RIKEN Patent applications |
Patent application number | Title | Published |
20160139394 | MICROSCOPE, FOCUSING UNIT, FLUID HOLDING UNIT, AND OPTICAL UNIT - A microscope includes: a sample placement part having a placement surface on which to place a sample and a bottom face opposite to the placement surface; an observation lens; and an optical unit for generating sheet light and use of the microscope. The microscope of an embodiment is arranged such that the sheet light enters the sample placement part from the bottom face and passing through the sample placement part to irradiate the sample, and fluorescence from the sample passes through the sample placement part toward the bottom face to be received by the observation lens. The microscope can, with this arrangement, utilize the advantages of a SPIM, and allows observation of a sample which observation is free from a restriction of the size of a sample. | 05-19-2016 |
20160120153 | ANIMAL TEST DEVICE - An animal test device for performing a behavior test of a test animal and which can automatically perform optimization of the test includes a cage configuring a living environment of the test animal; a chamber removably attached to the cage; a touch panel provided in the chamber, presenting a problem to the test animal, detecting a response of the test animal, and obtaining response data; a position measurement device that measures a position of the test animal in the cage and the chamber and obtains position data; a data storage unit that stores the response data and the position data as test data; and a problem improvement unit that improves the problem presented by the touch panel, based on the test data. | 05-05-2016 |
20160046912 | GLUCURONOSYLTRANSFERASE, GENE ENCODING SAME AND USE THEREOF - Provided are an enzyme involved in a glycyrrhizin biosynthetic system, a gene of the enzyme and use thereof in order to stably and continuously provide a large amount of glycyrrhizin. Glucuronosyltransferase with an activity of further transferring glucuronic acid to the hydroxy group at the 2-position of glucuronic acid in an oleanane-type triterpenoid monoglucuronide is identified to provide the transferase, a gene for the transferase and use thereof. | 02-18-2016 |
20160042291 | SOLUTION SEARCH SYSTEM, SOLUTION SEARCH METHOD, AND SOLUTION SEARCH PROGRAM - A solution search system, which can search for a test object, expected to output an optimal result, from at least two test objects each outputting a result based on a probability distribution, includes: a record superiority comparing unit which can obtain past records of the test objects based on an accumulation of the output results and can compare all records for superiority/inferiority; a controlling unit which can control a measurement variable of the test objects, based on the compared superiority/inferiority records, and a latest result output from the test object; and an output instructing unit which can instruct the test object, the measurement variable of which has exceeded a threshold value, to output a result, wherein the output instructing unit determines, as a desired solution, at least one test object to which the largest number of the output instructions have finally been given after repetition of the output instructions. | 02-11-2016 |
20150320350 | BRAIN FUNCTION EVALUATION SYSTEM AND BRAIN FUNCTION EVALUATION METHOD - In order to evaluate a motor-function disorder accompanying a brain disease by a non-conventional new method, a brain function evaluation system | 11-12-2015 |
20150313217 | CONTROL AGENT FOR PLANT PEST AND/OR PLANT DISEASE - The present invention provides a control agent for a plant pest and/or a plant disease, the control agent being environmentally friendly and having a high control effect. The control agent is a control agent for a plant pest and/or a plant disease, containing a polyglycerin fatty acid ester as an active ingredient. The polyglycerin fatty acid ester is an ester of at least one fatty acid selected from fatty acids having 8 to 10 carbon atoms, and at least one polyglycerin obtained by polymerizing 3 to 10 glycerins. | 11-05-2015 |
20150309053 | TEST METHOD AND TEST KIT FOR PSYCHIATRIC AILMENTS - A novel test method for testing for the presence or absence of a predisposition to autistic spectrum disorder or the presence or absence of development of autistic spectrum disorder is provided. The test method includes a test step of determining an amount of at least one of the fatty acid binding proteins FABP3, FABP4, FABP5, and FABP7 in a sample prepared from the living body of a human or determining an expression level of at least one of the FABP3, FABP4, FABP5, and FABP7 genes in the sample. | 10-29-2015 |
20150291934 | CELL PREPARATION CONTAINING MYOCARDIUM-COMMITTED CELL - The present invention relates to a method for producing a cell population comprising myocardium-committed cells that differentiate into and survive as myocardial cells under a myocardial tissue environment. Specifically, the method is characterized in that adipose-tissue-derived multi-lineage/multi-potent progenitor cells are cultured in the presence of a polyamine. The present invention further relates to a cell population comprising the myocardium-committed cells, a cell preparation comprising the cell population, or a cell sheet. The present invention further relates to a method for treating a heart disease, which comprises administering the cell population to a subject. | 10-15-2015 |
20150275379 | WATER SPLITTING CATALYST, AND METHOD FOR PRODUCING OXYGEN AND HYDROGEN USING THE SAME - Provided is a catalyst that exhibits a high catalyst activity in a water oxidation reaction within a neutral range. A water splitting catalyst comprises at least one 3d-block transition metal element selected from manganese, iron, cobalt, nickel, and copper or a compound containing the element, and a base and/or a carbonate having a pKa of 8 or less. | 10-01-2015 |
20150275191 | TRITERPENE OXIDASE DERIVED FROM PLANT BELONGING TO GENUS GLYCYRRHIZA, GENE ENCODING THE SAME, AND METHOD OF USING THE SAME - Identification of a protein having an activity of oxidizing oleanane-type triterpene, and a gene encoding the protein, the protein and the gene, and use thereof are provided. For example, a protein having an activity of oxidizing oleanane-type triterpene obtained from a plant in the family Fabaceae, a gene encoding the protein and use thereof are provided. The protein is shown in, for example, SEQ ID NO: 4, 14 or 18, and the gene encoding the protein is shown in, for example, SEQ ID NO: 3, 13 or 17. A transformant into which the gene is introduced can be produced, and thereby a triterpene oxidase can be obtained. | 10-01-2015 |
20150259653 | TRITERPENE OXIDASE DERIVED FROM PLANT BELONGING TO GENUS GLYCHYRRHIZA, GENE ENCODING THE TRITERPENE OXIDASE, AND USE OF THE PROTEIN OR THE GENE - The present invention provides a protein having an activity of oxidizing a dammarane-type triterpene, a gene encoding the same, and use of the protein and the gene. The present invention specifically relates to a protein obtainable from a plant belonging to the genus | 09-17-2015 |
20150230459 | PESTICIDAL/OVICIDAL COMPOSITION AND PESTICIDAL/OVICIDAL METHOD - A pesticidal/ovicidal composition comprising: (a) 50-99.9 parts by mass of a triglyceride containing not less than 50% of oleic acid as a fatty acid component; (b) 0.1-20 parts by mass of a nonionic surface active agent; and (c) 0-30 parts by mass of a glycerin derivative. The composition according to the invention has not only a pesticidal activity but also an ovicidal activity on crop pests, and provides a safe and high pesticidal/ovicidal effect. | 08-20-2015 |
20150227196 | CONTROL DEVICE FOR ALTERNATE REALITY SYSTEM, ALTERNATE REALITY SYSTEM, CONTROL METHOD FOR ALTERNATE REALITY SYSTEM, PROGRAM, AND RECORDING MEDIUM - A control device comprises a past video image acquirer acquiring a past video image captured at a given location, a live video image acquirer acquiring a live video image captured at the given location, and a video image switcher switching the video image displayed by a head-mounted display at the given location between the past video image and live video image. | 08-13-2015 |
20150225519 | METHOD FOR ADHERING HYDROGELS - There is provided a method for bonding together hydrogels by interposing a polyalkylene glycol between the gel surfaces to be bonded together of hydrogels. A method for bonding together hydrogels of the same type or different types, the method including: interposing a polyalkylene glycol between gel surfaces to be bonded together of the hydrogels and joining together the gel surfaces. | 08-13-2015 |
20150221502 | EPITAXIAL WAFER AND METHOD FOR PRODUCING SAME - The epitaxial wafer includes a silicon substrate, an aluminum nitride thin film feeing a main surface of the silicon substrate, and an aluminum deposit between the silicon substrate and the aluminum nitride thin film so as to inhibit formation of silicon nitride. In the method for producing the epitaxial wafer, to form the aluminum deposit on the main surface of the silicon substrate, trimethyl aluminum is supplied into a reactor after a substrate temperature defined as a temperature of the silicon substrate is adjusted to a first predetermined temperature equal to or mare than. 300° C. and less than 1200° C. Thereafter, to form the aluminum nitride thin film facing the main surface of the silicon substrate, trimethyl aluminum and ammonia are supplied into the reactor after the substrate temperature is adjusted to a second predetermined temperature equal to or more than 1200° C. and equal to or less than 1400° C. | 08-06-2015 |
20150219644 | MARKER FOR ACUTE CORONARY SYNDROME, AND USE THEREOF - The present invention provides a method of testing plasma and/or serum of a test subject for determining the pathology or onset risk of acute coronary syndrome, including
| 08-06-2015 |
20150218569 | METHOD OF INTRODUCING NUCLEIC ACID INTO PLANT CELLS - The object of the present invention is to provide a method of introducing a nucleic acid into plant cells, which is simple and widely applicable to various types of plant cells and nucleic acids. The present invention relates to a method of introducing a nucleic acid into a target plant cell, comprising a step of forming a complex by bringing a carrier peptide, wherein the carrier peptide comprises a cell-penetrating sequence and a polycationic sequence, into contact with a nucleic acid and a step of bringing the obtained complex into contact with a target plant cell. | 08-06-2015 |
20150210801 | POLYESTER RESIN COMPOSITION AND MOLDED ARTICLE CONTAINING THIS RESIN COMPOSITION - An object is to increase crystallization speed, which is a drawback of polyhydroxyalkanoate, to improve processability in processing such as injection molding or blow molding and increase the speed of processing and is, in addition, to refine the crystal of polyhydroxyalkanoate to suppress a change of mechanical properties with passage of time of a resulting molded article. Disclosed herein is a polyester resin composition containing polyhydroxyalkanoate and pentaerythritol. | 07-30-2015 |
20150210698 | AGENT FOR TREATING OR INHIBITING RECURRENCE OF ACUTE MYELOID LEUKEMIA - This invention relates to an agent for treating or inhibiting recurrence of acute myeloid leukemia and an agent for inhibiting growth of leukemia stem cells comprising a compound represented by formula (I) or a salt thereof: | 07-30-2015 |
20150176154 | NITRIDE SEMICONDUCTOR MULTILAYER STRUCTURE, METHOD FOR PRODUCING SAME, AND NITRIDE SEMICONDUCTOR LIGHT-EMITTING ELEMENT - The nitride semiconductor light-emitting element of the invention has a stacked structure of a buffer layer, an n-type nitride semiconductor layer, a light-emitting layer, and a p-type nitride semiconductor layer, on one surface side of a single crystal substrate of a sapphire substrate. A nitride semiconductor multilayer structure as the buffer layer includes: a plurality of island-like nuclei formed of AlN and formed on the one surface of the single crystal substrate; a first nitride semiconductor layer formed of an AlN layer and formed on the one surface side of the single crystal substrate so as to fill gaps between adjacent nuclei and to cover all the nuclei; and a second nitride semiconductor layer formed of an AlN layer and formed on the first nitride semiconductor layer. The nitride semiconductor multilayer structure is characterized in that the density of the nuclei is less than 6×10 | 06-25-2015 |
20150140652 | VESSEL FOR CULTURING HUMAN ES CELLS - Provided are a culture vessel with which an embryonic body can be formed efficiently from human embryonic stem cells, and a method for culturing human embryonic stem cells using the vessel. There is provided a vessel for culturing human embryonic stem cells, the culture vessel having two or more wells ( | 05-21-2015 |
20150132787 | METHOD FOR PRODUCING CILIARY MARGINAL ZONE-LIKE STRUCTURE - The invention provides a method for producing a cell aggregate containing a ciliary marginal zone-like structure by culturing a cell aggregate containing a retinal tissue in which Chx10 positive cells are present in a proportion of 20% or more of the tissue in a serum-free medium or serum-containing medium, each containing a substance acting on the Wnt signal pathway for only a period before the appearance of a RPE65 gene expressing cell, followed by culturing the “cell aggregate in which a RPE65 gene expressing cell does not appear” thus obtained in a serum-free medium or serum-containing medium, each not containing a substance acting on the Wnt signal pathway and so on. | 05-14-2015 |
20150117485 | QUANTUM CASCADE LASER ELEMENT - To raise the upper limit of the temperature range in which a quantum cascade laser (QCL) element for THz range operates at a single frequency. In a quantum cascade laser element in one embodiment of the present invention, each unit structure | 04-30-2015 |
20150071991 | DRUG HAVING REGULATORY CELL LIGAND CONTAINED IN LIPOSOME - A liposome containing a regulatory cell ligand such as α-galactosyl ceramide or β-galactosyl ceramide is employed as the active ingredient of a drug for preventing or treating immune diseases etc. | 03-12-2015 |
20150033408 | POLYPEPTIDE INVOLVED IN MORPHOGENESIS AND/OR ENVIRONMENTAL STRESS RESISTANCE OF PLANT - Provided is a plant having a desired phenotype and/or desired stress resistance. Provided is a transgenic plant overexpressing a polypeptide that has the activity to control plant morphology or the activity to enhance the environmental stress resistance of plants, wherein the polypeptide(s) is one polypeptide or are a plurality of polypeptides selected from among polypeptides comprising the amino acid sequences represented by SEQ ID NOS: 1-317. | 01-29-2015 |
