| PURDUE RESEARCH FOUNDATION Patent applications |
| Patent application number | Title | Published |
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| 20120122268 | SELENIZATION OF PRECURSOR LAYER CONTAINING CULNS2 NANOPARTICLES - A method of fabrication of thin films for photovoltaic or electronic applications is provided. The method includes fabricating a nanocrystal precursor layer and selenizing the nanocrystal precursor layer in a selenium containing atmosphere. The nanocrystal precursor layer includes one of CuInS | 05-17-2012 |
| 20120122112 | ANTIBODIES AS A CANCER DIAGNOSTIC - Method and kits are provided for the detection and diagnosis of metastatic disease. More particularly, the methods and kits employ compounds that can detect EphA2, a specific epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. In one embodiment the compound is an antibody capable of binding to an epitope of EphA2. | 05-17-2012 |
| 20120118036 | SYSTEM AND METHOD FOR REDUCING THE AMPLITUDE OF THERMALLY INDUCED VIBRATIONS IN MICROSCALE AND NANOSCALE SYSTEMS - The present invention generally relates to a system and method for improving the precision and applicability of microscale and nanoscale electromechanical systems. The system includes a device (such as an electrostatic sensor) for measuring parameters of a force associated with noise-induced background readings of a microscale or nanoscale electromechanical system, and a device (such as an electrostatic actuator) for applying a countering force to the electromechanical system. | 05-17-2012 |
| 20120115708 | METHOD OF PRODUCING PARTICULATE-REINFORCED COMPOSITES AND COMPOSITES PRODUCED THEREBY - A process for producing particle-reinforced composite materials through utilization of an in situ reaction to produce a uniform dispersion of a fine particulate reinforcement phase. The process includes forming a melt of a first material, and then introducing particles of a second material into the melt and subjecting the melt to high-intensity acoustic vibration. A chemical reaction initiates between the first and second materials to produce reaction products in the melt. The reaction products comprise a solid particulate phase, and the high-intensity acoustic vibration fragments and/or separates the reaction products into solid particles that are dispersed in the melt and are smaller than the particles of the second material. Also encompassed are particle-reinforced composite materials produced by such a process. | 05-10-2012 |
| 20120115312 | THIN FILMS FOR PHOTOVOLTAIC CELLS - In one aspect, a method for forming CIGSSe-based thin films includes depositing at least two layers of particles on a substrate. At least one layer includes a CIGSSe particle having a chemical composition denoted by Cu(InI-xGax)(S1-ySey)2 where 0≦x ≦1 and 0≦y≦1. The particle layers are annealed individually or in combination to form a CIGSSe thin film having a composition profile along the depth of the film In addition, one or more of the particle layers may be also deposited on a pre-existing absorber and annealed to form a film having a composition profile along the depth of the film After depositing thin film precursor layers containing CIGSSe nanoparticles (and/or any other particles) on a suitable substrate in accordance with a desired concentration profile, a subsequent treatment under an Se and/or S containing atmosphere at elevated temperature may be used to convert the precursor layers into a CIGSSe absorber film In a further aspect, a method for forming multinary metal chalcogenide semiconductor layers directly on a substrate from a solution of precursors, includes depositing a plurality of metal chalcogenide particles onto a substrate to form a precursor film A species containing a metal, chalcogen, or combination thereof is dissolved in a solution containing one or more solvents to form a liquid chalcogen medium. The precursor film is contacted with the liquid chalcogen medium at a temperature of at least 50 C to form a multinary metal chalcogenide thin film | 05-10-2012 |
| 20120115222 | COMPOSITION AND METHOD FOR MAINTENANCE, DIFFERENTIATION, AND PROLIFERATION OF STEM CELLS - Compositions and methods for the proliferation, differentiation, and maintenance of stem cells are described. Preferred are the use of hematopoietic stem cells in combination with a collagen matrix. | 05-10-2012 |
| 20120107955 | METABOLITE BIOMARKERS FOR THE DETECTION OF ESOPHAGEAL CANCER USING MS - Results of studies of nucleosides in biofluid specimens from patients with esophageal adenocarcinoma and related disorders have identified five biomarkers of the conditions: 1-methyladenosine, N | 05-03-2012 |
