| Regents of the University of Minnesota Patent applications |
| Patent application number | Title | Published |
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| 20130123003 | AUTOMATIC DETECTION OF DEVIANT PLAYERS IN MASSIVELY MULTIPLAYER ONLINE ROLE PLAYING GAMES (MMOGS) - Gold farming refers to the illicit practice of gathering and selling virtual goods in online games for real money. Although around one million gold farmers engage in gold farming related activities, to date a systematic study of identifying gold farmers has not been done. Here data is used from the Massively Multiplayer Online Role Playing Game (MMOG) EverQuest II to identify gold farmers. This is posed as a binary classification problem and a set of features is identified for classification purposes. Given the cost associated with investigating gold farmers, criteria are also given for evaluating gold farming detection techniques, and suggestions provided for future testing and evaluation techniques. | 05-16-2013 |
| 20130122581 | TAL EFFECTOR-MEDIATED DNA MODIFICATION - Materials and Methods related to gene targeting (e.g., gene targeting with transcription activator-like effector nucleases; “TALENS”) are provided. | 05-16-2013 |
| 20130115603 | NUCLEOTIDE REPEAT EXPANSION-ASSOCIATED POLYPEPTIDES AND USES THEREOF - Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repeats include at least five contiguous repeats of a single amino acid. In other cases, the repeats include at least six contiguous amino acids of a tetra- or penta-amino acid repeat block. | 05-09-2013 |
| 20130112608 | METHODS, COMPOSITIONS AND DEVICES UTILIZING STRUCTURALLY STABLE CYANURIC ACID HYDROLASE - The present invention relates to stable cyanuric acid hydrolase enzymes, compositions, and devices for use in the treatment of a liquid, such as water. The present invention also relates to methods of using these enzymes, compositions and devices for the treatment of a liquid, such as water. | 05-09-2013 |
| 20130096413 | OPTICAL ULTRASOUND TRANSDUCER - In general, this disclosure describes various optical ultrasound transducers and methods of producing such. As one example, an optical ultrasound transducer comprises an optical fiber and a polymer layer formed on the optical fiber to receive light from the optical fiber. The polymer layer may absorb light of a first wavelength and be substantially transparent to light of a second wavelength. In response to the light of the first wavelength, the polymer layer may generate an acoustic tone. The optical ultrasound transducer may further include an optical detector formed on the polymer layer, the optical detector comprising an etalon structure having a first mirror layer and a second mirror layer separated by a compressible layer, wherein the compressible layer resonates in response to the light of the second wavelength passing through the polymer layer and is compressible in response to acoustic pressure from echoes of the acoustic tone. | 04-18-2013 |
| 20130090698 | STRIPPED PEDICLE SCREW DRIVER BIT - A pedicle screw driver bit includes an elongated shank and a head. The shank includes a plurality of threads. The head is connected to one end of and configured to rotate relative to the shank. The head is configured to be received by a tulip connected to a pedicle screw. The threads of the shank are configured to engage a plurality of threads of the tulip such that when the shank is rotated the tulip is drawn into engagement with the head such that the shank, the head, the tulip, and the pedicle screw are substantially prevented from rotating relative to one another. | 04-11-2013 |
| 20130090692 | INTRAOPERATIVE SPINAL STABILIZATION - A number of spinal stabilization devices are disclosed for aligning and fixing vertebrae during surgery, e.g. to facilitate accurate placement of pedicle screws. One stabilization device includes a pair of spiked rails biased to clamp shut and thereby passively engage a number of vertebrae. Another stabilization device includes a tie-rod that connects two or more fiducial markers, each of which is connected to a vertebra, to stabilize the vertebrae including and between each vertebra to which the markers are attached. | 04-11-2013 |
| 20130085736 | SIMULATED, REPRESENTATIVE HIGH-FIDELITY ORGANOSILICATE TISSUE MODELS - A method of making a tissue model comprises determining one or more material properties of a tissue, wherein the one or more material properties include at least one of mechanical properties, electroconductive properties, optical properties, thermoconductive properties, chemical properties, and anisotropic properties, creating an anatomical structure of the tissue, selecting an artificial tissue material having one or more material properties that substantially correspond to the one or more material properties of the tissue, and coupling the artificial tissue material to the anatomical structure. | 04-04-2013 |
| 20130085374 | METHOD OF OSCILLOGRAM FILTERING FOR RADIAL MRI DATA - A system includes a data receiver, a sinogram generator, a processor, a filter module, and an output module. The data receiver is configured to receive radial ordered magnetic resonance data. The sinogram generator is configured to generate a first sinogram corresponding to a view angle as a function of a readout direction for the magnetic resonance data. The processor is configured to generate an oscillogram having an angular frequency axis. The oscillogram corresponds to a Fourier transform of the first sinogram. The filter module is configured to selectively filter a peak in a projection formed along a selected axis of the oscillogram, the peak being related to an interference signal such as an RF interference. The selected axis is orthogonal to the angular frequency axis. The output module is configured to form a second sinogram corresponding to a transform of the filtered projection | 04-04-2013 |
| 20130084023 | MULTISTEP CORRECTION FOR ANGLE CONSISTENT ARTIFACTS IN RADIAL SAMPLED DATASETS - This document discloses, among other things, a method for removing a bullseye artifact from a radial image generated using magnetic resonance and using a swept frequency pulse. | 04-04-2013 |
| 20130079871 | VASCULAR ELASTANCE - A device includes a balloon and an interface. The balloon has an outer surface and a central lumen aligned on a longitudinal axis. The balloon is configured to receive a compressible fluid. The interface is coupled to the outer surface and has an external surface configured to bond with a tissue. | 03-28-2013 |
| 20130075904 | COPLANER WAVEGUIDE TRANSITION - A coplanar waveguide transition includes a substrate, a first coplanar waveguide on a first side of the substrate, and a second coplanar waveguide on a second side of the substrate. The coplanar waveguide transition includes a first, a second, and a third via through the substrate electrically coupling the first coplanar waveguide to the second coplanar waveguide. The coplanar waveguide transition includes voids through the substrate between the first, second, and third vias and edges of the first coplanar waveguide and edges of the second coplanar waveguide. | 03-28-2013 |
| 20130072443 | STABILIZED MUTANT OPSIN PROTEINS - Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids. | 03-21-2013 |
| 20130069649 | MAGNETIZATION TRANSFER AND OFF-RESONANCE PROTOCOLS IN NMR - A method includes acquiring a signal intensity from a spin system after applying the radio frequency preparation pulses prior to the imaging readout or spectroscopic localization, and acquiring signal intensity starting with magnetization initially rotated to a certain angle by applying an initial pulse before the preparation scheme, and processing the data to generate an image or spectra corresponding to the spin system. The imaging or spectroscopy sequence is configured to provide data based on magnetization transfer or an off-resonance effect. | 03-21-2013 |
| 20130068841 | SYMBOL-BASED DECODING OF OPTICAL CODES - Techniques and systems for decoding optical codes using symbol-based algorithms are described. In one example, a method includes acquiring a signal representative of light reflected from an optical code comprising one or more symbols of a finite set of symbols and applying a decoding model to the signal. The decoding model may relate measured signals to the finite set of symbols, such that each of the symbols of the finite set of symbols are associated with a respective encoded character of a finite set of encoded characters. The method may also include determining, by a processor, a sequence of one or more of the encoded characters based on the application of the decoding model to the signal. In this manner, the optical code may be decoded by directly fitting an acquired signal from the optical code to possible symbols within the optical code and the associated encoded characters. | 03-21-2013 |
