RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY Patent applications |
Patent application number | Title | Published |
20160130211 | ANTIOXIDANT-BASED POLY(ANHYDRIDE-ESTERS) - Certain embodiments of the invention provide antioxidant-based diacids and polymers comprising glycol groups as described herein, and methods of use thereof. In certain embodiments the polymers described herein are formulated as microspheres or hydrogels. Described herein is the chemical incorporation of antioxidants, e.g., coumaric acid, ferulic acid, and sinapic acid, into a polymer backbone for use, e.g., in applications for localized release and rapid delivery. As provided, the chemical composition of the linker molecules used (of which hold together two bioactives via ester linkages) may be used to vary the hydrophilicity of the polymer. The bioactive release rate may also be altered for a tunable release delivery system, allowing for increased bioactive release compared to other linkers previously utilized. | 05-12-2016 |
20160106867 | NEAR INFRARED LABEL AND METHODS OF USE THEREOF - The present invention provides compounds useful as novel near-infrared labels, compositions containing these compounds, and methods of using the near-infrared labels to identify targets in vitro, in situ and in vivo. The invention also provides small or large molecule conjugates between targeting agents and NIR labels, as well as methods and kits thereof, that can be used in diagnostics and treatment of diseases related to microbes in mammalian animals. | 04-21-2016 |
20160083552 | IN SITU EXFOLIATION METHOD TO FABRICATE A GRAPHENE-REINFORCED POLYMER MATRIX COMPOSITE - A method for forming a graphene-reinforced-polymer matrix composite by distributing graphite microparticles into a molten thermoplastic polymer phase comprising one or more molten thermoplastic polymers; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphene successively with each event, until tearing of exfoliated multilayer graphene sheets occurs arid produces reactive edges on the multilayer sheets that react with and cross-link the one or more thermoplastic polymers; where the one or more thermoplastic polymers are selected from thermoplastic polymers subject to UV degradation. | 03-24-2016 |
20160082076 | BRIDGE-HELIX CAP: TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE - It has been discovered that the Sal target represents a new and promising target for antibacterial drug discovery. The Sal target is distinct from the rifamycin target and from the CBR703 target. This indicates that antibacterial compounds that function through the Sal target should exhibit no, or minimal, cross-resistance with rifamycins and CBR703. This further implies that it should be possible to co-administer antibacterial compounds that function through the Sal target together with a rifamycin, together with CBR703, or together with both a rifamycin and CBR703, in order to achieve additive or synergistic antibacterial effects and in order to suppress or eliminate the emergence of resistance. | 03-24-2016 |
20160068467 | AMPHIPHILIC MACROMOLECULES AND METHODS OF USE THEREOF - Certain embodiments of the invention provide a compound of formula (I): | 03-10-2016 |
20160041181 | NMR ASSAY TO SCREEN PROTEIN-PROTEIN INTERACTION INHIBITORS - This invention relates generally to a field of rational drug design. In particular, the present invention relates to a | 02-11-2016 |
20150368668 | HCV E2 CONSTRUCT COMPOSITIONS AND METHODS - Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described. | 12-24-2015 |
20150366937 | METHODS TO TREAT INFLAMMATION OF THE LUNG - The present invention provides pharmaceutical compositions comprising leukotoxin for the treatment of lung inflammation. | 12-24-2015 |
20150361475 | HIGHLY SELECTIVE NUCLEIC ACID AMPLIFICATION PRIMERS - This invention discloses multi-part primers for primer-dependent nucleic acid amplification methods. Also disclosed are primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions, reaction mixtures and reagent kits for such reactions. This invention relates to primer-dependent nucleic acid amplification reactions, particularly DNA amplification reactions such as PCR, and primers, reaction mixtures and reagent kits for such reactions and assays employing same. | 12-17-2015 |
20150352099 | Compositions and Methods of Reducing Sedation - Methods and compositions useful in reducing drug-induced sedation in subjects. | 12-10-2015 |
20150335783 | BIOCOMPATIBLE POLYMER COMPOSITIONS FOR TISSUE VOID FILLING - Biodegradable, bioabsorbable cross-linked polymer tissue scaffolds for filling a void in human or animal soft tissue, such as a surgical or other wound, are disclosed. Drugs incorporated into the polymer backbone and/or loaded into the matrix are released directly to the target site. Additional non-toxic chemical constituents can be used to tune the hydrophilio hydrophobic and other physical properties of the cross-linked polymer tissue scaffolds, and incorporating brominated or iodinated constituents provides radio-opacity. The radio-opaque cross-linked polymer tissue scaffolds can assist in the targeting of radiation therapy. | 11-26-2015 |
20150322022 | THERAPEUTIC CATECHOLS - The invention provides compounds of formula I: | 11-12-2015 |
20150318547 | COPPER FLUORIDE BASED NANOCOMPOSITES AS ELECTRODE MATERIALS - The present invention relates to primary and secondary electrochemical energy storage systems, particularly to such systems as battery cells, which use materials that take up and release ions as a means of storing and supplying electrical energy. | 11-05-2015 |
20150314047 | BORON COMPOSITE SURFACE COATINGS AND THEIR APPLICATION ON IMPLANTABLE DEVICES TO ACCELERATE OSSEOUS HEALING - The present invention discloses boron composite surface coatings, application of these coatings onto implantable devices, and use of the implantable devices for accelerating osseous healing. The implantable devices have wide applications, including but not limited to treating bone fracture, bone trauma, arthrodesis, and other bone deficit conditions, as well as bone injuries incurred in military and sports activities. | 11-05-2015 |
20150313946 | METHODS MODULATING IMMUNOREGULATORY EFFECT OF STEM CELLS - The present invention provides methods or kits with inflammatory cytokines to pretreat 1-ISCs to augment their immune modulatory effect, in prevention and treatment of various diseases such as multiple sclerosis, arthritis, lupus, sepsis, hepatitis, cirrhosis, Parkinson's disease, chronic infections, and GvHD. The present invention relates to novel methods for enhancing the immunosuppressive or the immune stimulatory activities of mesenchymal stem cells (JvfSCs). | 11-05-2015 |
20150307517 | ANTIMICROBIAL AGENTS - The invention provides compounds of formula (I): | 10-29-2015 |
20150297725 | COCHLEATES MADE WITH SOY PHOSPHATIDYLSERINE - Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B. | 10-22-2015 |
20150291531 | THERAPEUTIC HYDROXYQUINOLONES - The invention provides compounds of formula (I) and salts thereof wherein R | 10-15-2015 |
20150267030 | In Situ Exfoliation Method to Fabricate a Graphene-Reinforced Polymer Matrix Composite (G-PMC) - A method for forming a graphene -reinforced polymer matrix composite is disclosed. The method includes distributing graphite microparticles into a molten thermoplastic polymer phase; and applying a succession of shear strain events to the molten polymer phase so that the molten polymer phase exfoliates the graphite successively with each event until at least 50% of the graphite is exfoliated to form a distribution in the molten polymer phase of single- and multi-layer graphene nanoparticles less than 50 nanometers thick along the c-axis direction. | 09-24-2015 |
20150266778 | GRANITE-LIKE COMPOSITE MATERIALS AND METHODS OF PREPARATION THEREOF - The invention provides novel granite-like composite materials and methods for preparation thereof. The granite-like composite materials can be readily produced from widely available, low cost precursor materials by a process suitable for large-scale production. The precursor materials include calcium silicate, for example, wollastonite, and particulate filler materials which comprise silicon dioxide-rich materials such as quartz, mica, feldspar, sand and glass. Additives can include calcium carbonate-rich and magnesium carbonate-rich materials. Various additives can be used to fine-tune the physical appearance and mechanical properties of the composite material, such as colorants such as particles of colored materials, such as colored glass, colored sand, and colored quartz particles, and pigments (e.g., black iron oxide, cobalt oxide and chromium oxide). These granite-like composite materials exhibit visual patterns unique to granite as well as display compressive strength, flexural strength and water absorption similar to that of granite. | 09-24-2015 |
20150251171 | ALKANE DEHYDROGENATION PROCESS - Disclosed herein are processes for dehydrogenation of an alkane to an alkene using an iridium pincer complex. In the dehydrogenation reactions, hydrogen that is co-formed during the process must be removed for the chemical reaction to proceed and to prevent the excess hydrogen from poisoning the catalyst. In one embodiment the process comprises providing an alkane feedstock comprising at least one alkane and contacting the alkane with an iridium pincer complex in the presence of a hydrogen acceptor selected from the group consisting of ethylene, propene, or mixtures to form an alkene product. The processes disclosed herein can accomplish facile, low-temperature transfer dehydrogenation of alkanes with unprecedented selectivities and TONs at a reasonable rate of conversion. | 09-10-2015 |
20150236341 | COPPER FLUORIDE BASED NANOCOMPOSITES AS ELECTRODE MATERIALS - The present invention relates to primary and secondary electrochemical energy storage systems, particularly to such systems as battery cells, which use materials that take up and release ions as a means of storing and supplying electrical energy. | 08-20-2015 |
20150232454 | THERAPEUTIC HYDROXYPYRIDINONES, HYDROXYPYRIMIDINONES AND HYDROXYPYRIDAZINONES - The invention provides compounds of formula (I): and salts and prodrugs thereof wherein R4, X1 and X2 have any of the meanings defined in the specification, as well as pharmaceutical compositions comprising the compounds or salts and methods for their use in therapy. The compounds have useful antiviral properties. | 08-20-2015 |
20150214040 | THIN EPITAXIAL SILICON CARBIDE WAFER FABRICATION - Techniques for fabricating thin epitaxial SiC device wafers are described. A bulk SiC wafer is used to provide a seed layer of a thin layer of SiC for epitaxially growing SiC. The seed layer is exfoliated from the bulk SiC after bonding the bulk SiC to a handle substrate. The bulk SiC wafer from which the thin layer of SiC is exfoliated may be re-used in fabricating subsequent thin film epitaxial SiC wafers. After growing epitaxial SiC from the seed layer on the handle substrate, devices may be fabricated in the epitaxial SiC and the handle substrate can be removed. The handle substrate can be re-used in fabricating subsequent thin film epitaxial SiC wafers. The epitaxial SiC can be cut into dies and packaged as an SiC chip or bonded to another substrate, such as a silicon substrate with devices formed thereon. | 07-30-2015 |