| 20120100106 | COLLAGEN-BINDING SYNTHETIC PEPTIDOGLYCANS FOR WOUND HEALING - Methods and compositions for promoting wound healing in a patient by administering a collagen-binding synthetic peptidoglycan to the patient are described. Additionally, methods and compositions are described for decreasing scar formation in a patient by administering a collagen-binding synthetic peptidoglycan to the patient. | 04-26-2012 |
| 20120083688 | HEAD INJURY DIAGNOSTICS - Systems and methods for detecting the effects of concussion are disclosed. In various embodiments, fMRI or other live analysis technique captures data regarding the subject's brain activity while he or she is performing a task that exercises one or more particular functional centers. In some embodiments, post-collision activity is compared to baseline data, and the diagnosis operates as a function of the comparison. in other embodiments, post-collision activity is analyzed, such as by partitioning the activity data into regions of interest and calculating activity for one particular region in comparison with certain other, perhaps adjacent, regions. | 04-05-2012 |
| 20120079936 | POSITIVE DISPLACEMENT MACHINE PISTON WITH WAVY SURFACE FORM - A piston and cylinder assembly suitable for use in positive displacement machines ( | 04-05-2012 |
| 20120059161 | COMPOUNDS AND METHODS FOR TREATING AIDS AND HIV INFECTIONS - Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described. | 03-08-2012 |
| 20120046644 | TOUCH-ACTUATED MICROPUMP FOR TRANSDERMAL DRUG DELIVERY AND METHOD OF USE - A micropump device. The micropump device includes a first layer forming a first chamber configured to store a working material, a second chamber defined by a deflectable membrane in fluid communication with the first chamber and configured to deflect in response to a pressure increase in the first chamber in response to a volume increase in the first chamber, the second chamber configured to store a drug compound to be delivered to a subject's vascular system, and at least one needle in fluid communication with the second chamber and configured to penetrate a subject's skin to pump the drug compound in response to the deflection of the deflectable membrane. | 02-23-2012 |
| 20120041018 | OCTAHYDROBENZOISOQUINOLINE MODULATORS OF DOPAMINE RECEPTORS AND USES THEREFOR - Octahydrobenzoisoquinoline modulators of dopamine receptors are described herein. Methods for using octahydrobenzoisoquinoline modulators of dopamine receptors in the treatment of dopamine dysfunction are also described herein. | 02-16-2012 |
| 20120031193 | IDENTIFICATION OF LOADS ACTING ON AN OBJECT - Structural health monitoring systems can be limited to a minimum number of sensors due to cost, complexity, and weight restrictions. Some embodiments described herein pertain to a load and damage identification techniques that utilize one sensor. Several passive force estimation techniques are presented. Some techniques use either the shape or the amplitude of the magnitude of the applied force in the frequency domain. Several techniques iteratively reduce an underdetermined set of equations of motion into many overdetermined systems of equations to solve for the force estimates. The techniques are shown to locate and quantify impulsive impacts with over 97% accuracy and non-impulsive impacts with at least 87% accuracy. Impacts not acting at a specific input degree of freedom are also accurately located depending on the distance away from the modeled input degrees of freedom, and damaging impact forces are quantified by making assumptions about the impulsive nature of the applied force. | 02-09-2012 |
| 20120022245 | FOLATE TARGETING OF NUCLEOTIDES - The present invention relates to compounds, compositions, kits, and methods of use in targeting nucleotides, such as siRNA's, to cancer cells or to immune system cells involved in inflammation. More particularly, the invention is directed to receptor binding ligand-nucleotide delivery conjugates for use in specifically targeting the conjugates to cancer cells or to immune system cells, methods of treatment with these conjugates, methods of preparation of these conjugates, and methods of reducing the expression of a gene in vitro or in vivo with the conjugates described herein. | 01-26-2012 |
| 20120021918 | DNA Sequencing and Amplification Systems Using Nanoscale Field Effect Sensor Arrays - In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR. | 01-26-2012 |
| 20120021690 | ANTENNA AIMING SYSTEM AND METHOD FOR BROADBAND WIRELESS ACCESS - A system and method are provided for automatically aiming an antenna to communicate with a remote broadband wireless communication device. | 01-26-2012 |
