structure: | 05-28-2009 |
| 20090104279 | USE OF PAK INHIBITOR FOR THE TREATMENT OF A JOINT DISEASE - The invention refers to the use of a p21-activated kinase (PAK) inhibitor as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease. | 04-23-2009 |
| 20090104081 | MINIATURIZED MICROTITER PLATE FOR HT-SCREENING - The invention relates to a miniaturized microtiter plate which has a body made of plastic and a base made of glass, 1000 to 4000 vessels (wells) ( | 04-23-2009 |
| 20090088474 | USE OF SUBSTITUTED CYCLOPROPANE ACID DERIVATIVES FOR PRODUCING DRUGS FOR USE IN THE TREATMENT OF METABOLIC SYNDROME - The present invention comprises methods for reducing plasma lipids, plasma free fatty acids (FFA), plasma glycerol and triglycerides in a mammal through the administration of certain substituted cyclopropane acid derivatives of Formula 1: | 04-02-2009 |
| 20090082255 | Acidic Insulin Preparations Having Improved Stability - The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and combinations thereof; a surfactant or combinations of two or more surfactants; optionally a preservative or combinations of two or more preservatives; and optionally an isotonicizing agent, buffers or further excipients or combinations thereof, the pharmaceutical formulation having a pH in the acidic range. | 03-26-2009 |
| 20090069565 | NEW INDOLE DERIVATIVES AS FACTOR XA INHIBITORS - The present invention relates to compounds of formula I, | 03-12-2009 |
| 20090069358 | Use of IKappaB-Kinase Inhibitors in Pain Therapy - The present invention relates to the use of IκB-kinase Inhibitors and methods for the prophylaxis and therapy for treating pain comprising administering such compounds. | 03-12-2009 |
| 20090036704 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines - A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I | 02-05-2009 |
| 20090017509 | METHOD FOR THE PRODUCTION OF RAMIPRIL - An improved method for preparing ramipril is disclosed, and also an intermediate for use in the method. | 01-15-2009 |
| 20090017478 | HIGH-THROUGHPUT ENZYME-LINKED IMMUNO ABSORBENT ASSAY (ELISA) FOR DETERMINATION OF RHO-KINASE (ROK) ACTIVITY - The invention is referring to an assay for measuring the activity of a ROK (Rho Kinase) protein by means of a biotinylated peptide. | 01-15-2009 |
| 20090005299 | Method For Producing Carboxy-Terminal-Amidified Peptides - The invention relates to the production of carboxy-terminal (C-terminal) amidified peptides with C-terminal amidified lysin, in particular with the biological activity of GLP-1, the chemical and/or biotechnological precursors and intermediate products thereof. The invention also relates to a method for the production and use thereof for producing pharmaceutical products. | 01-01-2009 |
| 20080312605 | Drive Mechanism For A Drug Delivery Device - This invention relates to a drive mechanism for a drug delivery device, drug delivery devices comprising the drive mechanism of the invention and a method of assembling such drug delivery devices, which allow the user to select multiple doses of an injectable drug and to dispense the set dose of the drug. | 12-18-2008 |
| 20080306056 | PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS - The present invention is directed to a compound of formula I, | 12-11-2008 |
| 20080280946 | Azaindole-Derivatives As Factor Xa Inhibitors - Indazole-derivatives as factor Xa inhibitors The present invention relates to compounds of the formula I | 11-13-2008 |
| 20080279934 | EXTENDED RELEASE FORMULATION FOR PRALNACASAN - This invention relates to a sustained release tablet comprising at least two layers, wherein at least one layer rapidly releases pralnacasan and the other layer releases pralnacasan in a delayed manner. This tablet is particularly suitable for the treatment of a condition such as autoimmune diseases, type I and type II diabetes, rheumatoid arthritis, osteoarthritis or psoriasis. | 11-13-2008 |
| 20080275098 | NOVEL SUBSTITUTED 2-AMINOIMIDAZOLES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENT OR DIAGNOSTIC AID - The present invention comprises novel substituted 2-aminoimidazoles of formula I, processes for their preparation, pharmaceutical compositions thereof, and methods for their use in the treatment of disorders of the central nervous system, cardiovascular disorders, stroke and pulmonary disorders, urinary disorders such as acute or chronic renal failure, disorders of biliary function, respiratory disorders such as snoring or sleep apnea. | 11-06-2008 |
| 20080274947 | Hydroxy-Substituted Diphenylazetidinones for the Treatment of Hyperlipidemia - The present invention comprises compounds and compositions for the treatment of metabolic disorders and more particularly, those insulin-related metabolic disorders of the blood such as hyperlipidemia, diabetes, insulin-resistance and the like comprising diphenylazetidinones compounds which have an additional hydroxy function in the 2″ position and their salts. The invention therefore relates to compounds of formula I: | 11-06-2008 |
| 20080274487 | Use of Serum/Glucocorticoid-Regulated Kinase - The invention relates to the use of an SGK protein, a functional derivative or fragment thereof, or a nucleic acid coding for one such protein, fragment or derivative, in order to discover active ingredients for the prevention or treatment of degenerative cartilage changes. | 11-06-2008 |