20150207140 | METAL FLUORIDE AND PHOSPHATE NANOCOMPOSITES AS ELECTRODE MATERIALS - The present invention relates to primary and secondary electrochemical energy storage systems. More particularly, the present invention relates to such systems as battery cells, especially battery cells utilizing metal fluorides with the presence of phosphates or fluorophosphates, which use materials that take up and release ions as a means of storing and supplying electrical energy. | 07-23-2015 |
20150190073 | METHODS AND SYSTEMS FOR SCREENING AND TREATMENT OF YOUNG INFANTS DEMONSTRATING DEFICITS IN AUDITORY PROCESSING - The present invention provides a method and apparatus for screening infants at high risk for central auditory processing deficits and then remediating less efficient processing behaviorally using an adaptive training algorithm that gradually increases sensitivity to rapidly occurring stimuli streams. | 07-09-2015 |
20150175528 | MACROMOLECULES FOR TREATING ATHEROSCLEROSIS - The invention includes compounds of the formula I and formula II and salts thereof, as well as methods for using the compounds of formula I and formula II for treating atherosclerosis. The invention also includes compounds of formula III and (2l) and salts thereof, as well as methods of using the compounds of formula III and (2l) for treating atherosclerosis. The invention also includes methods of encapsulating molecules using the compounds of the invention. | 06-25-2015 |
20150158886 | CYCLIC DINUCLEOSIDES - Provided herein are compounds of formula Ia: | 06-11-2015 |
20150155552 | IRON OXYFLUORIDE ELECTRODES FOR ELECTROCHEMICAL ENERGY STORAGE - The present invention provides electrochemical energy storage systems comprising metallolyte composites, iron fluoride composites and iron oxyfluoride composites. The present invention further provides methods for fabricating metallolyte composites. | 06-04-2015 |
20150155334 | ZnO-Based System on Glass (SOG) for Advanced Displays - A ZnO based display pixel structure that includes system-on-glass (SOG) substrates with embedded non-volatile resistive random access memory iNV-RRAM) is provided. Such pixels feature high frame rates and low power consumption. The entire SOG is based on ZnO devices. Different devices including TFT, TCO, RRAM, inverters, and shift registers are obtained through doping of different elements into selected ZnO active regions. This reduces the cost to package control circuitry onto a backplane of a display system, resulting in a low cost, light weight and uUra-thin display. | 06-04-2015 |
20150122734 | Light Activated Cation Separation - A method of separating one or more valuable metal cations from an ionic solution by (a) contacting the ionic solution with an activated photoisomerizable host molecule containing a photoisomerizable moiety and a host moiety, where the photoisomerizable moiety has first and second states, and where the host moiety has a greater affinity for a metal cation when the photoisomerizable moiety is in the first state (active binding state) than when the photoisomerizable moiety is in the second state (release state), so that an ion-host molecule association is formed, and (b) separating the ion-host molecule association from the ionic solution. Also disclosed are photoisomerizable host molecules, a method of recovering valuable metals from a waste stream using the photoisomerizable host molecules, and an apparatus comprising a photoisomerizable host molecule attached to a support. | 05-07-2015 |
20150106803 | Richer Model of Cloud App Markets - In a cloud app market, a cloud infrastructure customer can purchase apps for performing services such as rootkit detection and network security for a customer virtual machine run by the cloud infrastructure customer. A cloud infrastructure provider executes a provider virtual machine monitor or hypervisor on cloud infrastructure. The cloud app is provided with a customer virtual machine monitor nested on the provider virtual machine monitor. The customer virtual machine, together with a nested management domain of the customer, execute on the customer virtual machine monitor. | 04-16-2015 |
20150098905 | METHODS TO DETECT A FUNGAL CELL - The present invention relates to targeting agents and methods: of using the targeting agents to detect a fungal cell in a subject. | 04-09-2015 |
20150079589 | DETECTION OF DRUG RESISTANT MYCOBACTERIUM TUBERCULOSIS - This invention relates to nucleic acids, reagents and methods for detecting Rifampicin-resistant | 03-19-2015 |
20150079134 | TREATMENT TO PROMOTE WOUND HEALING - The invention relates to a field of tissue repair and regeneration. More particularly, the invention relates to a composition for promoting cutaneous wound healing. In one embodiment, the composition is composed of one or more metazoan parasites or a mimic thereof sufficient to promote helminth-induced type-2 immune response. Preferably, the composition contains | 03-19-2015 |
20150073185 | Novel Catalyst Complex and Use Thereof in Alkane Oligomerization - Provided is a Group 9 novel metal catalyst complex further comprising a ketone-containing cocatalyst. The metal catalyst complex is useful in generating olefins from alkanes with great efficiency. In one embodiment, provided is an iridium catalyst complex useful in the dehydrogenation of alkanes comprising a ketone-containing cocatalyst and iridium complexed with a tridentate ligand. Also provided is a novel dehydrogenation method which utilizes the catalyst composition. In other embodiments, a novel process for preparing oligomers from alkanes utilizing the catalyst composition is provided. | 03-12-2015 |
20150065559 | METHODS FOR DELIVERY OF siRNA TO THE SPINAL CORD AND THERAPIES ARISING THEREFROM - The present application relates at least in part to methods for the administration of small interfering RNAs (siRNAs) to the spinal cord of a human or animal patient and also to a method of treatment for spinal cord injury and other diseases and disorders of the CNS. In particular, the application discloses methods to deliver an siRNA compound locally, directly and without the need for transduction vehicles and formulations in effective doses to the injured spinal cord to promote recovery of CNS function and or attenuation of allodynia. | 03-05-2015 |
20150045198 | METHOD AND APPARATUS FOR MICROFOLDING SHEET MATERIALS - A folding machine for folding sheet material into microfolds. The folding machine has a first series of rollers that imparts longitudinal folds to the material. The machine has a second series of rollers where each succeeding roller has double the tessellations as the roller immediately before it. Moreover, the tessellation height of the second series diminishes by half which each succeeding roller. Material leaving the second series of rollers is then fed into a final set of rollers. The final set of rollers imparts a pattern geometry to the folded sheet material. | 02-12-2015 |
20150030653 | Vanadium Compounds as Therapeutic Adjuncts for Cartilage Injury and Repair - A method for repairing an injury of cartilage in a patient by local administration of an organovanadium agent or use of an implantable device for delivery of an organovanadium agent. Implantable devices containing an organovanadium agent and methods of making these implantable devices are also disclosed. | 01-29-2015 |
20150030219 | METHOD AND APPARATUS FOR SHAPE BASED DEFORMABLE SEGMENTATION OF MULTIPLE OVERLAPPING OBJECTS - The present invention provides a system and method for simultaneous variational and adaptive segmentation of single non-overlapping and multiple overlapping/occluded-objects in an image scene. The method according to the present invention synergistically combines shape priors with boundary and region-based active contours in a level set formulation with a watershed scheme for model initialization for identifying and resolving multiple object overlaps in an image scene. The method according to the present invention comprises learning a shape prior for a target object of interest and applying the shape prior into a hybrid active contour model to segment overlapping and non-overlapping objects simultaneously. | 01-29-2015 |
20140356905 | Mammalian Cell Culture System for Large-Scale Expression of Recombinant Proteins - Compositions and methods for large-scale recombinant protein expression are disclosed. | 12-04-2014 |
20140347138 | METHODS FOR NOISE REDUCTION AND QUALITY FACTOR IMPROVEMENT IN RESONATORS - A low phase noise dual mode resonator and a method of making and using said resonator is disclosed. The dual mode resonator is capable of sustaining two frequency vibration modes simultaneously. The two frequency vibration modes are capable of exhibit non-linear coupling when one is driven at a higher voltage than the other. The dual mode resonator is configured such that the ratio of the two vibration frequency modes is a value that maximizes the non-linear coupling effect. As a result of the non-linear effect, the phase noise on the mode that is not overdriven is reduced. | 11-27-2014 |
20140336078 | HIGH THROUGHPUT SENSITIZATION DETECTION DEVICES AND METHODS - This invention discloses devices and methods for high throughput skin sensitization detection. The devices comprise a microfabricated chamber comprising a region having one or more input channels and an outlet, and a face suitable for mounting a skin tissue and in fluidic communication with the region. The devices can be used in the methods for determining a prognosis of sensitization in an animal subject and identifying compounds that do not cause sensitization and thus are suitable for preparing cosmetic compositions. | 11-13-2014 |
20140329700 | METHODS OF ISOLATING RNA AND MAPPING OF POLYADENYLATION ISOFORMS - The invention relates to compositions and methods to isolate nucleic acids, and the identification of polyadenylation sites in a gene of interest. In one aspect, the invention provides an oligonucleotide comprising at least one nucleic acid and an affinity moiety, wherein said nucleic acid is 30-60 nucleotides in length and said nucleic acid comprises 1-25 uracil and 5-50 thymine nucleotides. | 11-06-2014 |
20140328997 | Production of Enriched Products - Methods for the production of enriched plant polyphenols-dairy (e.g., milk) or polyphenols-ground edible material products that can be used in the preparation of functional foods, dietary supplements, medical foods, cosmetic products or pharmaceutical agents. The method of obtaining a polyphenol-dairy protein product comprising the steps of (a) combining a plant-derived polyphenol and a dairy product such as a dairy product comprising a protein, to form the polyphenol-dairy protein (e g, milk protein) product and a liquor; and (b) separating the polyphenol-dairy protein product from the liquor. In various embodiments, the plant-derived polyphenols and dairy product are a mixture of solid products, such as would be found in a dry composition. These methods also provide for the immobilization of these component(s) on the healthy, nutritious, and low-sugar food matrix provided by the ground edible material. | 11-06-2014 |
20140328763 | BIOACTIVE AMPHIPHILIC POLYMER STABILIZED NANOPARTICLES WITH ENHANCED STABILITY AND ACTIVITY - The present invention relates to nanoparticle compositions and treatment of cardiovascular disease using nanoparticles to target Class A and B scavenger receptors. This invention further relates to methods of detecting cells that express scavenger receptors, detecting atherosclerotic lesions, and targeting bioactive amphiphilic macromolecules to cells that express scavenger receptors. | 11-06-2014 |