20150022781 | METHOD OF MEASURING THE ELASTICITY OF CRYSTALLINE LENS, A METHOD OF DETERMINING WHETHER CRYSTALLINE LENS IS PRESBYOPIC, AN APPARATUS FOR MEASURING THE ELASTICITY OF CRYSTALLINE LENS AND AN APPARATUS FOR DETERMINING WHETHER CRYSTALLINE LENS IS PRESBYOPIC - The present invention provides a method of measuring the elasticity of crystalline lens and an apparatus for measuring the elasticity of the crystalline lens for measuring stiffness of the crystalline lens 1, wherein the crystalline lens 1 is irradiated with pulse laser light to generate photoelastic waves from the crystalline lens 1, and the photoelastic waves from the crystalline lens 1 are measured. | 01-22-2015 |
20140322751 | MUTANT PYRROLYSYL -tRNA SYNTHETASE, AND METHOD FOR PRODUCTION OF PROTEIN HAVING NON-NATURAL AMINO ACID INTEGRATED THEREIN BY USING THE SAME - Method for incorporating a lysine derivative (particularly an N | 10-30-2014 |
20140302572 | METHOD FOR PRODUCING POLYHYDROXYALKANOATE HAVING LONG MAIN CHAIN STRUCTURE - An object of the present invention is to provide a polyhydroxyalkanoate which forms a useful bioplastic or biomaterial. Specifically, the present invention relates to a method for producing a polyhydroxyalkanoate that includes at least a 5-hydroxyvalerate unit, in which the method for producing a polyhydroxyalkanoate includes culturing a microorganism belonging to | 10-09-2014 |
20140299773 | Terahertz Wave Detection Device and Method - The present invention includes a slanted periodically poled device | 10-09-2014 |
20140295564 | GEL DOSIMETER FOR MEASURING RADIATION DOSAGE AND MANUFACTURING METHOD THEREFOR - To measure three-dimensional dose distributions with a dosimeter, such as a gel dosimeter. In an embodiment of the present invention, provided is a gel dosimeter having water, as solvent or disperse medium, clay particles that swell with water, and recording material precursor, which are dissolved or dispersed with each other. The recording material precursor has an atom or ion, wherein the atom or ion changes its valence number by reacting with both of a radical and a molecular radical derivative. The radical is to be generated from the water ionized by irradiation of radiation rays, and the molecular radical derivative is a molecule to be formed by bonding the radicals with each other. By the time radiation rays are irradiated, the gel dosimeter has been free from a substance identical to the molecular radical derivative and has lost fluidity. | 10-02-2014 |
20140295447 | PRIMER SET, METHOD FOR AMPLIFYING TARGET NUCLEIC ACID SEQUENCE USING SAME, AND METHOD FOR DETECTING MUTATED NUCLEIC ACID USING SAME - The present invention provides a primer set including primers that can be designed easily, with which an amplification distance can be shortened. Provided is a primer set for use in a method for isothermally amplifying a target nucleic acid sequence 4. The primer set includes a first primer 1F and a second primer 1R. The first primer 1F includes, on the 3′ side thereof, a sequence (A′) that can hybridize to a sequence (A) on the 3′ side of the target nucleic acid sequence. The second primer 1R includes, on the 3′ side thereof, a sequence (B′) that can hybridize to a sequence (B) on the 3′ side of either a strand extended from the first primer or a complementary strand of the target nucleic acid sequence 4. The first primer 1F and the second primer 1R include, on the 5′ sides thereof, sequences (C) that are substantially identical to each other. | 10-02-2014 |
20140274788 | LEUKEMIA STEM CELL MARKERS - The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an LSC-targeting therapeutic agent for AML capable of suppressing the expression of a gene selected from among LSC marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for AML patients, comprising obtaining an LSC-purged sample with at least 1 kind of LSC marker as an index; and a method of preventing or treating AML. | 09-18-2014 |
20140256794 | ACTIVATION OF FUNCTIONAL NUCLEIC ACID BY SPECIFIC MODIFICATION - This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one 3′ end thereof, a hairpin-shaped DNA comprising: (A) a nucleic acid region consisting of 2 to 5 arbitrary nucleotides; (B) a nucleic acid region consisting of a “gna” or “gnna” base sequence, wherein each “n” represents “g”, “t”, “a”, or “c”, a base analogue, or a modified base; and (C) a nucleic acid region consisting of a base sequence complementary to the nucleic acid region (A), sequentially ligated from the 5′ end toward the 3′ end, wherein at least one of two 3′ terminal nucleotides from at least one 3′ end of the single-stranded nucleic acid fragment or the double-stranded nucleic acid fragment is modified. | 09-11-2014 |
20140239252 | LIGHT-EMITTING ELEMENT HAVING NITRIDE SEMICONDUCTOR MULTIQUANTUM BARRIER, AND PROCESS FOR PRODUCTION THEREOF | 08-28-2014 |
20140209857 | METHOD OF MANUFACTURE FOR NITRIDE SEMICONDUCTOR LIGHT EMITTING ELEMENT, WAFER, AND NITRIDE SEMICONDUCTOR LIGHT EMITTING ELEMENT - In a method of manufacture for a nitride semiconductor light emitting element including: a monocrystalline substrate; and an AlN layer; and a first nitride semiconductor layer of a first electrical conductivity type; and a light emitting layer made of an AlGaN-based material; and a second nitride semiconductor layer of a second electrical conductivity type, a step of forming the AlN layer includes: a first step of supplying an Al source gas and a N source gas into the reactor to generate a group of MN crystal nuclei having Al-polarity to be a part of the AlN layer on the surface of the monocrystalline substrate; and a second step of supplying the Al source gas and the N source gas into the reactor to form the AlN layer, after the first step. | 07-31-2014 |
20140206560 | NUCLEIC ACID CONSTRUCT, NUCLEIC ACID-PROTEIN COMPLEX, AND USE THEREOF - Using a nucleic acid construct, association of a polypeptide with a sequence coding therefor and screening of a polypeptide that binds to a target substance are carried out, which nucleic acid construct comprises a 5′-untranslated region and a coding region, wherein the above-mentioned coding region comprises a sequence coding for a polypeptide subjected to be displayed, a sequence coding for a first nucleic acid binding polypeptide, and a sequence coding for a second nucleic acid binding polypeptide; the above-mentioned 5′-untranslated region comprises a first sequence capable of binding to a first nucleic acid binding polypeptide and a second sequence capable of binding to second nucleic acid binding polypeptide; and, when the above-mentioned nucleic acid construct is introduced in a translation system, a fusion protein translated from the coding region of the above-mentioned nucleic acid construct forms a complex with an RNA corresponding to the above-mentioned nucleic acid construct. | 07-24-2014 |
20140194320 | METHOD FOR PREPARING NUCLEIC ACID APTAMER - An object of the present invention is to develop and provide a method for efficiently and conveniently producing a nucleic acid aptamer, particularly, a DNA aptamer, having high specificity for and high binding activity against a target substance. The present invention provides a method for producing a nucleic acid aptamer, comprising: a complex formation step of mixing a single-stranded nucleic acid library with a target substance in a solution to form a complex of a single-stranded nucleic acid and the target substance; an immobilization step of mixing the solution after the preceding step with a solid-phase support to immobilize the complex onto the solid-phase support via connector(s) adsorbed on the target substance and/or the solid-phase support; a recovery step of recovering the complex immobilized on the solid-phase support from the solution; an amplification step of recovering the single-stranded nucleic acid from the complex, followed by amplification by a nucleic acid amplification method; and a single-stranded nucleic acid preparation step of converting the double-stranded nucleic acids obtained in the amplification step into single strands and then forming an intramolecular conformation. | 07-10-2014 |
20140179004 | CELL FOR USE IN IMMUNOTHERAPY WHICH CONTAINS MODIFIED NUCLEIC ACID CONSTRUCT ENCODING WILMS TUMOR GENE PRODUCT OR FRAGMENT THEREOF, METHOD FOR PRODUCING SAID CELL, AND SAID NUCLEIC ACID CONSTRUCT - A cell of the present invention contains a nucleic acid construct encoding a WT1 gene product or a fragment of the WT1 gene product. The nucleic acid construct contains (i) a region encoding a desired fragment of the WT1 gene product and (ii) only AUG as a functional start codon. The present invention can provide a cell into which the nucleic acid construct is introduced so that an expression level of a WT1 gene product or a fragment of the WT1 gene product is remarkably enhanced. | 06-26-2014 |
20140178927 | CLARIFYING REAGENT FOR BIOLOGICAL MATERIALS AND USE THEREOF - A clearing reagent according to the present invention for making a biological material transparent is a solution containing: at a concentration of 1M or more and not more than 8.5M, at least one compound selected from the group consisting of urea and urea derivatives; and glycerol at a concentration of 25 (w/v) % or more and not more than 35 (w/v) %. | 06-26-2014 |
20140175293 | PET DEVICE AND IMAGING METHOD THEREFOR - In the present invention, to conduct multiple molecular imaging in a PET device, both a first probe and a second probe, each of which has a nuclide that emits unique gamma rays as a result of gamma decay after beta decay, are administered to a subject to be imaged, and then the image capturing is performed by a multiple probe PET device ( | 06-26-2014 |
20140167066 | LIGHT EMITTING ELEMENT AND METHOD FOR MANUFACTURING SAME - A semiconductor light emitting element including, in a light extraction layer thereof, a photonic crystal periodic structure including two systems (structures) with different refractive indices. An interface between the two systems (structures) satisfies Bragg scattering conditions, and the photonic crystal periodic structure has a photonic band gap. | 06-19-2014 |
20140162290 | PROBE FOR DETECTING DEAD CELL - Provided is a molecular imaging probe that accumulates specifically and highly sensitively at a tumor site in vivo, and enables quantitative analysis, e.g. a probe for detecting an apoptotic cell(s) and/or a necrotic cell(s), comprising a fusion protein of a Tim4 protein and a protein or polypeptide that forms a dimer, the protein or polypeptide being bound to the C-terminus of the Tim4 protein, wherein the mucin domain of the Tim4 protein and the C-terminal side domain thereof are replaced with a polypeptide consisting of the amino acid sequence of a) or b) below: a) an amino acid sequence having a length of 30 to 120 amino acid residues comprised in the amino acid sequence of the mucin domain of a wild-type Tim4 protein; b) an amino acid sequence having an identity of not less than 80% to the amino acid sequence of a). | 06-12-2014 |
20140154717 | METHOD FOR DETECTING CANCER CELL USING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE, AND CANCER CELL-IMAGING AGENT COMPRISING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE - The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient. | 06-05-2014 |
20140153603 | QUANTUM CASCADE LASER ELEMENT - [PROBLEM] To manufacture a quantum cascade laser (QCL) element having a reduced threshold current density (J | 06-05-2014 |
20140147834 | KIT FOR DETECTING BOVINE LEUKEMIA VIRUS(BLV), AND USE THEREOF - A kit for detecting Bovine leukemia virus (BLV) according to the present invention includes: a first PCR primer being oligonucleotide including successive 20 bases or more in the base sequence denoted by SEQ ID NO: 1, the first PCR primer being oligonucleotide having 50 bases or less; and second PCR primer being including successive 20 bases or more in the base sequence denoted by SEQ ID NO: 2, the second PCR primer being oligonucleotide having 50 bases or less is included. | 05-29-2014 |
20140143910 | COMPOSITION THAT AUGMENTS PLANT DISEASE RESISTANCE AND/OR BRANCHING - The objective of the present invention is to develop and provide: a composition that more inexpensively and safely augments plant disease resistance and/or plant branching by inducing new plant disease resistance via a brassinosteroids; and a method for suppressing microbial infection of plants and a method for augmenting branching using the composition. Provided is a composition containing as the active ingredient a peptide hormone obtained on the basis of isolating a disease resistant brassinosteroid variant and analyzing the causative gene thereof. | 05-22-2014 |
20140141987 | METHOD FOR DIAGNOSING ARRHYTHMIA BASED ON SINGLE NUCLEOTIDE POLYMORPHISM IN CHROMOSOME 1Q24, NEURL GENE, OR CUX2 GENE - A method for diagnosing arrhythmia such as atrial fibrillation is provided. A single nucleotide polymorphism present in the region 24 of the long arm of the chromosome 1, NEURL gene, or CUX2 gene is analyzed, and the risk of developing arrhythmia and/or the presence or absence of the onset of arrhythmia is diagnosed on the basis of the analysis result. | 05-22-2014 |
20140127626 | RESIST COMPOSITION FOR NEGATIVE DEVELOPMENT WHICH IS USED FOR FORMATION OF GUIDE PATTERN, GUIDE PATTERN FORMATION METHOD, AND METHOD FOR FORMING PATTERN ON LAYER CONTAINING BLOCK COPOLYMER - A negative tone-development resist composition for forming a guide pattern, including a base component (A) and an acid generator component (B), the base component (A) including a resin component (A1) having a structural unit (a1) derived from an acrylate ester containing an acid dissociable group, and at least one of the following structural units (a2): a structural unit derived from an acrylic acid ester containing a lactone-containing cyclic group, a structural unit derived from an acrylic acid ester containing an ether-containing cyclic group and a structural unit derived from an acrylic acid ester containing a carbonate-containing cyclic group, and a constituent unit (a1) derived from an acrylic acid ester containing an acid-labile group, the acid generator component (B) including an acid generator (B1) including at least one compound represented by general formula (b1) or (b2) shown below | 05-08-2014 |
20140117225 | METHOD FOR ANALYZING GLYCAN STRUCTURE - In order to provide an analysis method that is capable of determining a glycan structure with high detection sensitivity, a method of the present invention includes the steps of: carrying out triple quadrupole mass spectrometry at various values of CID energy; creating an energy-resolved profile including yield curves representing relationships between (i) a value of the CID energy and (ii) measured amounts of specific types of product ions; preparing a reference profile, and identifying a glycan structure of a test material by comparing the energy-resolved profile with the reference profile. | 05-01-2014 |
