| Research Foundation of the City University of New York Patent applications |
| Patent application number | Title | Published |
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| 20120034671 | Protein Matrix For Light-Initiated Electron Transfer - The present invention provides selective modification of polypeptide sequences with electron transfer moieties. The resulting polypeptide assemblies represent a novel class of electron transfer complexes that are capable of transferring electrons over very long distances at fast rates. These complexes possess unique structural features which enable the production of bioconductors and photoactive probes. | 02-09-2012 |
| 20120029331 | IDENTIFICATION, DIAGNOSIS, AND TREATMENT OF NEUROPATHOLOGIES, NEUROTOXICITIES, TUMORS, AND BRAIN AND SPINAL CORD INJURIES USING ELECTRODES WITH MICROVOLTAMMETRY - The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, Parkinson's disease, brain injuries, spinal cord injuries, and cancer. The invention also provides methods of differentiating white matter from gray matter. In some embodiments, regions of the brain to be resected or targeted for pharmaceutical therapy are identified using sensors. The invention further provides methods of measuring the neurotoxicity of a material by comparing microvoltammograms of a neural tissue in the presence and absence of the material using the inventive sensors. | 02-02-2012 |
| 20110319975 | Methods for Reducing Discomfort During Electrostimulation, and Compositions and Apparatus Therefor - An electrode assembly for neuro-cranial stimulation includes an electrode, a conductive gel, and an adapter including an interior compartment for positioning the electrode relative to the adapter and for receiving and retaining the conductive gel. The conductive gel contacts the electrode along an electrode-gel interface. An orifice at one end of the interior compartment and adjacent to a positioning surface of the adapter for positioning the electrode assembly against a skin surface of a user enables the conductive gel is able to contact the skin surface of the user to define a gel-skin interface, such that a minimum distance between the electrode-gel interface and the gel-skin interface is maintained between 0.25 cm and 1.3 cm. An electrode assembly mounting apparatus is provided for adjustably positioning a plurality of electrode assemblies against target positions on the cranium. | 12-29-2011 |
| 20110287557 | SINGLE QUANTUM-DOT BASED APTAMERIC NANOSENSORS - A signal-off-quantum-dot-based sensor for detecting the presence of a target molecule comprising: an aptamer probe having a nucleotide sequence which specifically interacts with the target molecule by sequence-dependent interaction, wherein the aptamer probe is sandwiched between (a) an oligonucleotide which is immobilized on the surface of a quantum dot (QD), and (b) a fluorophore-labeled oligonucleotide, wherein when the sensor is excited by an energy source: (i) in the absence of specific interaction between the target molecule and the aptamer probe, a baseline signal is emitted, and (ii) in the presence of specific interaction between the target molecule and the aptamer probe, a detection signal is emitted, wherein the baseline signal is greater than the detection signal, whereby the presence of the target molecule is detected. | 11-24-2011 |
| 20110277471 | SOLAR POWER PLANT AND METHOD AND/OR SYSTEM OF STORING ENERGY IN A CONCENTRATED SOLAR POWER PLANT - A method for storing heat from a solar collector CSTC in Concentrating Solar Power plants and delivering the heat to the power plant PP when needed. The method uses a compressed gas such as carbon dioxide or air as a heat transfer medium in the collectors CSTC and transferring the heat by depositing it on a bed of heat-resistant solids and later, recovering the heat by a second circuit of the same compressed gas. The storage system HSS is designed to allow the heat to be recovered at a high efficiency with practically no reduction in temperature. Unlike liquid heat transfer media, our storage method itself can operate at very high temperatures, up to 3000° F., a capability which can lead to greater efficiency. | 11-17-2011 |