| 20130063319 | METHOD AND REMOTELY ADJUSTABLE REACTIVE AND RESISTIVE ELECTRICAL ELEMENTS - Apparatus and method that includes providing a variable-parameter electrical component in a high-field environment and based on an electrical signal, automatically moving a movable portion of the electrical component in relation to another portion of the electrical component to vary at least one of its parameters. In some embodiments, the moving uses a mechanical movement device (e.g., a linear positioner, rotary motor, or pump). In some embodiments of the method, the electrical component has a variable inductance, capacitance, and/or resistance. Some embodiments include using a computer that controls the moving of the movable portion of the electrical component in order to vary an electrical parameter of the electrical component. Some embodiments include using a feedback signal to provide feedback control in order to adjust and/or maintain the electrical parameter. Some embodiments include a non-magnetic positioner connected to an electrical component configured to have its RLC parameters varied by the positioner. | 03-14-2013 |
| 20130062890 | CARBON DIOXIDE-BASED GEOTHERMAL ENERGY GENERATION SYSTEMS AND METHODS RELATED THERETO - Novel carbon dioxide-based geothermal energy generation systems, i.e., carbon plume geothermal (CPG) systems, and methods are provided. With the novel systems and methods described herein, geothermal energy can now be provided at lower temperatures and at locations other than hot, dry rock formations, without negatively impacting the surrounding area through use of large-scale hydrofracturing. Use of a carbon dioxide-based geothermal system further provides a means for sequestering and storing excess carbon dioxide, rather than having it released to the atmosphere. | 03-14-2013 |
| 20130043867 | SIDEBAND PROCESSING FOR MAGNETIC RESONANCE - A method includes applying a pulse train to a spin system in a scanner. The pulse train has a plurality of discontinuities in a time domain. The method includes receiving a response from the spin system. The response corresponds to a gated signal. The method includes accessing a correction factor corresponding to the scanner. The method includes calculating a correction to the response based on the correction factor. The method includes generating an output based on the correction. | 02-21-2013 |
| 20130043678 | CARBON DIOXIDE-BASED GEOTHERMAL ENERGY GENERATION SYSTEMS AND METHODS RELATED THERETO - A system comprises an injection well for accessing a reservoir containing a native fluid comprising a hydrocarbon. The reservoir is located below one or more caprocks, is at a first temperature, and is accessible without using large-scale hydrofracturing. The system further includes a production well in fluid communication with the reservoir, a supply apparatus configured to feed a non-water based working fluid at a second temperature that is lower than the first temperature through the injection well to the reservoir. The working fluid mixes with the native fluid to form a production fluid comprising at least a portion of the working fluid and at least a portion of the hydrocarbon at a third temperature that is higher than the second temperature. An energy recovery apparatus in fluid communication with the productions well converts energy contained in the production fluid to electricity, heat, or combinations thereof. | 02-21-2013 |
| 20130041055 | NANOPOROUS LINEAR POLYETHYLENE MEMBRANES AND BLOCK COPOLYMER PRECURSORS FOR SAME - A composition comprising a block copolymer that includes at least one polyester block and at least one linear polyolefin block, wherein the composition is in the form of a nano-structured, bicontinuous composite that includes a continuous matrix phase and a second continuous phase. The continuous matrix phase comprises the linear polyolefin block of the block copolymer, and the second continuous phase comprises the polyester block of the block copolymer. The composite may be treated to remove the polyester block, thereby forming a plurality of nano-pores. | 02-14-2013 |
| 20130035394 | Calixarene-Based Peptide Conformation Mimetics, Methods of Use, and Methods of Making - A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described. | 02-07-2013 |
| 20130034533 | High Molecular Weight Derivatives of Vitamin K-Dependent Polypeptides - Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both objectives are important for using vitamin K-dependent polypeptides for pro- and anti-coagulation therapies, as well as for other uses in the circulation. | 02-07-2013 |
| 20130029335 | SPINOCEREBELLAR ATAXIA TYPE 8 AND METHODS OF DETECTION - The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided. | 01-31-2013 |
| 20120314489 | SYSTEMS AND METHODS FOR DIRECT COMMUNICATION BETWEEN MAGNETIC TUNNEL JUNCTIONS - Systems and methods that enable direct communications between magnetic tunnel junctions are provided. In one embodiment, a device includes multiple input magnetic tunnel junctions and an output magnetic tunnel junction. The multiple input magnetic tunnel junctions are connected in parallel, and the output magnetic tunnel junction is connected in series to the input magnetic tunnel junctions. In another embodiment, a device includes a first magnetic tunnel junction, a second magnetic tunnel junction, and a nano-magnetic channel. Each of the first and the second magnetic tunnel junctions has a free layer, a nonmagnetic layer, and a fixed layer. The nano-magnetic channel connects the free layer of the first magnetic tunnel junction to the free layer of the second magnetic tunnel junction. | 12-13-2012 |
| 20120309801 | CALIXARENE-BASED PEPTIDE CONFORMATION MIMETICS, METHODS OF USE, AND METHODS OF MAKING - A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described. | 12-06-2012 |
| 20120288489 | INTRANASAL DELIVERY OF THERAPEUTIC ENZYMES TO THE CENTRAL NERVOUS SYSTEM FOR THE TREATMENT OF LYSOSOMAL STORAGE DISEASES - The invention provides a method to prevent, inhibit or treat one or more neurological symptoms associated with a lysosomal storage disease in a mammal in need thereof, which includes intranasally administering to the mammal a composition comprising an effective amount of a lysosomal storage enzyme or a recombinant adeno-associated virus vector comprising an open reading frame encoding a lysosomal storage enzyme. Also provided are compositions and devices useful in the methods. | 11-15-2012 |
| 20120286780 | MAGNETIC RESONANCE RELAXATION ALONG A FICTITIOUS FIELD - A system includes a driving module, a processor, and a readout module. The driving module is configured to apply a perturbation to a sample. The processor is configured to define a plurality of different rotating frames relative to the perturbation, wherein each frame has a corresponding fictitious field. The readout module is coupled to the processor and is configured to generate an output based on relaxation of the sample as a function of the perturbation. | 11-15-2012 |
| 20120283564 | VASCULAR CHARACTERIZATION USING ULTRASOUND IMAGING - Ultrasound methods and/or systems provide for the motion tracking of both vessel wall motion and blood flow (e.g., with use of high frame rate ultrasound pulse echo data and speckle tracking both wall motion and flow can be tracked simultaneously). | 11-08-2012 |
| 20120272518 | FLEXIBLE SENSORS AND RELATED SYSTEMS FOR DETERMINING FORCES APPLIED TO AN OBJECT, SUCH AS A SURGICAL INSTRUMENT, AND METHODS FOR MANUFACTURING SAME - Methods of manufacturing a flexible force sensor include forming a first sensor part providing a plurality of spaced first electrode plates in an electrically non-conductive material. A second sensor part is also formed and includes a plurality of second electrode plates in an electrically non-conductive material. The second electrode plates are identical to the first electrode plates at least in terms of spacing. The first part is assembled to the second part such that each of the first electrode plates are aligned with and parallel to, yet spaced from, respective ones of the second electrode plates, establishing a plurality of capacitive sensing components. The first electrode plates are movable relative to the corresponding second electrode plates, establishing a variable gap therebetween. The sensor parts can be ring-shaped. The sensor parts can be formed via MEMS techniques, with the non-conductive material being a polymer. | 11-01-2012 |
