QUEEN MARY UNIVERSITY OF LONDON Patent applications |
Patent application number | Title | Published |
20150210984 | METHOD FOR REPLICATING HCV IN VITRO - There is provided a method for replicating HCV virus in vitro which comprises the following steps: (i) fusing an HCV-infected white blood cell with a hepatocyte cell to produce a fused cell; and (ii) culturing the fused cell so that HCV replication may occur. There is also provided a fused cell capable of replicating HCV virus in vitro which is made by fusing an HCV-infected white blood cell with a hepatocyte cell, and uses of such a fused cell to screen for anti-HCV drugs and assessing patient responsiveness to therapy before treatment. | 07-30-2015 |
20150044713 | METHOD - The present invention provides a method of quantifying the activity of a protein modifying enzyme in a sample, comprising: (i) grouping modified peptides from a first sample and modified peptides from a second sample into a single group according to one of the following parameters: (a) modified peptides having a modification site that is modified by the same protein modifying enzyme; or (b) modified peptides having a modification site that is part of the same modification motif; (ii) calculating enrichment of the modified peptides from the first sample compared to the modified peptides from the second sample in the group; and (iii) calculating the statistical significance of said enrichment; wherein a statistically significant enrichment is indicative of a protein modifying enzyme being activated in the first sample compared to the second sample. In some embodiments, the method further comprises identifying modified peptides in a first sample and a second sample using mass spectrometry (MS) prior to step (i). | 02-12-2015 |