20140322292 | INSULIN-MIMETICS AS THERAPEUTIC ADJUNCTS FOR BONE REGENERATION - Methods of promoting bone healing or regeneration by locally administering insulin mimetic agents to patients in need thereof and new uses of insulin-mimetic compounds for accelerating bone-healing processes are disclosed. Bone injury treatment and void filler devices, products and kit suitable for local administration of insulin-mimetic agents or compositions thereof to patients in need of such treatment are also disclosed. | 10-30-2014 |
20140319415 | METHODS OF INCORPORATING AMINO ACID ANALOGUES INTO A PROTEIN - The present invention provides a novel use of a SPP system for replacing natural amino acid residues with non-naturally occurring amino acids in a protein or peptide, using cell based expression system. | 10-30-2014 |
20140315939 | ANTIMICROBIAL AGENTS - The invention provides a compound of formula I: | 10-23-2014 |
20140311016 | Beg Bug Lures - Various embodiments of the present invention provide a lure composition, lure arrangement, and/or method for attracting and capturing bed bugs and the like. In some embodiments, the present invention combines a collection structure with a chemical lure composition that has improved efficacy due to a synergistic combination of elements. The present invention reduces the need for sprayed or broadcast attractants. In one aspect of the invention, a lure composition for attracting bed bugs and the like is provided. The 5-chemical lure mixture comprises a combination of Nonanal, 1-octen-3-ol, L-lactic acid, spearmint oil, and coriander Egyptian oil. In another embodiment of the invention, the mixture comprises a 4-chemical lure mixture Nonanal, 1-octen-3-ol, spear mint oil, and coriander Egyptian oil. | 10-23-2014 |
20140308507 | SYSTEMS AND METHODS FOR CAPTURE AND SEQUESTRATION OF GASES AND COMPOSITIONS DERIVED THEREFROM - A composition is produced by a hydrothermal liquid phase sintering process, and the process includes providing a porous matrix, the porous matrix having a shape, and allowing a component of the porous matrix to undergo a reaction with an infiltrating medium to form a first product, the infiltrating medium including a greenhouse gas, a remainder of the porous matrix acting as a scaffold for facilitating the formation of the first product. The composition includes the first product and the reminder of the porous matrix. The composition has a microstructure that resembles a net-like interconnecting network. The composition maintains the shape of the porous matrix. The composition is free of hydraulic bonds. | 10-16-2014 |
20140308331 | INTERPOLYMER NETWORK DELIVERY SYSTEM - This invention relates to compositions and applications for an interpolymer network delivery system containing iodine. | 10-16-2014 |
20140303386 | COMPOSITIONS AND METHODS FOR ENHANCING LIPID PRODUCTION IN MICROALGAE VIA INDUCTION OF CELL CYCLE ARREST - Methods for enhancing lipid production in marine algae and compositions comprising lipids obtained therefrom are provided. | 10-09-2014 |
20140294801 | SEQUENCE-SPECIFIC MRNA INTERFERASE AND USES THEREOF - The present invention provides an improved and specific mRNA interferase and related methods of protein-based mRNA interference. | 10-02-2014 |
20140275709 | METHODS AND SYSTEMS FOR DETERMINING THE DISTRIBUTION OF RADIATION DOSE AND RESPONSE - A system, method and computer program product to determine radiation dose from radionuclides used to treat a patient in need thereof. The present invention allows users to visualize and understand the impact of radionuclide choice, distribution of activity in the cell, distribution of activity among the cells, cell dimensions, cell separation distance, cluster size, and radiobiological response parameters on the capacity to kill populations of cells. All of these parameters can play a substantial role in determining the surviving fraction of cells. Accordingly, this system, method and computer program product can assist in designing treatment plans for therapeutic radiopharmaceuticals suited to individual needs. | 09-18-2014 |
20140271864 | THERAPEUTIC COMPOSITIONS FOR BONE REPAIR - Individuals having diabetes are more prone to fractures, periodontitis, and other bone related issues as compared to healthy individuals. Furthermore, bone healing in diabetic patients is prolonged. The invention provides a method for decreasing bone resorption or increasing bone formation or promoting bone healing in diabetic patients. In particular, a biodegradeable polymer, such as a polyanhydride salicylate is administered at or near a bone defect site, and upon hydrolysis of the polymer will releases biologically active salicylic acid. | 09-18-2014 |
20140256767 | DIRECT INHIBITORS OF KEAP1-NRF2 INTERACTION AS ANTIOXIDANT INFLAMMATION MODULATORS - A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed. | 09-11-2014 |
20140256583 | DETECTION OF HUMAN ENDOGENOUS RETROVIRUS EXPRESSION IN CANCER AND NORMAL CELLS - The invention relates to human endogenous retrovirus env (HERV-WL) polypeptides, nucleotide sequences, HERV-WL antibodies, methods to detect cancer, and methods to determine the effectiveness of the treatment of cancer. | 09-11-2014 |
20140250766 | ARTHROPOD MONITORING TRAP - An insect trap has a “U” or similar shaped cross-section view, forming a circle or square, with a dark-colored coarse outer surface and a light-colored smooth inner surface. The trap can be placed around an arthropod-infested object such as furniture leg, luggage, food to form a barrier to prevent movement of arthropods between the infested object and its surrounding areas. | 09-11-2014 |
20140242153 | NOVEL ENCOCHLEATION METHODS, COCHLEATES AND METHODS OF USE - Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed. | 08-28-2014 |
20140235593 | SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARB- OXAMIDES FOR ANTIMALARIAL THERAPIES - In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | 08-21-2014 |
20140235578 | METHODS FOR TREATING NEOPLASIA AND FOR IDENTIFYING COMPOSITIONS USEFUL IN SUCH THERAPY - Various methods for treating a patient with neoplasia are disclosed, in particular, methods using topoisomerase Ila-preferential poisons, methods using a combination of a topoisomerase Illi-preferential inhibitor and a topoisomerase II poison, and methods using a combination of a topoisomerase II poison and a proteasome inhibitor are disclosed. Novel topoisomerase Ila-preferential poisons are disclosed, particularly, several novel 13-carboline derivatives are identified. Methods for identifying the novel topoisomerase Ila-preferential poisons and methods for identifying the novel topoisomerase EP-preferential inhibitors are also provided herein. | 08-21-2014 |
20140235481 | CANCER BIOMARKER AND METHODS OF USE THEREOF - Certain embodiments of the present invention provide methods for identifying subjects that have, or are at risk for developing, cancer. Certain embodiments of the present invention provide methods for determining the effectiveness of cancer treatments. | 08-21-2014 |
20140221415 | Method of Treating Dyskinesia - Methods of treating patients with dyskinesias, by administering a therapeutically effective amount of a dual-action mu-opioid receptor antagonist/kappa-opioid receptor agonist or prodrug thereof to a subject in need thereof, sufficient to mitigate the dyskinesia. Alternatively, a combination of both a mu-opioid receptor antagonist or prodrug thereof, and a kappa-opioid receptor agonist or prodrug thereof can be administered, either together or separately. | 08-07-2014 |
20140220600 | PROTEINS EXPRESSED BY MYCOBACTERIUM TUBERCULOSIS AND NOT BY BCG AND THEIR USE AS DIAGNOSTIC REAGENTS AND VACCINES - The present invention is directed to reagents useful for generating immune responses to | 08-07-2014 |
20140220109 | NOVEL COCHLEATE FORMULATIONS - A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca | 08-07-2014 |
20140219921 | IMMUNOMODULATING COMPOSITIONS AND METHODS - The disclosure provides compositions in the form of cells exhibiting the phenotype of a mesenchymal stem cell and uses of such cells in the preparation of medicament and the treatment of an allergic reaction in an asthmatic subject. Also provided are methods of inducing tolerance to an allergen in an asthmatic subject and methods of assessing a non-asthmatic subject for amenability to allergy treatment by administering mesenchymal stem cells. | 08-07-2014 |
20140213466 | HIGH-THROUGHPUT ASSESSMENT METHOD FOR CONTACT HYPERSENSITIVITY - The present invention provides methods for high-throughput assessment of in vivo skin sensitizing activity of chemical compounds through detection of secretion levels of cytokine markers implicated in skin sensitization in combination with a multivariate analysis, using support vector machine (SVM) for feature selection. The invention includes a computational algorithm that will provide unbiased analysis on the skin cell secretome data and predict the level of skin sensitization. The invention allows accurate assessment of the level sensitizing potency of any chemicals in a high-throughput manner, which can eliminate the needs for animal experiments, potentially saving money and time. | 07-31-2014 |
20140212918 | IN VITRO MODEL OF MACROSTEATOTIC (FATTY) LIVER - The present invention relates to a system and methods for identifying a compound for de-fatting and functional recovery of macrosteatotic hepatocytes. | 07-31-2014 |
20140206637 | Inhibition of Nonsense Mediated mRNA Decay by Drugs that Prevent Hypusination of Eukaryotic Initiation Factor 5A - Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked. | 07-24-2014 |
20140206010 | METHODS AND KITS FOR DETECTING MASTITIS - Methods and kits for determining if one or more animals have mastitis and for monitoring animals and the quality of the milk they produce are disclosed. Kits and test assays disclosed are used to determine the quantity of proteasomes and proteins thereof, the activity of proteasome enzymes, the quantity of proteasome bound and regulating proteins, and the quantity of ubiquinated protein. Components and reagents for use in the kits and assays are also disclosed. | 07-24-2014 |
20140200405 | EXTENDABLE INTUBATION STYLET - An extendable Intubation stylet including a handle member and a trigger mechanism moveable relative to the handle member between a retracted position and an extended position. A hollow semi-rigid stylet member extends from the handle member from a proximal end to a distal end. A flexible stylet member has a proximal end and a distal end and extends through the semi-rigid stylet member with the proximal end of the flexible stylet member connected with the trigger mechanism and configured such that when the trigger mechanism is in the retracted position, the flexible stylet member distal end is proximate the semi-rigid stylet member distal end and when the trigger mechanism is in the extended position, the flexible stylet member distal end is extended from the semi-rigid stylet member distal end. | 07-17-2014 |
20140197400 | SOLID-STATE COMPOSITIONS AND METHODS FOR GENERATING WHITE LIGHT - This application discloses a new family of inorganic-organic hybrid semiconductor bulk materials built on periodic nanostructured 2D layers of ZnS that emit bright white light with high quantum efficiency. These ZnS-based crystalline inorganic-organic hybrid semiconductors have well defined and precisely controllable crystal structure and composition. Their optical emission properties, including intensity, quantum yield, and color quality, can be systematically tuned by varying the composition of both inorganic and organic components. Methods for preparing these materials, use of these materials as a new type of single-phased white light emitting phosphors, and their applications in making WLED devices are also disclosed. | 07-17-2014 |