| 20120269815 | NEUROTROPHINS AND USES THEREOF - A neurotrophin polypeptide, and a biologically active fragment thereof, are described. Also, methods are disclosed that include providing a composition comprising the neurotrophin polypeptide to a subject, wherein the composition is effective to ameliorate at least one symptom or clinical sign of a condition treatable with a neurotrophin when the composition is administered to a subject in need of treatment for a condition treatable with a neurotrophin. | 10-25-2012 |
| 20120253192 | METHODS AND SYSTEMS FOR CHEMICAL ABLATION - Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. | 10-04-2012 |
| 20120252090 | HEAT RESISTANT BIOACTIVE COMPOSITION - A process for stabilizing a bioactive composition includes forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores while keeping the protein molecules biologically active. | 10-04-2012 |
| 20120238529 | TRIPTOLIDE PRODRUGS - The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using the compounds of formula I. | 09-20-2012 |
| 20120181171 | Nanoparticle Deposition Systems - Nanoparticle deposition systems including one or more of: a hollow target of a material; at least one rotating magnet providing a magnetic field that controls movement of ions and crystallization of nanoparticles from released atoms; a nanoparticle collection device that collects crystallized nanoparticles on a substrate, wherein relative motion between the substrate and at least a target continuously expose new surface areas of the substrate to the crystallized nanoparticles; a hollow anode with a target at least partially inside the hollow anode; or a first nanoparticle source providing first nanoparticles of a first material and a second nanoparticle source providing second nanoparticles of a second material. | 07-19-2012 |
| 20120179070 | SPINAL PROBE WITH TACTILE FORCE FEEDBACK AND PEDICLE BREACH PREDICTION - A spinal probe comprises a handle, a shaft coupled to the handle and a force sensor to detect forces applied to a tip of the shaft. A controller that executes a predictive algorithm to predict whether or not the tip of the shaft is going to breach a cortex of a pedicle based on the detected forces. The controller may be embedded within the spinal probe or external within a computer or other device coupled to the probe by a data acquisition component. | 07-12-2012 |
| 20120158455 | ESTIMATING VALUE OF USER'S SOCIAL INFLUENCE ON OTHER USERS OF COMPUTER NETWORK SYSTEM - The social influence that each person in a computer network system exercises over others in the system may be valued by aggregating the differences in value of each of the others to the network both with and without the person being present. This calculated influence may be used as a basis for charging advertisers for advertisements to the users, as well as for providing preferential treatment to users that exert the greatest influence. | 06-21-2012 |
| 20120155512 | ESTIMATING FREQUENCY-OFFSETS AND MULTI-ANTENNA CHANNELS IN MIMO OFDM SYSTEMS - Techniques are described for carrier frequency offset (CFO) and channel estimation of orthogonal frequency division multiplexing (OFDM) transmissions over multiple-input multiple-output (MIMO) frequency-selective fading channels. A wireless transmitter forms blocks of symbols by inserting training symbols within two or more blocks of information-bearing symbols. The transmitter applies a hopping code to each of the blocks of symbols to insert a null subcarrier at a different position within each of the blocks of symbols, and a modulator outputs a wireless signal in accordance with the blocks of symbols. A receiver receives the wireless signal and estimates the CFO, and outputs a stream of estimated symbols based on the estimated CFO. | 06-21-2012 |
| 20120149096 | PRRS VIRUSES, INFECTIOUS CLONES, MUTANTS THEREOF, AND METHOD OF USE - The present invention provides isolated infectious polynucleotides, such as infectious clones, having a nucleotide sequence with identity to PRRS viruses such as VR-2332, Lelystad, or others, and optionally further including a deletion in a region of ORF1 that encodes the nsp2 polypeptide. | 06-14-2012 |
| 20120143038 | FUNCTIONAL ASSESSMENT OF A NETWORK - A computer-implemented method for performing a functional assessment of a network is disclosed. The network includes a plurality of interacting network elements. The method includes measuring a state of each of the elements at a plurality of time instances, thereby determining a plurality of state values associated with each of the elements, and calculating for each element an associated median value representing a median of the state values associated with that element. The method further includes identifying for each time instance a first total number of elements with an associated state value at that time instance that is above its median value, and a second total number of elements with an associated state value at that time instance that is below its median value, and determining whether the network has departed from an equilibrium state based on the first total number and the second total number for each time instance. | 06-07-2012 |
| 20120142750 | INDOLEAMINE 2,3-DIOXYGENASE PATHWAYS IN THE GENERATION OF REGULATORY T CELLS - The present invention provides methods for the control of the generation of regulatory T cells (Tregs) and uses thereof. | 06-07-2012 |
| 20120130232 | Illustrating a Three-Dimensional Nature of a Data Set on a Two-Dimensional Display - A volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data. | 05-24-2012 |
| 20120094299 | NUCLEOTIDE REPEAT EXPANSION-ASSOCIATED POLYPEPTIDES AND USES THEREOF - Isolated polypeptides that are endogenously expressed from nucleotide repeat expansions are disclosed. In some cases, the polypeptides include polypeptide repeats. In some cases, the polypeptide repeats include at least five contiguous repeats of a single amino acid. In other cases, the repeats include at least six contiguous amino acids of a tetra- or penta-amino acid repeat block. | 04-19-2012 |
| 20120041345 | SENSING TISSUE PROPERTIES - Some embodiments of a tissue sensor may include a micro-fabricated structure that can be coupled to a medical instrument, such as a probe, an endoscopic tool, or another minimally invasive instrument. The tissue sensor can be configured to provide information indicate of tissue properties, such as tissue elasticity characteristics or the type of tissue. | 02-16-2012 |
| 20120041073 | STABILIZED MUTANT OPSIN PROTEINS - Methods and compositions for stabilizing opsin protein in a vertebrate visual system are provided by administration of opsin-binding synthetic retinoids. | 02-16-2012 |
| 20120031851 | STORM DRAIN BAFFLE TO DECREASE SEDIMENT WASHOUT - Some examples includes a flow-through stormwater sump having a bottom and defining an inlet opening, an outlet opening and a top access opening, an inlet conduit coupled to the flow-through stormwater sump at the inlet opening, an outlet conduit coupled to the flow-through stormwater sump at the outlet opening and a flow-path baffle disposed in the stormwater sump, the flow-path baffle being substantially planar and defining a plurality of openings, the flow-path baffle oriented such that a centerline of the inlet conduit intersects a major plane of the baffle at a point and a centerline of the outlet conduit intersects the major plane at a further point, the flow-path baffle disposed in the stormwater sump in a direct impingement inlet flow-path of the inlet conduit and a direct impingement outlet back-flow-path of the outlet conduit. | 02-09-2012 |
| 20120023050 | CLASSIFYING AN ITEM TO ONE OF A PLURALITY OF GROUPS - A method of classifying an item to one of a plurality of groups includes providing a plurality of predictors associated with the item. For each predictor, the item is assigned to one of the groups. An assignment number is determined for each group. The item is classified to one of the groups based on the assignment number for each group. | 01-26-2012 |
| 20120001429 | CARBON DIOXIDE-BASED GEOTHERMAL ENERGY GENERATION SYSTEMS AND METHODS RELATED THERETO - Novel carbon dioxide-based geothermal energy generation systems, i.e., carbon plume geothermal (CPG) systems, and methods are provided. With the novel systems and methods described herein, geothermal energy can now be provided at lower temperatures and at locations other than hot, dry rock formations, without negatively impacting the surrounding area through use of large-scale hydrofracturing. Use of a carbon dioxide-based geothermal system further provides a means for sequestering and storing excess carbon dioxide, rather than having it released to the atmosphere. | 01-05-2012 |
