| Qiagen GMBH Patent applications |
| Patent application number | Title | Published |
|---|
| 20120130061 | Method FMethod For Isolating And Purifying Nucleic Acids - The present invention relates to a method for the isolation and purification of nucleic acids by elution of nucleic acids from nucleic acid-containing samples and biological materials. The present invention further relates to a kit for carrying out the method of the invention. | 05-24-2012 |
| 20120107818 | DETECTION OF MULTIPLE NUCLEIC ACID SEQUENCES IN A REACTION CARTRIDGE - The present invention relates to a method for amplifying and detecting nucleic acid sequences in a reaction cartridge comprising the following steps, (i) providing a sample comprising at least one nucleic acid molecule, (ii) in a first reaction chamber of the cartridge providing reagents for an amplification reaction, (iii) mixing the sample with the amplification reagents, (iv) amplifying the at least one nucleic acid in the first reaction chamber of the cartridge, (v) transferring at least parts of the amplification reaction into a second and third reaction chamber of the cartridge each comprising a probe set, wherein (a) each probe set consists of at least three probes, (b) each of the probes is specific for a nucleic acid sequence, (c) there are at least two probes in each set which carry an identical label, (d) each of the probes in a given probe set that carries an identical label has a melting temperature (T | 05-03-2012 |
| 20120077969 | NUCLEIC ACID PURIFICATION METHOD - The present invention relates to a method for purifying a defined amount of nucleic acids from a nucleic acid-containing sample, which has at least the following steps: (a.) contacting the nucleic acid-containing sample with a defined amount of a nucleic acid binding phase with the following features: (i) the nucleic acid binding phase has nucleic acid binding ligands that have at least one protonatable group; (ii) the nucleic acid binding ligands are bound to a carrier; (iii) the nucleic acid binding phase has a surface with a low charge density, wherein the amount of nucleic acids in the sample exceeds the binding capacity of the amount of nucleic acid binding phase used; (b.) binding of the nucleic acids to the nucleic acid binding phase at a pH (binding pH) that is below the pKs value of at least one of the protonatable groups; (c.) elution of the nucleic acids at a pH that is above the binding pH, wherein a defined amount of nucleic acids is obtained. Furthermore, corresponding kits and nucleic acid binding phases, which can be used for the purification of nucleic acids, are disclosed. | 03-29-2012 |
| 20120070823 | METHOD AND DEVICE FOR AUTOMATICALLY PROCESSING A SAMPLE - The invention relates to a method and a device for processing a biological sample. According to the invention, the processing comprises binding, washing and eluting biomolecules of the biological sample. The aim of the invention is to provide a method and a device for the automatic processing of biological samples which can have a relatively large volume and which can be further process by a microfluidic system. According to the invention, a container ( | 03-22-2012 |
| 20120024417 | Bellows-Type Reservoir For Microsystems - The invention relates to a storage and dispensing vessel for microsystems and to a method for storing and dispensing a liquid. It is the object of the invention to be able to store a liquid with volatile and/or creeping substances in very small vessels over many months, preferably over at least one year, and to be able to dispense it automatically with comparatively little technical effort. For accomplishing this object, a bellows configured as a vessel is provided which is sealed, preferably welded, in an air-tight and liquid-tight manner once the bellows vessel has been filled. This bellows vessel at the same time serves as a dispensing vessel. The vessel can be emptied automatically with relatively simple means. For this purpose, it is, for example, clamped into a device which compresses the bellows, namely in the direction of a hollow needle—also referred to as cannula or hypodermic needle—or of a comparable means. In the process, the hollow needle or the comparable means pierces a vessel wall. The vessel is then automatically emptied via the hollow needle or the comparable means. | 02-02-2012 |
| 20110311985 | RNAI BASED SELECTION SYSTEM - The present invention provides a novel RNAi based selection system for selecting host cells that have incorporated an expression vector. | 12-22-2011 |
