| Research Triangle Institute Patent applications |
| Patent application number | Title | Published |
|---|
| 20120122987 | TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) - Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation. | 05-17-2012 |
| 20120080612 | CANTILEVER-BASED MEMS OPTICAL SCANNING APPARATUS, SYSTEM AND METHOD - The present invention relates to an optical scanning apparatus and an optical scanning system The optical system includes an optical engine connected to an optical scanning probe The optical scanning probe images a sample at different lateral positions of the sample The optical scanning probe includes a housing having a longitudinal axis extending in a direction towards a sample to be scanned, a first base having a first moveable mirror supported thereon by a first cantilever connecting the first moveable mirror to the first base, a second base having a second moveable mirror supported thereon by a second cantilever connecting the second moveable mirror to the second base, and a support attaching the first and second bases so that the first moveable mirror and the second moveable mirror are disposed along the longitudinal axis apart from each other | 04-05-2012 |
| 20120033403 | STIMULATED LIGHTING DEVICES - A stimulated lighting device for stimulatable light emission including a luminescent sheet including light stimulatable particles which emit secondary light upon receiving primary light. The lighting device includes a source configured to generate and direct the primary light obliquely onto the luminescent sheet, at least one reflector configured to reflect at least a part of the primary light and a part of the secondary light onto the luminescent sheet and configured to reflect at least a part of scattered primary light and a part of the secondary light from the luminescent sheet toward the light exit, and a light exit configured to emanate light as a combination of the primary light and the secondary light. | 02-09-2012 |
| 20110298134 | THREE DIMENSIONAL INTERCONNECT STRUCTURE AND METHOD THEREOF - A three-dimensional interconnect includes a first substrate bonded to a second substrate, the first substrate including a device layer and a bulk semiconductor layer, a metal pad disposed on the second substrate, an electrically insulating layer disposed between the first and second substrates. The structure has a via-hole extending through the device layer, the bulk semi-conductor layer and the electrically insulating layer to the metal pad on the second substrate. The structure has a dielectric coating on a sidewall of the via-hole, and a plasma-treated region of the metal pad disposed on the second substrate. The structure includes a via metal monolithically extending from the plasma-treated region of the metal pad through the via-hole and electrically interconnecting the device layer of the first substrate to the metal pad of the second substrate. | 12-08-2011 |
| 20110198570 | SELF ASSEMBLED NANO DOTS (SAND) AND NON-SELF ASSEMBLED NANO-DOTS (NSAND) DEVICE STRUCTURES AND FABRICATION METHODS THEREOF TO CREATE SPACERS FOR ENERGY TRANSFER - A structure and method for transferring electronic charge or heat or light between substrates. The structure includes first and second substrates separated from one another and a plurality of localized spacers connecting the first and second substrates together. At least one of the localized spacers having a lateral dimension less than 350 nm. A sub-micron separation distance between the first and second substrates is configured to provide carrier tunneling or to provide heat transfer or light transfer between the first and second substrates. The method provides charge carriers or heat or light to a first substrate. The first substrate is separated from a second substrate by at least one localized spacer having a lateral dimension less than 350 nm and tunnels the charge carriers or couples the heat or couples light from the first substrate to the second substrate across a sub-micron gap between the first and second substrates formed by the at least one localized spacer. | 08-18-2011 |
| 20110194304 | POROUS AND NON-POROUS NANOSTRUCTURES AND APPLICATION THEREOF - A method for producing a fiber membrane of nanofibers that have both smooth and porous surface features. The method includes materials processing using polymer mixes with solvents and melt polymers with additives. The method includes nanomaterial incorporation onto a fiber structure after formation of the fiber structure. The fiber structure can be a part of a nanoparticle carrier material, a nanoparticle disposal medium, a lighting medium, and a catalysis medium. | 08-11-2011 |
| 20110174158 | PARTICLE FILTER SYSTEM INCORPORATING ELECTRET NANOFIBERS - A filtration device including a filtration medium having a plurality of nanofibers of diameters less than 1 micron formed into a fiber mat in the presence of an abruptly varying electric field during electrospinning of the plurality of nanofibers. The nanofibers retain charge in the filtration medium from the electrospinning. The filtration device includes a support attached to the filtration medium and having openings for fluid flow therethrough. A method for making a filter material. The method provides a support having openings for fluid flow therethrough, electrospins nanofibers across an entirety of the openings, abruptly varies an electric field at the collector at least once during electrospinning of the fibers, and retains charge on the nanofibers after formation of the filtration medium. | 07-21-2011 |