| 20110306575 | MEDICAL AND NUTRITIONAL APPLICATIONS OF HIGHLY REFINED CELLULOSE - The present invention provides a method for using processed-cellulose. Preferably, the processed cellulose is a highly refined cellulose (HRC). The HRC is useful in a number of medical and nutritional applications. These medical and nutritional applications can include, but are not limited to, administering effective amounts of the HRC for lowering values of risk factor measurements for such diseases as arteriosclerotic cardiovascular disease and diabetes. Treatment of other diseases and conditions with the HRC is also possible. | 12-15-2011 |
| 20110305763 | LANTIBIOTICS AND USES THEREOF - The present invention provides isolated lantibiotics that inhibit. Gram negative and Gram positive microbes. The antibiotic includes an amino acid sequence, wherein the amino acid sequence of the compound and the amino acid sequence of SEQ ID NO:21 or SEQ ID NO:22 have at least 80% identity. The lantibiotics have the characteristic of inhibiting growth of a Gram negative microbe in conditions that do not damage the outer membrane of the Gram negative microbe. The present invention also provides methods for making and using the lantibiotics. | 12-15-2011 |
| 20110303997 | MAGNETIC TUNNEL JUNCTION DEVICE - A magnetic tunnel junction device comprises a fixed magnetic layer having a first side and a second side, the fixed magnetic layer having a magnetic anisotropy that is out of the film plane of the fixed magnetic layer; a stack of a plurality of bilayers adjacent to the first side of the fixed magnetic layer, each bilayer comprising a first layer comprising at least one of cobalt, iron, a CoFeB alloy, or a CoB alloy and a second layer in contact with the first layer, the second layer comprising palladium or platinum, wherein the plurality of bilayers has a magnetic anisotropy that is out of the film plane of each of the bilayers, wherein the fixed magnetic layer is exchange coupled to the stack of the plurality of bilayers, and a tunnel barrier layer in contact with the second side of the fixed magnetic layer. | 12-15-2011 |
| 20110297354 | SYSTEM AND METHOD THAT DISSIPATE HEAT FROM AN ELECTRONIC DEVICE - The electronic system includes an electronic device and a liquid holding section that is thermally coupled to the electronic device. The electronic system further includes an impermeable section that engages the liquid holding section. The impermeable section includes a channel and a plurality of passages that provide fluid communication between the liquid holding section and the channel. The electronic system further includes (i) a first fluid that flows through the channel in the impermeable section to facilitate heat transfer from the electronic device to the first fluid; and (ii) a second fluid that flows from the liquid holding section through the plurality of passages into the channel when the second fluid boils within the liquid holding section due to heat transfer from the electronic device to the second fluid. In some embodiments, the first and second fluids are different types of substances. | 12-08-2011 |
| 20110294960 | POLYLACTIDE COPOLYMERS - A polylactide copolymer comprises a graft copolymer of a hydrophobic backbone polymer having a plurality of pendant hydroxyl groups and lactide. In one example, a polylactide includes a graft copolymer of a poly(1,5-cyclooctadiene-co5-norbornene-2-methanol) copolymer and lactide. A method of preparing a toughened polylactide comprises forming a hydrophobic backbone copolymer having a plurality of pendant hydroxyl groups and forming a polylactide graft copolymer by reacting the hydrophobic backbone copolymer having a plurality of pendant hydroxyl groups with lactide, wherein polymerized lactide stems from at least one of the plurality of pendant hydroxyl groups. In one example, a method comprises forming poly(1,5-cyclooctadiene-co-5-norbornene-2-menthanol) by reacting 1,5-cyclooctadiene and 5-norbornene-2-methanol in the presence of a 2 | 12-01-2011 |
| 20110288398 | SHORT TE 3D RADIAL SAMPLING SEQUENCE FOR MRI - A method for magnetic resonance imaging includes providing a radio frequency excitation pulse to a specimen. The pulse has a duration. The method includes, concurrent with providing the radio frequency excitation pulse, applying a first gradient having a first polarity. The method includes applying a readout gradient at a time after the duration. The readout gradient has inverse polarity relative to the first polarity. The method includes, concurrent with applying the readout gradient, acquiring magnetic resonance data from the specimen. The method includes generating an image based on the magnetic resonance data. | 11-24-2011 |
| 20110269810 | SELECTIVE INHIBITORS OF C-JUN N-TERMINAL KINASE - Compositions and methods for treating, preventing, or ameliorating one or more symptoms, disorders, or conditions associated with particular c-Jun N-terminal kinase(s) (JNKs) activity are provided. Compositions contain small molecules such as pyrazoloanthrones. | 11-03-2011 |
| 20110268752 | Inducible Regulatory T-Cell Generation for Hematopoietic Transplants - The present invention provides methods and compositions for converting non-Tregs into Tregs. The converted Tregs are referred to as inducible Tregs (iTregs). The iTregs are useful for preventing, suppressing, blocking or inhibiting an immune response. For example the iTregs are useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft vs host disease. The iTregs can also be used to treat autoimmune diseases. | 11-03-2011 |
| 20110251227 | ANALGESIC AGENTS - The invention provides a compound of formula (I) or a salt thereof, as well as compositions comprising such compounds. The compounds and compositions are useful as analgesics. | 10-13-2011 |
| 20110243901 | Compositions and Methods for the Treatment of Lysosomal Storage Disorders - The present invention relates to methods for providing lysosomal enzymes to a subject by administering stem cells, preferably Multipotent Adult Progenitor Cells (MAPCs). The invention further relates to methods for treating lysosomal storage disorders by administering stem cells. | 10-06-2011 |
| 20110229627 | ELECTROSPRAY COATING OF OBJECTS - Electrospray methods and systems for coating of objects (e.g., medical devices such as a stent structure) with selected types of coatings (e.g., open matrix coating and closed film coating) | 09-22-2011 |
| 20110218045 | PREDICTING GAME PLAYER MONETIZATION BASED ON PLAYER LOGS - A massively multiplayer online game (MMOG) monetization analysis computer system may include an electronic data processing system configured to electronically analyze data, including player behavioral logs, in accordance with one or more algorithms. Based on the analysis, the electronic data processing system may predict player changes that are relevant to monetization of the MMOG and generate a report relating to these predicted changes. The analysis may identify players whom are predicted to terminate their subscriptions to the MMOG, an amount of time each of several players is likely to spend playing the MMOG, and/or a number of transactions each of a several players is likely to engage in while playing the MMOG. | 09-08-2011 |
| 20110212986 | ANTI-FLAVIVIRUS THERAPEUTIC - The present invention relates to anti-flavivirus compounds, including lycorine and derivatives thereof, and their use in treating a subject infected by a flavivirus. The present invention also relates to the use of the anti-flavivirus compounds for the prophylaxis of flavivirus infection. The present invention further relates to a method of suppressing viral RNA synthesis of a flavivirus. Also described is a method of preparing an anti-flavivirus compound for use in the treatment or prophylaxis of flavivirus infection. | 09-01-2011 |
| 20110177595 | Multipotent Adult Stem Cells, Sources Thereof, Methods of Obtaining and Maintaining Same, Methods of Differentiation Thereof, Methods of Use Thereof and Cells Derived Thereof - Methods and compositions are provided for circularizing target sequences in a sample. In particular, ligation oligonucleotides are employed to selectively hybridize with the target such that the target can be ligated into a closed circular target. Rolling circle amplification can then be performed directly on the target sequence for subsequent detection and analysis. | 07-21-2011 |