| 20110144716 | Apparatus and Method for Neurocranial Electrostimulation - There is provided method and apparatus for enhancing focality of neurocranial electrostimulation, including: providing a first plurality of electrodes having at least one electrode; providing a second plurality of electrodes having at least two electrodes; locating the first and the second plurality of electrodes on cranium of a subject and supplying electric current of opposite polarities to the first and the second plurality of electrodes. At least one electrode of the first plurality of electrodes is surrounded by at least two electrodes of the second plurality of electrodes. The enhanced focal stimulation may be used to treat ailments or augment cognitive performance. There are also provided methods for treating brain related ailments and performance augmentation. | 06-16-2011 |
| 20110098317 | USE OF UNSATURATED SPHINGOSINE COMPOUNDS AS CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER - The present invention is directed to unsaturated sphingosine compounds which are useful as therapeutic agents for the treatment of cancer and for the treatment of other diseases including diabetes and infection with intracellular bacteria. This invention is also directed to methods of using the compounds and pharmaceutical compositions comprising the compounds in treating these diseases. | 04-28-2011 |
| 20110082300 | Boron Dipyrromethene Difluoro (Bodipy) Conjugates - The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection. | 04-07-2011 |
| 20110071022 | PROCESS TO PREPARE ADSORBENTS FROM ORGANIC FERTILIZER AND THEIR APPLICATIONS FOR REMOVAL OF ACIDIC GASES FROM WET AIR STREAMS - The invention is directed to an adsorbent comprising: a) 20-30% porous carbon with incorporated organic nitrogen species; and b) 70-80% inorganic matter. The invention is directed to a method of making an adsorbent which comprises: a) thermally drying dewatered sewage sludge to form granulated organic fertilizer; and b) pyrolyzing said the organic fertilizer at temperatures between 600 and 1000° C. The invention is additionally directed to the process of removing acidic gases from wet air streams comprising putting an adsorbent in contact with the wet air stream and allowing the adsorbent to adsorb the acidic gases. | 03-24-2011 |
| 20110045482 | SCREENING METHODS FOR IDENTIFYING TARGET ANTIFUNGAL GENES AND COMPOUNDS BY DETECTING CELL SURFACE GLYCOPROTEINS - The present invention relates to an assay method that can be used for high-throughput detection of cell surface glycoproteins. Specifically, the secretion of a chimeric glycoprotein reporter signals disruption of GPI anchor-mediated attachment of the glycoprotein to the cell surface. This method provides a high signal-to-noise ratio and is particularly useful for screening compounds that affect GP1 anchor biosynthesis. The method of the present invention thus permits genome-wide screens for genes that are needed for GPI anchor-mediated attachment of a glycoprotein to the surface of a cell as well as chemical inhibitors of proteins that promote GP1 anchor-mediated attachment of a glycoprotein to the surface of a cell. Protein inhibitors identified by the present method could be useful in antifungal drug treatments as well. | 02-24-2011 |
| 20110019189 | SUB-WAVELENGTH STRUCTURES, DEVICES AND METHODS FOR LIGHT CONTROL IN MATERIAL COMPOSITES - A device for enhancing transmission of incident electromagnetic radiation at a predetermined wavelength is presented that includes an aperture array structure in a thin film. The structure includes a repealing unit cell having more than one aperture including a first aperture and a second aperture, wherein a parameter of the first aperture differs from that of the second aperture. The unit cell repeats with a periodicity on the order of or less than said predetermined wavelength, The structure parameters are configured to preferentially support cavity modes for coupling to and enhancing transmission of a predetermined polarization state at the predetermined wavelength. By structuring the unit cell with apertures that differ by appropriate degrees in at least one of dimension, height, dielectric constant of material filling the apertures, shape, and orientation, the devices can be adapted for polarization and/or wavelength filtering- and/or light circulating, weaving, or channeling. | 01-27-2011 |