| 20110167932 | COARSE PARTICLE EXPOSURE MONITOR - A filter apparatus that includes a housing having at least one opening by which a fluid is Introduced thereto, a first plate inside the housing and having a plurality of inlets offset from a central axis of the housing and angularly separated from each other. The inlets are configured to pass the fluid thereto. The filter apparatus includes a second plate inside the housing and disposed downstream from the first plate. The second plate has angularly extending outlets disposed at a radial distance from the central axis which is beyond the plurality of inlets such that the fluid is diverted radially outward in passing from the first plate through the second plate. The filter apparatus includes a first filter provided on the second plate underneath the plurality of inlets and configured to trap particles in the fluid which are not diverted to the angularly extending outlets, and includes an exit. | 07-14-2011 |
| 20110092473 | ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES - This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage. | 04-21-2011 |
| 20110065743 | KAPPA OPIOID RECEPTOR LIGANDS - Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions. | 03-17-2011 |
| 20110031638 | ELECTROSPRAY/ELECTROSPINNING APPARATUS AND METHOD - Apparatus and method for producing fibrous materials in which the apparatus includes an enclosure having an inlet configured to receive a substance from which the fibrous materials are to be composed, a common electrode disposed in the enclosure, and plural extrusion elements provided in a wall of the enclosure opposite the common electrode so as to define between the plural extrusion elements and the common electrode a space in communication with the inlet to receive the substance in the space. In the method, a substance from which the fibrous materials are to be composed is fed to the enclosure having the plural extrusion elements, a common electric field is applied to the extrusion elements in a direction in which the substance is to be extruded, the substance is extruded through the extrusion elements to tips of the extrusion elements, and the substance is electrosprayed from the tips to form the fibrous materials. | 02-10-2011 |
| 20110031388 | FARADAY CUP ARRAY INTEGRATED WITH A READOUT IC AND METHOD FOR MANUFACTURE THEREOF - A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors. | 02-10-2011 |
| 20110017703 | SELECTIVE PLANARIZATION METHOD AND DEVICES FABRICATED ON PLANARIZED STRUCTURES - A method and system for treating a surface structure of a workpiece. The method provides a carrier-gel to the surface structure of the workpiece. The carrier-gel includes an etchant for selectively etching a first material of the surface structure and has a gel particle size larger than the surface structure. The method etches the first material from the surface structure by a reaction of the etchant included in the carrier-gel with the first material of the surface structure in order to remove a part of the first material from the surface structure for subsequent device fabrication. The system includes a chemical reactor supporting the workpiece. The chemical reactor is configured to flow the carrier-gel noted to the surface structure of the workpiece in order to remove the first material from the surface structure. | 01-27-2011 |
| 20110006204 | HIGH DENSITY FARADAY CUP ARRAY OR OTHER OPEN TRENCH STRUCTURES AND METHOD OF MANUFACTURE THEREOF - A detector array and method for making the detector array. The detector array includes a substrate including a plurality of trenches formed therein, and a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charged particles incident on respective ones of the collectors and to output from the collectors signals indicative of charged particle collection. In the detector array, adjacent ones of the plurality of trenches are disposed in a staggered configuration relative to one another. The method forms in a substrate a plurality of trenches across a surface of the substrate such that adjacent ones of the trenches are in a staggered sequence relative to one another, forms in the plurality of trenches a plurality of collectors, and connects a plurality of electrodes respectively to the collectors. | 01-13-2011 |
| 20100270685 | DIE BONDING UTILIZING A PATTERNED ADHESION LAYER - An electronic package and method and system for forming the electronic package. The electronic package has a first substrate including a first electronic device and including through-holes extending through an entire thickness of the first substrate. The electronic package has a second substrate bonded to the first substrate, metallizations formed in the through-holes of the first substrate to connect to components of the first electronic device, and a patternable substance disposed between the first substrate and the second substrate and adhering the first substrate and the second substrate together in regions apart from the metallizations. The method and system form through-holes extending through an entire thickness of the first substrate, deposit and pattern an adherable substance on the second substrate in a pattern having openings which expose connections for a second electronic device of the second substrate, align and attach the first substrate and the second substrate together, and form metallizations in the through-holes to connect to the connections for the second electronic device. | 10-28-2010 |