| 20110281259 | Method And Apparatus For the Simultaneous, Automated Decomposition Of A Plurality Of Biological Samples - The invention relates to a method for decomposing a biological sample ( | 11-17-2011 |
| 20110244468 | PARALLEL EXTRACTION OF DIFFERENT BIOMOLECULES FROM FORMALIN-FIXED TISSUE - The present invention relates to a method of isolating/extracting in parallel various biomolecules, in particular nucleic acids and proteins, from the same fixed biological samples, to the quantification and analysis of the biomolecules isolated by the method of the invention, and to a kit for isolating/extracting in parallel various biomolecules from a fixed sample, to the use of said kit for diagnosing, prognosing, deciding the therapy of and monitoring the therapy of a disease. | 10-06-2011 |
| 20110224419 | Method For Isolating And Purifying Nucleic Acids - The present invention relates to a method for the isolation and purification of nucleic acids by elution of nucleic acids from nucleic acid-containing samples, and biological materials. The present invention further relates to a kit for carrying out the method of the invention. | 09-15-2011 |
| 20110224063 | Rotor For A Centrifuge - An apparatus ( | 09-15-2011 |
| 20110205835 | METHOD FOR SUSPENDING OR RE-SUSPENDING PARTICLES IN A SOLUTION AND APPARATUS ADAPTED THERETO - A method for suspending or re-suspending magnetically attractable particles is provided. In the present method at least a mixing vessel ( | 08-25-2011 |
| 20110189654 | DIAGNOSTIC REAGENT, CONTAINING BIOPARTICLES, METHOD FOR PRODUCTION THEREOF AND USE THEREOF AS INTERNAL STANDARD IN NUCLEIC ACID PREPARATION AND NUCLEIC ACID DETECTION METHODS - A diagnostic reagent in the form of a composition dimensionally stable under standard conditions, comprising bioparticles and also customary pharmaceutical excipients, wherein the bioparticles are selected from the group consisting of bacteria, viruses, fungi, protozoa, bacteriophages, yeasts, spores, parasites, plant cells, animal or human cells, gametes, plasmids, and viroids. | 08-04-2011 |
| 20110163255 | METHOD FOR PROTEIN PURIFICATION UNDER DENATURING CONDITIONS - The invention relates to a method for the preparation of an application buffer for the purification of proteins by means of immobilized metal ion affinity chromatography (IMAC) under denaturing conditions, which is characterized in that a defined amount of a buffer concentrate having a defined pH value is mixed with a defined amount of a urea concentrate, whereby an application buffer having a defined pH value is provided. According to the invention, a corresponding kit is provided in addition. The components are stable in storage and by mixing produce an application buffer having a defined composition and a defined pH value. The need for pH adjustment or a new preparation is eliminated. The invention can thus be used in an automated manner and as a closed kit concept. | 07-07-2011 |
| 20110162755 | APPARATUS AND PROCESS FOR REMOVING SUBSTANCES FROM PRE-FILLED CONTAINERS | 07-07-2011 |
| 20110160446 | METHOD FOR ISOLATING SHORT-CHAIN NUCLEIC ACIDS - The invention relates to a method and kits for isolating and/or purifying nucleic acids, in particular, short-chain nucleic acids, from a nucleic acid containing starting material, characterised by the following method steps: (a) bonding the nucleic acids to a nucleic acid bonding support material, wherein the starting material is brought into contact with the nucleic acid bonding support material in the presence of at least one chaotropic compound and preferably isopropanol, wherein the isopropanol is present in a concentration of ≧25% (v/v) and ≦35% (v/v), (b) optional elution of the bonded nucleic acids from the nucleic acid bonding support material. Said method is particularly suitable for the purification of foetal DNA from maternal blood. | 06-30-2011 |
| 20110151459 | SIMULTANEOUS DETECTION OF MULTIPLE NUCLEIC ACID SEQUENCES IN A REACTION - The present invention relates to a method for simultaneously amplifying and detecting nucleic acid sequences in a reaction comprising the following steps: (i) providing a sample comprising at least one nucleic acid molecule; (ii) providing reagents for performing an amplification reaction, wherein the reagents comprise at least four, preferably at least five, more preferably at least six probes, wherein (a) each of the probes is specific for a nucleic acid sequence; (b) at least two, preferably at least three probes carry the same label; and (c) each of the probes that carry the same label has a melting temperature (Tm) which differs by more than 2° C. from the other probes with the same label when they are dissociated from their target nucleic acid sequence by heating; (iii) amplifying the nucleic acid sequences in the reaction; (iv) detecting the amplified nucleic acids by determining whether the labeled probe has bound its nucleic acid sequence; and (v) detecting the temperature at which each given labeled probe dissociates from the nucleic acid sequence to which it has bound. The invention also relates to kits for the use in such a method. | 06-23-2011 |