20140194344 | FUSION PEPTIDE DESIGNED TO REDUCE PLAQUE BACTERIA AND YEAST IN THE ORAL CAVITY - The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and PAK fusion peptides (PAK-LF), along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease. | 07-10-2014 |
20140193331 | MULTIFUNCTIONAL INFRARED-EMITTING COMPOSITES - Disclosed is a method of non-invasive infrared imaging, comprising (a) administering a composition containing infrared-emitting particles which contain rare earth elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles; and (b) irradiating with infrared radiation, where both excitation and emission spectra of the encapsulated particles are in the infrared region. Analogous methods of image-guided biomedical intervention, and drug tracking and delivery are also disclosed. Also disclosed is a composition for biomedical applications, containing infrared-emitting particles which contain rare earth-elements that emit in the short-wavelength infrared (SWIR) spectrum, where the particles are encapsulated with a biocompatible matrix to form downconverting encapsulated particles. | 07-10-2014 |
20140187546 | Cystine Diamide Analogs for the Prevention of Cystine Stone Formation in Cystinuria - Cystine analogs that improve the solubility of L-cystine in urine for treatment of cystinuria and which have the structure: | 07-03-2014 |
20140186430 | COCHLEATE COMPOSITIONS DIRECTED AGAINST EXPRESSION OF PROTEINS - Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions. | 07-03-2014 |
20140180420 | TISSUE ENGINEERED FIBROCARTILAGE REPLACEMENT - Fibrocartilage implants characterized by circumferential fiber networks embedded in arcuate or torroidal scaffolds with orthogonal fiber networks embedded therein to prevent separation of the circumferential fiber networks. The fiber networks convert axial compressive forces on the scaffolds to tensile loads on the circumferential fibers. Artificial knee meniscus and vertebral disc implants are disclosed, as well as articular disc implants for joints such as the temporomandibular joint and wrist. Methods for implanting the fibrocartilage devices are also disclosed. | 06-26-2014 |
20140163258 | THERMO-REVERSIBLE PHASE SELECTIVE XEROGEL COMPOSITIONS - Described herein are xerogels consisting essentially of 12-hydroxy-stearic acid (12-HSA) wherein the xerogel is characterized by a spherulitic fibrillar network structure. Also provided is a method for adsorbing an apolar liquid by contacting a 12-HSA xerogel composition with the apolar liquid. | 06-12-2014 |
20140155345 | BIOTINYLATED COMPOUNDS - The invention provides new biotinylated compounds and methods for their use. | 06-05-2014 |
20140154770 | Chemically Modified Graphene - This disclosure relates to graphene derivatives, as well as related devices including graphene derivatives and methods of using graphene derivatives. | 06-05-2014 |
20140154349 | APPARATUS FOR THERMOFORMING POLYMER COMPOSITE PANELS - A system and apparatus for making a plastic panel, combining:
| 06-05-2014 |
20140154207 | KIT CONTAINING STEM CELLS AND CYTOKINES FOR USE IN ATTENUATING IMMUNE RESPONSES - The present invention relates to a composition and methods of treatment for inflammation comprising of adult stem cells and inflammatory cytokines. The invention further relates to the treatment of inflammation associated with autoimmune disorders, allergies, sepsis, cancer as well as to preventing, reducing or treating transplant rejection and/or graft-versus-host disease (GvHD). | 06-05-2014 |
20140150842 | COMPOSITE ARTICLES COMPRESSION MOLDED FROM RECYCLED PLASTIC - Compression molded articles containing a polymer component and optionally distributed therein between about 1% and about 45% by weight of a glass bead or fiber reinforcing component based on the weight of the finished composite article, wherein the polymer component contains between about 80% and about 100% by weight of HDPE based on the weight of the polymer component, in which at least about 20% or more by weight of said HDPE is post-consumer HDPE. Plastic panels, uses thereof and methods of manufacturing are also disclosed. | 06-05-2014 |
20140135375 | Edible Transgenic Plants as Oral Delivery Vehicles for RNA-Based Therapeutics - Compositions and methods for delivery of therapeutic RNA molecules are disclosed. | 05-15-2014 |
20140134661 | THERAPEUTIC MODULATION OF AUTOPHAGY - Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimulate autophagy, as well as compounds that inhibit autophagy. Cell lines that may be used in the methods of identification are also disclosed. | 05-15-2014 |
20140120057 | POLYMERS AND METHODS THEREOF FOR WOUND HEALING - Certain embodiments of the invention provide a copolymer having a backbone, wherein the backbone comprises a) one or more units that comprise a group that will yield a biologically active agent upon hydrolysis of the backbone; and b) one or more units of formula (II): | 05-01-2014 |
20140113306 | DIAGNOSTIC AND SCREENING METHODS FOR INFLAMMATION - This invention is directed to methods, kits and compositions for the diagnosis and treatment of conditions associated with sub-clinical inflammatory conditions such as diabetes mellitus. | 04-24-2014 |
20140106011 | USE OF TEA-DERIVED, THEAFLAVIN ENRICHED EXTRACT TO INCREASE PERFORMANCE AND REDUCE EXERCISE RECOVERY TIME - This invention provides various methods such as a method for enhancing athletic exercise performance of a subject by administering to the subject a composition comprising a physiologically acceptable carrier and an extract of tea, wherein the extract comprises at least 20% by weight of theaflavins and wherein the composition is administered in an amount effective to enhance the subject's athletic performance. | 04-17-2014 |
20140093659 | Precursors and Transport Methods for Hydrothermal Liquid Phase Sintering (HLPS) - A method of producing a monolithic ceramic body from a porous matrix includes providing a porous matrix having interstitial spaces, providing an infiltrating medium comprising a solvent and at least one reactive species, and infiltrating at least a portion of the interstitial space of the porous matrix with the infiltrating medium. The solvent is an inert medium that is not chemically reactive with the porous matrix, and is in a liquid phase when in the portion of the interstitial space of the porous matrix. The infiltrating medium is mechanically convected through the porous matrix. The at least one reactive species, when in a portion of the interstitial space of the porous matrix, reacts with a portion of the porous matrix to form a product, and the product fills at least a portion of the interstitial space. | 04-03-2014 |
20140086975 | HYDROGEL FORMULATION FOR DERMAL AND OCULAR DELIVERY - Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (SM), nitrogen mustard (NM) or half mustard (2-chloroethyl ethyl sulfide (CEES)) are also disclosed. | 03-27-2014 |
20140073685 | METHOD OF INHIBITING NONSENSE-MEDIATED mRNA DECAY - Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD a composition comprising an eIF5A inhibitor compound in an amount effective to prevent intracellular hypusination of eIF5A, whereby gene expression of NMD-susceptible mRNA is increased. | 03-13-2014 |
20140073586 | Compositions for the treatment of cancer, and methods for testing and using the same - A composition comprising leukotoxin proteins isolated from a bacterium is provided. In this composition, greater than 85% of the leukotoxin proteins are chemically modified at a basic amino acid residue, and the proteins induce cell death in myeloid leukocytes, while remaining substantially non-toxic to lymphoid leukocytes, lymphocytes, and red blood cells. Also provided is a method of selectively inducing cell death in myeloid leukocytes. The method comprises contacting the myeloid leukocytes with a composition comprising leukotoxin proteins. These leukotoxin proteins may be isolated from the NJ4500 strain of | 03-13-2014 |
20140073578 | Combination Therapy with Leukotoxin - The invention relates to pharmaceutical compositions comprising leukotoxin, a chemotherapeutic agent and a pharmaceutically acceptable carrier, including methods to treat cancer, and methods to induce apoptosis. | 03-13-2014 |
20140070663 | ELECTROKINETIC NANOTHRUSTERS AND APPLICATIONS THEREOF - An electrokinetic actuator for a propulsion system is described. The actuator includes an array of channels, with each channel having an inlet and an outlet. A reservoir is included that contains an ionic solution of particles. A first electrode proximate to (or deposited at) the inlet and a second electrode proximate to (or deposited at) the outlet are connected to a voltage source. The voltage source and electrodes apply a voltage across the length of the channels to generate an electric field parallel to each channel. The electric field causes an electro-osmotic flow of ions from the reservoir to the outlet producing electrokinetic thrust at the outlet. By varying the concentration of the ionic solution and the magnitude of the electric field, the electro-osmotic flow of ions is controlled. | 03-13-2014 |
20140066767 | SYSTEM AND METHOD FOR NOISE REDUCTION AND SIGNAL ENHANCEMENT OF COHERENT IMAGING SYSTEMS - A system and method of processing an ultrasound signal may include, in response to receiving a set of complex frequency samples of the ultrasound signal inclusive of content data and noise at a first noise level and being used to image an anatomical region of a body, resampling multiple subsets of complex frequency samples from the set of complex frequency samples. The resampled subsets of complex frequency samples may be resampled from a first domain into a second domain. The transformed resampled subsets of complex frequency samples may be combined in the second domain to produce a result signal with a second noise level reduced from the first noise level. An image derived from the result signal may be displayed. | 03-06-2014 |
20140064581 | BOOSTED CONSENSUS CLASSIFIER FOR LARGE IMAGES USING FIELDS OF VIEW OF VARIOUS SIZES - A system and method for predicting disease outcome by analyzing a large, heterogeneous image by a boosted, multi-field-of-view (FOV) framework, based on image-based features from multi-parametric heterogeneous images, comprises (a) inputting the heterogeneous image; (b) generating a plurality of FOVs at a plurality of fixed FOV sizes, the method for generating the plurality of FOVs at a plurality of fixed FOV sizes comprising dividing simultaneously, via the computing device, the large, heterogeneous image into (i) a plurality of FOVs at a first fixed FOV size from among the plurality of fixed FOV sizes; and (ii) a plurality of FOVs at a second fixed FOV size from among the plurality of fixed FOV sizes; (c) producing simultaneously for the heterogeneous image a combined class decision for: (i) the plurality of FOVs at the first fixed FOV size, and (ii) the plurality of FOV s at the second fixed FOV size. | 03-06-2014 |