| 20100317974 | DETECTION OF VULNERABLE PLAQUES BY RAMAN SPECTROSCOPY - An apparatus and method of use for detecting vulnerable plaque (VP) in arterial walls is provided. The method includes measuring whether the Raman spectrum of adipose (lipid) tissue signal is present in a Raman signal from aortic intimal wall tissue. The Raman vibration modes for VP are strong bands at about 1435 cm | 12-16-2010 |
| 20100233207 | C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE - The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants. | 09-16-2010 |
| 20100216710 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY REGULATING ARGINASE I AND POLYAMINE SYNTHESIS - This invention relates to the novel identification of arginase as an enzymatic activity which can reverse inhibition of neuronal regeneration in the central and peripheral nervous system. Assays to monitor the effects of various agents on arginase expression and thus on neuronal regeneration and repair and to identify agents which will block or promote the inhibitory effects on neuronal outgrowth are provided. This invention also relates to compositions and methods using agents that can reverse the inhibitory effects of myelin on neural regeneration by affecting arginase activity or putrescine and derivative polyamine levels in a neuron. Methods for regulating and for promoting (or repressing) neuronal growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with conditions, disorders or diseases, comprising the step of administering at least one of the compositions according to this invention, are provided. | 08-26-2010 |
| 20100202582 | SYSTEM AND METHOD FOR STORING ENERGY IN A NUCLEAR POWER PLANT - A method of storing heat includes moving a portion of a heated fluid from at least one reactor core to at least one tank having solid media, storing heat from the portion of the heated fluid in the solid media, and transferring the stored heat from the solid media to a fluid that can be used by a power plant to generate electrical energy. A system for storing heat in a nuclear power plant includes at least one tank comprising solid media structured and arranged to store heat and an arrangement structured and arranged to pass a first fluid through the at least one tank, transfer heat from the first fluid to the solid media, store the heat in the solid media, and transfer the heat from the solid media to a second fluid. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way. | 08-12-2010 |
| 20100171063 | PREPARATION OF PEROVSKITE NANOCRYSTALS VIA REVERSE MICELLES - The present invention is directed to perovskite nanostructures of Formula ABO | 07-08-2010 |
| 20100152038 | CATALYTIC ADSORBENTS OBTAINED FROM MUNICIPAL SLUDGES, INDUSTRIAL SLUDGES, COMPOST AND TOBACCO WASTE AND PROCESS FOR THEIR PRODUCTION - Industrial waste derived adsorbents were obtained by pyrolysis of sewage sludge, metal sludge, waste oil sludge and tobacco waste in some combination. The materials were used as media to remove hydrogen sulfide at room temperature in the presence of moisture. The initial and exhausted adsorbents after the breakthrough tests were characterized using sorption of nitrogen, thermal analysis, XRD, ICP, and surface pH measurements. Mixing tobacco and sludges result in a strong synergy enhancing the catalytic properties of adsorbents. During pyrolysis new mineral phases are formed as a result of solid state reaction between the components of the sludges. High temperature of pyrolysis is beneficial for the adsorbents due to the enhanced activation of carbonaceous phase and chemical stabilization of inorganic phase. Samples obtained at low temperature are sensitive to water, which deactivates their catalytic centers. | 06-17-2010 |
| 20100119827 | POLYMER SUBMICRON PARTICLE PREPARATION BY SURFACTANT-MEDIATED PRECIPITATION - The present invention is directed to methods for the fabrication of polymer nanoparticles comprising the addition polymer solutions to aqueous solutions containing surfactants, wherein the concentration of the surfactants in the aqueous solution are lower than the critical micelle concentration of the surfactants. The methods of the present invention provide for the precipitation of uniformly dispersed polymer particles in the submicron size range, preferably from about 5 nm to about 100 nm. | 05-13-2010 |