| 20110130558 | METHOD FOR ISOLATING NUCLEIC ACIDS - The invention relates to a method and kits for isolating and/or purifying nucleic acids, in particular, short-chain nucleic acids, from a nucleic acid containing starting material, characterised by the following method steps: (a) bonding the nucleic acids to a nucleic acid bonding support material, wherein the starting material is brought into contact with the nucleic acid bonding support material in the presence of at least one chaotropic compound and preferably isopropanol, wherein the isopropanol is present in a concentration of ≧15% (v/v) and ≦35% (v/v), (b) optional elution of the bonded nucleic acids from the nucleic acid bonding support material. Said method is particularly suitable for the purification of foetal DNA from maternal blood | 06-02-2011 |
| 20110091364 | APPARATUS FOR DELIVERING PIPETTABLE SUBSTANCES | 04-21-2011 |
| 20110076751 | LYSIS, BINDING AND/OR WASH REAGENT FOR ISOLATING AND/OR PURIFYING NUCLEIC ACIDS - The present invention relates to a lysis, binding and/or wash reagent for isolating and/or purifying nucleic acids and a method for isolating and/or purifying nucleic acids. | 03-31-2011 |
| 20110071031 | COMPOSITIONS, METHODS, AND KITS FOR ISOLATING AND ANALYZING NUCLEIC ACIDS USING AN ANION EXCHANGE MATERIAL - The present disclosure relates to methods for isolating, amplifying, and/or analyzing nucleic acids in the presence of an anion exchange material by performing the isolation, amplification and/or analysis step in the presence of at least one anionic compound. | 03-24-2011 |
| 20110054054 | HYDRAZINE-MODIFIED MATRICES AND USE THEREOF IN METHODS FOR ISOLATING BIOMOLECULES - The invention relates to novel functionalized matrices or matrix materials comprising structures of general formula Carrier-Linker-Spacer-NR | 03-03-2011 |
| 20110039709 | APPARATUS FOR PROCESSING BIOLOGICAL MATERIAL - The invention relates to an apparatus for purification, respectively processing and/or analysis of biological target molecules with a detection device for detecting at least one object, which includes at least one detection area, wherein the detection device is adapted to detect at least one height value of the detection area and is adapted to determine, from the at least one height value, a spatial position and/or orientation and/or a type and/or a presence and/or a number and/or a state of the at least one object. Further, the invention relates to a receiving device for receiving material for the processing, purification and/or analysis of biological target molecules with at least one identification element, wherein the at least one identification element defines a height profile for identifying the receiving device, wherein the height profile is provided for at least one height measurement and extends at least in sections along a line, preferably a straight line. Finally, the invention relates to a method for inventorying, position determining and/or orientation determining of objects, which are needed for the automatic processing of a material, which contains biological target molecules, on a corresponding apparatus, in which at least one height value of a detection area of the respective object is detected, and, from the height value, a spatial position and/or an orientation and/or a type and/or a presence and/or a number and/or a state of the respective object is determined on the apparatus. | 02-17-2011 |
| 20110034535 | POSITIVE CONTROLS FOR EXPRESSION MODULATING EXPERIMENTS - The invention pertains to the use of an apoptosis inducing combination of at least a. a first expression modulating compound silencing the expression of at least a first target gene involved in apoptosis and b. a second expression modulating compound silencing the expression of at least a second target gene involved in apoptosis as a positive control in expression modulating assays. Also provided are suitable methods, kits and compositions. | 02-10-2011 |
