| QUEEN MARY & WESTFIELD COLLEGE Patent applications |
| Patent application number | Title | Published |
|---|
| 20120070844 | Method For Quantifying Modified Peptides - The present invention provides a method for quantifying modified peptides in a sample, the method comprising: (a) obtaining peptides from the sample; (b) adding reference modified peptides to the peptides obtained in step (a) to produce a mixture of peptides and reference modified peptides; (c) carrying out mass spectrometry (MS) on said mixture of peptides and reference modified peptides to obtain data relating to the peptides in the sample; and (d) comparing the data relating to the peptides in the sample with data in a database of modified peptides using a computer programme; wherein the database of modified peptides is compiled by a method comprising: (i) obtaining peptides from a sample; (ii) enriching modified peptides from the peptides obtained in step (i); (iii) carrying out liquid chromatography-tandem mass spectrometry (LC-MS/MS) on the enriched modified peptides obtained in step (ii); (iv) comparing the modified peptides detected in step (iii) to a known reference database in order to identify the modified peptides; and (v) compiling data relating to the modified peptides identified in step (iv) into a database. | 03-22-2012 |
| 20120065665 | Forceps Comprising A Trocar Tip - The present invention relates to a forceps comprising an elongate body, a grip region at end of the elongate body, the grip region comprising a lever, a grasping assembly at the opposite end of the elongate body, the grasping assembly comprising a movable grasper and a trocar, and an actuating mechanism coupling the lever to the grasping assembly for effecting movement of the grasper relative to the elongate body. The present invention also relates to a kit of parts comprising a forceps of the invention and additional components. The invention further relates to a method of forming an anastomosis between two surfaces and a method of forming a stoma trephine in a subject using the kit of parts of the invention. The present invention also relates to the use of the forceps and the kit or parts of the invention in such methods. | 03-15-2012 |
| 20120061447 | Method And Apparatus For Forming Stoma Trephines And Anastomoses - The present invention relates to a stapler apparatus, comprising a stapler having a proximal end, a distal end and a longitudinal axis, the stapler further comprising a trigger, an anvil docking pin aligned substantially parallel with the longitudinal axis of the stapler, and a stapling means, the anvil docking pin and stapling means being at the distal end of the stapler, and a detachable anvil, comprising an anvil head and an anvil shaft, wherein the anvil shaft is adapted to receive the anvil docking pin and operation of the trigger causes the stapling means to be actuated, characterised in that the length of the anvil shaft is at least 4 cm. The present invention also relates to a method of forming an anastomosis between two surfaces using the stapler apparatus of the invention and a method of forming a stoma trephine in a subject using the stapler apparatus of the invention. The present invention further relates to the use of the stapler apparatus or anvil for a stapler apparatus in such methods and a kit of parts comprising the stapler apparatus of the invention and additional components. | 03-15-2012 |
| 20120034209 | Treatment - The present invention provides a specific binding molecule which binds to Annexin-1 (Anx-A1) for use in the treatment of T cell-mediated disease. | 02-09-2012 |
| 20110081350 | Synthetic scFv Analogue To The 6313/G2 (Anti Angiotensin II Type 1 Receptor) Monoclonal Antibody Variable Regions - The present invention provides a specific binding molecule which specifically binds to a peptide having the amino acid sequence of EDGIKRIQDD and comprises a polypeptide having an immunoglobulin V | 04-07-2011 |
| 20100310515 | Latency Associated Protein Construct With Aggrecanase Sensitive Cleavage Site - The present provides a fusion protein comprising a latency associated peptide (LAP) and a pharmaceutically active agent in which the LAP and the pharmaceutically active agent are connected by an amino acid sequence comprising an aggrecanase proteolytic cleavage site. | 12-09-2010 |
| 20100297683 | METHOD - The present invention provides a method for the detection of a protease comprising the use of a substrate partially coated with a film of a synthetic polymeric matrix comprising a peptide of up to 20 amino acids. Apparatus for performing such methods is also disclosed. | 11-25-2010 |
| 20100204183 | Substituted Phosphonates and Their Use In Decreasing Amyloid Aggregates - The invention relates to novel and known substituted phosphonates for use in ameliorating amyloid aggregates, particularly for use in the treatment of Alzheimer's disease. | 08-12-2010 |
| 20100160392 | HISTONE DEACETYLASE INHIBITORS - The present invention provides histone deacetylase inhibitors of general formula (I), a process for the preparation of such compounds and uses of the compounds in medicine, especially in the treatment of cancers: in which R | 06-24-2010 |
| 20100155496 | ELECTROSTATIC SPRAYING DEVICE AND A METHOD OF ELECTROSTATIC SPRAYING - An electrostatic spraying device ( | 06-24-2010 |
| 20100040655 | Anti-viral Formulations Nanomaterials And Nanoparticles - The present invention provides the use of nanoparticles of a compound of general formula M | 02-18-2010 |
| 20090232766 | Compositions for Inducing Immune Response Comprising Inverted Microsomes - A vaccine composition is provided which comprises inverted microsomes or fragments thereof from an animal cell in association with an externally disposed peptide antigen and a protein of the MHC. | 09-17-2009 |
| 20090208445 | Compositions Comprising Eucalyptol And/Or Ocimene And/Or Farnesol For Use As Bumblebee Pheromones - Compositions comprising eucalyptol and/or ocimene and/or farnesol are provided for use as bumblebee pheromones. The compositions are useful in agriculture to assist in the pollination of angiosperm plant species. Such compositions can attract insects of the genus | 08-20-2009 |
| 20090152371 | Electrospray Device And A Method of Electrospraying - An electrospray apparatus for dispensing a controlled volume of liquid in pulses at a constant frequency is provided. The apparatus comprises an emitter ( | 06-18-2009 |
| 20090074680 | STATHERIN PEPTIDE AND USE IN MEDICINE - A synthetic statherin peptide of general formula (I) X | 03-19-2009 |
| 20080309529 | Sigma Delta Modulators - A method is provided for detecting limit cycles in a sigma delta modulator having an output signal that varies over a series of time intervals. In this method a first value that is indicative of the level of the modulator output signal after a predetermined time interval is stored in a first memory, and a second value that is indicative of the level of the modulator output signal after a further time interval subsequent to the predetermined time interval is stored in a second memory. The first value stored in the first memory is compared with the second value stored in the second memory, and an output indicative of a tendency for limit cycles to be produced in the modulator output signal is provided in response to such comparison. Such a method is particularly advantageous for detecting limit cycles in a sigma delta modulator as it can be implemented in a straightforward manner and offers a very accurate limit cycle detection mechanism. As a result it only becomes necessary to activate a limit cycle removal mechanism when limit cycle behaviour has been observed, and major changes to design are not normally required to implement the detection mechanism. | 12-18-2008 |
| 20080226751 | PHARMACEUTICAL COMPOSITION CONTAINING NITRATE SOURCE AND AN ACIDIFYING AGENT FOR TREATING SKIN ISCHAEMIA - The use of acidified nitrate as an agent to produce local production of nitrate oxide at the skin surface is described in the treatment of peripheral ischaemia and associated conditions. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. A barrier consisting of a membrane allows diffusions of the nitrate ions while preventing direct contact of the skin and acidifying agent. Amongst the many potential applications for the invention is the management of chronic skin wounds, peripheral ischaemia conditions such as Raynaud's phenomenon. Compositions and methods of use for these applications are described. | 09-18-2008 |