| 20110174902 | High Mass Throughput Particle Generation Using Multiple Nozzle Spraying - Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an interozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom. | 07-21-2011 |
| 20110171659 | Multipotent Adult Stem Cells, Sources Thereof, Methods of Obtaining and Maintaining Same, Methods of Differentiation Thereof, Methods of Use Thereof and Cells Derived Thereof - The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided. | 07-14-2011 |
| 20110153266 | AUGMENTED VEHICLE LOCATION SYSTEM - A system comprises a mobile vehicle, a global positioning system (GPS) based vehicle position and heading system, at least one two-dimensional (2D) velocity sensor, a yaw rate system, and a vehicle position and heading estimator. The GPS based vehicle position and heading system is supported on the vehicle and measures global easting and global northing (measured position) of the vehicle, and determines a heading (measured heading) of the vehicle. The 2D velocity sensor measures the velocity of the vehicle with respect to the ground, over which the vehicle travels, in two orthogonal directions (measured velocity). The yaw rate system is supported on the vehicle and measures a yaw rate of the vehicle (yaw rate measurement). The vehicle position and heading estimator comprises at least one processor that computes a position of the vehicle (estimated position) and a heading of the vehicle (estimated heading) based on the measured position, the measured heading, the measured velocity and the yaw rate measurement. | 06-23-2011 |
| 20110152852 | THERMOCHEMICAL ABLATION SYSTEM USING HEAT FROM DELIVERY OF ELECTROPHILES - Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. The chemical reaction energy is provided by chemical reactions including a highly reactive electrophilic reagent provided to a target tissue location. | 06-23-2011 |
| 20110116696 | DIPOLE MATCHED FILTER FOR MRI - A method includes receiving k-space data corresponding to magnetic resonance data for a subject and selecting a template for analysis. In addition, the method includes generating an image using the k-space data and using the template. | 05-19-2011 |
| 20110111492 | Stem Cell Aggregates and Methods for Making and Using - The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stern cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells. | 05-12-2011 |
| 20110091460 | RECEPTOR-TARGETING REAGENTS - The present disclosure features, inter alia, receptor-targeting reagents (e.g., immunotoxic receptor-targeting reagents), which are useful in, e.g., methods of binding a receptor-targeting reagent to a cell and methods for treating a variety of disorders such as, but not limited to, cancers and inflammatory disorders. Also featured are methods, compositions, and kits useful for selecting an appropriate treatment modality for a subject (e.g., a subject with a cancer or inflammatory disorder) and/or treating a variety of disorders such as cell proliferative disorders. | 04-21-2011 |
| 20110082427 | BIORESORBABLE EMBOLIZATION MICROSPHERES - The present disclosure is generally directed to an embolic material which, in some embodiments, may be in the form of a microsphere or a plurality of microspheres. The embolic material generally comprises carboxymethyl chitosan (CCN) crosslinked with carboxymethyl cellulose (CMC). In some embodiments, the embolic material may further comprise a therapeutic agent, such as doxorubicin. | 04-07-2011 |
| 20110076738 | SOLVENT-BORNE POLYMERIC BIOACTIVE COATINGS FOR THE FACILITATED REMOVAL OF BIOORGANIC STAINS - Protein-polymer composite materials are provided according to embodiments of the present invention that include an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material that is useful for facilitating removal of bioorganic stains. | 03-31-2011 |
| 20110068790 | Method for Magnetic Resonance Imaging - A method of magnetic resonance imaging based on rapid acquisition by sequential excitation and refocusing is provided. The method comprises turning on a first time-encoding gradient and applying an excitation pulse in the presence of the first time-encoding gradient. The excitation pulse excites magnetization sequentially along one spatial axis. Thereafter, a first refocusing pulse is applied. A second time-encoding gradient is turned on followed by a second refocusing pulse. A third time-encoding gradient is turned on and a signal is acquired in the presence of the third time-encoding gradient. The third time-encoding gradient sums to zero with the first time-encoding gradient and the second time-encoding gradient for sequential points in space. | 03-24-2011 |
| 20110054293 | Combination Localization System - A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation. | 03-03-2011 |
| 20110047864 | METHOD AND APPARATUS FOR PRODUCING A FUEL FROM A BIOMASS OR BIO-OIL - Methods and reactors for producing a fuel are disclosed herein. In some embodiments, the method uses a biomass feedstock and alkane and/or alcohol feedstock, which can be contacted with a metal-containing catalyst to form products including a bio-oil. In some embodiments, oxygen-containing functional groups can be removed from a bio-oil using one or more zeolite thin films. | 03-03-2011 |
| 20110046287 | CLAY-ISOCYANATE NANODISPERSIONS AND POLYURETHANE NANOCOMPOSITE PRODUCED THEREWITH - Nanodispersions of inorganic clays in isocyanate may be created via pre-exfoliation, delamination, or both of the clay and subsequent mixing with isocyanate. In an embodiment, such an isocyanate nanodispersion is reacted with an isocyanate-reactive material or substrate to form a polyurethane nanocomposite. | 02-24-2011 |
| 20110044521 | TRACKING AND REPRESENTATION OF MULTI-DIMENSIONAL ORGANS - A method includes receiving data corresponding to a sequence of deformations of a surface of an object. The method also includes generating spherical harmonics expressions based on the data. The method includes identifying a subspace of the spherical harmonics expression corresponding to the surface. | 02-24-2011 |
| 20110029007 | TREATMENT AND PLACEMENT DEVICE FOR SINUSITIS APPLICATIONS - Devices, methods and kits which, when installed or used, access, aspire, dilate, insufflate, drain or deliver fluid medicaments to, or place a patency device within a sinus area, such as a maxillary sinus or a maxillary sinus ostium. The device can include a hollow catheter and probe, and can be configured to permit gradual and incremental probe extension. The device can be constructed to enhance the precision and maneuverability within the nasal and sinus passageways, while also accommodating the natural anatomical geometry of a targeted paranasal treatment site. For example, the present treatment and placement device can accomplish access to the maxillary sinus ostium by utilizing an uncinate process to guide a probe tip into the ostium in a retrograde manner. The probe can be slidably, bi-directionally or co-axially positioned within the catheter. A distal portion of the probe can be biased away from a longitudinal axis of the catheter. | 02-03-2011 |
| 20110027258 | MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES - The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. | 02-03-2011 |
| 20110021430 | MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES - The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. | 01-27-2011 |
| 20110015612 | IMPLANTABLE DEVICES FOR TREATMENT OF SINUSITIS - Devices, methods and kits which, when installed or used, urge or maintain patency of sinus ostia, such as the ostium between a nasal passageway and a maxillary sinus, while maintaining some function of cilia extending within or near the ostium. In various examples, the devices comprise a first portion, a second medial portion including a partially open cross-sectional configuration, and a third portion including one or more flexible and outwardly-biased projections. The partially open cross-sectional configuration can maintain a track of uncovered cilia within and near the ostium. In some examples, the devices can include an asymmetric body configuration. In some examples, the first portion includes a U-shaped configuration and the third portion includes at least two flexible and outwardly-biased projections. In some examples, the first, second or third portion includes a medication for delivery into sinus tissues. | 01-20-2011 |