| 20110008846 | MODIFIED ENZYMES AND THEIR USES - The invention relates to an active enzyme of bacterial, fungal, viral, or archae origin, wherein the enzyme is coupled, preferably covalently coupled with at least one polymer having a molecular weight between about 500 to about 20,000 daltons selected from the group consisting of polyethylene glycol and polypropylene glycol. The invention relates in particular to uses thereof of such as in molecular biology as well as kits comprising such enzymes. In preferred embodiments the enzymes of the invention are nucleic acid modifying or replicating enzymes. | 01-13-2011 |
| 20110008771 | METHOD AND MATERIALS FOR TRIGGERED RELEASE OF A BIOLOGICAL SAMPLE - The invention relates to a method for releasing a biological sample from a solid matrix substantially without disintegration of biomolecules comtained in said biological sample by at least partially transferring the solid state of said matrix into a dissolved or liquid state by changing at least one physico-chemical property of the environment of said matrix. | 01-13-2011 |
| 20100323363 | METHOD FOR THE TREATMENT OF A SAMPLE CONTAINING BIOMOLECULES - The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo- oder heteropolymeres, which comprise these nitrogenous compounds, d) amines of the type R | 12-23-2010 |
| 20100297614 | PROCESS FOR THE DETECTION OF CYTOSINE METHYLATIONS - The invention concerns a method for the detection of cytosine methylations in DNA and a kit for undertaking an assay according to the method of the invention. | 11-25-2010 |
| 20100291658 | PROCESS FOR SEPARATING NONPROTEINANEOUS BIOMOLECULES, IN PARTICULAR NUCLEIC ACIDS, FROM PROTEINANEOUS SAMPLES - The present invention relates to method of isolating non-protein-containing biomolecules, in particular nucleic acids, characterized in that protein degradation is carried out on a solid phase. | 11-18-2010 |
| 20100273984 | METHOD FOR ENRICHING PHOSPHOPEPTIDES - The invention relates to a method for enriching phosphopeptides. Said method is characterized in that a carrier is used which carries phosphate groups and/or phosphonate groups on the surface thereof. The phosphate groups and/or phosphonate groups are functionalized with zirconium ions and are bonded to the carrier by means of linker structures which have at least one alkyl chain containing at least 5 C atoms. Also disclosed are corresponding carriers and suitable kits for enriching phosphopeptides. | 10-28-2010 |
| 20100267081 | METHOD AND DEVICE FOR FIXING/STABILISING A SAMPLE - The present invention provides a method for fixing and/or stabilizing a sample, in which the sample is put into a permeable container with a maximum overall height of 10 mm, preferably of 5 mm, and the container filled with the sample is immersed in fixing and/or stabilizing agents and the sample is fixed and/or stabilized. | 10-21-2010 |
| 20100255524 | METHOD FOR STABILISING A BIOLOGICAL SAMPLE - The present invention relates to a method of stabilizing a biological sample, having the steps of preparation of a biological sample, and of contacting the biological sample with a composition, having a substance according to the following structural formula: | 10-07-2010 |
| 20100209993 | PERMANENT INACTIVATION OF NUCLEASES - The present invention relates to the use of reagent for permanently inactivating nucleases wherein the reagent comprises an oxidizing agent, a protein denaturant and optionally a pH adjustor and to a method for permanently inactivating nucleases using said reagent. | 08-19-2010 |
| 20100209912 | METHOD FOR THE TREATMENT OF A SAMPLE CONTAINING BIOMOLECULES - The invention generally provides a method for the sample preparation for a subsequent preparation, processing or analysis method of a sample containing an at least one species of nucleic acid and/or one species of protein, whereby the method comprises the following steps: A) providing a sample which contains at least one species of a nucleic acid and/or of a protein, B) contacting the sample with a fluid or solid composition to produce a fluid sample preparation, whereby the composition contains at least a nitrogenous compound, which is selected from the group consisting of a) polyamines, b) amino acids, and oligo- and polypeptides, c) nitrogenous heterocyclic compounds, including homo- oder heteropolymers, which comprise these nitrogenous compounds, d) amines of the type R | 08-19-2010 |