20140113236 | SOLVENT DEVELOPABLE NEGATIVE RESIST COMPOSITION, RESIST PATTERN FORMATION METHOD, AND METHOD FOR FORMING PATTERN OF LAYER INCLUDING BLOCK COPOLYMER - A solvent developing negative-tone resist composition containing a base component (A) which exhibits increased polarity and reduced solubility in an organic solvent under action of an acid and an acid generator component (B) which generates an acid upon exposure, the component (A) including a resin component (A1) containing: a structural unit (a2) derived from an acrylate ester containing a 4- to 12-membered lactone-containing cyclic group, a 3- to 7-membered ether-containing cyclic group or a 5- to 7-membered carbonate-containing cyclic group; and a structural unit (a1) derived from an acrylate ester containing an acid decomposable group which exhibited increased polarity by the action of acid, and the acid generator component (B) including an acid generator (B1) containing a compound which generates a sulfonic acid upon exposure. | 04-24-2014 |
20140107187 | FUNCTIONAL NUCLEIC ACID MOLECULE AND USE THEREOF - The present invention provides (a) a functional nucleic acid molecule comprises: a target determinant sequence comprising antisense sequence to a target sequence in the protein-encoding RNA for which protein synthesis efficiency is to be increased and a regulatory sequence having an activity of increasing of the protein synthesis efficiency, and (b) a use of the functional nucleic acid molecule. | 04-17-2014 |
20140088276 | MANUFACTURING METHOD FOR MULTIDIMENSIONAL POLYMER, AND MULTIDIMENSIONAL POLYMER - A multidimensional polymer production method for producing a multidimensional polymer containing a repeating unit derived from a first monomer and a repeating unit derived from a second monomer, the multidimensional polymer production method including the steps of: (a) using a first catalyst and a second catalyst; and (b) carrying out a polymerization reaction in the presence of the first catalyst, the second catalyst, the first monomer, the second monomer, and a chain shuttling agent in an identical reaction system, the first catalyst selectively catalyzing a positionally selective or stereoselective polymerization reaction of the first monomer per se, and the second catalyst selectively catalyzing a positionally selective or stereoselective polymerization reaction of the second monomer per se. | 03-27-2014 |
20140087419 | METHOD FOR MAKING BIOLOGICAL MATERIAL TRANSPARENT AND USE THEREOF - A method for making a biological material transparent according to the present invention includes: a first permeation step of causing a first solution to permeate into a biological material, the first solution containing at least one compound selected from the group consisting of urea and urea derivatives at a predetermined concentration; and then a second permeation step of causing a second solution to permeate into the biological material, the second solution containing at least one compound selected from the group consisting of urea and urea derivatives at a concentration higher than the concentration of the at least one compound contained in the first solution. | 03-27-2014 |
20140066314 | COATED HIGH-TEMPERATURE SUPERCONDUCTING WIRE AND HIGH-TEMPERATURE SUPERCONDUCTING COIL INCLUDING THE SAME - In a coated high-temperature superconducting wire | 03-06-2014 |
20140057281 | METHOD OF PRODUCING RETINAL PIGMENT EPITHELIAL CELL SHEET - The present invention provides a method of producing a cell sheet including the following steps
| 02-27-2014 |
20140054265 | METHOD OF FORMING FINE PATTERN, AND DEVELOPER - A method of forming a fine pattern, including: a phase separation step in which a layer containing a block copolymer having a plurality of blocks bonded is formed on a substrate, and then the layer is heated for phase separation of the layer; a decomposition step in which at least a portion of a phase of at least one block of the plurality of blocks constituting the block copolymer is decomposed; a selective removal step in which the layer is immersed in a developing solution to selectively remove a phase containing decomposed blocks to form a nano structure; and an etching step in which the substrate is subjected to etching by using the nano structure as a mask; and a main component of the developing solution is an organic solvent having an SP value of 7.5 to 11.5 (cal/cm | 02-27-2014 |
20140051074 | METHOD OF JUDGING INFLAMMATORY DISEASE BY USING SINGLE NUCLEOTIDE POLYMORPHISM - An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene. | 02-20-2014 |
20140045183 | METHOD AND KIT FOR DETECTING 5-HYDROXYMETHYLCYTOSINE IN NUCLEIC ACIDS - Provided are a method and a kit for detecting 5-hydroxymethylcytosine in a nucleic acid. The method is a method for detecting 5-hydroxymethylcytosine in a nucleic acid, comprising the steps of: (1) oxidizing 5-hydroxymethylcytosine in a nucleic acid sample by treating the nucleic acid sample with a tungstic acid-based oxidizing agent comprising peroxotungstic acid, tungstic acid, a salt thereof, or a combination thereof with a reoxidizing agent; and (2) determining the position of the oxidized 5-hydroxymethylcytosine in the nucleic acid sample. | 02-13-2014 |
20140030652 | PRIMER AND PATTERN FORMING METHOD FOR LAYER INCLUDING BLOCK COPOLYMER - An undercoat agent usable in phase separation of a layer formed on a substrate, the layer containing a block copolymer having a plurality of polymers bonded, the undercoat agent including a resin component, and 20 mol % to 80 mol % of all the structural units of the resin component being a structural unit derived from an aromatic ring-containing monomer; and a method of forming a pattern of a layer containing a block copolymer, the method including: step (1) coating the undercoat agent on a substrate ( | 01-30-2014 |
20140024825 | ESTER COMPOUND OF CELLULOSE DERIVATIVE AND MANUFACTURING METHOD OF SAME - A manufacturing method for an esterification product of a cellulose derivative by comprising esterification of a cellulose derivative in a mixture of an ionic liquid, cellulose derivative and agent that is at least one selected from the group consisting of carboxylic anhydride, carboxylic acid halide, and carboxylic acid. | 01-23-2014 |
20140024118 | HUMAN ERYTHROID PROGENITOR CELL LINE AND METHOD FOR PRODUCING HUMAN ENUCLEATED RED BLOOD CELLS - Provided are: a method for producing an immortalized human erythroid progenitor cell line, enabling efficient and stable production of enucleated red blood cells; and a method for producing human enucleated red blood cells from a human erythroid progenitor cell line obtained by the aforementioned production method. An expression cassette capable of inducing expression of HPV-E6/E7 genes in the presence of DOX was introduced into the genomic DNA of blood stem cells. Then, the blood stem cells were cultured in the presence of DOX and a blood growth factor. Thereby, immortalized cell lines of human erythroid progenitor cells were established. Further, it was revealed that culturing the cell lines under a condition where the expression of the HPV-E6/E7 genes was not induced enabled differentiation induction into enucleated red blood cells at a high ratio. | 01-23-2014 |
20140017790 | CONTROL AGENT FOR CONTROLLING UNDIFFERENTIATED STATE AND USE THEREOF - The present invention aims to provide a novel undifferentiated state-control agent that maintains and/or improves an undifferentiated state of undifferentiated cells. CCL2 or a protein containing a functional domain thereof is used as the undifferentiated state-control agent. By culturing undifferentiated cells in the presence of the control agent, it is possible to maintain and/or improve an undifferentiated state of the undifferentiated cells. Examples of the undifferentiated cells include embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells). The origin of the cells is not particularly limited, and may be a human, mouse, or the like, for example. | 01-16-2014 |
20140010735 | FLUID-CONTROLLING DEVICE FOR MICROCHIP AND USE THEREOF - The present invention relates to a fluid-controlling device ( | 01-09-2014 |
20130334429 | IMAGING DEVICE USING GAMMA RAYS, IMAGE SIGNAL PROCESSOR, AND IMAGE PROCESSING METHOD FOR GAMMA RAY MEASUREMENT DATA - To simultaneously image a plurality types of tracer molecules for a Compton image and a PET image. Provided is an imaging device comprising: a first Compton camera ( | 12-19-2013 |
20130323769 | ENDOPLASMIC RETICULUM CALCIUM ATPASE KINETICS INDICATOR AND USE THEREOF - The present invention provides a fusion protein including sarco/endoplasmic reticulum calcium ATPase, a fluorescence donor for FRET, and a fluorescence acceptor, one of the fluorescence donor and the fluorescence acceptor being linked to the N-terminus side of the ATPase, the other of the fluorescence donor and the fluorescence acceptor being inserted between the above one of the fluorescence donor and the fluorescence acceptor and the ATPase or being inserted in an amino acid sequence of the ATPase, the amino acid sequence corresponding to (i) amino acids 1 through 6 in SERCA2a, (ii) amino acids 369 through 380 in the SERCA2a or (iii) amino acids 572 through 583 in the SERCA2a. | 12-05-2013 |
20130317202 | TEST AGENT FOR VISCERAL OBESITY AND USE THEREOF - Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used. | 11-28-2013 |
20130313223 | METHOD FOR PRODUCING SUBSTRATE HAVING SURFACE NANOSTRUCTURE - A method for producing a substrate having a surface nanostructure, including a forming, on a substrate, a layer containing a block copolymer having a plurality of blocks bonded together, and subsequently heating this layer to cause phase separation of the layer; a decomposing at least a portion of the phase including at least one block of the plurality of blocks that constitute the block copolymer of this layer; and immersing the layer in a developing solution and selectively removing the phase containing the decomposed block(s), the developing solution containing, as the main component, an organic solvent having an SP value of 7.5 to 11.5 (cal/cm | 11-28-2013 |
20130305411 | METHOD FOR CONFERRING DISEASE RESISTANCE TO PLANT - Disease resistance is conferred to a plant by a technique completely differing from conventional techniques. The method of the present invention comprises a step of introducing at least one of the genes belonging to the TIFY family to a plant or enhancing the expression of the gene endogenous to the plant. | 11-14-2013 |
20130302872 | PRODUCTION OF CELL TISSUE HAVING THREE-DIMENSIONAL STRUCTURE USING ELECTROSTATIC INK JET PHENOMENON - A method and an apparatus for producing a cell tissue of blood vessels or the like with the use of an electrostatic ink jet phenomenon are provided. A pattern generator for cell tissue patterning on a substrate includes at least one vessel for holding a solution containing materials used for cell tissue formation, a substrate that is an object of patterning, and a pattern generator including a voltage applying unit for applying a voltage to the vessel. The voltage is applied to the vessel by the voltage applying unit to generate an electric field between the vessel and the substrate, causing the solution to be ejected from the vessel as a result of an electrostatic ink jet phenomenon and allowing the ejected solution to adhere to the substrate. | 11-14-2013 |
20130298263 | NUCLEIC ACID CONSTRUCT FOR EXPRESSION OF OXIDATIVE STRESS INDICATOR AND USE THEREOF - The present invention provides a nucleic acid construct for expressing an oxidative stress indicator comprising: a nucleic acid sequence encoding an Nrf2 protein-derived partial protein that comprises at least an Neh2 domain sequence and substantially lacks or is functionally deficient in an Neh1 domain sequence or an Neh1-Neh3 domain sequence; a stress-inducible promoter sequence positioned upstream of the nucleic acid sequence encoding an Nrf2 protein-derived partial protein; and a nucleic acid sequence encoding a protein capable of generating a detectable signal, the nucleic acid sequence being positioned downstream of the nucleic acid sequence encoding an Nrf2 protein-derived partial protein. The present invention also provides a method for measuring oxidative stress and a method for screening for an anti-oxidative stress agent, using the nucleic acid construct. | 11-07-2013 |
20130296230 | METHOD FOR TREATING MALARIA, METHOD FOR KILLING MALARIA PARASITE, AND USE OF THE METHODS - A method of the present invention for treating malaria includes the step of administering, to a human or an animal, a therapeutically effective amount of drug for suppressing calcium ion exit from an intracellular organelle of the malaria parasite to an outside of the intracellular organelle and/or calcium ion entry from an outside of a cell of the malaria parasite into the cell. | 11-07-2013 |
20130295142 | IMMUNOTHERAPY USING ALLO-NKT CELLS, CELLS FOR IMMUNOTHERAPY IN WHICH ALPHA CHAIN OF T-CELL RECEPTOR (TCR) GENE HAS BEEN REARRANGED TO UNIFORM V-ALPHA-J-ALPHA, AND BANKING OF NKT CELLS DERIVED FROM SAID CELLS - The present invention provides an agent for an immunocyte therapy, comprising an NKT cell obtained by differentiating in vitro a cell having the α-chain region of the T cell receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, wherein an administration subject is an allogenic individual having MHC gene loci including at least one locus having a genotype different from that of the NKT cell. In addition, the present invention provides a bank of a human cell or an NKT cell derived from said cell, wherein the α-chain region of a T cell receptor (TCR) gene has been rearranged to uniform Vα-Jα. The agent and cell bank of the present invention are useful for the prophylaxis and/or treatment of cancer, infection, an allergic disease or an autoimmune disease. | 11-07-2013 |
20130289263 | COMPOUND, NUCLEIC ACID, METHOD FOR PRODUCING NUCLEIC ACID, AND KIT FOR PRODUCING NUCLEIC ACID - A compound is represented by the following formula ( | 10-31-2013 |
20130288977 | METHOD OF REGULATING NEURONAL AXON ELONGATION - The present invention includes a treating step of treating neuronal growth cone with a regulatory factor to regulate macropinocytosis caused by a repulsive axon guidance molecule. The present invention can provide a new neuronal axon elongation regulating method etc. | 10-31-2013 |