| 20110009256 | NOVEL MICROPOROUS SILICATE MATERIALS AND METHODS FOR MAKING AND USING THE SAME - With an amino acid as a buffer, a method is disclosed for producing a proton-exchanged three-dimensional layered silicate material. Additional embodiments include a method for producing a swollen proton-exchanged three-dimensional layered silicate material. This new material is a result of reactive swelling which accompanies one or more major changes of the layer structure. The materials can be further processed such as with exfoliation. The materials may be combined with polymers to produce film membranes such as thin film porous membranes. The membranes are useful in separating gases and as absorbents. | 01-13-2011 |
| 20110008886 | METHODS AND MATERIALS FOR ISOLATING ISOGENIC ISLET CELLS - Compositions and methods for isolating and purifying islet cells are described. Islets obtained using such compositions and methods can be transplanted into diabetic patients. | 01-13-2011 |
| 20110007534 | SOFT SWITCHING POWER ELECTRONIC TRANSFORMER - This patent document discloses power electronic transformers having a high-frequency link. An example apparatus include a transformer having a primary winding and a secondary winding, the transformer is configured to receive a primary power signal having a first frequency, a primary converter configured to selectively oscillate polarity of the primary windings with respect to the secondary windings at a second frequency, the second frequency substantially substantially higher than the first frequency, a secondary converter coupled to the secondary winding, the secondary converter configured to provide a load power signal using a high frequency power signal generated using the secondary winding. The secondary converter can be configured to reduce current flow in the primary winding when the polarity of the primary winding is switched, the reduced current follow is configured to reduce disturbances resulting from leakage inductance of the transformer. | 01-13-2011 |
| 20100317015 | SPINOCEREBELLAR ATAXIA TYPE 8 AND METHODS OF DETECTION - The present invention provides an isolated nucleic acid molecule containing a repeat region of an isolated spinocerebellar ataxia type 8 (SCA8) coding sequence, the coding sequence located within the long arm of chromosome 13, and the complement of the nucleic acid molecule. Diagnostic methods based on identification of this repeat region are also provided. | 12-16-2010 |
| 20100315082 | FREQUENCY SWEPT EXCITATION FOR MAGNETIC RESONANCE - A method of magnetic resonance is provided that uses a frequency swept excitation wherein the acquired signal is a time domain signal is provided. In one embodiment, the method comprises, applying a sweeping frequency excitation and acquiring a time domain signal. The sweeping frequency excitation has a duration and is configured to sequentially excite isochromats having different resonant frequencies. Acquisition of the time domain signal is done during the duration of the sweeping frequency excitation. The time domain signal is based on evolution of the isochromats. | 12-16-2010 |
| 20100311658 | MODIFIED VITAMIN K-DEPENDENT POLYPEPTIDES - The invention provides vitamin K-dependent polypeptides with enhanced membrane binding affinity. These polypeptides can be used to modulate clot formation in mammals. Methods of modulating clot formation in mammals are also described. | 12-09-2010 |
| 20100295566 | APPARATUS HAVING REDUCED NOISE AND METHOD OF USING THE APPARATUS FOR DETECTING IONIC MATERIALS - An apparatus and method for detecting ionic materials includes a sensing electrode which contacts a liquid sample and detects a sensing voltage corresponding to a surface potential which is changed by a concentration of ionic materials in the liquid sample, a first switching transistor having a first terminal connected to the sensing electrode and a second terminal connected to a first node, a second switching transistor having a first terminal connected to a reset voltage and a second terminal connected to the first node, and a sensing transistor having a gate connected to the first node. | 11-25-2010 |
| 20100294351 | Graded Organic Photovoltaic Device - A photovoltaic device includes a first heterojunction layer having a first donor type organic material and a first acceptor type organic material, in which a concentration of at least one of the first donor type organic material and the first acceptor type organic material is graded continuously from a first side of the first heterojunction layer to a second side of the first heterojunction layer. | 11-25-2010 |
| 20100290989 | COMPOSITIONS AFFECTING HYALURONIC ACID MEDIATED ACTIVITY - Compositions comprising hyaluronic acid (HA) or agents that interfere with HA binding of HA receptors and methods of using the same are provided. For example, there is provided a composition comprising HA oligomers ranging in size from 10-mer to 80-mer and use of the same for promoting migration, growth or survival of wild-type or transformed/cancerous cells. There is also provided a composition comprising an agent that interferes with binding between an HA oligomer of a size of about 10-mer to about 80-mer and an HA receptor. Such compositions may be useful for therapeutic, diagnostic or imaging applications. Examples of therapeutic use are wound repair or cancer treatment. | 11-18-2010 |
| 20100285590 | Homologous Recombination in Multipotent Adult Progenitor Cells - The invention relates to methods of altering gene expression by homologous recombination in a multipotent adult progenitor cell (MAPC). In particular, methods of producing a recombinant MAPC, of correcting a genetic defect in a mammal, of providing a functional and/or therapeutic protein to a mammal, and of transforming a MAPC are provided. MAPCs containing an erogenous DNA as well as recombinant MAPCs and their differentiated progeny are also provided. | 11-11-2010 |
| 20100279376 | PREPARATION OF SOLVENT-BORNE POLYMERIC BIOACTIVE COATINGS - Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material. | 11-04-2010 |
| 20100278859 | DIAGNOSTIC TEST KITS - This invention provides kits, devices, and methods for the detection of antibodies that recognize one or more proteins and/or antigens from porcine reproductive and respiratory syndrome virus (PRRSV). The antibodies may be in a biological fluid of a PRRSV infected or at risk subject. The invention may be advantageously applied to both the diagnosis and prevention of PRRSV infection. | 11-04-2010 |
| 20100277607 | IMAGE SENSOR WITH HIGH DYNAMIC RANGE IMAGING AND INTEGRATED MOTION DETECTION - This disclosure describes: (1) two different schemes to enhance dynamic range, (2) a new motion detection scheme using in-pixel digital storage, and (3) the motion detection in high illumination for CMOS image sensors. The schemes may be implemented in a small pixel size and easily incorporated in simple column-level circuits for existing CMOS image sensor systems. | 11-04-2010 |
| 20100253341 | PULSE GAP CYCLING FOR IMPROVED SWIFT - A magnetic resonance image is produced by shifting a gap during acquisition of spin data for a specimen. The spin data is generated by a gapped excitation sequence. | 10-07-2010 |
| 20100253340 | ADIABATIC MAGNETIZATION PREPARATION FOR B1 AND B0 INSENSITIVE HIGH CONTRAST MRI - A magnetic resonance image is produced by radial imaging using one or more preparatory pulses. The magnetic preparation pulse can include one or more adiabatic pulses. | 10-07-2010 |
| 20100237866 | MAGNETIC RESONANCE CONTRAST USING FICTITIOUS FIELD RELAXATION - A system includes a signal generator and a processor. The signal generator is configured to couple with a magnetic resonance transmitter coil. The processor is configured to execute instructions to control the signal generator. The instructions include forming a sequence of waveforms. The sequence is configured to generate spin relaxation in a fictitious field in a third rotating frame of reference based on at least one magnetic field component that arises based on an effective field in a second rotating frame of reference. The third rotating frame of reference is of a higher order than the second rotating frame of reference and the second rotating frame of reference is of a higher order than the first rotating frame of reference. | 09-23-2010 |
| 20100213934 | HIGH MAGNETIC MOMENT PARTICLE DETECTION - A device includes a sensor surface and a pair of electrodes. The sensor surface includes a first conductive layer separated from a second conductive layer by an intermediary layer, a magnetization direction of the first conductive layer and a magnetization direction of the second conductive layer having a ground state orientation of approximately 0 degrees. An electrical resistance between the pair of electrodes is determined by a magnetic field proximate the sensor surface. | 08-26-2010 |