| 20100173295 | FIXATION OF A BIOLOGICAL MATERIAL - The present invention relates to a method for the treatment of a biological material, comprising the steps i) providing a biological material, and ii) contacting the biological material with a first non-aqueous composition comprising: (a1) 10 to 90 vol. % methanol, and (a2) at least one additional additive, and (a3) optionally an acid. iii) transferring the biological material into a second composition (B) comprising up to 99 vol. % ethanol as well as to a new composition for preservation of a biological material usable in said method and the biological material resulting from this method, a method for the analysis of a treated biological material, various kits as well as the use of the composition in such a method. | 07-08-2010 |
| 20100159532 | METHOD AND DEVICE FOR PERFORMING A NUCLEIC ACID PREPARATION AND/OR AMPLIFICATION - The invention relates to a method and a device for performing a nucleic acid preparation and/or amplification. | 06-24-2010 |
| 20100137567 | PULVERIZER AND CORRESPONDING METHOD FOR PREPARING A BIOLOGICAL SAMPLE FOR PROCESSING - The invention relates, for example, to methods for preparing a plant or animal sample for processing, i.e. for example for the isolation of nucleic acids or proteins from the sample, as well as to a pulverizer. | 06-03-2010 |
| 20100120044 | MODIFIED POLYNUCLEOTIDES COMPRISING RIBOSE RINGS - The invention pertains to different methods employing the use of a polynucleotide comprising ribose rings which carry a modification at the 2′-OH group. | 05-13-2010 |
| 20100113758 | METHOD FOR PURIFYING BIOMOLECULES - The present invention relates to a process for the purification of biomolecules, in particular of nucleic acids, such as DNA and RNA molecules. | 05-06-2010 |
| 20100099191 | RNA INTERFERENCE TAGS - The invention relates to a composition for inhibiting the expression of a target gene in a eukaryotic cell by RNA interference, the composition comprising a genetic construct and the target gene being introduced into the eukaryotic cell by means of said construct, and the construct having a first target gene and a first siRNA tag. The invention also relates to a composition for inhibiting the expression of one or more target genes in a eukaryotic cell by RNA interference. The composition comprises at least two genetic constructs and the target genes are introduced into the eukaryotic cell by means of said constructs, a) the first construct containing a first target gene and a first siRNA tag and b) the second construct containing a second target gene and a second siRNA tag, and the first and the second siRNA tag having different nucleic acid sequences. The invention finally relates to a method for inhibiting the expression of a target gene in a eukaryotic cell. Said method comprises the following steps: a) providing at least one eukaryotic cell, said cell being capable of RNA interference, b) transfecting the cells with a composition according to the invention and c) introducing at least one siRNA that is complementary to a siRNA tag of a transfected construct to inhibit the expression of the target gene that forms a transcription unit together with the siRNA tag. | 04-22-2010 |
| 20100075422 | TRANSFECTION MICROARRAYS - A transfection method of introducing sample molecules into cells is provided, comprising:
| 03-25-2010 |
| 20100056769 | METHODS AND KIT FOR ISOLATING NUCLEIC ACIDS - The present invention is related to a method for isolating a target nucleic acid from a sample comprising said target nucleic acid, comprising the steps of mixing a sample containing said target nucleic acid with a binding solution and a nucleic acid binding matrix, binding at least part of said target nucleic acid to said nucleic acid binding matrix, wherein said nucleic acid binding matrix is treated simultaneously or has been previously treated with at least one compound comprising a metal substance selected from the group consisting of metals of the main groups 13 to 16, semimetals and transition metals for reducing non-target nucleic acid contaminations or wherein said nucleic acid binding matrix is modified with hydrophobic groups. Furthermore, respective kits and reagents are provided with the teaching of the present invention. | 03-04-2010 |
| 20100048867 | DEVICE AND PROCESS FOR PURIFYING NUCLEIC ACIDS - An apparatus for purifying nucleic acids by negative chromatography is disclosed, which comprises a hollow body with an opening, respectively, at the top and at the bottom end, said hollow body containing a stationary solid phase, characterized in that the stationary phase contains at least 2 different chromatography resins, such as size e.g. exclusion gel filtration materials (SEC materials), as well as a method for purifying nucleic acids and the use of the apparatus. | 02-25-2010 |