| 20120013230 | COLLAPSIBLE FURNITURE JOINTING SYSTEM - Methods for constructing and apparatus for furniture. In some embodiments, the furniture includes a plurality of subassemblies, with each component within the subassembly being interlocked with adjacent components. Preferably, there is additional interlocking between adjacent subassemblies. Preferably, the furniture is easily and simply constructed without the use of fasteners or tools. Prior to assembly, the components are generally planar, which facilitates storage of the disassembled furniture. In some embodiments, each of the components within a subassembly are substantially identical to the other components, thus minimizing fabrication costs. | 01-19-2012 |
| 20120006022 | ORGANIC RANKINE CYCLE WITH FLOODED EXPANSION AND INTERNAL REGENERATION - A heat engine system configured to extract thermal energy from a heat source, convert a first portion of the thermal energy to work using an expansion device, and reject a second portion of the thermal energy to a heat sink. The system utilizes a second fluid to inhibit a temperature drop of the first fluid within the expansion device. | 01-12-2012 |
| 20120003151 | METHOD FOR EARLY IMAGING OF ATHEROSCLEROSIS - The invention relates to methods of detecting active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. In one embodiment, plaques that block from about 2% to about 60% of the lumen of a blood vessel can be detected. | 01-05-2012 |
| 20110317017 | PREDICTIVE DUTY CYCLE ADAPTATION SCHEME FOR EVENT-DRIVEN WIRELESS SENSOR NETWORKS - Embodiments of a method for controlling access to a shared communications medium by a plurality of nodes are disclosed. The method may comprise predicting, for each node of the plurality of nodes, whether an event will occur within a sensing field of that node at a future time and adapting a communications schedule of each node in response to the prediction regarding that node. Wireless sensor networks and computer readable media implementing embodiments of a method for controlling access to a shared communications medium by a plurality of nodes are also disclosed. | 12-29-2011 |
| 20110314915 | DAMAGE DETECTION USING LASER VIBROMETRY - Methods and apparatus for exciting a structure and determining its structural integrity. In particular, methods of nonlinear analysis are used to compare first and second response datasets, each dataset resulting from a different excitation amplitude that the other dataset. | 12-29-2011 |
| 20110310255 | CALIBRATION OF LARGE CAMERA NETWORKS - The present disclosure relates to a sensor network including a plurality of nodes, each node having a directional sensor, a communication module, and a processor configured to receive local measurements of a calibration object from the directional sensor, receive additional measurements of the calibration object from neighboring nodes via the communication module, estimate an initial set of calibration parameters in response to the local and additional measurements, receive additional sets of calibration parameters from neighboring nodes via the communication module, and recursively estimate an updated set of calibration parameters in response to the additional sets of calibration parameters. Additional systems and methods for calibrating a large network of camera nodes are disclosed. | 12-22-2011 |
| 20110303541 | CONTROLLED FLOW OF A THIN LIQUID FILM BY ELECTROWETTING - Apparatus and methods for controllably wetting a microstructured surface. | 12-15-2011 |
| 20110302928 | LIQUID-GAS HEAT EXCHANGER - The heat exchanger includes a large number of small, closely-spaced modules. Within each module of one embodiment, the fuel flows through a series of parallel micro-channels, while the air flows externally over rows of short, straight fins perpendicular to the direction of fuel flow. A theoretical model was developed to predict the thermal performance of the module for various operating conditions. To confirm the accuracy of the model, a module was constructed and tested using water to simulate the aircraft fuel. | 12-15-2011 |
| 20110292926 | MULTIPLE INPUT MULTIPLE OUTPUT COMMUNICATION SYSTEM AND COMMUNICATION METHOD OF CONFIGURING CODEBOOK - A multiple input multiple output (MIMO) communication system and communication method of configuring a codebook are provided. A channel may be formed between a transmitter and a receiver, and a cross-polarization discrimination value (XPD) may be detected. The XPD may vary based on a location of the transmitter and the receiver, a mobility thereof, or a peripheral environment, among other factors. The codebook may be configured based on the XPD. | 12-01-2011 |