20130284925 | ELECTRON BEAM DEVICE - An electron beam device includes a first electron biprism between an acceleration tube and irradiation lens systems, and an electron biprism in the image forming lens system. The first electron biprism splits the electron beam into first and second electron beams, radiated to differently positioned first and second regions on objective plane of an objective lens system having a specimen perpendicular to an optical axis. The first and second electron beams are superposed on the observation plane by the electron biprism of the image forming lens system. The superposed region of those electron beams is observed or recorded. Optical action of the irradiation lens system controls each current density of the first and second electron beams on the objective plane of the objective lens system having the specimen, and distance on electron optics between the first electron biprism and the objective plane of the objective lens system having the specimen. | 10-31-2013 |
20130244253 | COMPOUNDS HAVING ACTIVITY OF SUPPRESSING ACTIVATION OF TGF-BETA RECEPTOR, METHOD FOR SCREENING OF THE COMPOUNDS, AND COMPOSITION FOR PREVENTING OR TREATING DISEASE CAUSED BY HEPATITIS C VIRUS - An object is to provide a compound capable of inhibiting activation of TGF-β receptors due to HCV, and a screening method for the compound. It has been found that a HCV-derived NS3 protease binds to type I TGF-β receptor, and this binding results in activation of TGF-β receptors. Moreover, binding sites between the NS3 protease and type I TGF-β receptor were identified, and it has been found that antibodies recognizing these binding sites inhibit activation of TGF-β receptors due to NS3 protease. Furthermore, it has been also found that screening for a compound capable of inhibiting activation of TGF-β receptors can be performed by using the inhibition of the binding between NS3 protease and type I TGF-β receptor or the like as an index. | 09-19-2013 |
20130236893 | METHOD OF DETECTING TYPE II DIABETES - A single-nucleotide polymorphism in the UBE2E2 locus or C2CD4A-C2CD4B locus is analyzed and type II diabetes is examined based on the results of the analysis. | 09-12-2013 |
20130236470 | THERAPEUTIC AGENT FOR MALIGNANT TUMORS EXPRESSING MHC CLASS II - Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56). | 09-12-2013 |
20130224824 | ELECTRODE HAVING ENZYME CRYSTALS IMMOBILIZED THEREON, METHOD FOR PRODUCING ELECTRODE HAVING ENZYME CRYSTALS IMMOBILIZED THEREON, AND BIOLOGICAL FUEL CELL AND BIOSENSOR PROVIDED WITH ELECTRODE HAVING ENZYME CRYSTALS IMMOBILIZED THEREON - An objective of the present invention is to establish a technique for making it possible to immobilize an enzyme on an electrically conductive base material in a uniformly, high density, and constantly aligned orientation, for the purpose of constructing an enzyme electrode having improved electrode performance. An electrode having enzyme crystals immobilized thereon, the electrode being provided with an electrically conductive base material that can be connected to an external circuit and enzyme crystals that serve as an electrode catalyst, wherein the enzyme crystals are immobilized on the electrically conducive base material; a method for producing an electrode having enzyme crystals immobilized thereon; and a biological fuel cell and a biosensor which are provided with an electrode having enzyme crystals immobilized thereon. | 08-29-2013 |
20130224208 | GLIOMA TREATMENT METHOD, GLIOMA TESTING METHOD, METHOD FOR DELIVERING DESIRED SUBSTANCE TO GLIOMA, AND DRUGS USED IN THESE METHODS - An object is to provide glioma treatment and testing methods, and a method for delivering a desired substance to a glioma, all of which target a molecule specifically expressed in a glioma, as well as drugs and so forth used in these methods. It has been found out that targeting Eva1 or Ceacam1 enables glioma treatment and testing, and delivering of a desired substance to a glioma. | 08-29-2013 |
20130224156 | METHOD OF PRODUCING HUMAN RETINAL PIGMENT EPITHELIAL CELLS - The invention relates to a method of producing a retinal pigment epithelial cell from a human pluripotent stem cell, and a method of treating or preventing a retinal disease by using the produced cell. The retinal pigment epithelial cell is prepared by (a) inducing differentiation of a human pluripotent stem cell into a pigment cell by adhesion cultivation of a human pluripotent stem cell in a medium containing a Nodal signal inhibitor and a Wnt signal inhibitor in the absence of a feeder cell to give a culture containing the pigment cell, (b) subjecting the obtained culture to further adhesion culture to give a culture containing a pigment cell colony, and (c) isolating the pigment cell from the obtained culture and culturing the cell to give a retinal pigment epithelial cell. | 08-29-2013 |
20130224145 | COMPLEX HAVING TUMOR VACCINE EFFECT, AND USE THEREOF - The present invention provides a tumor cell-soluble TNF family member molecule complex containing a tumor cell and an isolated soluble TNF family member molecule, wherein the soluble TNF family member molecule is bound on a surface of the tumor cell such that it binds to a receptor of the TNF family member expressed on a surface of a cell other than the tumor cell, and stimulates the cell other than the tumor cell via the receptor, and a composition and a tumor vaccine, each containing the complex. | 08-29-2013 |
20130212743 | METHOD FOR INCREASING PLANT BIOMASS BY CONTROLLING ACTIVE CYTOKININ EXPRESSION LEVEL - An object of the present invention is to provide a means for conferring a useful phenotype to a plant by efficiently controlling the quantitative productivity of iP-type and tZ-type active cytokinins in plant aerial organs. According to the present invention, a method for increasing plant biomass by causing the overexpression of an active cytokinin synthase gene and a cytokinin hydroxylase gene in a plant body is provided. | 08-15-2013 |
20130210231 | METHOD OF FORMING CONTACT HOLE PATTERN - A method of forming a contact hole pattern, including: a block copolymer layer forming step in which a layer containing a block copolymer having a plurality of blocks bonded is formed on a substrate having on a surface thereof a thin film with a hole pattern formed, so as to cover the thin film; a phase separation step in which the layer containing the block copolymer is subjected to phase separation; a selective removing step in which phase of at least one block of the plurality of blocks constituting the block copolymer is removed, wherein hole diameter of the hole pattern formed on the thin film is 0.8 to 3.1 times period of the block copolymer, and in the layer forming step, thickness between upper face of the thin film and surface of the layer containing the block copolymer is 70% or less of thickness of the thin film. | 08-15-2013 |
20130210045 | BIOMARKER FOR FATIGUE, AND USE THEREOF - Ratios of measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a subject to measured values of glucose, citrate, and cis-aconitate in a biological sample obtained from a healthy subject are calculated, and the glucose ratio, the citrate ratio, and the cis-aconitate ratio are used to evaluate and/or assess fatigue. Similarly, an isocitrate ratio, a succinate ratio, a malate ratio, and a lactate ratio are calculated, and these ratios are used together with the three ratios to evaluate and/or assess fatigue. This makes it possible to objectively and easily diagnose and evaluate fatigue. | 08-15-2013 |
20130209485 | THERAPEUTIC AGENT OF NON-ALLERGIC AIRWAY INFLAMMATION AND/OR NON-ALLERGIC HYPERRESPONSIVE AIRWAY - The invention provides a therapeutic agent for non-allergic airway inflammation and/or non-allergic airway hyperreactivity, containing a substance capable of inhibiting or eliminating the Th17 cell-like function of an IL-17RB positive NKT cells as an active ingredient; a prophylactic or therapeutic method for non-allergic airway inflammation and/or non-allergic airway hyperreactivity, using the substance, and a method of screening for a therapeutic agent for non-allergic airway inflammation and/or non-allergic airway hyperreactivity, containing a step of measuring a Th17 cell-like function of IL-17RB positive NKT cells. | 08-15-2013 |
20130203184 | METHOD FOR DETECTION OF CLEAVAGE PRODUCT OF SOLUBLE AMYLOID-B PRECURSOR PROTEIN 770B FOR DIAGNOSIS OF DISEASES ASSOCIATED WITH ACCUMULATION OF AMYLOID-B PEPTIDE - The present invention provides a method of detecting soluble amyloid β precursor protein 770β derived from vascular endothelial cell, comprising the following steps:
| 08-08-2013 |
20130198894 | USE OF ACTIVE CYTOKININ SYNTHASE GENE - Cytokinin is a plant hormone that regulates various physiological activities including cell division, cell cycle, cellular senescence, and axillary buds outgrowth. The present invention provides a method for producing a transformed plant by introducing an isolated nucleic acid or recombinant vector containing the isolated nucleic acid into a plant cell such that the amount of active cytokinin synthesized from nucleotide cytokinin is increased in the plant cell and by regenerating a plant body from the plant cell. | 08-01-2013 |
20130196160 | METHOD FOR FORMING PROTEIN CRYSTAL - A method for producing a capsule for protein crystallization is provided. The method comprises adding a solution containing a protein and a gelling agent to an ionic cross-linking solution to form an ionically cross-linked gel capsule that encapsulates a solution of the protein. | 08-01-2013 |
20130189302 | IMMUNOTHERAPEUTIC METHOD USING ARTIFICIAL ADJUVANT VECTOR CELLS THAT CO-EXPRESS CD1D AND TARGET ANTIGEN - Provided is immunotherapy of cancer or infection utilizing activation of dendritic cell (DC) by innate immunity, namely, a method of preparing an artificial adjuvant vector cell co-expressing a target antigen and CD1d and having an ability to activate immunity against the target antigen, comprising treating the target antigen and CD1d co-expressing cell with a CD1d ligand in a culture medium. | 07-25-2013 |
20130177950 | PROCESS FOR PRODUCING REVEROMYCIN A OR A SYNTHETIC INTERMEDIATE THEREOF, PROCESS FOR PRODUCING COMPOUNDS CONTAINING A SPIROKETAL RING AND NOVEL ANTINEOPLASTICS, FUNGICIDES AND THERAPEUTIC AGENTS FOR BONE DISORDERS - A bacterium belonging to the genus | 07-11-2013 |
20130172189 | PLANT ACTIVATOR - A compound useful as a plant activator for activating an endogenous defense system of a plant to control disease damage is provided. A compound represented by the formula: (R | 07-04-2013 |
20130154633 | ELECTRIC CURRENT-SPIN CURRENT CONVERSION DEVICE - An electric current-spin current conversion device according to the invention performs conversion between electric current and spin current utilizing the spin Hall effect or the inverse spin Hall effect of a 5 | 06-20-2013 |
20130142813 | ANTIBODY BINDING TO LYSOPHOSPHATIDYLGLUCOSIDE, AND COMPOSITION COMPRISING THE SAME - In order to identify a factor demonstrating a repellent effect on axon extension of a neuron, lysophosphatidylglucoside (LPG) has been found to have an activity as a chemorepellent effect on axon guidance of a DRG sensory neuron specific to a neuron expressing TrkA, an NGF receptor. | 06-06-2013 |
20130130313 | METHOD OF SYNTHESIZING A SUPPRESSOR tRNA, DNA CONSTRUCT AND USE THEREOF FOR PRODUCING A NON-NATURAL AMINO ACID-INCORPORATED PROTEIN - There are provided a DNA construct comprising a suppressor tRNA gene of a non-eukaryote containing no internal promoter functioning in a eukaryotic cell, and a eukaryotic or bacteriophage promoter linked at the 5′ end of the tRNA gene, a method for synthesizing a suppressor tRNA by using the DNA construct, and a process for producing protein incorporating a non-natural amino acid by using the same. | 05-23-2013 |
20130122506 | NUCLEIC ACID BASE ANALOGS WITH QUENCHING AND FLUORESCENT ACTIVITIES AND APPLICATIONS THEREOF - It is an object of the present invention to provide quenching or fluorescent nucleic acid base analogs and applications thereof. The quencher of the present invention has a 2-nitropyrrole structure represented by Formula I: | 05-16-2013 |
20130115625 | NOVEL PROTEIN AND USE THEREOF - A protein being the following (A), (B), or (C): (A) a protein represented by the amino acid sequence of SEQ ID NO: 1; (B) a protein represented by an amino acid sequence in which one or a plurality of amino acid is substituted, deleted, inserted or added in the amino acid sequence of SEQ ID NO: 1, the protein having binding activity specific for a mixture of a sphingolipid and cholesterol; or (C) a protein represented by an amino acid sequence being at least 70% identical to the amino acid sequence of SEQ ID NO: 1. | 05-09-2013 |
20130108853 | BNA CRYSTAL | 05-02-2013 |
20130108590 | METHOD FOR PRODUCING CELL SHEET | 05-02-2013 |
20130102776 | ANTICANCER AGENT - An anticancer agent comprising a compound represented by the formula (I) [R | 04-25-2013 |
20130095538 | XYLOSE ISOMERASE AND USE THEREOF - It is an object of the disclosure of the present description to provide an eukaryotic cell having xylose utilization ability. The disclosure of the present description provides a novel eukaryotic cell having xylose utilization ability by transforming a yeast or other eukaryotic cell using DNA that codes a xylose isomerase from a termite protist. | 04-18-2013 |
20130095524 | METHOD FOR CONSTRUCTING RECOMBINANT BACTERIUM FOR PRODUCING NON-NATIVE PROTEIN, AND UTILIZATION OF SAME - The present invention provides a novel method of producing a recombinant bacterium for production of a non-natural protein, including: (1) expressing tRNA in a bacterium, which tRNA recognizes UAG codon; (2) expressing an aminoacyl-tRNA synthetase in the bacterium, which aminoacyl-tRNA synthetase acylates the tRNA with a non-natural amino acid or an α-hydroxy acid; (3) (i) introducing a DNA construct into the bacterium, which DNA construct is for expressing, in the absence of a release factor for terminating translation at UAG codon, a function of at least one gene selected from the group consisting of genes each of which loses its function when a gene that codes for the release factor is defective and/or introducing an alteration into said at least one gene in a chromosome of the bacterium, which alteration is for expressing the function of said at least one gene in the absence of the release factor; and (4) causing the gene that codes for the release factor in the bacterium to be defective. | 04-18-2013 |
20130069034 | LIGHT-EMITTING ELEMENT HAVING NITRIDE SEMICONDUCTOR MULTIQUANTUM BARRIER, AND PROCESS FOR PRODUCTION THEREOF | 03-21-2013 |
20130065234 | METHOD FOR DIAGNOSING BONE AND JOINT DISEASE BASED ON SINGLE NUCLEOTIDE POLYMORPHISM IN CHROMOSOME 10Q24 - Provided is a method for diagnosing a bone and joint is disease such as scoliosis. A single nucleotide polymorphism present in region 24 on the long arm of chromosome 10 (region 10q24) is analyzed and the risk of onset of a bone and joint disease and/or the presence or absence of onset of the same are diagnosed on the basis of a result of the analysis. | 03-14-2013 |