| 20100097691 | SPIN-COATED POLYMER MICROCAVITY FOR LIGHT EMITTERS AND LASERS - A spin-coated polymer microcavity for light emitters and lasers producing enhancement of spontaneous emission rate from colloidal CdSe/ZnS core/shell quantum dots embedded in a one dimensional polymer microcavity structure at room temperature. The polymer microcavity structures are fabricated using spin coating. Alternating layers of polymers of two different refractive indices were stacked to form the Distributed Bragg reflectors (DBRs). To achieve high reflectivity, the polymers for the DBR structures were chosen so that they have a relatively high refractive index ratio. The high and low refractive index polymers chosen were poly-N(vinylcarbazole) (PVK) and poly acrylic acid (PAA), with refractive indices of 1.683 and 1.420 at 600 nm, respectively. Thin films of quarter wavelength thickness of the two polymers are alternately spin coated on a glass substrate to make the DBR structures. Greater than 90% reflectivity is obtained using ten periods of the structure. A PVK cavity layer of λ thickness embedded with CdSe/ZnS core/shell quantum dots is sandwiched between two of these DBRs to form the entire microcavity structure. The bottom and top DBRs comprise ten and five periods, respectively. | 04-22-2010 |
| 20100056604 | METHODS FOR STIMULATING NERVOUS SYSTEM REGENERATION AND REPAIR BY INHIBITING PHOSPHODIESTERASE TYPE IV - The invention relates to the novel identification of inhibitors of phosphodiesterase type 4 (“PDE4”) as agents which can reverse inhibition of neural regeneration in the mammalian central and peripheral nervous system. The invention provides compositions and methods using agents that can reverse the inhibitory effects on neural regeneration by regulating PDE4 expression. A composition comprising at least one PDE4 inhibitor in an amount effective to inhibit PDE4 activity in a neuron when administered to an animal is provided. Methods for regulating (e.g., promoting) neural growth or regeneration in the nervous system, methods for treating injuries or damage to nervous tissue or neurons, and methods for treating neural degeneration associated with disorders or diseases, comprising the step of administering to an animal a composition comprising a therapeutically effective amount of an agent which inhibits phosphodiesterase IV activity in a neuron are provided. | 03-04-2010 |
| 20100034159 | SENSOR NETWORK MEDIUM ACCESS CONTROL (MAC) SYSTEM FOR MULTIHOP COMMUNICATION - A medium access control (MAC) technique of a multihop sensor network. In the multihop sensor network, the MAC technique may contribute to significantly reducing transmission delay, and allow real-time services to be provided to all nodes by extending a guaranteed time slot (GTS) restricted to one hop in a personal area network (PAN) coordinator (PNC) to all nodes. Furthermore, the MAC technique may allow the number of available GTSs to be significantly increased, by using all 16 frequency band channels instead of using only a single frequency band and setting a multi-superframe. | 02-11-2010 |
| 20100027901 | PREDICTIVE-TRANSFORM SOURCE CODING WITH SUBBANDS - A method, system, and apparatus are directed towards computing minimum mean squared error (MMSE) predictive-transform (PT) source coding integrated with subband compression to further improve the performance of low bit rate MMSE PT source coders. A desirable byproduct of the advanced scheme is that the incorporation of joint optimum prediction and transformation from subband to subband is ideally suited to its integration with JPEG2000 to yield even higher compression levels while producing an outstanding objective as well as subjective visual performance | 02-04-2010 |
| 20100027097 | DEFECT MULTIPLE-QUANTUM-WELL STRUCTURE FOR MANIPULATION OF REFLECTION AND TRANSMISSION OF LIGHT ACHIEVED BY WAY OF OPTICAL CONTROL OF SPATIAL DISTRIBUTION OF ELECTRIC FIELD ACROSS THE DEFECT MULTIPLE-QUANTUM-WELL STRUCTURE - In one aspect, the invention provides a defect multiple-quantum-well structure for manipulation of reflection and transmission of light by way of optical control of spatial distribution of electric field across the defect multiple-quantum-well structure. The defect multiple-quantum-well structure includes a pair of terminal multiple-quantum-well structures and a central multiple-quantum-well structure. The central multiple-quantum-well structure is sandwiched between the pair of terminal multiple-quantum-well structures. Each of the pair of terminal multiple-quantum-well structures has a band gap profile, and the central multiple-quantum-well structure has a band gap profile. The band gap profile of the central multiple-quantum-well structure is greater than the band gap profile of each of the pair of terminal multiple-quantum-well structures. | 02-04-2010 |