| 20100209602 | LUMINESCENT DEVICE - A device for stimulable light emission that includes a fiber mat of nanofibers having an average fiber diameter in a range between 100 and 2000 nm, and includes plural stimulable particles disposed in association with the nanofibers. The stimulable particles produce secondary light emission upon receiving primary light at a wavelength λ. The average fiber diameter is comparable in size to the wavelength λ in order to provide scattering sites within the fiber mat for the primary light. Various methods for making suitable luminescent nanofiber mats include: electrospinning a polymer solution including or not including the stimulable particles and forming from the electrospun solution nanofibers having an average fiber diameter between 100 and 2000 nm. Methods, which electrospin without the stimulable particles, introduce the stimulable particles during electrospinning or after electrospinning to the fibers and therefore to the resultant fiber mat. | 08-19-2010 |
| 20100183302 | OPTICAL SWITCH - An optical device for switching an optical signal between a first optical path and a second optical path, including a substrate, a first guide forming at least a portion of the first optical path, formed on the substrate, and having a movable portion separated from the substrate, a second guide forming at least a portion of the second optical path and disposed adjacent to the first guide, and means for electro statically bending the movable portion so as to optically couple the first guide to the second guide. | 07-22-2010 |
| 20100177518 | LONG-PASS OPTICAL FILTER MADE FROM NANOFIBERS - An optical device having a mat including plural nanofibers configured to transmit light having wavelengths above a cutoff wavelength and to reject light at wavelengths below the cutoff wavelength. The nanofibers have an average fiber diameter comparable in size to the cutoff wavelength. | 07-15-2010 |
| 20100168583 | ENHANCED ULTRASOUND IMAGING PROBES USING FLEXURE MODE PIEZOELECTRIC TRANSDUCERS - A method of generating an enhanced receive signal from a piezoelectric ultrasound transducer is described. The method comprises providing a piezoelectric ultrasound transducer comprising a piezoelectric element operable in flexural mode, receiving a acoustic signal by the piezoelectric element, applying a DC bias to the piezoelectric element prior to receiving the acoustic signal and/or concurrently with receiving the acoustic signal, and generating an enhanced receive signal from the piezoelectric element as a result of receiving the acoustic signal by the piezoelectric element. pMUT-based imaging probes using the above method are also described. | 07-01-2010 |
| 20090264462 | KAPPA OPIOID RECEPTOR LIGANDS - Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions. | 10-22-2009 |
| 20090238760 | ANTISPERMATOGENIC, SPERMICIDAL AND/OR ANTIFUNGAL COMPOSITION AND METHODS OF USING THE SAME - Hexahydroindenopyridine compounds are disclosed which act as contraceptive agents by disrupting spermatogenesis, acting as spermicides or sperm motility inhibitors and/or act as antifungals; antispermatogenic, sperm motility inhibitors, spermicidal or antifungal compositions containing the compounds; and methods for disrupting spermatogenesis, inhibiting sperm motility, killing motile sperm or treating fungi using the compounds and compositions. Also disclosed are radioactive compounds which may be used to study the binding of antifertility compounds to specific sites in the body and the use of such compounds for that purpose. | 09-24-2009 |
| 20090220626 | GRAPE SEED EXTRACT AND ITS CONSTITUENTS FOR USE AS CYP2A6 INHIBITORS - The present invention relates to a use of grape seed extract or its constituents to treat conditions which benefit from an inhibition of cytochrome P450 2A6 (CYP2A6). In particular conditions which benefit from the inhibition of CYP2A6 are conditions which benefit from decreased metabolism of nicotine to cotinine, for example, preventing, reducing or treating smoking, and conditions which benefit from a decrease in the in vivo formation of carcinogens, for example prevention or treatment of cancer. | 09-03-2009 |
| 20090149490 | SPERMICIDAL AND/OR ANTIFUNGAL COMPOSITION AND METHODS OF USING THE SAME - Hexahydroindenopyridine compounds are provided which act as spermicides and/or fungicides, spermicidal and/or fungicidal compositions containing the same, and methods for killing motile sperm and/or fungi using the compounds and compositions. | 06-11-2009 |
| 20090071827 | METHOD AND APPARATUS TO REDUCE FALSE POSITIVE AND FALSE NEGATIVE IDENTIFICATIONS OF COMPOUNDS - A method, computer program medium, and system for analyzing a protein sample that obtains a mass spectrum of the derived peptides, and determines from the mass spectrum a first set of peptide identifications for the peptides. In the method, computer program medium, and system, incorrect identifications can be filtered from the first set of peptide identifications by removal from the first set those peptide identifications ascertained to be false identifications; and the filtered first set can be filtered to generate a second set of the peptide identifications corresponding to the protein sample. | 03-19-2009 |
| 20080251423 | Regenerable Sorbents for Removal of Sulfur from Hydrocarbons and Processes for Their Preparation and Use - A sorbent for use in removing sulfur contaminants from hydrocarbon feedstocks is provided, wherein the sorbent contains zinc aluminate in an amount of at least 40 wt % (calculated as ZnAl | 10-16-2008 |