20130059375 | METHOD FOR PREPARING ES CELLS - The present invention provides a method of producing a mammalian ES cell, including cultivating a mammalian inner cell mass in a medium containing adrenocorticotropic hormone, an FGF receptor inhibitor, an MEK activation inhibitor and a GSK3 inhibitor, and isolating a mammalian ES cell from the culture. | 03-07-2013 |
20130045917 | METHOD OF SELECTING POLYPEPTIDE SEQUENCE, AND METAL OXIDE OR SILICON-CONTAINING COMPOUND BINDING PEPTIDE AND USE THEREOF - Provided is a peptide including the following amino acid sequence. Tyr-Xaa | 02-21-2013 |
20130045503 | CLEARING REAGENT FOR BIOLOGICAL MATERIAL, AND USE THEREOF - A clearing reagent according to this invention for making a biological material transparent is a solution containing, as an active component, at least one compound selected from the group consisting of urea and urea derivatives, in order to provide a novel clearing reagent for making a biological material transparent. | 02-21-2013 |
20130040330 | METHOD FOR DIFFERENTIATION INDUCTION IN CULTURED STEM CELLS - Provided is a method of inducing the differentiation of a stem cell into nerve progenitor cells, comprising the step (1) of forming a homogenous aggregate of stem cells in a serum-free medium (1) and the step (2) of suspension-culturing the homogenous aggregate of stem cells in the presence of a basement membrane reference standard. | 02-14-2013 |
20130028890 | METHOD FOR DETECTING REGULATORY T CELLS USING EXPRESSION OF FOLATE RECEPTOR 4 AS INDICATOR, METHOD FOR TREATING DISEASES USING THE DETECTION METHOD, PHARMACEUTICAL COMPOSITION FOR IMMUNOSTIMULATION, AND METHOD FOR TREATING DISEASES USING THE COMPOSITION - An object of the present invention is to provide a technique to distinguish between T | 01-31-2013 |
20130022975 | METHOD FOR DETECTING ARTERIOSCLEROTIC DISEASES ON THE BASIS OF SINGLE NUCLEOTIDE POLYMORPHISM AT HUMAN CHROMOSOME 5P15.3 - An atherosclerotic disease such as myocardial infarction or angina pectoris is detected by analyzing a single nucleotide polymorphism on human chromosome 5p15.3, and by associating results of the analysis with the risk of the onset thereof. Examples of the single nucleotide polymorphism on human chromosome 5p15.3 include a nucleotide corresponding to the nucleotide at position 61 in the nucleotide sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, and a polymorphism at a nucleotide which is in linkage disequilibrium with the above nucleotide. | 01-24-2013 |
20130019340 | PLANT RESISTANT TO ENVIRONMENTAL STRESS AND METHOD FOR PRODUCING THE SAMEAANM Maruyama; KaoruAACI Yokohama-ShiAACO JPAAGP Maruyama; Kaoru Yokohama-Shi JPAANM Shinozaki; KazuoAACI KanagawaAACO JPAAGP Shinozaki; Kazuo Kanagawa JP - An object of the present invention is to provide a plant having environmental stress resistance. The present invention provides a transgenic plant having environmental stress resistance, in which an exogenous DNA encoding a transcription factor selected from the group consisting of transcription factors from | 01-17-2013 |
20130018270 | OPTICAL OBSERVATION SYSTEM AND METHOD OF OBSERVING EXAMINATION SUBJECTAANM MIZUNAKA; MasaruAACI TokyoAACO JPAAGP MIZUNAKA; Masaru Tokyo JPAANM MURAYAMA; MasanoriAACI Wako-shiAACO JPAAGP MURAYAMA; Masanori Wako-shi JPAANM MIYAWAKI; AtsushiAACI Wako-shiAACO JPAAGP MIYAWAKI; Atsushi Wako-shi JP - Provided is an optical observation system that is provided with a portable device, which is secured to an examination subject A and is moved together with the movement of the examination subject, and an external device disposed away from the examination subject, wherein the portable device is provided with a light source; an illumination optical system radiates light coming from the light source onto an observation target site in the examination subject; a detection optical system optically guides light coming from the observation target site; a photodetector detects the light optically guided thereto by the detection optical system and converts the light to an electrical signal; and a transmitter wirelessly transmits the electrical signal output from the photodetector; and the external device is provided with a receiver receives the electrical signal transmitted from the portable device and a signal processor processes the electrical signal received by the receiver. | 01-17-2013 |
20130007915 | PLANT WITH ENHANCED GROWTH AND METHOD FOR PRODUCING THE SAME - This invention provides a method for producing a plant with enhanced or suppressed growth through introduction of a mutated gene and a plant including such a mutated gene. This invention provides a method for producing a plant with enhanced growth or suppressed growth. Such method includes a step of introducing a gene encoding a chimeric myosin protein into a host plant so as to transform the host plant, wherein the chimeric myosin protein comprises: a neck domain, a coiled-coil domain, and a globular tail domain from a myosin protein involved in cytoplasmic streaming of a donor plant; and a motor domain from a myosin protein other than the myosin protein of the host plant, which has sliding velocity that is higher or lower, respectively, than that of the myosin protein involved in cytoplasmic streaming of the donor plant. | 01-03-2013 |
20130005669 | NOVEL SYNTHETIC GLYCOLIPID AND USE THEREOF - A compound represented by the following formula (1): | 01-03-2013 |
20120289716 | METHOD FOR HIGH-SPEED FLUOROMETHYLATION AND PROCESS FOR PREPARATION OF PET TRACER USING SAME - Provided are: a method for rapid fluoromethylation, by which a fluoromethyl group can be easily bonded to an aromatic-ring carbon of an aromatic compound with little generation of by-products; and a process for preparation of a PET tracer using the same. The method is characterized by cross-coupling an organoboron compound in which an aromatic ring is bonded to a boron atom with FCX | 11-15-2012 |
20120288883 | PROBE REAGENT FOR MEASUREMENT OF PROTEOLYTIC ACTIVITY - This invention relates to a probe reagent comprising, in order from the N-terminus to the C-terminus, the amino acid sequences of a fluorescent protein I, a peptide capable of terminating protein degradation (i.e., a degradation-terminating peptide), a spacer peptide, a fluorescent protein II, and a protein to be degraded, wherein the protein to be degraded is a protein degraded by the ubiquitin-proteasome system, and the probe reagent is degraded from the C-terminus, but that the degradation of the probe reagent is terminated at the degradation-terminating peptide, a nucleic acid encoding the probe reagent, and use of the probe reagent or the nucleic acid. | 11-15-2012 |
20120278948 | TRANSGENIC PLANT HAVING INCREASED BIOMASS AND IMPROVED ENVIRONMENTAL STRESS RESISTANCE, AND PROCESS FOR PRODUCTION THEREOF - An object of the present invention is to provide a transgenic plant on which a useful phenotype is conferred by regulating expression of pseudo-response regulator (PRR) genes with an approach that is different from deletion of PRR genes. According to the present invention, there is provided a transgenic plant into which a polynucleotide encoding a protein comprising a CCT motif and a pseudo-receiver domain which is a common motif of plant pseudo-response regulator genes, a fusion polynucleotide of said polynucleotide and a polynucleotide encoding at least one transcription activation domain of a transcription factor, or a recombinant vector comprising said polynucleotide or fusion polynucleotide has been introduced. | 11-01-2012 |
20120276589 | METHOD FOR PRODUCING PROTEINS COMPRISING NON-NATURAL AMINO ACIDS INCORPORATED THEREIN - Producing proteins incorporating non-natural amino acids can involve introducing genes into and knocking inherent genes out of eukaryote-type cells. Genes to be introduced include genes encoding eukaryote-type aminoacyl tRNA synthetase mutants having enhanced specificity to non-natural amino acids, compared with specificity to similar natural amino acids, and tRNA genes for non-natural amino acids capable of binding to the non-natural amino acids in the presence of the eukaryote-type aminoacyl tRNA synthetase mutants. Inherent genes to be knocked out include genes encoding aminoacyl tRNA synthetase having specificity to natural amino acids and tRNA genes capable of binding to the natural amino acids in the presence of the inherent aminoacyl tRNA synthetase. | 11-01-2012 |
20120263645 | RADIOLABELED COMPOUND DIRECTABLE IN VIVO TO TARGET TISSUE AND USE THEREOF - The present invention provides a clinically usable radiolabeled compound that is precisely directable in vivo to a target tissue. The compound of the present invention has a first polypeptide or an analogue thereof, and a second polypeptide bonded to an N-terminus of the first polypeptide or the analogue thereof. In the compound, the first polypeptide is a polypeptide that specifically binds with a protein expressed in a target tissue, the second polypeptide has an amino acid region that has a high affinity for a radioactive metal nuclide, and the radioactive metal nuclide that has a high affinity for the amino acid region is held in the amino acid region. | 10-18-2012 |
20120248456 | NITRIDE SEMICONDUCTOR MULTILAYER STRUCTURE, METHOD FOR PRODUCING SAME, AND NITRIDE SEMICONDUCTOR LIGHT-EMITTING ELEMENT - The nitride semiconductor light-emitting element of the invention has a stacked structure of a buffer layer, an n-type nitride semiconductor layer, a light-emitting layer, and a p-type nitride semiconductor layer, on one surface side of a single crystal substrate of a sapphire substrate. A nitride semiconductor multilayer structure as the buffer layer includes: a plurality of island-like nuclei formed of AlN and formed on the one surface of the single crystal substrate; a first nitride semiconductor layer formed of an AlN layer and formed on the one surface side of the single crystal substrate so as to fill gaps between adjacent nuclei and to cover all the nuclei; and a second nitride semiconductor layer formed of an AlN layer and formed on the first nitride semiconductor layer. | 10-04-2012 |
20120246760 | TRITERPENE OXIDASE DERIVED FROM PLANT BELONGING TO GENUS GLYCYRRHIZA, GENE ENCODING THE SAME, AND METHOD OF USING THE SAME - Identification of a protein having an activity of oxidizing oleanane-type triterpene, and a gene encoding the protein, the protein and the gene, and use thereof are provided. For example, a protein having an activity of oxidizing oleanane-type triterpene obtained from a plant in the family Fabaceae, a gene encoding the protein and use thereof are provided. The protein is shown in, for example, SEQ ID NO: 4, 14 or 18, and the gene encoding the protein is shown in, for example, SEQ ID NO: 3, 13 or 17. A transformant into which the gene is introduced can be produced, and thereby a triterpene oxidase can be obtained. | 09-27-2012 |
20120245340 | NOVEL ARTIFICIAL FLUORESCENT BASES - The present invention relates to novel unnatural fluorescent nucleic acid bases, that is, a purine base, a 1-deazapurine base, and a 1,7-deazapurine base each having a functional group which consists of two or more heterocyclic moieties linked together, at the 6-position thereof (the 6-position of purine ring). The present invention also relates to a compound containing the unnatural base, a derivative thereof, and a nucleic acid containing a nucleotide having the unnatural base. The present invention also relates to a method of preparing the nucleic acid. The unnatural base of the present invention has excellent fluorescence characteristics and also has excellent properties as a universal base. | 09-27-2012 |
20120238455 | METHOD FOR DIAGNOSING DRUG ERUPTION RISK INDUCED BY ANTIEPILEPTIC DRUG BASED ON SINGLE NUCLEOTIDE POLYMORPHISM IN 21.33 REGION OF SHORT ARM OF CHROMOSOME 6 - The genotype of a single nucleotide polymorphism (SNP) existing in the 21.33 region of the short arm of chromosome 6, such as an SNP at the HLA-A locus, is analyzed, and, based on the results, drug eruption risk induced by an antiepileptic drug is diagnosed. | 09-20-2012 |
20120230914 | LABELING COMPOUND FOR PET - A labeling compound of the present invention includes a structure represented by formula (1) | 09-13-2012 |
20120227135 | PLANT HAVING ENHANCED RESISTANCE TO ENVIRONMENTAL STRESS - An object of the present invention is to provide a plant having enhanced resistance to environmental stress by controlling the expression of a histone modifying enzyme in a plant. The present invention relates to a method of producing a plant having enhanced resistance to environmental stress, comprising a step of suppressing or increasing the expression of a histone deacetylase gene. | 09-06-2012 |
20120208861 | IFN TYPE-I PRODUCTION INHIBITOR AND METHOD FOR SCREENING FOR SAME - It has been found that Spi-B, in cooperation with IRF-7, induces type I IFN production. This invention is based on the finding, and provides a type I IFN production inhibitor comprising an antisense nucleic acid or siRNA against Spi-B, or an expression vector capable of expressing the same; a screening method for a substance capable of inhibiting type I IFN production, comprising selecting a substance that suppresses the expression or function of Spi-B as a substance capable of inhibiting type I IFN production; and a type I IFN production inducer comprising an expression vector capable of expressing Spi-B and an expression vector capable of expressing IRF-7 in combination, and the like. | 08-16-2012 |
20120196377 | FLUORESCENT MOLECULE AND METHOD FOR DETECTING TARGET NUCLEIC ACID - Provided are a fluorescent on/off switchable compound for a gene analysis, which is highly stable and highly sensitive, and enables amplification and observation of a trace gene signal, and a labeling reagent for detection of a bio-related material, which uses the fluorescent on/off switchable compound. A compound represented by the following formula (I′): | 08-02-2012 |
20120177571 | PANCREATIC ENDOCRINE CELL INDICATING AGENT AND UTILIZATION OF SAME - A pancreatic endocrine cell indicating agent of the present invention includes a modified polypeptide in which a metal chelator binds only to an amino acid that is located at a site other than a somatostatin receptor-binding active site in a polypeptide selected from the group consisting of somatostatin and somatostatin analogs; and a radioactive metal nuclide held by the metal chelator. According to the present invention, it is therefore possible to provide a novel pancreatic endocrine cell indicating agent. | 07-12-2012 |
20120165553 | IMMUNOSTIMULANT - [Problem to be Solved] | 06-28-2012 |