| 20090322612 | METHODS AND APPLICATIONS UTILIZING SIGNAL SOURCE MEMORY SPACE COMPRESSION AND SIGNAL PROCESSOR COMPUTATIONAL TIME COMPRESSION - A method and apparatus for a simplified approach for determining the output of a total covariance signal processor. A single set of offline calculations is performed and then used to estimate the output of the total covariance signal processor. A simplified approach for performing matrix inversion may also be used in determining the output of the total covariance processor. | 12-31-2009 |
| 20090314998 | SYNTHESIS OF POLYMER NANOSTRUCTURES WITH CONDUCTANCE SWITCHING PROPERTIES - The present invention is directed to crystalline organic polymer nanoparticles comprising a conductive organic polymer; wherein the crystalline organic polymer nanoparticles have a size of from 10 nm to 200 nm and exhibits two current-voltage states: (1) a high resistance current-voltage state, and (2) a low resistance current-voltage state, wherein when a first positive threshold voltage (V | 12-24-2009 |
| 20090178409 | APPARATUS AND METHOD FOR STORING HEAT ENERGY - Method and apparatus for storing heat in industrial systems where large sources of stored energy are called upon to meet a work load, storing the heat content of a hot working fluid by using the hot working fluid as a heat transfer fluid in vapor form and depositing its heat content on a heat storage medium and then removing the cooled and condensed liquid phase of that heat transfer fluid, and when hot working fluid again is needed, the liquid heat transfer fluid is returned to the heated storage medium and is reheated as it passes through the hot storage medium and then is returned to the working system to be used as a hot working fluid. | 07-16-2009 |
| 20090147699 | METHOD OF SUPPORTING NODE PORTABILITY IN SENSOR NETWORK - Provided is a method of supporting node portability in a sensor network, wherein data transmission to a portable node can be guaranteed since even when the portable node is assigned with a different address by being associated with another network, the newly assigned address is transmitted to a parent node or a sink node that was previously associated with the portable node. | 06-11-2009 |
| 20090053505 | METHOD OF ELIMINATING AND MONITORING THE ELIMINATION OF ALUMINUM OXIDE AND OTHER MATERIALS AT THE BASE OF PORES IN POROUS ANODIZED ALUMINUM - The present invention is directed to the development of a nanoporous alumina template comprising a multilayer metal film structure that allows for the in situ removal of an electrically insulating barrier layer, thus exposing an electrode at the pore bases. An exemplary multilayer thin film precursor is developed herein which contains an aluminum anodization layer, a diffusion barrier and an electrode. Aluminum anodization in an acidic electrolyte solution with a subsequent voltage pulse sequence produces a nanoporous alumina template with a barrier free conductive electrode surface. The nanoporous template of the present invention provides an efficient means for electrodeposition of nanomaterials. | 02-26-2009 |
| 20080300131 | CATALYTIC ADSORBENTS OBTAINED FROM MUNICIPAL SLUDGES, INDUSTRIAL SLUDGES, COMPOST AND TOBACCO WASTE AND A ROTARY DRYING PROCESS FOR THEIR PRODUCTION - A method for producing an adsorbent, having the steps of combining a first sludge and a second material to form a mixture, thermally drying the mixture, and pyrolizing the mixture using at least four temperature zones wherein each temperature zone is set between about 600° C. and 1,100° C. The first sludge is a municipal sludge or an industrial sludge, and the second material is a compost material or one of municipal sludge or industrial sludge differing from the first sludge. The compost material is at least one of tobacco waste, waste paper and wood char, or a combination thereof. Further, the drying can happen in two stages. Each stage can include two separate temperatures. | 12-04-2008 |