20140064580 | METHOD AND APPARATUS FOR SEGMENTATION AND REGISTRATION OF LONGITUDINAL IMAGES - The described invention provides systems and methods for detecting and segmenting a lesion from longitudinal, time series, or multi-parametric imaging by utilizing spectral embedding-based active contour (SEAC). In addition, the described invention further provides systems and methods for registering time series data by utilizing reduced-dimension eigenvectors derived from spectral embedding (SE) of feature scenes (SERg). | 03-06-2014 |
20140054505 | Scalable Multiple-Inverse Diffusion Flame Burner for Synthesis and Processing of Carbon-Based and Other Nanostructured Materials and Films and Fuels - Apparatus and methods of use thereof for the production of carbon-based and other nanostructures, as well as fuels and reformed products, are provided. | 02-27-2014 |
20140050692 | POLYESTERS AND METHODS OF USE THEREOF - The invention provides polymers and methods for the treatment of pain and inflammation. | 02-20-2014 |
20140044745 | Influenza A Virus Vaccines and Inhibitors - The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. | 02-13-2014 |
20140041519 | ELECTROSTATIC SCREEN DEVICE AND METHOD FOR EMISSION CONTROL - An electrostatic screen battery for emission control (ESBEC) system includes a plurality of screens arranged in an alternating manner, so that screens at a first electric potential are interposed with screens at a second electric potential, with an ionizer disposed upstream of the screens, wherein a particulate-containing exhaust stream passing by the ionizer and then through the screens deposits particulates onto the screens. In preferred embodiments the screens have hydrophobic surfaces. | 02-13-2014 |
20140039232 | GENETICALLY ENGINEERED MICROBES AND USES THEREOF - This invention concerns methods of identifying genetic alterations with which a microbe can be used to produce fatty acids at a large amount for making biofuels. Also disclosed are microbes with such genetic alterations and uses thereof. | 02-06-2014 |
20140039044 | Hydroxylated Polymethoxyflavone Compositions - Provided herein are compositions enriched in polyhydroxylated polymethoxyflavones useful as dietary supplements, food additives, pharmaceutical compositions, nutraceutical compositions and cosmetic compositions. | 02-06-2014 |
20140037172 | ENHANCED MULTI-PROTOCOL ANALYSIS VIA INTELLIGENT SUPERVISED EMBEDDING (EMPRAVISE) FOR MULTIMODAL DATA FUSION - The present invention provides a system and method for analysis of multimodal imaging and non-imaging biomedical data, using a multi-parametric data representation and integration framework. The present invention makes use of (1) dimensionality reduction to account for differing dimensionalities and scale in multimodal biomedical data, and (2) a supervised ensemble of embeddings to accurately capture maximum available class information from the data. | 02-06-2014 |
20140030341 | POLYMERS AND METHODS FOR THE TREATMENT OF PAIN - Polymers, microspheres, and associated methods are presented for the treatment of chronic and acute pain. An anhydride polymer comprising a biodegradable backbone that comprises one or more pendant residues of a non-steroidal anti-inflammatory (NSAID). NSAIDs may be incorporated in to the polymers as pendant groups that are not part of the polymer backbone. The polymer comprises repeating units that form the biodegradable backbone, wherein in each repeating unit comprises a pendant residue of the NSAID. | 01-30-2014 |
20140027702 | MULTIFUNCTIONAL ZINC OXIDE NANO-STRUCTURE-BASED CIRCUIT BUILDING BLOCKS FOR RE-CONFIGURABLE ELECTRONICS AND OPTOELECTRONICS - A vertically integrated reconfigurable and programmable diode/memory resistor (1D1R) and thin film transistor/memory resistor (1T1R) structures built on substrates are disclosed. | 01-30-2014 |
20140023309 | PARALLEL-COUPLED DUAL RACETRACK SILICON MICRO-RESONATOR - An apparatus, resonator and method for modulating light including a mechanism to compensate for parameter deviations. The apparatus may be capable of phase shift keying and quadrature amplitude modulation, and includes a waveguide, a plurality of micro-resonators, and an electronic structure. The plurality of micro-resonators are positioned adjacent to the waveguide and have a parameter deviation in at least one resonator characteristic. The electronic structure is electrically biased so as to cause electro-optic modulation of amplitude and a phase of the light output by the apparatus, each bias voltage comprising a numerical offset that is determined based upon the parameter deviation, thereby reducing any overall effect caused by the material or manufacturing imperfections. An electronic encoder may provide driving voltage levels for phase shift keying or quadrature amplitude modulation. The number of output amplitude and phase states of light depends on the number of output voltage levels of the encoder. | 01-23-2014 |
20140013470 | PLANT GENES THAT CONFER RESISTANCE TO TRICHOTHECENE MYCOTOXINS AND FUSARIUM HEAD BLIGHT - Compositions and methods are disclosed for modulating disease resistance in plants. | 01-09-2014 |
20140010862 | MULTIFUNCTIONAL BIODEGRADABLE PEG NANOCARRIER-BASED HYDROGELS FOR PREVENTING HIV TRANSMISSION - A multifunctional polyethylene glycol-based hydrogel that includes a multi-arm polyethylene glycol cross-linking unit covalently bound to at least four multi-arm polyethylene glycol nanocarrier units, wherein each nanocarrier unit includes an agent coupled to the nanocarrier unit and each agent is selected from pH-lowering agents, bioadhesion agents, microbicidal-spermicidal agents, and agents that inhibit free and cell-associated HIV binding, provided that each nanocarrier unit comprises a different agent. | 01-09-2014 |
20130345143 | MODULATION OF p62 FUNCTION THROUGH THE PB1 DOMAIN - Provided are methods, compositions, and kits employing a molecule that exhibits a function of the PB | 12-26-2013 |
20130343996 | GRAPHITE-COATED MAGNETIC NANOPARTICLES - The present invention relates to graphite-coated magnetic nanoparticles, methods for the synthesis of graphite-coated magnetic nanoparticles, and methods of using graphite-coated magnetic nanoparticles for targeted delivery of siRNA-based therapy, as multimodal imaging probes and for hyperthermia cancer treatment. | 12-26-2013 |
20130331502 | USE OF RECYCLED PLASTICS FOR STRUCTURAL BUILDING FORMS - Modular plastic structural composites formed from a mixture of (A) high density polyolefin and one or both of: (B) a thermoplastic-coated fiber material, or (C) polystyrene, poly(methyl methacrylate), or a combination thereof. Composites molded in the form of I-Beams and bridges constructed therefrom are also disclosed. | 12-12-2013 |
20130323753 | METHODS AND KITS FOR IDENTIFICATION OF ANTI-EXCITOTOXIC COMPOUNDS - The instant invention provides methods and kits for screening for anti-excitotoxic compounds which increase the total amount of EAAT-1 protein or the surface amount of EAAT-1 protein. | 12-05-2013 |
20130302279 | IDENTIFICATION OF NATURAL PLANT EXTRACTS HARBORING ANTI-HEPATITIS C VIRUS NS5B POLYMERASE ACTIVITY - The present invention relates to a novel use of naturally occurring plants, mushroom, extracts thereof that exhibit properties as HCV NS5B polymerase inhibitors. | 11-14-2013 |
20130302257 | Compositions and Methods for Delivering Nucleic Acid Molecules and Treating Cancer - The present invention provides compositions and methods for the delivery of nucleic acids to a cell. The present invention additionally provides compositions and methods for the treatment of a disease or disorder, particularly cancer. | 11-14-2013 |
20130302249 | INTESTINAL PEPTIDE TARGETING LIGANDS - Peptide ligands for transporting therapeutic agents across the intestinal epithelial barrier that ordinarily are inadequately absorbed and must be delivered by alternative means, which contain an isolated amino acid sequence wherein at least one pair of amino acids are of an opposite charge and the pair members are separated by a spacer of 1-12 amino acid residues including at least one hydrophobic amino acid, and wherein the length of the amino acid sequence is greater than 5 and less than 20 amino acids. Pharmaceutical compositions for gastro-intestinal delivery and methods for the gastrointestinal delivery of poorly absorbed therapeutic agents are also disclosed. | 11-14-2013 |
20130273164 | NANOTECHNOLOGY APPROACH FOR INHALATION THERAPIES - This invention relates to lipid nanoparticle compositions and methods for the localized delivery of active agents via inhalation therapy. | 10-17-2013 |
20130266501 | Direct Production of Large and Highly Conductive Low-Oxygen Graphene Sheets and Monodispersed Low-Oxygen Graphene Nanosheets - Method for making graphene sheets exfoliated by oxidation from graphite by mixing graphite powder with a solution of concentrated sulfuric acid and nitric acid and subjecting the resultant mixture to microware irradiation until a finely dispersed suspension graphene sheets is formed in the solution. Graphene sheets exfoliated by oxidation from graphite are also disclosed. | 10-10-2013 |
20130257804 | Method, apparatus, and system for capacitive touch communication - A method, apparatus, and system for using a user device to communicate with a touch-screen of an electronic device includes generating, by an electronic circuit of the user device, a signal by encoding a data sequence that may be stored in a memory of the user device and communicating the signal from the user device, to the electronic device by varying a capacitance of the touch-screen thereof. The electronic device receives the signal to obtain the data sequence. The electronic device may use the data sequence to at least authenticate a user of the user device. | 10-03-2013 |
20130236552 | NANOTOPOGRAPHY-MEDIATED REVERSE UPTAKE PLATFORM FOR NUCLEIC ACID DELIVERY AND APPLICATIONS THEREOF - This application discloses a nanotopography-mediated reverse uptake (NanoRU) platform useful for intracellular delivery of nucleic acids into mammalian cells, in particular stem cells, as well as methods of preparation and applications thereof. In particular, this system can be used to deliver small interfering ribonucleic acids (siRNAs) into neural stem cells and enhance neuronal differentiation of the stem cells. | 09-12-2013 |
20130236511 | FORMULATION AND MANUFACTURE OF PHARMACEUTICALS BY IMPREGNATION ONTO POROUS CARRIERS - The present invention provides methods for impregnating a porous carrier with an active pharmaceutical ingredient (“AP”), the methods comprising steps: a) dissolving at least one API in a solvent to form an API solution; b) contacting a porous carrier with the at least one API of step (a) in a contactor to form an API impregnated porous carrier; and c) drying the at least one API impregnated porous carrier. | 09-12-2013 |
20130221346 | Zinc Oxide-Based Thin Film Transistor Biosensors with High Sensitivity and Selectivity - This application discloses ZnO film transistor-based immunosensors ZnO-bioTFT), 2T biosensor arrays formed from two integrated ZnO-bioTFTs. ITIR-based nonvolatile memory (NVM) arrays formed from ZnO-bioTFT (T) integrated with ZnO-based resistive switches (R), as well as integrated bioTFT (IBTFT) sensor systems formed from 2T biosensor arrays and ITIR NVM arrays. Through biofunctionalization, these biosensors can perform immunosensing with high seminvity and selectivity, and therefore have a wide range of applications, for example, in detecting target biomolecules or small molecules, and potential application in cancer diagnosis and treatment. | 08-29-2013 |