| 20100036109 | METHOD FOR SELECTIVELY AND REVERSIBLY ADSORBING NUCLEIC ACIDS ON A CARRIER MATERIAL - The invention relates to a process for selective, reversible adsorption of nucleic acids to a support material, which process is characterized in that (a) a nucleic acid-containing mixture having a cosmotropic salt content of at least 1 mole is contacted with said support material, whereupon the nucleic acid(s) is (are) adsorbed from said nucleic acid-containing mixture to said support material, and (b) the nucleic acid(s) bound to the support material is (are) detached from the support material by means of an aqueous solution having a salt content of no more than 1 mole. | 02-11-2010 |
| 20100021351 | COLLECTION OF BIOLOGICAL SAMPLES - The present invention relates to a container for receiving a liquid biological sample, with a volume for receiving the liquid biological sample, and with a filling and/or removal opening for filling the volume with the sample and for removing the sample from the volume. The invention is distinguished in that a constriction or partition forming an aperture is arranged in the volume in order to partition off a predefined measured volume from the volume. | 01-28-2010 |
| 20100015602 | REVERSE TRANSCRIPTION AND AMPLIFICATION OF RNA WITH SIMULTANEOUS DEGRADATION OF DNA - The invention relates to a method for processing RNA, in particular, a RNA reaction method and kits for carrying out said RNA reaction method. | 01-21-2010 |
| 20090317906 | GENE SILENCING USING SENSE DNA AND ANTISENSE RNA HYBRID CONSTRUCTS COUPLED TO PEPTIDES FACILITATING THE UPTAKE INTO CELLS - The present invention generally relates to gene silencing using sense DNA (sDNA)-antisense RNA (aRNA) hybrids wherein the sense DNA strand is coupled to a peptide which facilitates the uptake of the hybrid into cells. | 12-24-2009 |
| 20090306177 | Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification - Double-stranded short interfering ribonucleic acid (siRNA) are modified to reduce or eliminate their immunostimulatory effect without significantly affecting their gene silencing effect. Modified siRNA include one or more 2′ sugar modifications and, optionally, internucleotide linkages on the sense strand. Compositions containing the modified siRNA and methods of making and using the modified siRNA are disclosed. New and previously characterized siRNA can be synthesized to incorporate modifications according to the invention. | 12-10-2009 |
| 20090305392 | DEVICE FOR PROCESSING SAMPLES - Device for sample processing, particularly sample conditioning as well as for the preparation and/or optionally for implementing a sequential process for an analyte from a biological sample, said device comprising a module for receiving and/or outputting at least one sample vessel or process vessel, a module for transporting a process vessel, a module for sample conditioning and a module for initiating a sequential process for an analyte. The modules are divided into at least two units that each possesses a control system, and which are connected through a first data bus. | 12-10-2009 |
| 20090299047 | Method for Activating a Nucleic Acid for a Polymerase Reaction - The present invention concerns a method for activating a nucleic acid for a polymerase reaction with the steps: (a) Heating a nucleic acid to a temperature of 55° C. to 80° C., (b) cooling the nucleic acid to a temperature at which a polymerase shows no substantial decrease in activity, and (c) starting the polymerase reaction by the addition of a heat-labile polymerase to the nucleic acid. | 12-03-2009 |
| 20090212233 | MALDI CHIP HOLDER - The invention relates to a holder for a MALDI chip, having a broken corner contour, comprising a first and second respectively accessible bearing surface and a moveable fixing means which interacts with the broken corner contour and which pre-tenses the MALDI chip against the bearing surfaces. The invention also relates to a MALDI chip and a system consisting of the holder and the MALDI chip. | 08-27-2009 |
| 20090202998 | METHOD FOR THE EXTRACTION OF BIOMOLECULES FROM FIXED TISSUES - The present invention relates to a method for treating a fixed biological sample, comprising the steps of the method: i) provision of a fixed biological sample, ii) contacting the fixed biological sample with an aqueous solution comprising at least one nucleophilic reagent, and iii) heating the biological sample contacted with the aqueous solution. The invention also relates to the biological sample obtainable by this method, to the use of a nucleophilic reagent for the treatment of a fixed biological sample, to a kit for isolating a biomolecule from a fixed biological sample, to the use of this kit, and to a method for the treatment of a disease. | 08-13-2009 |