20120160058 | PHOTOREDUCTION PROCESSING METHOD OF THREE-DIMENSIONAL METAL NANOSTRUCTURE - In a method of producing a metal structure by photoreducing metal ion, a substance capable of suppressing growth of metal crystal is added to a medium in which metal ion is dispersed to prevent growth of the metal crystal produced by photoreduction of the metal ion, thereby processing resolution of a metal structure formed of the metal crystal is improved. | 06-28-2012 |
20120136135 | THERMOSTABLE BIOPOLYESTER - A biopolyester which is poly(3-hydroxyalkanoate) or poly(3-hydroxyalkanoate) copolymer and has a reduced calcium content. It has improved thermal stability due to the reduced calcium content. | 05-31-2012 |
20120135934 | COMBINED PREPARATION FOR TREATING JOINT DISEASES - An object of the present invention is to enable the repair and regeneration of articular cartilage, which could not be achieved by conventional therapies, and to provide a safe and inexpensive agent that is effective for the treatment of joint diseases such as osteoarthritis. According to the present invention, a combined formulation for simultaneously, separately, or sequentially administering a hyaluronic acid and an animal mucin-type glycoprotein for the treatment of joint diseases is provided. | 05-31-2012 |
20120121535 | AGENT FOR PREVENTING RECURRENCE OF LEUKEMIA - The present invention provides a drug capable of initiating the progression of the cell cycle of leukemia stem cells to overcome the resistance of the leukemia stem cells to cell cycle-dependent chemotherapeutic agents, and a drug for suppressing recurrence of leukemia containing the same, and the like, an agent containing G-CSF, wherein the agent is for inducing the progression of the cell cycle of leukemia stem cells, a drug for suppressing recurrence of leukemia containing a combination of G-CSF and a cell cycle-dependent antitumor agent, and the like. | 05-17-2012 |
20120110699 | METHOD FOR PROMOTING THE FORMATION OF SECONDARY CELL WALL OF PLANT - Provided is a method for increasing the thickness of the secondary cell wall of a plant. A method for increasing the thickness of the secondary cell wall of a plant by using a tracheary element differentiation (TED)-associated protein or a C-terminal fragment of the same, which comprises constructing a transgenic (Tg) plant containing, in an expressible manner, a DNA encoding protein(s) selected from the group consisting of a combination of TED6 with TED7, a C-terminal fragment of TED6, a C-terminal fragment of TED7, and a combination of a C-terminal fragment of TED6 with a C-terminal fragment of TED7, and expressing said DNA in said plant; the Tg plant; and a progeny, a cell, a tissue or a seed of the same. | 05-03-2012 |
20120101266 | 18F-LABELED AZIDE COMPOUND, REAGENT FOR 18F-LABELING AND METHOD FOR 18F-LABELING OF ALKYNE COMPOUND USING SAME | 04-26-2012 |
20120070450 | LEUKEMIA STEM CELL MARKERS - The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (AML) comprising (1) measuring the expression level of human leukemic stem cell (LSC) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an LSC-targeting therapeutic agent for AML capable of suppressing the expression of a gene selected from among LSC marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for AML patients comprising obtaining an LSC-purged sample with at least 1 kind of LSC marker as an index; and a method of preventing or treating AML. | 03-22-2012 |
20120067172 | METAL RECOVERY METHOD USING PROTONEMATA OF MOSS PLANTS - Disclosed is a method for recovery of a metal using plants. The method for recovery of a metal involves bringing a protonema of a moss plant belonging to the family Funariaceae into contact with a metal-containing solution in which a metal(s) having an ionization tendency lower than that of silver is dissolved. | 03-22-2012 |
20120066777 | TEST AGENT FOR VISCERAL OBESITY AND USE THEREOF - Disclosed are: a method for detecting (diagnosing) visceral obesity in a subject; a test agent useful for the method; a method for searching for a substance that can be used as an active ingredient for ameliorating visceral obesity; and an ameliorating agent for visceral obesity or a medicinal agent for preventing a metabolic disease developed as a result of the progression of visceral obesity. As the test agent, a polynucleotide which comprises at least 15 nucleotides and can hybridize with a nucleotide sequence for coiled-coil domain containing protein 3 (CCDC3) gene or a nucleotide sequence complementary to the nucleotide sequence under stringent conditions or an antibody capable of recognizing CCDC3 protein is used. | 03-15-2012 |
20120040464 | METHOD FOR GENERATING HOMOPLASMIC CELLS FROM HETEROPLASMIC CELLS - It is an object of the present invention to provide a method, which comprises allowing a eukaryotic cell to come into contact with a reactive oxygen species or a chemical species that generates such a reactive oxygen species in the cell, and thereby changing the percentage of mutant mtDNA (mitochondrial genomic DNA) in the cell, and cells obtained by the above-described method. | 02-16-2012 |
20120040376 | LUNG CANCER DIAGNOSTIC POLYPEPTIDE, METHOD FOR DETECTING LUNG CANCER, AND METHOD FOR EVALUATING THERAPEUTIC EFFECT - A novel biomarker for use in lung cancer diagnosis is provided. | 02-16-2012 |
20120034643 | FLUORESCENT PROTEIN - An object of the present invention is to provide a red or orange fluorescent protein, which is characterized in that the difference (stokes shift) between an excitation peak value (wavelength of maximum absorption) and a fluorescence peak value (wavelength of maximum fluorescence) is greatened, so that the maximum fluorescence can be obtained by the maximum excitation. The present invention provides a novel fluorescent protein monomerized by introducing a mutation into a florescent protein derived from | 02-09-2012 |
20120034226 | DIAGNOSTIC METHOD OF SKIN INFLAMMATORY DISEASE - The invention provides a method of determining (or diagnosing) the presence or absence of a functional abnormality in the skin barrier, a kit therefor, a method of ameliorating a functional abnormality in the skin barrier based on the onset mechanism, and a drug therefor. The method of determining the presence or absence of a functional abnormality in the skin barrier comprises measuring the expression of a protease and/or an inhibitor thereof on the skin surface of a test object, and the like. | 02-09-2012 |
20120028330 | POLYPEPTIDE HAVING ACTIVITY OF AMINOACYL-tRNA SYNTHETASE AND USE THEREOF - A polypeptide according to the present invention includes: an altered polypeptide obtained by altering an ArgRS, a CysRS, a MetRS, a GlnRS, a GluRS, a LysRS, a TyrRS, or a TrpRS so that an unnatural amino acid is recognized; and an editing polypeptide derived from a PheRS, a LeuRS, an IleRS, a ValRS, an AlaRS, a ProRS, or a ThrRS, the editing polypeptide having been either inserted between a Rossman-fold N domain and a Rossman-fold C domain that exist in the altered polypeptide, or bound to an N terminal of the altered polypeptide. Thus provided are a new aaRS that exhibits high substrate specificity to an unnatural amino acid and a technique that involves the use of such an aaRS. | 02-02-2012 |
20120028313 | OLIGONUCLEOTIDE LINKERS COMPRISING A VARIABLE COHESIVE PORTION AND METHOD FOR THE PREPARATION OF POLYNUCLEOTIDE LIBRARIES BY USING SAID LINKERS - The present invention relates to a linker or population of linkers that include an oligonucleotide fixed portion and an oligonucleotide variable portion represented by formula (N)n, wherein N is A, C, G, T or U, or their derivatives, and n is an integer equal to or higher than 1. A linker-polynucleotide or a population of linker-polynucleotides of the invention may be constituted by said linker or population of linkers and a target first strand polynucleotide bound to said linker. The invention also encompasses a method of preparing said linker or population of linkers and a method of preparing a linker-polynucleotide using said linker or population of linkers. The linkers or polynucleotide-linkers of the invention can be used in a method of preparing a cDNA library. | 02-02-2012 |
20120025252 | COMPOSITE SUBSTRATE FOR FORMATION OF LIGHT-EMITTING DEVICE, LIGHT-EMITTING DIODE DEVICE AND MANUFACTURING METHOD THEREOF - A composite substrate for the formation of a light-emitting device, ensuring that a high-quality nitride-based light-emitting diode can be easily formed on its top surface and the obtained substrate-attached light-emitting diode functions as a light-emitting device capable of emitting light for an arbitrary color such as white, is provided. A composite substrate for the formation of a light-emitting device, comprising a light-converting material substrate for radiating at least a part of incident light as light different in the wavelength through the surface opposite the incident surface, and at least two or more Al-containing nitride layers formed on the light-converting material substrate, wherein the light-converting material substrate has a texture comprising two or more oxide phases continuously and three-dimensionally entangled with each other, including an Al | 02-02-2012 |
20120002850 | REGION DATA EDITING APPARATUS, REGION DATA EDITING METHOD, AND RECORDING MEDIUM - A region data editing apparatus includes a contour deforming section for receiving a contour deforming operation in which a contour of a region in a three-dimensional image is deformed, a boundary surface deforming section for deforming a boundary surface ∂D in such a manner that the boundary surface ∂D follows the contour deformed by the contour deforming operation, and a region data updating section for updating region data in such a manner that the region data thus updated represents an inside of the boundary surface which has been deformed by the boundary surface deforming section. | 01-05-2012 |
20120001910 | IMAGE DISPLAY APPARATUS, IMAGE DISPLAY METHOD, CURVED LINE SPECIFYING APPARATUS, CURVED LINE SPECIFYING METHOD, AND RECORDING MEDIUM - A curved line specifying apparatus includes a curved surface specifying section for receiving a curved surface specifying operation in which a curved surface S in a virtual three-dimensional space is specified and a cross section image display section for outputting, to a display, the curved surface in which a cross section image of a three-dimensional image is embedded, pixel values of the cross section image being voxel values assigned to voxels on the curved surface S. | 01-05-2012 |
20120001067 | DIFFERENTIAL MOBILITY ANALYZER, PARTICLE MEASURING SYSTEM, AND PARTICLE SORTING SYSTEM - In order to provide a differential mobility analyzer and the like that allows (i) easy increase of an upper limit of particle size of charged particle which can be classified and (ii) analysis of charged particles whose particle size is variable, a DMA (Differential Mobility Analyzer) includes: a classification tank in which an inlet electrode having an inlet slit, an intermediate electrode having a slit, and an outlet electrode having an outlet slit are arranged in sequence in such a manner that adjacent electrodes are disposed opposing each other at predetermined intervals; a gas supply section supplying the classification tank with sheath gas; and a voltage generator applying a predetermined voltage between the electrodes disposed opposing each other, the classification tank including a first classification section and a second classification section each formed by the electrodes disposed opposing each other, and the gas supply section controlling a flow rate of the sheath gas to be supplied to the classification tank individually per first classification section and second classification section. | 01-05-2012 |
20110307964 | MOUSE HAVING HUMAN LEUKEMIC STEM CELL AND LEUKEMIC NON-STEM CELL AMPLIFIED THEREIN, AND METHOD FOR PRODUCTION THEREOF - The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rg | 12-15-2011 |
20110306653 | STABILIZATION METHOD OF FUNCTIONAL NUCLEIC ACID - This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one end thereof, hairpin-shaped DNA comprising: (A) a nucleic acid region comprising 2 to 5 arbitrary nucleotides; (B) a nucleic acid region comprising a “gna” or “gnna” base sequence, wherein each “n” represents “g”, “t”, “a”, or “c”, a base analogue, or a modified base; and (C) a nucleic acid region comprising a base sequence complementary to the nucleic acid region (A), sequentially from the 5′ end toward the 3′ end. | 12-15-2011 |
20110301043 | RISK ASSESSMENT FOR CUTANEOUS ADVERSE DRUG REACTIONS FROM ANTIRETROVIRAL AGENT - The present invention provides a method of predicting the risk of a patient for developing cutaneous adverse drug reaction to non-nucleoside reverse transcriptase inhibitors such as nevirapine by using HLA-B*3505 allele and/or polymorphisms in the CCHCR1 gene. | 12-08-2011 |
20110300575 | CELL-FREE SYSTEM FOR SYNTHESIS OF PROTEINS DERIVED FROM CULTURED MAMMALIAN CELLS - Prepared is an extract composition having an improved protein synthetic activity in a cell-free protein synthesis system using a mammalian cultured cell extract. An eukaryotic translation initiation factor and/or translational regulator are added to a cell-free protein synthesis system comprising an extract prepared from cultured mammalian cells and a template mRNA. These factors are one or more selected from the group consisting of eukaryotic translation initiation factors 4E (eIF4E), 2 (eIF2) and 2B (eIF2B), and eukaryotic translational regulator p97. | 12-08-2011 |
20110287036 | NOVEL CANCER TARGETING THERAPY USING COMPLEX OF SUBTANCE CAPABLE OF BINDING SPECIFICALLY TO CONSTITUENT FACTOR OF CANCER STROMA AND ANTI-TUMOR COMPOUND - The present invention is intended to provide a pharmaceutical for tumor treatment that stays specifically in interstitium for a long time and exhibits an effect, and provides a complex consisting of a substance having specific binding affinity for stroma and an antitumor compound bound to the substance via a linker. | 11-24-2011 |
20110282014 | NORBORNENE COPOLYMER AND PRODUCTION METHOD THEREOF - The invention relates to a norbornene copolymer having excellent properties such as transparency, heat resistance, low water absorption and electric insulating property, which copolymer comprises a monomer unit represented by formula (1) and formula (2) | 11-17-2011 |
20110280895 | IMMUNOTHERAPEUTIC METHOD USING ALLO-CELLS WHICH CO-EXPRESS CD1d AND TARGET ANTIGEN - The present invention provides a means to be used for a new immunotherapy of cancer or infection utilizing activation of dendritic cell (DC) by innate immunity, namely, a method of preparing a cell co-expressing a target antigen and CD1d and having an ability to activate immunity against the target antigen, comprising the following steps (a) and (b): | 11-17-2011 |