| 20110288391 | Titanium-Based Multi-Channel Microelectrode Array for Electrophysiological Recording and Stimulation of Neural Tissue - A microelectrode array including a top portion, a plurality of pads positioned on the top portion, and a shank portion, the shank portion including a titanium substrate, a dielectric structure positioned on the titanium substrate, and a metallization layer embedded in the dielectric structure, the metallization layer including a plurality of electrode sites distributed longitudinally along the shank portion, and a plurality of electrical traces, wherein the dielectric structure provides an access window over each of the plurality of the electrode sites and each of the plurality of electrical traces electrically connects a corresponding electrode site of the plurality of electrode sites to a corresponding pad of the plurality of pads. | 11-24-2011 |
| 20110288152 | PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING - Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for targeting prostate cancer cells. Also described herein are compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them. | 11-24-2011 |
| 20110284262 | Controlled Self Assembly of Anisotropic Conductive Adhesives Based on Ferromagnetic Particles - An anisotropic conductive adhesive (ACA) arrangement is disclosed, including a thermosetting resin disposed between a connector of a first structure and a connector of a second structure, and a plurality of ferromagnetic conductive particles dispersed through the thermosetting resin, wherein the plurality of ferromagnetic conductive particles form columns between the connector of the first structure and the connector of the second structure, and wherein a density of the ferromagnetic particles in the columns is substantially higher than a density of the plurality of ferromagnetic particles away from the columns. | 11-24-2011 |
| 20110284184 | COILED AND MICROCHANNEL HEAT EXCHANGERS FOR METAL HYDRIDE STORAGE SYSTEMS - Various apparatus and methods for exchanging heat from a solid to a liquid. Some embodiments pertain to removing heat from a pressure vessel in which a gas absorption reaction is occurring. Yet other embodiments pertain to pressure vessels in which hydrogen is being absorbed into a metal hydride. | 11-24-2011 |
| 20110278533 | DOUBLE GYROID STRUCTURE NANOPOROUS FILMS AND NANOWIRE NETWORKS - A method of forming a nanoporous film is disclosed. The method comprises forming a coating solution including clusters, surfactant molecules, a solvent, and one of an acid catalyst and a base catalyst. The clusters comprise inorganic groups. The method further comprises aging the coating solution for a time period to select a predetermined phase that will self-assemble and applying the coating solution on a substrate. The method further comprises evaporating the solvent from the coating solution and removing the surfactant molecules to yield the nanoporous film. | 11-17-2011 |
| 20110277972 | FINNED HEAT EXCHANGERS FOR METAL HYDRIDE STORAGE SYSTEMS - Various apparatus and methods for exchanging heat from a solid to a liquid. Some embodiments pertain to removing heat from a pressure vessel in which a gas absorption reaction is occurring. Yet other embodiments pertain to pressure vessels in which hydrogen is being absorbed into a metal hydride. | 11-17-2011 |
| 20110275619 | INHIBITORS OF BACE1 AND METHODS FOR TREATING ALZHEIMER'S DISEASE - Inhibitors of BACE1 and compositions containing them are described. Use of the inhibitors and compositions containing them to treat Alzheimer's disease are described. | 11-10-2011 |
| 20110272571 | LASER-INDUCED ACOUSTIC DESORPTION / ATMOSPHERIC PRESSURE CHEMICAL IONIZATION OF COMPOUNDS - The present disclosure provides a novel system and method for evaporating and ionizing compounds comprising an LIAD source and an ionization source that operates at atmospheric pressure. This system is readily adaptable for use with most commercially available mass spectrometers. Ionization sources include Atmospheric Pressure Chemical Ionization sources (APCI) and Atmospheric Pressure Photo Ionization (APPI) sources. The ionization sources are positioned such that the analyte desorbing from the surface of the LIAD is fed into the ion stream produced by the ionization source and ionized analyte and ionized fragments of the analyte are fed into the sample inlet of a mass spectrometer. These systems allow for the mass spectrometric analysis of non-polar compounds that lack readily ionizable functional groups, such as saturated and unsaturated hydrocarbons and compounds with medium to low polarity, as well as hydrocarbon mixtures, such as petroleum. | 11-10-2011 |