| 20100209628 | GROWTH OF COATINGS OF NANOPARTICLES BY PHOTOINDUCED CHEMICAL VAPOR DEPOSITION - Photoinduced chemical vapor deposition was used to grow coatings on nanoparticles. Aerosolized nanoparticles were mixed with a vapor-phase coating reactant and introduced into a coating reactor, where the mixture was exposed to ultraviolet radiation. Tandem differential mobility analysis was used to determine coating thicknesses as a function of initial particle size. | 08-19-2010 |
| 20100200810 | SOLID FUEL VOLATILIZATION TO PRODUCE SYNTHESIS GAS - A method comprising contacting a carbon and hydrogen-containing solid fuel and a metal-based catalyst in the presence of oxygen to produce hydrogen gas and carbon monoxide gas, wherein the contacting occurs at a temperature sufficiently high to prevent char formation in an amount capable of stopping production of the hydrogen gas and the carbon monoxide gas is provided. In one embodiment, the metal-based catalyst comprises a rhodium-cerium catalyst. Embodiments further include a system for producing syngas. The systems and methods described herein provide shorter residence time and high selectivity for hydrogen and carbon monoxide. | 08-12-2010 |
| 20100197686 | THERAPEUTIC COMPOUNDS - The invention provides compounds of Formula (I) and (IV): as described herein, as well as salts thereof. The compounds have anti-cancer properties and/or chemosensitization properties. | 08-05-2010 |
| 20100174533 | AUTOMATIC MEASUREMENT OF SPEECH FLUENCY - Techniques are described for automatically measuring fluency of a patient's speech based on prosodic characteristics thereof. The prosodic characteristics may include statistics regarding silent pauses, filled pauses, repetitions, or fundamental frequency of the patient's speech. The statistics may include a count, average number of occurrences, duration, average duration, frequency of occurrence, standard deviation, or other statistics. In one embodiment, a method includes receiving an audio sample that includes speech of a patient, analyzing the audio sample to identify prosodic characteristics of the speech of the patient, and automatically measuring fluency of the speech of the patient based on the prosodic characteristics. These techniques may present several advantages, such as objectively measuring fluency of a patient's speech without requiring a manual transcription or other manual intervention in the analysis process. | 07-08-2010 |
| 20100093066 | DECELLULARIZATION AND RECELLULARIZATION APPARATUSES AND SYSTEMS CONTAINING THE SAME - The invention described herein provides systems and apparatuses for an initial preparation of an organ or tissue scaffold comprising an extracellular matrix, and subsequent recellularization of the scaffold to ultimately form a resultant artificial organ or tissue incorporating the natural and original extracellular matrix. The techniques and equipment of the invention collectively minimize scaffold collapse, compression or physical damage to the organ as well as afford the advantages of significant maintenance of the initial natural structural and biochemical attributes of the organ or tissue. The invention is particularly useful in organ and tissue transplantation and repair. | 04-15-2010 |
| 20100079306 | TRAFFIC FLOW MONITORING FOR INTERSECTIONS WITH SIGNAL CONTROLS - A method and system are provided for determining travel time through intersections by assigning an initial position for a virtual probe in the intersection and updating the position and velocity for the virtual probe such that the position and velocity of the virtual probe are determined multiple times from a time when the virtual probe is at an initial position until the time when the updated position of the virtual probe is past a stop line at the intersection. Updating the position and velocity of the virtual probe involves retrieving vehicle detection data and traffic control signal data to determine a distance from the virtual probe to the closer of a stop line and a vehicle in a queue in front of the virtual probe. The length of the queue is determined using the intersection of two shockwaves. | 04-01-2010 |
| 20100055111 | INDOLEAMINE 2,3-DIOXYGENASE, PD-1/PD-L PATHWAYS, AND CTLA4 PATHWAYS IN THE ACTIVATION OF REGULATORY T CELLS - The present invention includes methods of enhancing immune responses by administering an inhibitor of indoleamine-2,3-dioxygenase (IDO) along with one or more inhibitors of the PD-1/PD-L pathway and/or one or more inhibitors of the CTLA4 pathway. | 03-04-2010 |
| 20100049482 | SYSTEM AND METHOD FOR ICTAL SOURCE ANALYSIS - This document discloses, among other things, ictal source analysis and causal interaction estimation which considers the structure of seizures in the space, time, and frequency domains. The dynamic causal interaction can distinguish the primary source, which initiates the ictal activity, from the secondary source, which is generated due to the ictal activity propagation. | 02-25-2010 |
| 20100039855 | EXCHANGE-ASSISTED SPIN TRANSFER TORQUE SWITCHING - In general, the invention is directed to techniques for reducing the amount of switching current that is utilized within a magnetic storage (e.g., MRAM) device. An example apparatus includes a fixed magnetic layer that provides a fixed direction of magnetization, an exchange-coupled magnetic multi-layer structure, and a non-magnetic layer placed between the fixed magnetic layer and the exchange-coupled magnetic multi-layer structure. The exchange-coupled magnetic multi-layer structure includes a recording layer configured to record information and an assisting layer having a lower anisotropy than the recording layer. The exchange coupling between the recording and assisting layers is operable to switch a magnetization direction of the recording layer. In some cases, the exchange-coupled magnetic multi-layer structure may further include a spacer separating the recording and assisting layers and configured to weaken an exchange coupling between the recording and assisting layers. | 02-18-2010 |
| 20100021438 | KIDNEY DERIVED STEM CELLS AND METHODS FOR THEIR ISOLATION, DIFFERENTIATION AND USE - The invention relates generally to methods for isolation and culture of kidney stem cells, cells isolated by the methods, and therapeutic uses for those cells. | 01-28-2010 |
| 20100006437 | DETECTION OF NUCLEIC ACID SEQUENCE DIFFERENCES USING COUPLED LIGASE DETECTION AND POLYMERASE CHAIN REACTIONS - The present invention relates to a method for identifying a target nucleotide sequence. This method involves forming a ligation product on a target nucleotide sequence in a ligase detection reaction mixture, amplifying the ligation product to form an amplified ligation product in a polymerase chain reaction (PCR) mixture, detecting the amplified ligation product, and identifying the target nucleotide sequence. Such coupling of the ligase detection reaction and the polymerase chain reaction permits multiplex detection of nucleic acid sequence differences. | 01-14-2010 |
| 20090306333 | BIFUNCTIONAL LACTIDE MONOMER DERIVATIVE AND POLYMERS AND MATERIALS PREPARED USING THE SAME - The invention described herein provides a novel lactide monomer derivative and process for preparing the lactide monomer derivative. The monomer derivative of the invention is bifunctional in nature, and can be employed a variety of efficient synthesis processes to prepare various polymers. Further, the bifunctional monomer derivative can be used to prepare various intermediate-stage compounds and polymers, which in turn can be used to synthesize other compounds, polymers, copolymers and composites. The lactide monomer derivative has a bifunctional norbornene spiro lactide structure, spiro[6-methyl-1,4-dioxane-2,5-dione-3,2′-bicyclo[2.2.1]hept[5]ene], and structure as follows: | 12-10-2009 |
| 20090306007 | NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY - The invention provides a compound of formula (I), wherein R | 12-10-2009 |
| 20090280165 | COMPOUNDS THAT BIND ALPHA5BETA1 INTEGRIN AND METHODS OF USE - The present invention provides biologically active compounds that bind an αsβi integrin. Also included in the present invention are methods for using such biologically active compounds. | 11-12-2009 |
| 20090266924 | HIGH MASS THROUGHPUT PARTICLE GENERATION USING MULTIPLE NOZZLE SPRAYING - Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom. | 10-29-2009 |