20110280881 | NOVEL ANTI-HSP90 MONOCLONAL ANTIBODY - [Summary] The present invention relates an anti-HSP90 antibody and use thereof, more specifically to an anti-HSP90 antibody capable of recognizing cell surface HSP90, a vaccine that utilizes the antibody, a drug that utilizes the antibody, an adjuvant comprising the antibody, a method of detecting a cell expressing HSP90 on the cell surface using the antibody, and the like. | 11-17-2011 |
20110277189 | MUTANT PLANT, A METHOD FOR PRODUCING THEREOF AND A METHOD OF INCREASING FREQUENCY OF A GENETIC RECOMBINATION - According to the present invention, a technique of increasing the frequency of genetic recombination in genomic DNA of a plant is established. Such technique comprises: introducing a restriction enzyme gene that can be expressed in a target plant cell into the plant cell and causing the restriction enzyme gene to be transiently expressed so as to induce genetic recombination of genomic DNA; or introducing a promoter and a restriction enzyme gene using the | 11-10-2011 |
20110270566 | SCHEDULING DEVICE, SCHEDULING METHOD, SCHEDULING PROGRAM, STORAGE MEDIUM, AND MASS SPECTROMETRY SYSTEM - The present invention provides a scheduling device which can carry out scheduling of process execution periods of time, included in plural pieces of processing target data, respectively. The scheduling device sorts out plural pieces of substance data by looking up a retention time, included in each of the plural pieces of substance data. The scheduling device groups the plural pieces of substance data into a plurality of functions Fn so that pieces of substance data, included in each of the plurality of functions Fn, is successively arrayed in an order resulting from the sorting. Further, the scheduling device finds, for each of the plurality of functions Fn, a function range between a detection start time included in that function Fn and a detection end time included in that function Fn, and groups the plurality of functions Fn into a measurement group(s) In so that an interval between functions Fn included in the same measurement group is more than a condition set in advance. | 11-03-2011 |
20110269945 | FLUORESCENT PROTEIN - An object of the present invention is to provide a novel fluorescent protein derived from | 11-03-2011 |
20110265225 | TRANSGENIC PLANT HAVING INCREASED SEED SIZE - The present invention relates to a transgenic plant having increased seed size prepared via introduction of DNA encoding a protein consisting of a specific amino acid sequence derived from a plant, such as rice, and a method for producing the same. | 10-27-2011 |
20110263849 | METHOD FOR RAPIDLY METHYLATING HETEROAROMATIC ARENE AND METHOD FOR PRODUCING TRACER FOR USE IN PET - Provided is a method whereby a heteroaromatic ring aryl can be very rapidly methylated at a high yield. In an N-alkyl-2-pyrrolidinone, a heteroaromatic ring aryltrialkylstannan is cross-coupled with methyl iodide in the presence of a palladium complex, a phosphine ligand, a cuprous halide, a carbonic acid salt and/or an alkali metal fluoride to thereby rapidly methylate the heteroaromatic ring aryl. (Formula shows a case wherein the heteroaromatic ring aryl is a pyridyl group.) | 10-27-2011 |
20110263687 | RNA MOLECULES AND USES THEREOF - The present invention relates to substantially single-stranded isolated RNA molecules comprising 18 to 19 contiguous nucleotides that corresponds to a non-protein-coding genomic DNA sequence located between −60 and +120 nucleotides from a transcription start site in a mammalian genome. Specifically, the isolated RNA molecules have a high GC content (>60%), are nuclear specific, and may be associated with aberrant gene regulation and/or transcription in various mammalian diseases and conditions. The isolated RNA molecules, modified RNA molecules and fragments thereof may be particularly useful for the diagnosis, prognosis and treatment of diseases such as Crohn's disease, Alzheimer's disease, Parkinson's disease, rheumatoid arthritis, myocardial infarction, diabetes, congenital developmental disorders, coronary heart disease and cancer such as breast cancer, lymphoma, leukemia, aggressive metastatic brain cancers, colorectal cancer, gastric cancer, ovarian cancer and pituitary tumors. | 10-27-2011 |
20110258737 | RICE GENE CAPABLE OF IMPARTING WIDE-SPECTRUM DISEASE RESISTANCE - A three-step screening of selection for resistance against pathogenic bacteria infection, selection for resistance against pathogenic fungi infection, and selection for sensitivity to salicylic acid was carried out on | 10-20-2011 |
20110243910 | MAMMALIAN RNA DEPENDENT RNA POLYMERASE - The invention provides compositions comprising a TERT-RMRP or TERT-RNA complex and methods of treating subjects with genetic diseases in which gene silencing is either increased by administering the compositions of the invention or decreased by administering an inhibitor of the RNA-dependent RNA polymerase (RdRP) activity of these compositions. Moreover, the invention provides methods of screening for agonists and antagonists of RdRP activity and TERT-RMRP complex formation. Finally, the invention provides a method of identifying a RNA molecule that forms a complex with a TERT polypeptide and has RdRP activity. | 10-06-2011 |
20110241863 | DRIVER OPERATION PREDICTION DEVICE, METHOD, AND DRIVER OPERATION PREDICTION PROGRAM - A deviation angle, between a progression direction of a vehicle and a direction of a target destination point after a predetermined forward gaze duration on a target course the vehicle is travelling on, is detected by target destination point deviation angle detection unit. A yaw angular speed proportional to the deviation angle detected by the target destination point deviation angle detection unit is predicted by yaw angular speed prediction unit, as a yaw angular speed realized by steering wheel operation by a driver after a predetermined lag time for matching a timing of change in the vehicle movement with a timing of change in curvature of the target course. By so doing, the yaw angular speed due to steering wheel operation by a driver can be predicted with good precision. | 10-06-2011 |
20110237774 | METHOD FOR INTRODUCING DOTA - The invention provides a method for introducing 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetraacetic acid (DOTA) into a compound such as a peptide. The method comprises a first step for preparing a mixed liquid of DOTA having no protecting group and dimethylsulfoxide, and a second step for contacting the mixed liquid with the compound carried on a solid-phase carrier. | 09-29-2011 |
20110236900 | NOVEL MUTS PROTEIN AND METHOD FOR DETERMING MUTATION USING THE SAME - A method for determining the presence or absence of a mutation on the basis of the presence or absence of amplification with high reliability is provided. A target sequence including a target site contained in a sample nucleic acid is amplified using a primer that can hybridize to a region including the target site contained in the sample nucleic acid in the presence of a novel MutS having an amino acid sequence of SEQ ID NO: 2, and then the presence or absence of a mutation at the target site is determined on the basis of the presence or absence of amplification. The novel MutS binds more specifically to a mismatched base pair than to a fully-matched base pair, whereby an extension reaction caused by a mismatch-binding primer is suppressed. Thus, according to the present invention, the presence or absence of a mutation can be determined with high reliability. | 09-29-2011 |
20110236362 | NKT CELL-DERIVED iPS CELLS AND NKT CELLS DERIVED THEREFROM - Provided are an iPS cell derived from a somatic cell such as an NKT cell, having the α-chain region of the T cell antigen receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, NKT cells differentiated from the iPS cell, a method of creating the same, and an immune cell therapy agent prepared using cells differentiated from the iPS cell. Also provided are an iPS cell having TCRα rearranged to NKT-TCR (NKT-iPS cell), obtained by contacting a somatic cell, such as an NKT cell, having the α-chain region of the T cell antigen receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, with nuclear reprogramming factors, isolated NKT cells obtained by differentiating the iPS cell ex vivo (iPS-NKT cell), a method of generating CD4/CD8-double positive NKT cells (DP-NKT cells) and mature NKT cells from NKT-iPS cells by altering the combination of feeder cells and/or cytokines, a method of expanding the iPS-NKT cells, and an NKT cell cytotherapy agent comprising NKT cells activated with α-galactosyl ceramide (α-GalCer), or iPS-NKT cells, and α-GalCer in combination. | 09-29-2011 |
20110231944 | B CELL-DERIVED IPS CELLS AND APPLICATION THEREOF - Provided are a B cell-derived iPS cell generated using a convenient technique, a technology for providing a human antibody at low cost using the iPS cell, an immunologically humanized mouse prepared using cells differentiated from the iPS cell, and the like. Also provided are a cloned cell obtained by contacting a B cell with nuclear reprogramming factors excluding C/EBPα and Pax5 expression inhibiting substances, particularly nucleic acids that encode Oct3/4, Sox2, Klf4 and c-Myc, wherein the cloned cell has an immunoglobulin gene rearranged therein and possesses pluripotency and replication competence (B-iPS cell). Still also provided are a method of producing a monoclonal antibody against a specified antigen, comprising recovering an antibody from a culture of B cells obtained by differentiating a B-iPS cell derived from a B cell immunized with the specified antigen, and a method of generating an immunologically humanized mouse, comprising transplanting to an immunodeficient mouse a human immunohematological system cell obtained by differentiating a B-iPS cell. | 09-22-2011 |
20110225674 | Transformed plants or algae with highly expressed chloroplast protein BPG2 - This invention provides a transformed plant or alga with increased chlorophyll, comprising an overexpressed foreign DNA which codes for a chloroplast protein BPG2 or a homologue thereof, and a method for producing the transformed plant or alga. | 09-15-2011 |
20110224158 | ESTERIFIED ALPHA-GALACTOSYLCERAMIDE - The invention provides esterified α-galactosylceramides effective for cancer treatment and the like, and a medicament containing same. In particular, the invention relates to a compound represented by the formula (I): | 09-15-2011 |
20110223636 | FLUORESCENT PROTEIN AND CHROMOPROTEIN - It is an object of the present invention to provide a novel fluorescent protein and a novel chromoprotein. The present invention provides a novel fluorescent protein derived from | 09-15-2011 |
20110216312 | SEMICONDUCTOR INSPECTION DEVICE AND INSPECTION METHOD - For a semiconductor device S, an inspection is performed in a zero-bias state by use of electromagnetic waves generated by irradiation of pulsed laser light, and an inspection range is set with reference to layout information of the semiconductor device S to perform two-dimensional scanning by inspection light L | 09-08-2011 |
20110206615 | PROBE REAGENT FOR MEASURING OXIDATIVE STRESS - The present invention relates to fluorescent or luminescent probe reagents for measuring oxidative stress in a cell or an organism. Examples of the probe reagents include: a fluorescent or luminescent protein and a marker protein; a fluorescent or luminescent protein, a marker protein, and a regulatory factor; or a fluorescent or luminescent protein, a marker protein, a cleavage sequence, and a regulatory factor. In the probe reagents, the marker protein makes it possible to detect the oxidative stress caused by reactive oxygen species and comprises a regulatory factor-binding site and a ubiquitin-binding site; and the regulatory factor is a protein making it possible to regulate degradation of the marker protein in response to the reactive oxygen species. The present invention also relates to a method of measuring oxidative stress in a cell or an organism, or a method of screening a substance which suppresses or promotes the oxidative stress in a cell or an organism by using the probe reagent. | 08-25-2011 |
20110201142 | Method of Manufacturing a Light-Emitting Device - To provide a light-emitting device using a nitride semiconductor which can attain high-power light emission by highly efficient light emission, a method of manufacturing the light-emitting device involves forming a first AlGaN layer of a first conductivity type on a side of a first main surface of a nitride semiconductor substrate, forming a light-emitting layer including an InAlGaN quaternary alloy on the first AlGaN layer, forming a second AlGaN layer of a second conductivity type on the light-emitting layer, and removing the nitride semiconductor substrate after forming the second AlGaN layer. | 08-18-2011 |
20110196415 | MATERIAL FOR ANEURYSM CURING - It is an object of the present invention to provide a polymer material, the histocompatibility of which has been improved by irradiation of ion beam, which prevents an aneurysm having a risk of rupture from actually rupturing. The present invention provides a material for treating aneurysms, which is composed of a polymer material containing carbon as a constitutional element, and which is produced by modifying at least a portion of the surface thereof by ion bombardment. | 08-11-2011 |
20110179521 | PLANT SHOWING RESISTANCE TO MULTIPLE DISEASES AND METHOD FOR PRODUCING THE SAME - It is found that multiple different resistance genes adjacent to each other on the genome of | 07-21-2011 |
20110177084 | NOVEL USE APPLICATION OF SUGAR CHAIN-RECOGNIZING RECEPTOR - Provided are a novel means for regulating inflammatory reactions by regulating the signaling in inflammatory responses caused by non-homeostatic cell death, specifically an anti-inflammatory agent comprising a substance that inhibits the expression of Mincle or the interaction of Mincle and SAP130 or FcRγ, a screening method for a substance that regulates inflammatory reactions, comprising contacting Mincle or a fragment containing an extracellular region thereof and SAP130 in the presence and absence of a test substance, and comparing the degrees of the interaction of Mincle or the fragment thereof and SAP130 under the two conditions, a method of detecting non-homeostatic cell death, comprising measuring the amount of SAP130 in a sample collected from a subject animal, and the like. | 07-21-2011 |