20130217753 | AMPHIPHILIC MACROMOLECULES FOR NUCLEIC ACID DELIVERY - The invention provides amphiphilic macromolecules that are useful for delivering nucleic acids to cells and that are useful as delivery agents for gene therapy. | 08-22-2013 |
20130203713 | POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES - The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers. | 08-08-2013 |
20130202582 | AGENT DELIVERY SYSTEM CAPABLE OF SELECTIVELY RELEASING AN AGENT - The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism. | 08-08-2013 |
20130202173 | CLASSIFICATION OF BIOLOGICAL TISSUE BY MULTI-MODE DATA REGISTRATION, SEGMENTATION AND CHARACTERIZATION - A method and apparatus for classifying possibly vulnerable plaques from sets of DCE-MRI images includes receiving a set of MRI slice images obtained at respectively different times, where each slice image includes voxels representative of at least one region of interest (ROI). The images are processed to determine the boundaries of the ROIs and the voxels within the identified boundaries in corresponding regions of the images from each time period are processed to extract kinetic texture features. The kinetic texture features are then used in a classification process which classifies the ROIs as vulnerable or stable. | 08-08-2013 |
20130185729 | ACCELERATING RESOURCE ALLOCATION IN VIRTUALIZED ENVIRONMENTS USING WORKLOAD CLASSES AND/OR WORKLOAD SIGNATURES - Systems, methods, and apparatus for managing resources assigned to an application or service. A resource manager maintains a set of workload classes and classifies workloads using workload signatures. In specific embodiments, the resource manager minimizes or reduces resource management costs by identifying a relatively small set of workload classes during a learning phase, determining preferred resource allocations for each workload class, and then during a monitoring phase, classifying workloads and allocating resources based on the preferred resource allocation for the classified workload. In some embodiments, interference is accounted for by estimating and using an “interference index”. | 07-18-2013 |
20130183379 | GRAFT COPOLYMER POLYELECTROLYTE COMPLEXES FOR DRUG DELIVERY - Graft copolymer polyelectrolyte complexes are disclosed for the efficient delivery of anionic, cationic or polyelectrolyte therapeutic agents into biological cells, and for maintaining the biological activity of these molecules while in serum and other aqueous environments are provided. Such complexes comprise (1) an anionic graft copolymer containing an anionic polymer backbone, with pendent carboxylic acid groups and pendant chains containing amphipathic or hydrophilic polymers covalently bonded to a portion of the pendant carboxylic acid groups, (2) one or more anionic, cationic or polyelectrolyte therapeutic agents, and (3) optionally a liposome optionally containing an additional therapeutic agent. Also disclosed are functional nanoparticles containing the complexes. | 07-18-2013 |
20130178463 | ENHANCED TRANSBUCCAL DRUG DELIVERY SYSTEM AND COMPOSITIONS - A buccal delivery system is disclosed suitable for delivery of a therapeutic agent to the oral cavity of a patient. The delivery system comprises a matrix for containing and releasing the therapeutic agent into the oral cavity and an alkyl N,N-disubstituted amino acetate in said matrix. A particularly preferred delivery system comprises a matrix containing an effective amount of therapeutic agent together with an alkyl N,N-disubstituted amino acetate, such as dodecyl 2-(N,N-dimethylamino) propionate salt. | 07-11-2013 |
20130178382 | Identification of Modulators of Autophagy - Methods for identifying compounds that inhibit or stimulate the autophagy pathway are described. Devices for detecting the expression of autophagy-related genes and kits for assaying the expression of autophagy-related genes are also described. Also described are methods for identifying individuals susceptible to or afflicted with a disease state associated with an autophagy pathway defect. | 07-11-2013 |
20130178376 | Compositions and Methods for High-Throughput Nucleic Acid Analysis and Quality Control - Methods for improved quality control of nucleic acid containing biological samples utilized in high-throughput situations such as biorepositories engaged in the collection, processing, storage, distribution and analysis of such samples are disclosed. | 07-11-2013 |
20130171191 | Compositions and Methods for Enhancing Dendritic Cell Resistance to Bacterial Infection and for Enhancing the Mobility of Dendritic Cells for Dendritic Cell-Based Immunotherapy - Compositions and methods comprising dendritic cells expressing elevated levels of fascin 1 useful in immunotherapy are disclosed. | 07-04-2013 |
20130143921 | NOVEL PEPERIDINE-FLAVAN ALKALOID COMPOUNDS DERIVED FROM AFRICAN HERB TEA KINKELIBA AS ANTI-DIABETIC AGENTS - This invention provides the methods of separation and identification of a novel type of piperidine flavan alkaloids from an African herbal tea, the leaves of | 06-06-2013 |
20130137749 | Compositions and Methods for Gene Silencing - Compositions and methods for modulating the expression of a protein of interest are provided. | 05-30-2013 |
20130122267 | BONDING ELEMENT, BONDING MATRIX AND COMPOSITE MATERIAL HAVING THE BONDING ELEMENT, AND METHOD OF MANUFACTURING THEREOF - A bonding element, a bonding element matrix and composite materials with a wide range of attractive properties that may be optimized, including, but not limited to, mechanical properties, thermal properties, magnetic properties, optical properties and nuclear properties, as a result of a first layer and second layer structure or core, first layer, and second layer structure of the bonding elements, as well as methods for making the bonding elements and the corresponding ceramic and/or composite materials. | 05-16-2013 |
20130122053 | SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH - The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids include CDDO, CDDO-Me, CDDO-Im, and CDDO-Ethylamide. Examples of tricyclic-bis-enones include TBE-31 and TBE-34. | 05-16-2013 |
20130116274 | THERAPEUTIC COMBINATIONS CONTAINING RILUZOLE - Disclosed is a method of treating melanoma in a mammal comprising administering (a) a therapeutically effective amount of an inhibitor of metabotropic glutamate receptor 1 (GRM1); and (b) a therapeutically effective amount of an inhibitor of at least one downstream signaling target of GRM1. Also disclosed are compositions and kits for treating melanoma comprising (a) a therapeutically effective amount of an inhibitor of GRM1; and (b) a therapeutically effective amount of an inhibitor of at least one downstream signaling target of GRM1. | 05-09-2013 |
20130096532 | Polymer-Based Micro-Needle Array Designs, Fabrication Processes, and Methods of Use Thereof for Drug Delivery - A micro-needle array is provided that may be used to deliver a bioactive agent to a therapeutic target. The micro-needle array preferably includes a substrate, a plurality of micro-needles integral with the substrate, and a bioactive agent. At least one micro-needle preferably includes a top surface, a bottom surface, a side surface, and a cavity defined by an inner surface. The bioactive agent may be disposed on the substrate and the plurality of micro-needles. The at least one micro-needle may further include a slit connecting the cavity to an aperture, the slit extending from the top surface to the bottom surface. A plurality of micro-needles on a patch is also disclosed for transdermal drug delivery applications. | 04-18-2013 |
20130094486 | Wireless Network Virtualization For Wireless Local Area Networks - An access point of a wireless network including: a controller for emulating a first virtual access point of a first service provider and a second virtual access point of second service provider; a transceiver port for communicating control signals to clients of the first and service providers to limit the uplink air-time of the clients; and a connection port for linking the first and second service providers to a backhaul. | 04-18-2013 |
20130087095 | SELF-GETTERING DIFFERENTIAL PUMP - A self-gettering differential pump for a molecular beam epitaxy system has a collimator with a length greater than its diameter mounted in front of a source in extended port geometry, wherein the reactant delivered by the source also serves as a gettering agent. | 04-11-2013 |
20130085238 | BIOCOMPATIBLE POLYMERS FOR MEDICAL DEVICES - The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations. | 04-04-2013 |
20130078476 | HYDROXYAPATITE WITH CONTROLLABLE SIZE AND MORPHOLOGY - Methods are presented for a continuous, two-step, phase sequenced deposition of hydroxyapatite film over the surface of the substrate. | 03-28-2013 |
20130073724 | Autonomic Workflow Management in Dynamically Federated, Hybrid Cloud Infrastructures - An autonomic workflow framework may include a federated cloud that includes a plurality of clouds, where each cloud in the federated cloud includes one or more nodes. An autonomic workflow framework may include a workflow manager configured to receive a workflow. The workflow may include a plurality of stages, and the workflow may be associated with a user objective. An autonomic workflow framework may include an autonomic scheduler in communication with the workflow manager. The autonomic scheduler may be configured to provision one or more of the one or more nodes to process the stages to achieve the user objective. | 03-21-2013 |
20130072627 | JUST-IN-TIME COMPOUNDING IN AN INJECTION MOLDING MACHINE - A plastication unit for an injection molding machine, combining a heated plastication barrel with an entrance port and an exit port on opposing ends of the barrel; a hopper positioned to deliver ingredients to be compounded for injection molding to the entrance port of the barrel; and a helical plastication screw rotatably carried within the barrel and running the length of the barrel between the entrance and exit ports, which is operable to rotate and transmit the ingredients along the length of the barrel; wherein the plastication screw has at least one axial fluted extensional mixing element segment and the ingredients include at least one polymer for injection molding. Methods for injection molding with the plastication unit of the present invention and articles formed by the inventive methods are also disclosed. | 03-21-2013 |
20130072447 | ENHANCED ORAL TRANSCOMPARTMENTAL DELIVERY OF THERAPEUTIC OR DIAGANOSTIC AGENTS - The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent. | 03-21-2013 |
20130066048 | Methods of Obtaining Natural Products from the Comestible Fluids and Methods of Use - Described herein is an enriched substance containing a ground edible material comprising one or more concentrated bioactive natural products from plant juice, as well as methods of producing such enriched substances and methods of using such solids to provide beneficial effects to humans or other animals. Enriched foods comprising the enriched substance(s) are also provided. Also provided are non-sorbed natural products such as sugars, fats oils, and carotenoids found in the non-sorbed plant liquor fraction of plant juice. | 03-14-2013 |