| 20110269834 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES - Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS). | 11-03-2011 |
| 20110263688 | COFERONS AND METHODS OF MAKING AND USING THEM - A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof | 10-27-2011 |
| 20110262646 | Surfactant-Assisted Inorganic Nanoparticle Deposition on a Cellulose Nanocrystals - Natural biopolymers in the form of cellulose nanocrystals (CNC) are shown to have the required characteristics to serve as chemically reactive biotemplates for metallic and semiconductor nanomaterial synthesis. Silver (Ag), gold (Au), copper (Cu) and platinum (Pt), cadmium sulfide (CdS), zinc sulfide (ZnS) and lead sulfide (PbS) nanoparticles, nanoparticle chains and nanowires may be synthesized on CNCs by exposing metallic precursor salts to a cationic surfactant, cetyltrimethylammonium bromide (CTAB), and a reducing agent. The nanoparticle density and particle size may be controlled by varying the concentration of CTAB, pH of the salt solution, as well as the reduction time or reaction time between the reducing agent and the metal precursor. | 10-27-2011 |
| 20110260536 | Efficient Power Conversion for Ultra Low Voltage Micro Scale Energy Transducers - A power converter is provided for an energy harvesting system of a micro-scale electronic device. The power converter is configured to transfer electrical energy from an energy transducer to an energy storage device. The power converter illustratively includes a tree topology charge pump. | 10-27-2011 |
| 20110257900 | METHODS AND APPARATUS FOR DIAGNOSING FAULTS OF A VEHICLE - A rubber cleat is instrumented with two triaxial accelerometers to measure the multi-directional response of the cleat due to the forces within the tire footprint of a ground vehicle. The cleat data is used to detect faults in the front and rear suspension in addition to the wheel tire despite variability in the data. This offboard diagnostic technique is proposed to enable condition-based maintenance. | 10-20-2011 |
| 20110240844 | SYSTEMS AND METHODS FOR TRANSFER OF IONS FOR ANALYSIS - The invention generally relates to systems and methods for transferring ions for analysis. In certain embodiments, the invention provides a system for analyzing a sample including an ionizing source for converting molecules of a sample into gas phase ions in a region at about atmospheric pressure, an ion analysis device, and an ion transfer member operably coupled to a gas flow generating device, in which the gas flow generating device produces a laminar gas flow that transfers the gas phase ions through the ion transfer member to an inlet of the ion analysis device. | 10-06-2011 |
| 20110233446 | Microfluidic Purge Valve - A microfluidic purge valve in a microfluidics system includes a notch defined in the valve seat of a microfluidic valve. The notch is sized so that gas entrained within a liquid pumped through the microfluidics system can pass freely therethrough but the liquid cannot. The notch is sized so that the resistant force generated by the surface tension of the liquid is equal to or greater than the force generated by the fluid pressure. | 09-29-2011 |
| 20110230505 | QUINAZOLINE INHIBITORS OF BACE 1 AND METHODS OF USING - Dihydroquinazoline compounds, compositions containing them, the use of the compounds and compositions for the treatment of Alzheimer's disease are described. | 09-22-2011 |
| 20110225665 | Stable dw3 Allele for Sorghum and a Molecular Marker to Facilitate Selection - The identification of a stable dw | 09-15-2011 |
| 20110207808 | LONG-CHAIN CARBOXYCHROMANOLS AND ANALOGS FOR USE AS ANTI-INFLAMMATORY AGENTS - Provided are long-chain carboxychromanol compounds useful for treating conditions associated with the need to inhibit cyclooxygenase-1, cyclooxygenase-2, and/or 5-lipoxygenase, and pharmaceutical formulations containing the compounds. | 08-25-2011 |
| 20110202285 | NMR METHOD FOR DIFFERENTIATING COMPLEX MIXTURES - A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis. | 08-18-2011 |
| 20110195978 | COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE - Described herein are compounds, and pharmaceutical compositions, methods, and uses thereof for treating Alzheimer's disease. | 08-11-2011 |
| 20110183430 | GROUP SPECIFIC INTERNAL STANDARD TECHNOLOGY (GSIST) FOR SIMULTANEOUS IDENTIFICATION AND QUANTIFICATION OF SMALL MOLECULES - Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distinct forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups. | 07-28-2011 |