20110171738 | METHOD FOR ESTIMATING THE AMOUNT OF IMMOBILIZED PROBES AND USE THEREOF - The present invention provides a method for estimating an amount of immobilized probes, including the successive steps of: providing a sample on a substrate to form one or more spots of the sample on the substrate, the sample containing particulate substances and probes in a predetermined ratio, the probes being reactive with a predetermined target; measuring the number of the particulate substances contained in at least one of the spots; and estimating the amount of the probes contained in the at least one of the spots from the thus measured number of the particulate substances. | 07-14-2011 |
20110161273 | RIBONUCLEIC ACID IDENTIFICATION APPARATUS, RIBONUCLEIC ACID IDENTIFICATION METHOD, PROGRAM AND RIBONUCLEIC ACID IDENTIFICATION SYSTEM - Disclosed are an apparatus for the identification of a ribonucleic acid, whereby not only the molecular weights of digestion products, from which nothing but the nucleic acid residue composition can be understood, but also nucleic acid residue sequence data is obtained from a product ion mass set and thus the identification reliability for the individual digestion products can be remarkably improved; a method for the identification of a ribonucleic acid; and a program and system for the identification of a ribonucleic acid. The method as described above comprises: searching for nucleic acid sequence database by using a fragment mass set indicating the molecular weights and inner structural data of individual oligonucleotides that are obtained by tandem mass spectrometry on digested oligonucleotides formed by chemically or enzymatically cleaving a ribonucleic acid; scoring candidate sequences; among candidate sequences showing the highest scores, referring those showing scores exceeding the threshold as identified sequences; and using these identified sequences in mapping on nucleic acid sequence database including genomic sequences. | 06-30-2011 |
20110159505 | Method of Manufacturing a Mixture of Amplified Double-Stranded Nucleic Acids Comprising Unknown Sequence - The purpose of the subject invention is to provide a method of manufacturing a mixture of amplified double-stranded nucleic acids comprising unknown sequence including the complete 5′ end sequence, | 06-30-2011 |
20110158955 | METHOD FOR PRODUCING CELLS HAVING CHARACTERISTIC OF HEMATOPOIETIC STEM CELLS/PROGENITOR CELLS - Provided are a new method of producing cells having characteristics of hematopoietic stem/progenitor cells, for use in hematopoietic stem cell transplantation, and hematopoietic stem/progenitor cell-like cells produced by the method. Provided in particular are a method of producing hematopoietic stem/progenitor cell-like cells retaining differentiation pluripotency and self-replication potential, comprising (1) a step for providing a mammalian pro-B cell or progenitor cell thereof, and (2) a step for culturing the cell (1) above under conditions for induction of differentiation into B cells, wherein the function and/or expression of the transcription factor E2A is suppressed at least at the stage of pre-pro-B cells or pro-B cells in the process (2) above; a hematopoietic stem/progenitor cell-like cell produced by the method; and an immunotherapeutic agent comprising the hematopoietic stem/progenitor cell-like cell, and the like. | 06-30-2011 |
20110152709 | MOBILE BODY CONTROL DEVICE AND MOBILE BODY CONTROL METHOD - A mobile body control device includes: a brain activity detecting unit that detects brain activity information of a user; a brain signal separating unit that separates an artifact component from the brain activity information detected by the brain activity detecting unit; a control signal generating unit that slides a sampling period for extracting brain data, at predetermined intervals in an overlapped manner in the brain activity information from which the artifact component is separated, successively calculates feature values for the brain data within each of the sampling periods obtained by sliding, and generates a control signal based on the feature values calculated; and a drive control unit that drives and controls a mobile body with a user riding thereon, based on the control signal generated. | 06-23-2011 |
20110152502 | FLUORESCENT PROTEIN - The object of the present invention is to provide a novel fluorescent protein in which on and off of fluorescence thereof can be controlled by irradiation with lights of two different wavelengths. The present invention provides a fluorescent protein shown in the following (a) or (b); | 06-23-2011 |
20110150312 | BIODATA MODEL PREPARATION METHOD AND APPARATUS, DATA STRUCTURE OF BIODATA MODEL AND DATA STORAGE DEVICE OF BIODATA MODEL, AND LOAD DISPERSION METHOD AND APPARATUS OF 3D DATA MODEL - Medical image data is utilized, physical values are assigned to body parts based on image information, and the target organs are separated from the image data to prepare a 3D biodata model to thereby realize a data model unique to a patient, having an internal structure, and enabling dynamic simulation of a live body. The same target part of a body is captured by CT and MRI to obtain medical images. Sets of pairs of CT images and MRI images are set, a plurality of features showing the same locations are selected and set from the sets of CT images and MRI images, a conversion coefficient between the CT images and MRI images is obtained, and this conversion coefficient is used to rearrange the MRI images by projection transforms and linear interpolation, combine them with the contours of the CT images, and correct their positions in the contours. Further, the images are used to prepare a 3D data model. | 06-23-2011 |
20110136995 | AROMATIC VINYL COMPOUND-CONJUGATED DIENE COMPOUND COPOLYMER AND METHOD OF PRODUCING THE SAME AS WELL AS RUBBER COMPOSITION AND TIRE - This invention relates to an aromatic vinyl compound-conjugated diene compound copolymer capable of giving excellent wear resistance and resistance to wet skid to a tire, and more particularly to an aromatic vinyl compound-conjugated diene compound copolymer obtained by an addition polymerization of an aromatic vinyl compound and a conjugated diene compound in the presence of a polymerization catalyst composition comprising at least one specified metallocene complex selected from the group consisting of a metallocene complex represented by the following general formula (I): | 06-09-2011 |
20110136204 | EXTRACT OF E. COLI CELLS HAVING MUTATION IN RIBOSOMAL PROTEIN S12, AND METHOD FOR PRODUCING PROTEIN IN CELL-FREE SYSTEM USING THE EXTRACT - It is intended to provide an extract, kit and a process for synthesizing a protein in a cell-free system. The extract is characterized by being prepared from mutant | 06-09-2011 |
20110129892 | PRODUCTION OF CELL TISSUE HAVING THREE-DIMENSIONAL STRUCTURE USING ELECTROSTATIC INK JET PHENOMENON - According to the present invention, a method and an apparatus for producing a cell tissue of blood vessels or the like with the use of an electrostatic ink jet phenomenon are provided. | 06-02-2011 |
20110129826 | METHOD FOR DETERMINATION OF INFLAMMATORY DISEASE BY USING SINGLE NUCLEOTIDE POLYMORPHISM IN BRCA1-RELATED PROTEIN (BRAP) GENE - It is an object of the present invention to identify a novel single nucleotide polymorphism (SNP) associated with the development and advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging inflammatory diseases, which comprises detecting at least one gene polymorphism in the BRCA1-associated protein (BRAP) gene. | 06-02-2011 |
20110111529 | METHOD FOR QUANTIFICATION OF ANTIGEN-SPECIFIC CANINE OR HUMAN IGE - Disclosed is a convenient and effective means for quantifying an antigen-specific canine or human IgE. Specifically disclosed is a method for quantifying an antigen-specific canine IgE, which comprises the following steps (A) to (D): (A) contacting a biological sample collected from a subject with an antigen to conjugate IgE contained in the sample with the antigen; (B) measuring the quantity of IgE in a standard sample collected from an experimental animal which is different from the subject and has been sensitized with the same antigen as that used in step (A) by using a substance capable of recognizing both IgE from the subject and IgE from the experimental animal, thereby producing a standard curve; (C) detecting a conjugate formed in step (A) by using the same substance capable of recognizing both IgE from the subject and IgE from the experimental animal as that used in step (B); and (D) determining the quantity of IgE in the biological sample collected from the subject by utilizing the quantity of the conjugate detected in step (C) and the standard curve produced in step (B). Also specifically disclosed is a method for quantifying an antigen-specific human IgE. | 05-12-2011 |
20110111446 | THIOL DETECTION METHOD - It is an object of the present invention to provide: a novel thiol-detecting reagent, which can be used in vivo and which solves the problem regarding the generation of background fluorescence due to hydrolysis; and a method for detecting thiol using the aforementioned reagent. The present invention provides a compound represented by the following formula (1): | 05-12-2011 |
20110104188 | NOVEL GLYCOLIPID AND USE THEREOF - The invention provides a glycolipid effective for cancer treatment and the like and a synthetic intermediate therefor, as well as a medicament containing the glycolipid and the like. The glycolipid is represented by the formula (1) or a salt thereof | 05-05-2011 |
20110097711 | METHOD OF JUDGING INFLAMMATORY DISEASE BY USING SINGLE NUCLEOTDIE POLYMORPHISM - An object of the present invention is to identify a novel single nucleotide polymorphism (SNP) associated with the onset and the advancement of inflammatory diseases such as myocardial infarction. The present invention provides a method for judging an inflammatory disease which comprises detecting at least 1 type of genetic polymorphism existing in at least one gene selected from the group consisting of the LBP-32 gene, the TSBP gene, and the WAP gene. | 04-28-2011 |
20110093985 | TRANSCRIPTION FACTOR FOR PROMOTING LATERAL ROOT GROWTH UNDER NITROGEN-LIMITING CONDITIONS - This invention provides a transcription factor AGL21 (AGAMOUS-LIKE 21), which can positively regulate the lateral root growth of a plant when the external supply of N is limited, a homologue thereof or a mutant thereof, gene encoding thereof and a transformed plant with the gene. | 04-21-2011 |
20110091869 | METHOD FOR CULTURE OF STEM CELL - The present invention enables efficient suspension culture of stem cells in a serum-free medium by comprising a step for quickly forming a homogenous aggregate of stem cells, and provides a method of selectively inducing the differentiation of nerves from a stem cell, a method of forming a cerebral cortical nerve network in vitro, and a method of producing a steric structure of a brain tissue in vitro, as well as a method of producing hypothalamic neuron progenitor cells, comprising culturing pluripotent stem cells as a suspended aggregate in a serum-free medium that substantially does not contain a Nodal signal promoter, a Wnt signal promoter, an FGF signal promoter, a BMP signal promoter, retinoic acid and an insulin, and isolating hypothalamic neuron progenitor cells from the culture. | 04-21-2011 |
20110087015 | Nucleoside and nucleotide having an unnatural base and use thereof - The object of the present invention is to provide a nucleoside or a nucleotide, or a derivative thereof, which has an unnatural base. The nucleoside and others of the present invention are characterized by having a 2-amino-6-(2-thiazolyl)purin-9-yl group or a 2-amino-6-(2-oxazolyl)purin-9-yl group as a base, wherein the 4- and/or 5-position of the thiazolyl or oxazolyl group may be substituted. | 04-14-2011 |
20110076704 | Method for diagnosing alzheimer's disease using serum glycoprotein as biomarker - It is an object of the present invention to detect a change in the metabolism of a glycoprotein having an α2,6-sialyl residue, which is contained in blood, so as to provide an agent and a method for diagnosing sporadic Alzheimer's disease. The present invention provides an agent for diagnosing Alzheimer's disease, which comprises lectin used for detecting an α2,6-sialyl residue-containing glycoprotein. | 03-31-2011 |
20110076680 | FLUORESCENT MOLECULE - It is an object of the present invention to provide an on-off type fluorescent compound (a fluorescence-producing molecule system) used in gene analyses, which is highly stable (namely, being active for a long period of time) and highly sensitive, and which enables amplification of a trace amount of gene signal and observation thereof. The present invention provides a nonfluorescent molecule having a fluorescent substance skeleton such as fluorescein skeleton and having a group represented by —O—C(Y1)(Y2)-N | 03-31-2011 |
20110071278 | ANTIBODIES THAT RECOGNIZE CUTTING EDGE WITHIN THE TGF- BETA ACTIVATION CONTROLLING REGION - It is an object of the present invention to provide antibodies capable of detecting an active TGF-β generation reaction that is specific to pathogenesis, tissues, or isoforms. The present invention provides antibodies against an LAP fragment (or latent TGF-β) generated as a result of generation of active form of human TGF-β1, human TGF-β2 and human TGF-β3. The antibodies are able to specifically recognize respective cutting edges within protease cleavage sites existing in the region from the amino acid residue glycine at position 51 to the amino acid residue arginine at position 110 of human TGF-β1, and corresponding regions of human TGF-β2 and human TGF-β3. | 03-24-2011 |
20110065126 | SUBSTANCE-IMMOBILIZING SUBSTRATE, SUBSTANCE-IMMOBILIZED SUBTRATE, AND ANALYSIS METHOD - The present invention relates to a substance-immobilizing substrate for immobilizing a substance to be detected by chemiluminescence. The substance-immobilizing substrate of the present invention comprises a metal portion composed of at least one metal selected from the group consisting of chromium and molybdenum, or an alloy of the metal on at least a portion of a surface of the substrate. The present invention further relates to a substance-immobilized substrate wherein a substance is immobilized on the substance-immobilizing substrate. The substance is immobilized on the metal portion and the substrate is used for detecting the immobilized substance by chemiluminescence. The present invention further relates to an analysis method comprising directly or indirectly detecting by chemiluminescence a substance that is immobilized on a substrate. The substrate comprises a metal portion composed of at least one metal selected from the group consisting of chromium and molybdenum, or an alloy of the metal on at least a portion of a surface of the substrate, and the substance is immobilized on the metal portion. | 03-17-2011 |