20130053446 | PHARMACEUTICAL PREPARATIONS HAVING INDIVIDUALIZED DOSAGE AND STRUCTURE - A manufacturing device capable of creating individualized dosages of pharmaceutical preparations in which a metering system and a means of performing non-destructive chemical analysis of individual manufactured units are controlled by a microprocessor to precisely control the content and structure of each individual unit. | 02-28-2013 |
20130042758 | METHODS AND COMPOSITIONS FOR REMOVING CARBON DIOXIDE FROM A GASEOUS MIXTURE - Provided is a method for adsorbing or separating carbon dioxide from a mixture of gases by passing the gas mixture through a porous three-dimensional polymeric coordination compound having a plurality of layers of two-dimensional arrays of repeating structural units, which results in a lower carbon dioxide content in the gas mixture. Thus, this invention provides useful compositions and methods for removal of greenhouse gases, in particular CO | 02-21-2013 |
20130040806 | SPINEL CATALYSTS FOR WATER AND HYDROCARBON OXIDATION - A catalyst for the electrolysis of water molecules and hydrocarbons, the catalyst including catalytic groups comprising A | 02-14-2013 |
20130037092 | FERROELECTRIC DIODE AND PHOTOVOLTAIC DEVICES AND METHODS - Provided are diodes and photovoltaic devices incorporating a single-crystalline ferroelectric or pyroelectric with remnant electric polarization sandwiched with transparent or semitransparent electrodes. | 02-14-2013 |
20130032759 | NEAR INFRARED-EMITTING ER AND YB/ER DOPED CEF3 NANOPARTICULATES WITH NO VISIBLE UPCONVERSION - A rare earth element composition comprising CeF | 02-07-2013 |
20130030152 | TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE - Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species. | 01-31-2013 |
20130029346 | VECTOR AND SCREENING ASSAY FOR CD44 EXPRESSING CARCINOMAS - The present invention relates, in part, to the discovery of cis-regulatory regions for the expression of CD44 in normal cells and/or and over-expression in cancer cells or cancer stem cells. To this end, the present invention provides isolated DNA, vectors, kits, and methods that may be used for the evaluation and/or screening one or more therapeutic agents for the treatment of a CD44 expressing carcinoma. | 01-31-2013 |
20130022653 | BIOMIMETIC HYDROXYAPATITE SYNTHESIS - A method for preparing nanoscale hydroxyapatite particles by combining an amount of a calcium ion source, which includes calcium acetate, and an amount of a phosphate ion source, wherein the amounts are sufficient to produce nanoscale hydroxyapatite particles and the amounts are combined under ambient conditions to produce the hydroxyapatite particles. Nanoscale hydroxyapatite particles are also presented. | 01-24-2013 |
20130022527 | BIOMIMETIC HYDROXYAPATITE SYNTHESIS - A method for preparing nanoscale hydroxyapatite particles by combining an amount of a calcium ion source, which includes calcium acetate, and an amount of a phosphate ion source, wherein the amounts are sufficient to produce nanoscale hydroxyapatite particles and the amounts are combined under ambient conditions to produce the hydroxyapatite particles. Nanoscale hydroxyapatite particles are also presented. | 01-24-2013 |
20130017567 | ZINC OXIDE-BASED NANOSTRUCTURE MODIFIED QCM FOR DYNAMIC MONITORING OF CELL ADHESION AND PROLIFERATION - A dynamic and noninvasive method of monitoring the adhesion and proliferation of biological cells through multimode operation (acoustic and optical) using a ZnO nanostructure-modified quartz crystal microbalance (ZnO | 01-17-2013 |
20130008973 | POLYMER BASED RAILROAD TIE SHAPED TO REDUCE CENTER BOUNDING - A railroad tie composed of an immiscible polymer blend having a portion of the underside curved orthogonal to the longitudinal axis of the tie or curved both orthogonal and parallel to the longitudinal axis of the tie, forming a saddle shape, for purposes of reducing the center bounding problems encountered in prior art synthetic railroad ties. | 01-10-2013 |
20120324462 | VIRTUAL FLOW PIPELINING PROCESSING ARCHITECTURE - A computer system for embodying a virtual flow pipeline programmable processing architecture for a plurality of wireless protocol applications is disclosed. The computer system includes a plurality of functional units for executing a plurality of tasks, a synchronous task queue and a plurality of asynchronous task queues for linking the plurality of tasks to be executed by the functional units in a priority order, and a virtual flow pipeline controller. The virtual flow pipeline controller includes a processing engine for processing a plurality of commands; a scheduler, communicatively coupled to the processing engine, for selecting a next task for processing at run time for each of the plurality of functional units; a processing engine controller, communicatively coupled to the processing engine, for providing commands and arguments to the processing engine and monitoring command completion; and a task flow manager, communicatively coupled to the processing engine controller, for activating the next task for processing. Also disclosed is a computer-implemented method for executing a plurality of wireless protocol applications embodying a virtual flow pipeline programmable processing architecture in a computer system. | 12-20-2012 |
20120322768 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING PROTOZOAN INFECTIONS - Provided are compounds, compositions and methods for treating protozoan infections. | 12-20-2012 |
20120322056 | RNA-EXIT-CHANNEL: TARGET AND METHOD FOR INHIBITION OF BACTERIAL RNA POLYMERASE - The invention provides a target and methods for specific binding and inhibition of RNAP from bacterial species. The invention is directed to a method for identifying agents that bind to a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, comprising preparing a reaction solution comprising the agent to be tested and an entity comprising a bacterial RNAP homologous RNA-exit-channel amino-acid sequence, and detecting presence or amount of binding. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy. | 12-20-2012 |
20120312194 | SYNTHETIC FORMULATIONS AND METHODS OF MANUFACTURING AND USING THEREOF - A method for producing a reaction product including at least one synthetic formulation that carbonates sufficiently, said method comprising: providing a first raw material, having a first concentration of M; providing a second raw material, having a second concentration of Me; and mixing the first raw material and the second raw material to produce a reaction product that includes at least one synthetic formulation having the general formula M | 12-13-2012 |
20120309808 | COMPOSITIONS AND METHODS FOR EPIGENETIC MODIFICATION OF NUCLEIC ACID SEQUENCES - Provided herein are pharmaceutical compositions and methods for treating disorders characterized by reduced expression of anti-oxidative stress enzymes in a subject. In one aspect, the present invention provides a method for inducing expression of anti-oxidative stress enzymes in a subject in need thereof. The method includes administering to the subject a therapeutically effective amount of a demethylating agent. The demethylating agent includes a phytochemical that induces expression of Nrf2 and Nrf2-mediated genes expressing anti-oxidative stress. Such phytochemicals include indoles, such as 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C), and isothiocyanates, such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN). | 12-06-2012 |
20120302719 | BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITES - New bioresorbable polymers are synthesized from monomer analogs of natural metabolites In particular, polymers are polymerized from analogs of amino acids that contribute advantageous synthesis, processing and material properties to the polymers prepared therefrom, including particularly advantageous degradation profiles | 11-29-2012 |
20120291126 | Balancing Malware Rootkit Detection with Power Consumption on Mobile Devices - The subject disclosure presents a novel technique for balancing the tradeoff between security monitoring and energy consumption on mobile devices. Security/energy tradeoffs for host-based detectors focusing on rootkits are analyzed along two axes: a scanning frequency, and a surface of attack. Experimental results are applied to a hypervisor-based framework, and a sweet spot is identified to minimize both energy consumption and a window of vulnerability for critical operating system objects such as code pages and kernel data. | 11-15-2012 |
20120271195 | METHODS AND SYSTEMS FOR SCREENING AND TREATMENT OF YOUNG INFANTS DEMONSTRATING DEFICITS IN AUDITORY PROCESSING - The present invention provides a method and apparatus for screening infants at high risk for central auditory processing deficits and then remediating less efficient processing behaviorally using an adaptive training algorithm that gradually increases sensitivity to rapidly occurring stimuli streams. | 10-25-2012 |
20120271002 | METHOD OF RECYCLING PAINTS AS A COMPONENT OF AN IMMISCIBLE POLYMER BLEND - An immiscible polymer blend including a first polymer component including a paint polymer phase and a second polymer component immiscible with the first polymer component and selected from polyolefins and polymethylmethacrylate (PMMA). A method of recycling paint by blending a first polymer component including a paint polymer phase with a second polymer component immiscible with the first polymer component and selected from polyolefins and polymethylmethacrylate (PMMA) is also presented. | 10-25-2012 |
20120265586 | SYSTEM AND METHOD TO MEASURE AND CONTROL POWER CONSUMPTION IN A RESIDENTIAL OR COMMERCIAL BUILDING VIA A WALL SOCKET TO ENSURE OPTIMUM ENERGY USAGE THEREIN - A system and method to measure and control power usage within a residential or commercial building plurality having of electrical circuits electrically connected to an over-current protection device to ensure optimum energy usage therein. The system and method includes a power measurement and control device electrically connected to one of the electrical circuits by which a load draws power that is operable to (i) measure an electrical parameter of the electrical circuits, (ii) compare the measured electrical parameter to an ideal electrical parameter, and (iii) adjust power supplied to one or more of the electrical circuits based on the comparison of the measured electrical parameter and the ideal electrical parameter via a wall socket. The adjustment of power may be automatic or manual deactivation, decrease, and/or increase of power supplied to the electrical circuits via the wall socket so that such is equivalent to or less than the ideal electrical parameter. | 10-18-2012 |
20120252891 | Vanilloid Fatty Hydroxamates as Therapeutic Anti-inflammatory Pharmaceuticals - Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye. | 10-04-2012 |
20120252138 | Methods and Related Devices for Continuous Sensing Utilizing Magnetic Beads - Provided is a fluidic device including a main channel, wherein a first inlet fluidly connects to an upstream end of the main channel and introduces magnetic beads into a first side of the main channel. A second inlet is fluidly connected to the upstream end of the main channel and introduces a sample stream into a second side of the main channel. A magnet disposed adjacent to the second side of the main channel pulls the magnetic beads towards a sidewall of the second side, and thus into the sample stream. The beads continue through an extended incubation channel before entering a return channel. The return channel includes a detection region. Also provided is a multi-layer micro-fluidic assay device. An assay method that utilizes a microfluidic assay device is provided as well. | 10-04-2012 |