| 20090176296 | PROCESS FOR ISOLATING NUCLEIC ACIDS - The present invention relates to a process for isolating total nucleic acid from a nucleic acid-containing sample and a kit for carrying out said process. More specifically, it relates to the isolation of RNA from a nucleic-acid containing sample. | 07-09-2009 |
| 20090117622 | MIXTURE OF REVERSIBLY INHIBITED ENZYMES - The invention relates to composition or a kit containing an enzyme that is reversibly inhibited by means of a chemical modification and an enzyme which is reversibly inhibited using non-covalent binding, the use of a mixture of enzymes reversibly inhibited in such a manner for processing or multiplying polynucleotides, and a method for specifically amplifying DNA by simultaneously using both types of reversibly inhibited enzymes. | 05-07-2009 |
| 20090081802 | METHOD FOR ENRICHING SHORT-CHAIN NUCLEIC ACIDS - The present invention relates to a method for enriching nucleic acids with a length of not more than 300 nucleotides | 03-26-2009 |
| 20090063290 | System and Method Utilizing A Customer Relationship Management Software Application To Convert A Price Quote Into An Electronic Shopping Cart - A customer requests a price quote for certain goods or services. The requisite information is entered into a customer relationship management (CRM) software application, which is capable of sending a price quote to the customer. The CRM application is provisioned with a feature that creates an e-mail containing a weblink to an electronic shopping basket, along with other information pertaining to the price quote. Once finalized, the e-mail is sent to the customer who had requested the price quote. If the customer then activates the weblink, the web site application displays the electronic shopping cart to the customer, and gives the customer the opportunity to conclude the sale. This makes it easy for the customer to purchase the goods or services in the shopping cart, without further the delay. For the vendor, it increases the likelihood of converting a price quote into a sale. | 03-05-2009 |
| 20090047674 | METHOD FOR NUCLEIC ACID ISOLATION AND AMPLIFICATION - The present invention provides methods and compositions for sequence-specific isolation of polynucleotide molecules from nucleic acid populations and subsequent amplification of isolated polynucleotide molecules or fragments thereof. | 02-19-2009 |
| 20090018323 | METHOD FOR EXTRACTING NUCLEIC ACID FROM BLOOD - The present invention relates to an improved method for isolating nucleic acids, particularly genomic desoxyribonucleic acid (DNA) from blood. | 01-15-2009 |
| 20090010871 | Method for Production of a Transformed Cell - The invention relates to a method for incorporation of a biomolecule into a cell including the method steps: i) production of a complex from a biomolecule, preferably a nucleic acid and a polymer which may be obtained by reaction of an amine monomer having at least two amine groups with an epoxide monomer having at least two epoxide groups and ii) incorporation of the biomolecule into a cell bx bringing the cell into contact with the complex. The invention further relates to the transformed cell obtained by said method, the use of a particular polymer for incorporation of a biomolecule into a cell, a kit for incorporation of a biomolecule into a cell, the use of said kit, a complex made from a biomolecule and a polymer, a therapeutic composition, the use of a complex of a biomolecule and a polymer for therapeutic treatment of the human or animal being and a method for treatment of a disease by means of gene therapy. | 01-08-2009 |
| 20080311562 | Nucleic Acid Sequencing - A method for determining a target nucleic acid sequence, wherein the target nucleic acid sequence is comprised in a preparation comprising a non-target nucleic acid sequence, the target nucleic acid sequence and the non-target nucleic acid sequence each having a first region of common sequence upstream of a first region of dissimilar sequence upstream of a second region of dissimilar sequence, the method comprising: | 12-18-2008 |
| 20080299557 | Sample Lysis and Coating of Reaction Surface - The present invention provides copolymers that facilitate nucleic acid analysis, compositions that comprise such copolymers, and methods for making or using such copolymers. | 12-04-2008 |