| 20080262052 | METHODS FOR THE TREATMENT OF METABOLIC AND GLUCOSE UTILIZATION DISORDERS THROUGH THE ADMINISTRATION OF OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS - The invention relates to oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. | 10-23-2008 |
| 20080255212 | OXADIAZOLONES AND DERIVATIVES THEREOF AS PEROXISOME PROLIFERATOR - ACTIVATED RECEPTOR (PPAR) DELTA AGONISTS - The invention relates to oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing peroxisome proliferator activator receptor (PPAR) delta agonist activity comprising compounds of formula I, | 10-16-2008 |
| 20080254475 | NEMATODES AS MODEL ORGANISMS FOR THE INVESTIGATION OF NEURODEGENERATIVE DISEASES, IN PARTICULAR PARKINSONS DISEASE, USES AND METHODS FOR THE DISCOVERY OF SUBSTANCES AND GENES WHICH CAN USED IN THE TREATMENT OF THE ABOVE DISEASE STATES AND IDENTIFICATION OF A NEMATODE GENE - The invention relates to nematodes as model organisms for the investigation of neurodegenerative diseases, in particular, Parkinsons disease, uses and methods for the discovery of substances and genes which can be used in the treatment of the above disease states and identification of a nematode gene, From | 10-16-2008 |
| 20080249298 | USE OF HEPARINOID DERIVATIVES FOR THE TREATMENT AND DIAGNOSIS OF DISORDERS WHICH CAN BE TREATED WITH HEPARINOIDS - Heparinoid derivatives comprising a chelating agent which is covalently bonded to the heparinoid, and a paramagnetic metal cation from the series of transition metals Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Mo, Ru or of the lanthanides, are suitable for producing medicaments both for therapy and for diagnostic purposes, for localizing the dose employed, and for monitoring the result of treatment of disorders such as thrombosis and osteoarthrosis. | 10-09-2008 |
| 20080249126 | 1,3-SUBSTITUTED CYCLOALKYL DERIVATIVES HAVING ACIDIC, MOSTLY HETEROCYCLIC GROUPS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS - The invention relates to 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups and to their physiologically acceptable salts and physiologically functional derivatives. | 10-09-2008 |
| 20080230700 | METHOD AND DEVICE FOR THE QUANTITATIVE ANALYSIS OF SOLUTIONS AND DISPERSIONS BY MEANS OF NEAR INFRARED SPECTROSCOPY - The present invention relates to a method for quantifying the composition of a product, including: irradiating the product with a radiation source in the near infrared range; receiving radiation which is reflected by or transmitted through the product; providing an output signal corresponding to the intensity of the radiation received at a number of different wavelengths; and determining whether or not the product lies within predetermined integrity criteria on the basis of the output signal using a mathematical method. The moving product contains a solution or homogeneous dispersion and the content of at least one substance contained in the dispersion or solution is quantitatively determined on the basis of the output signal. The invention also relates to a device for carrying out this method. | 09-25-2008 |
| 20080221113 | SUBSTITUTED HEXAHYDROPYRAZINO [1,2-A] PYRIMIDINE-4,7-DIONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS - Substituted hexahydropyrazino[1,2-a]pyrimidine-4,7-dione derivatives, processes for their preparation and their use as medicaments | 09-11-2008 |
| 20080221025 | Use of Trpc Channel for the Treatment of a Cardiovascular Disease - The invention refers to the use of a TRPC channel, an inactivating mutant thereof, or a nucleotide sequence coding for the TRPC channel or for the inactivating mutant for the production of a medicament for the treatment of a cardiovascular disease and a method of screening a modulator of the TRPC channel or an inactivating mutant thereof. | 09-11-2008 |
| 20080213798 | NOVEL C. ELEGANS P21-ACTIVATED KINASE (PAK) GENE AND ASSOCIATED LOSS-OF-FUNCTION PHENOTYPES THAT FACILITATE SCREENING FOR SMALL MOLECULE MODULATORS OF PAK ACTIVITY IN THE NEMATODE, CAENORHABDITIS ELEGANS - The invention refers to a novel | 09-04-2008 |
| 20080211485 | Process for Identification of Compounds for Modulating the Activity of Sodium/Calcium Exchange Transporter - The invention refers to a cell free assay for determining the activity of a Na | 09-04-2008 |
| 20080207882 | METHOD FOR PRODUCING THIOPHENE GLYCOSIDE DERIVATIVES - The present invention relates to a process for preparing thiophene-glycoside derivatives of the general formula (I) | 08-28-2008 |
| 20080207707 | ARYL-SUBSTITUTED HETEROCYCLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS - The invention relates to substituted aryl-substituted heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to process for their preparation and to their use as medicaments. | 08-28-2008 |
| 20080207592 | Novel 1,4-benzothiazepine-1,1-dioxide derivative having improved properties, method for the production thereof, medicaments containing said compound, and use thereof - The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic. | 08-28-2008 |
| 20080207534 | 1,4-BENZOTHIAZEPINE 1,1-DIOXIDE DERIVATIVE, PROCESS FOR ITS PREPARATION, MEDICAMENTS COMPRISING THIS COMPOUND, AND USE THEREOF AS A HYPOLIPIDAEMIC - The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic. | 08-28-2008 |
| 20080200553 | PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS OR DIAGNOSTIC AIDS, AND MEDICAMENTS COMPRISING THEM - Pentafluorosulfanylbenzoylguanidines of the formula I and II | 08-21-2008 |