20120247232 | METHOD AND DEVICE FOR THE COLLECTION OF AIRBORNE PARTICLES AND THEIR CONCENTRATION IN SMALL AMOUNTS OF LIQUID - A method and its possible embodiments are presented for collecting airborne biological and non-biological agents and concentrating them into small amounts of liquid. Airborne particles are drawn into the sampler and by the action of an electrostatic field are deposited on the collection electrode covered with superhydrophobic substance (surface contact angle >150°). At the end of the sampling period a small liquid droplet (5-60 μL) is injected at the top of the sampling chamber. Since the sampler is positioned at an angle to the horizontal, the droplet rolls-off of collection electrode's surface under the force of gravity and removes the deposited particles. The droplet is then collected by a liquid capture system. The particles concentrated in such small amounts of liquid facilitate sample analysis by various techniques. The suggested sampler's embodiments achieve sample concentration rates higher than 1×10 | 10-04-2012 |
20120245216 | COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROPATHIC PAIN - The present invention relates to compounds, compositions, methods, systems and kits for treating neuropathic pain regulated by SIP30. The present invention provides SIP30 antagonists for the treatment of neuropathic pain. | 09-27-2012 |
20120240299 | Interspecific cornus hybrid designated KV10-105v1 - An interspecific hybrid of | 09-20-2012 |
20120238595 | THERAPEUTIC COMPOUNDS - The invention provides compounds of formula (I) wherein u, d, v, m, n, R | 09-20-2012 |
20120237557 | BIOACTIVE CARBON-NANOTUBE AGAROSE COMPOSITES FOR NEURAL ENGINEERING - Nanocomposite fibers containing one or more carbon nanotubes encapsulated in an polysaccharide gel matrix. | 09-20-2012 |
20120231519 | Molecular Surface Design of Tyrosine-Derived Polycarbonates for Attachment of Biomolecules - Methods for constructing tyrosine-derived biotinylated polymers. Biotinylated polymers and polymer scaffolds constructed with the biotinylated polymers are also disclosed. | 09-13-2012 |
20120226013 | BIOCOMPATIBLE POLYMERS FOR MEDIAL DEVICES - The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations. | 09-06-2012 |
20120220691 | PROCESS FOR THE SYNTHESIS OF METHACRYLATE-DERIVATIZED TYPE-1 COLLAGEN AND DERIVATIVES THEREOF - Methods for synthesizing a methacrylate-derivatized type-I collagen in which methacrylic acid is reacted with a carboxylic acid activating reagent in the presence of a carbodiimide to form a methacrylic acid with an activated carboxylic acid group, which is then reacted with free amino groups on type-I collagen to form a collagen methacrylamide. Methacrylate-derivatized collagen, cross-linked collagens formed therefrom and products containing the cross-linked collagen are also disclosed. | 08-30-2012 |
20120220053 | GRAPHENE-ENCAPSULATED NANOPARTICLE-BASED BIOSENSOR FOR THE SELECTIVE DETECTION OF BIOMARKERS - A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers. | 08-30-2012 |
20120207796 | POLYMERIC DRUG DELIVERY COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DISEASES - Degradable polymeric compositions containing water-insoluble drugs blended with copolymers of biocompatible diphenol compound monomer units with pendant carboxylic acid groups polymerized with biocompatible diphenol compound monomer units with pendant carboxylic acid ester groups and poly(alkylene oxide) blocks, wherein the molar fraction in the copolymer of biocompatible diphenol compound monomer units with pendant carboxylic acid groups and poly(alkylene oxide) blocks relative to the weight percentage of the drug in the composition is effective to provide pseudo-zero order release of the drug from the composition during the sustained-release phase of drug delivery under physiological conditions. Ocular treatment methods and manufacturing methods are also disclosed. | 08-16-2012 |
20120202707 | CELL LINES USEFUL FOR ASSESSING MODULATION OF AUTOPHAGY - Methods for screening for modulators of autophagy are disclosed. Methods for identifying genes whose expression inhibits autophagy, as well as genes whose expression promotes autophagy, are disclosed. Also disclosed are methods for identifying compounds that stimulate autophagy, as well as compounds that inhibit autophagy. Cell lines that may be used in the methods of identification are also disclosed. | 08-09-2012 |
20120202298 | HTS Fluorescence Polarization Assay for Inhibitors of Keap1-Nrf2 Interaction - Disclosed are methods and kits for identifying modulators of the Keap1-Nrf2-ARE pathway. In particular, a high throughput fluorescent polarization assay is described that identifies small molecules that inhibit the binding of a fluorescently labeled Nrf2 peptide with the kelch domain of the Keap1 protein. Also provided are probes that can be used in the described fluorescent polarization assay. The small molecules identified using the described assay are useful for combating oxidative stress-related disorders, such as those associated with cancer, emphysema, Huntington's disease, light-induced retinal damage, and stroke. | 08-09-2012 |
20120197001 | BIORESORBABLE POLYMERS SYNTHESIZED FROM MONOMER ANALOGS OF NATURAL METABOLITES - This invention discloses biocompatible polymers prepared from monomers (IV), and (IVa), or derivatives thereof, for which the variables are described in the claims and specification. These polymers may be bioresorbable and thus useful for manufacture of medical devices. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure. | 08-02-2012 |
20120189713 | MONOMERS AND PHASE-SEPARATED BIOCOMPATIBLE POLYMER COMPOSITIONS PREPARED THEREFROM FOR MEDICAL USES - The invention relates to novel monomers of Formula (I) useful for preparation of phase-separated biocompatible polymers or polymer compositions. These polymers or polymer compositions may be bioresorbable and/or biodegradable and have desirable mechanical properties, such as fracture and/or fatigue toughness, which have not been a primary design criteria for such polymers previously. The polymers or polymer compositions are useful in a variety of medical applications, such as in the fabrication of medical devices. Therefore, methods for preparing these polymers or polymer compositions and medical devices are also encompassed by this disclosure. | 07-26-2012 |
20120183621 | SYNERGISTIC COMBINATIONS TO REDUCE PARTICLE DOSE FOR TARGETED TREATMENT OF CANCER AND ITS METASTASES - Non-Small Cell Lung Carcinomas (NSCLCs) are treated with Gel Micro-Particles (GMPs) that passively accumulate in the lungs and contain Nano-Particles (NPs) combining one or more therapeutic agents that are cytotoxic to the NSCLC with one or more NSCLC active targeting ligands, as well as one or more other optional agents that increase cellular uptake, enhance the pro-apoptotic effect of the chemotherapeutic agent(s), and the like. NPs targeting other cancer cells are also disclosed, as well as NP-containing GMPs that reduce the occurrence of tumor metastasis. | 07-19-2012 |
20120183578 | POLYETHYLENE GLYCOL-BASED DENDRONS - The instant invention relates to polyethylene glycol-based dendrons, otherwise known as PEGtide dendrons, compositions thereof and methods of use. | 07-19-2012 |
20120178885 | BIOCOMPATIBLE POLYMERS FOR MEDICAL DEVICES - The present invention relates to new classes of biocompatible polymers comprising at least one repeating unit derived from a compound of Formula (I) as defined in the claims and specification. These polymers may be biodegradable and bioresorble, and, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations. Therefore, methods for preparing these polymers and medical devices prepared therefrom are also encompassed by this disclosure. | 07-12-2012 |
20120178710 | SYNTHESIS OF CYCLIC DIGUANOSINE MONOPHOSPHATE AND THIOPHOSPHATE ANALOGS THEREOF - The invention provides methods for the synthesis of cyclic dinucleotides and thiophosphate analogs thereof as well as a new family of analogs of cyclic diguanosine monophosphate that includes a series of seven phosphorothioate derivatives that includes diastereomers of mono-, di-, and trithiophosphates. | 07-12-2012 |
20120149781 | STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS - This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI). | 06-14-2012 |
20120135523 | PREPARATION AND USES OF POLYARYLATES - The present invention is directed to polyarylates comprising repeating units having the structure: | 05-31-2012 |
20120135094 | OREGANO AND MINT ANTI-INFLAMMATORY COMPOSITIONS AND METHODS - The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and/or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC/MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants. | 05-31-2012 |
20120115962 | CYCLODEXTRIN-MODIFIED POLYAMINES FOR DELIVERY OF THERAPEUTIC MOLECULES - The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles. | 05-10-2012 |
20120108677 | IMINIC MONOMERS AND POLYMERS THEREOF - Disclosed are biocompatible, bioresorbable polymers comprising a plurality of monomeric repeating units containing an imine group, wherein the inclusion of said imine group is effective to lower the melt viscosity, the solution viscosity, or both, compared to the same polymer without an imine group. | 05-03-2012 |
20120106821 | IMAGE-BASED RISK SCORE-A PROGNOSTIC PREDICTOR OF SURVIVAL AND OUTCOME FROM DIGITAL HISTOPATHOLOGY - The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digital slide scanning, and a computer, the present invention relates to an image-based CAP system and method which aims to overcome many of the drawbacks associated with prognostic molecular assays (e.g. Oncotype DX) including the high cost associated with the assay, limited laboratory facilities with specialized equipment, and length of time between biopsy and prognostic prediction. | 05-03-2012 |
20120093919 | E2F AS A TARGET OF HORMONE REFRACTORY PROSTATE CANCER - The instant invention provides amino acid sequences competing with E2F for DNA binding. Methods of using said amino acid sequences for treatment of hormone-refractory prostate cancer are also provided. | 04-19-2012 |
20120093723 | NANOCARRIER COMPOSITIONS AND METHODS - This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier. | 04-19-2012 |
20120071527 | THERAPEUTIC COMPOUNDS - The invention provides compounds of formula I: | 03-22-2012 |
20120061660 | ZnO NANOSTRUCTURE-BASED LIGHT EMITTING DEVICE - A Light Emitting Diode (LED) formed on a substrate of a material selected from at least one of a semiconductor, an insulator and a metal; at least one semiconductor film layer of ZnO or GaN deposited on the substrate; a nanotips array of ZnO or its ternary compound, the array being grown either directly or indirectly on a surface of at least one semiconductor film layer; at least one transparent and conductive oxide (TCO) layer deposited on at least one semiconductor film layer; and a semiconductor p-n junction under a forward bias voltage. | 03-15-2012 |
20120059026 | ANTIMICROBIAL AGENTS - The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z | 03-08-2012 |
20120058155 | SLOW-DEGRADING POLYMERS FOR UNDELAYED AND SUSTAINED DRUG DELIVERY - The invention provides polymers and methods for their use. Certain embodiments of the invention provide slow degrading microspheres for undelayed and sustained drug delivery. | 03-08-2012 |