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Rapid Pharmaceuticals, AG

Rapid Pharmaceuticals, AG Patent applications
Patent application numberTitlePublished
20110245180Modified Peptide that reduces pain in peripheral neuropathy - Chemokine signaling is important in neuropathic pain, with microglial cells expressing CCR2 playing a well established key role. DAPTA, a gp120-derived CCR5 entry-inhibitor has been shown to inhibit CCR5-mediated monocyte migration and to attenuate neuroinflammation. We disclose here that as a stabilized analog of DAPTA, the short peptide All D TTNYT exhibits potent antagonism for both CCR2 (IC10-06-2011