RIJKSUNIVERSITEIT GRONINGEN Patent applications |
Patent application number | Title | Published |
20160000838 | Use of Faecalibacterium Prausnitzii Htf-f (DSM 26943) to Suppress Inflammation - The present invention relates to medicine, particularly immunology and gastroenterology. Specifically, it relates to probiotic bacteria and extracts thereof for therapeutic use for the treatment of inflammatory disorders such as inflammatory bowel disease. Provided is a composition comprising as active ingredient | 01-07-2016 |
20150152076 | Geranyl Geranyl Acetone Analogs and Uses Thereof - The invention relates to novel therapeutic compounds, more in particular to biologically active analogs and uses thereof as medicament, for instance for the treatment of atrial fibrillation. Provided is a compound of the general formula (formula I) wherein R | 06-04-2015 |
20150098908 | Biolubricant Polypeptides and Therapeutic Uses Thereof - The invention relates to the field of medicine. In particular, it relates to recombinant cationic polypeptides and their use as biolubricant. Provided is a biolubricant substance comprising the amino acid sequence[(GKGVP)9] | 04-09-2015 |
20140348773 | ARTIFICIAL BONE IMPLANTS, OR BONE GRAFTS, OF POLYMERIC COMPOSITES WITH BONE FORMING PROPERTIES - The present invention relates to methods for providing polymeric composites with bone forming, such as with osteogenic and/or osteoinductive and/or osteoconductive, properties. The present invention further relates to polymeric composites provided by the present method and the use of thereof for bone implants, or grafts, specifically the use thereof for orbital floor reconstruction. Specifically, the present invention relates to methods for providing a composite with bone forming properties, the method comprises the steps of: a) providing a liquid, or liquefied, polymeric composition of homopolymers or copolymers of 1,3-trimethylene carbonate (TMC); b) adding to said liquid, or liquefied, polymeric composition one or more agents with osteogenic and/or osteoinductive and/or osteoconductive properties thereby providing a dispersion of said agents in said liquid or liquefied polymeric composition; and c) crosslinking the product obtained, thereby providing a composite with bone forming properties. | 11-27-2014 |
20140243280 | Methods for chemical synthesis of biologically active compounds using supramolecular protective groups and novel compounds obtainable Thereby - The invention relates to drug development and synthetic chemistry, in particular to the manufacture of biologically active compounds based on naturally occurring molecules. It also relates to novel biologically active compounds, for example aminoglycoside antibiotics, in a substantially pure regioisomeric form. | 08-28-2014 |
20140005799 | Lower Leg Prosthesis | 01-02-2014 |
20130196931 | MEANS AND METHODS FOR COUNTERACTING PROTEIN AGGREGATION - The invention provides a use of a substance that is capable of enhancing the amount and/or activity of DnaJB8, or a functional part, derivative and/or analogue thereof, for counteracting protein aggregation. | 08-01-2013 |
20120090621 | TRACHEOSTOMA VALVE - A tracheostoma valve ( | 04-19-2012 |
20120058977 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING TUBERCULOSIS - A pharmaceutical composition for the treatment of a disease caused by a bacterium that belongs to the group of nocardioform actinomycetes, said composition comprising an effective amount of a compound selected from compound I, (+)-compound II, (−)-compound II, compound III, or mixtures thereof. | 03-08-2012 |
20110237508 | Peptide Formulations and Uses Thereof - The present invention relates to the field of preventive and therapeutic medicine, in particular to peptide formulations. Provided is a pH-buffered aqueous formulation comprising oxytocin, vasopressin or an analogue thereof and at least one non-toxic source of divalent metal ions in a concentration of at least 2 mM, and the use of the formulation for the manufacture of a medicament for therapeutic and/or prophylactic treatments. Also provided is a method for treating or preventing haemorrhage in a subject in need thereof, comprising administering to said subject an effective dosage amount of an oxytocin formulation according to the invention. Further provided is a method for treating or preventing diabetes insipidus or vasodilatory shock in a subject in need thereof, comprising administering to said subject an effective dosage amount of a vasopressin formulation according to the invention. | 09-29-2011 |