| 20090264733 | MRI CONTRAST USING HIGH TRANSVERSE RELAXATION RATE CONTRAST AGENT - This document discloses, among other things, a system and method of creating a positive contrast magnetic resonance imaging (MRI) feature using a high transverse relaxation rate contrast agent. | 10-22-2009 |
| 20090257634 | RF pulse distortion correction - This document discloses, among other things, a method for removing a bullseye artifact from a radial image generated using magnetic resonance and using a swept frequency pulse. | 10-15-2009 |
| 20090248304 | Vision-aided inertial navigation - This document discloses, among other things, a system and method for implementing an algorithm to determine pose, velocity, acceleration or other navigation information using feature tracking data. The algorithm has computational complexity that is linear with the number of features tracked. | 10-01-2009 |
| 20090237077 | RF COIL FOR IMAGING SYSTEMS AND METHODS OF OPERATION - An RF coil system for magnetic resonance applications includes a multi-channel RF coil transceiver and a multi-channel RF coil. The RF coil system is structured for reconfiguration between a plurality of operational modes. | 09-24-2009 |
| 20090202977 | DECELLULARIZATION AND RECELLULARIZATION OF ORGANS AND TISSUES - The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ. | 08-13-2009 |
| 20090187075 | GUIDE WIRE ENGAGING URETEROSCOPE - This document discusses, among other things, a ureteroscope having a notch or other structure at a distal end configured to engage a guide wire and facilitate cannulation. | 07-23-2009 |
| 20090177437 | Indoor navigation system and method - This document discusses, among other things, a portable device that generates position and orientation data to facilitate movement within a building. The device can be, for example, handheld or affixed to a cane. Data for navigation is derived from reflections from interior surfaces and dead reckoning sensors. | 07-09-2009 |
| 20090171364 | SCLERAL DEPRESSOR - A remotely controllable system and method for positioning and operating a scleral depressor. A track is positioned to encircle at least a portion of the eye. One or more independent thrusters, or actuators, are radially positionable about the eye. An actuator is selectively deployable and selectively retractable by remote control. Thrusters may be mechanically operated and include pneumatic, hydraulic, electrical, chemical or other power supply forces. Remote control is provided by hand-operated controls, foot-operated switches or voice-operated control. A light source is positioned about at least a portion of the eye to provide transcleral illumination. | 07-02-2009 |
| 20090136566 | THERAPEUTIC TRITERPENOIDS - The present invention relates generally to compositions that can be obtained by extraction of birch bark, methods of using such compositions (e.g., methods of medical use, cosmetic use and/or pharmaceutical use), food products and methods of manufacturing such compounds. The compositions are triterpenes, triterpene alcohols, or derivatives of triterpene alcohols. | 05-28-2009 |
| 20090131866 | Veinous Occlusion Device and Methods of Using - The invention provides for methods of delivering compositions to an individual via the vasculature, and provides for a device that can be used to deliver compositions to an individual via the vasculature. | 05-21-2009 |
| 20090117265 | ROAD AND REPAIR MATERIALS INCLUDING MAGNETITE AND METHODS REGARDING SAME - A road and repair system and/or method using one or more components including a plurality of magnetite concentrate particles, at least one acidic activator including phosphate anions, and a plurality of reactive aggregate particles including iron. | 05-07-2009 |
| 20090115417 | Three dimensional RF coil structures for field profiling - In one illustrative embodiment, a radio frequency (RF) coil is disclosed. The RF coil may include a plurality of transmission line elements, wherein at least one of the plurality of transmission line elements may have at least one dimension different than a dimension of another one of the plurality of transmission line elements. In some cases, each of the transmission line elements may include a signal line conductor and a ground plane conductor separated by a dielectric. | 05-07-2009 |
| 20090104249 | Exotoxin Inhibitory Factor - The invention provides an exotoxin inhibitory factor, compositions containing the factor, methods of using the compositions. | 04-23-2009 |
| 20090081770 | HIGH THROUGHPUT BIOREACTOR - A continuous flow bioreactor system that includes a bioreactor, an optional post-bioreactor preparation chamber, a cell sorter, and an optional pre-bioreactor preparation chamber in a closed loop, useful for enriching a heterogeneous cell population growing in the bioreactor with an isolated subpopulation of cells. | 03-26-2009 |
| 20090076290 | SELECTIVE OXIDATION OF TRITERPENES EMPLOYING TEMPO - The present invention provides a process of preparing betulin-28-aldehyde from betulin. The process includes contacting betulin with a compound of formula (I), e.g., TEMPO (2,2,6,6-tetramethylpiperidine 1-oxyl) for a period of time effective to provide betulin-28-aldehyde. The present invention also provides a process of preparing betulinic acid. The process includes contacting betulin with a composition that includes: sodium hypochlorite (NaOCl); sodium chlorite (NaClO | 03-19-2009 |
| 20090066782 | SPATIAL-TEMPORAL MULTI-RESOLUTION IMAGE SENSOR WITH ADAPTIVE FRAME RATES FOR TRACKING MOVEMENT IN A REGION OF INTEREST - A sensor includes an array of pixels to capture an image, the array of pixels arranged as a plurality of pixel groups, each of the pixel groups having a two or more pixels coupled to a shared floating diffusion node for outputting merged image signals from the pixel groups, at least one inter-pixel switch to control transfer of electrical charge from a floating diffusion node for a first one of the pixel groups to a floating diffusion node for a second one of the pixel groups to temporarily store a portion of a previous image frame within the floating diffusion node for the second one of the pixel groups, and a motion comparator to compare an image signal from the first one of the pixel groups with an image signal from the second one of the pixel groups to detect motion between a current frame and the previous frame. | 03-12-2009 |
| 20090049563 | USING CYTOSINE DEAMINASES TO DIMINISH RETROELEMENT TRANSFER FROM PIGS TO HUMANS - Transgenic pigs that express one or more non-porcine cytosine deaminases are described as well as methods of making and using such pigs. | 02-19-2009 |
| 20080300164 | Calixarene-Based Peptide Conformation Mimetics, Methods of Use, and Methods of Making - A class of topomimetic calixarene-based peptide mimetics is described. Calixarene-based peptide mimetics have various biological activities such as, for example, bactericidal activity, antiangiogenic activity, and/or antitumor activity. Methods of use and methods of designing calixarene-based peptide mimetics are described. | 12-04-2008 |
| 20080293666 | Antibacterial Agents - The invention provides compounds of formula (I) and salts thereof: R | 11-27-2008 |
| 20080268426 | IDENTIFYING VIRALLY INFECTED AND VACCINATED ORGANISMS - This document provides methods and materials related to assessing organisms for the presence or absence of anti-virus antibodies. For example, this document provides methods and materials that can be used to determine whether or not an organism (e.g., a member of a swine species such as a pig) contains anti-PRRS virus antibodies. In other embodiments, this document provides methods and materials that can be used to determine if a particular organism received a vaccine version of a virus, was infected with a naturally-occurring version of the virus, or is naïve with respect to the virus. | 10-30-2008 |
| 20080261880 | Synthetic approach to designed chemical structures - This invention relates to the chemical design and production of peptides, peptide structure and three dimensional conformation was assessed using NMR, circular dichroisin and pulsed field gradient NMR. In addition, this invention relates to peptides produced by these methods and to methods for using the peptides. | 10-23-2008 |
| 20080237542 | REACTIVE FLASH VOLATILIZATION OF FLUID FUELS - The invention provides methods for the production of synthesis gas. More particularly, various embodiments of the invention relate to systems and methods for volatilizing fluid fuel to produce synthesis gas by using a metal catalyst on a solid support matrix. | 10-02-2008 |