20110200552 | CYTOKINE DESIGN - The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1) over the decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4). | 08-18-2011 |
20110165265 | TRAIL VARIANTS FOR TREATING CANCER - The present invention relates to the use of a mutant TRAIL protein to treat various cancers in mammals. The invention provides a variant TRAIL protein, which has superior selectivity for the death receptor 5, for treating a mammal diagnosed with cancer. | 07-07-2011 |
20110110918 | ROLE OF (DE)ACETYLATION IN COUNTERACTING PROTEIN AGGREGATION - The invention provides a method for influencing an activity of a heat shock protein which is a member of the Hsp40/DnaJ family, the method comprising acetylating or deacetylating said heat shock protein. | 05-12-2011 |
20110033909 | MEANS AND METHODS FOR CLONING NUCLEIC ACID SEQUENCES - The invention provides means and methods for efficiently cloning nucleic acid sequences of interest in micro-organisms that are less amenable to conventional nucleic acid manipulations, as compared to, for instance, | 02-10-2011 |
20110015427 | Organic Material Photodiode - The present invention relates to a photodiode, comprising a photo-active layer which layer comprises at least one electron donating material, and at least one fullerene derivative as an electron accepting material. The present invention further relates to a method for making such a photo diode, to a photo-active layer and to a fullerene derivative. | 01-20-2011 |
20090157331 | SYSTEM AND A METHOD FOR DETERMINING ONE OR MORE PARAMETERS OF A SOURCE OF A POTENTIAL-ENERGY FIELD - A sensor system for determining parameters of a source of a potential-energy field. The system has a sensor array for sensing a property of the potential-energy field generated by the source, with a first sensor at a first position and a second sensor at a second position. The first and second sensor each have a sensor output for outputting a sensor signal representing the sensed property. A signal processor can determine the sensed property as a function of the position of the at least one first sensor and the at least one second sensor. A correlator is connected to the signal processor and arranged to correlate the determined result to a predetermined result derived for a template source positioned at a predetermined position and/or orientation with respect to the sensor array. A calculator is connected to the correlator. The calculator can determine the parameter from the correlation result. | 06-18-2009 |
20080267877 | Peptide-based carrier devices for stellate cells - A compound includes a carrier molecule wherein the carrier molecule is linked to a further molecule, wherein the further molecule is at least one cyclic peptide in which the cyclic peptide portion thereof contains at least one sequence encoding a cell receptor recognizing peptide (RRP) and with the proviso that the compound is not a naturally occurring receptor agonist or antagonist. Preferably, the RRP is a receptor specific for Hepatic Stellate Cells (HSC) or a receptor that is up-regulated on HSC during disease. The RFP may be chosen from among a PDGF receptor, a collagen type VI receptor, cytokine receptor(s) such as TGBβ, INFα and interleukinβ. The cyclic portion of the peptide can contain at least one amino acid sequence RGD or KPT. The compounds can be used as an active targeting ingredient for manufacturing a pharmaceutical composition for therapy, prophylaxis or diagnosis of a disease chosen from fibrotic disease, sclerotic disease, and chronic or acute inflammatory processes including glomeruloscherosis, interstitial fibrosis, lung fibrosis, atherosclerosis, rheumatoid arthritis, Crohns disease, colitis ulcerosa, glomerulonephritis and sepsis, and particularly for targeting HSC. Pharmaceutical compositions contain the above-compound(s). | 10-30-2008 |
20080220485 | ENZYMATIC CONVERSION OF EPOXIDES - The invention relates to a process for converting an epoxide to an alcohol. The process according to the invention is enzymatically catalyzed and highly enantioselective and regiospecific. | 09-11-2008 |