| 20110178123 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS - Novel compounds and compositions for treating patients in need of relief from HIV, AIDS, and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described. | 07-21-2011 |
| 20110165126 | Enhanced Submucosal Tissue Graft Constructs - An improved tissue graft construct comprising submucosa of a warm-blooded vertebrate and a preselected group of eukaryotic cells are described. The improved tissue graft constructs can be used in accordance with the present invention to enhance the repair of damaged or diseased tissues in vivo. | 07-07-2011 |
| 20110151649 | METHOD FOR FABRICATING A SEMICONDUCTOR DEVICE - A method for fabricating a semiconductor device includes forming a first semiconductor layer on a front side of the semiconductor substrate. Additional semiconductor layers may be formed on a font side of the first semiconductor layer. The substrate is subsequently removed. In some embodiments, one or more additional semiconductor layers may be formed on the back side of the first semiconductor layer after the semiconductor substrate has been removed. Additionally, in some embodiments, a portion of the first semiconductor layer is removed along with the semiconductor substrate. In such embodiments, the first semiconductor layer is subsequently etched to a known thickness. Source regions and device electrodes may be then be formed. | 06-23-2011 |
| 20110150898 | EPHA2 as a therapeutic target for cancer - The present invention is directed to compounds and methods for the treatment of metastatic disease. The compounds of this invention have specificity for EphA2, an epithelial cell tyrosine kinase that is overexpressed in metastatic tumor cells. The compounds used in accordance with this invention may be provided in a pharmaceutical composition for treatment of metastatic disease. | 06-23-2011 |
| 20110147715 | Medium Scale Carbon Nanotube Thin Film Integrated Circuits on Flexible Plastic Substrates - The present invention provides device components geometries and fabrication strategies for enhancing the electronic performance of electronic devices based on thin films of randomly oriented or partially aligned semiconducting nanotubes. In certain aspects, devices and methods of the present invention incorporate a patterned layer of randomly oriented or partially aligned carbon nanotubes, such as one or more interconnected SWNT networks, providing a semiconductor channel exhibiting improved electronic properties relative to conventional nanotubes-based electronic systems. | 06-23-2011 |
| 20110130429 | PYRIDINES FOR TREATING INJURED MAMMALIAN NERVE TISSUE - Embodiments of the present disclosure provide a novel pyridine, pharmaceutical compositions comprising such pyridine, and the use of such compositions in treating injured mammalian nerve tissue, including but not limited to an injured spinal cord. In at least one embodiment of the method, the method comprises the step of administering to the mammal in need thereof with a pharmaceutical composition, or pharmaceutically acceptable salt, comprising 4-aminopyridine-3-methanol. | 06-02-2011 |
| 20110123976 | Biomarkers and identification methods for the early detection and recurrence prediction of breast cancer using NMR - A method is provided for the parallel identification of one or more metabolite species within a biological sample. The method comprises analyzing the sample to produce a spectrum containing individual spectral peaks representative of the one or more metabolite species contained within the sample; subjecting each of the individual spectral peaks to a statistical pattern recognition analysis to identify the one or more metabolite species contained within the sample; and identifying the one or more metabolite species contained within the sample by analyzing the individual spectral peaks of the spectra. | 05-26-2011 |
| 20110118330 | HIV PROTEASE INHIBITORS AND METHODS FOR USING - Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described. | 05-19-2011 |
| 20110108725 | NON-DESTRUCTIVE, HIGH ORDER HARMONIC ION MOTION IMAGE CURRENT DETECTION - The invention herein generally relates to non-destructive, high order harmonic ion motion image current detection. In certain embodiments, ion motion corresponding to high order harmonic frequencies, instead of the secular frequencies, is detected using image current detection with a constant excitation applied to the waveform signal. | 05-12-2011 |
| 20110081324 | COLLAGEN PEPTIDE CONJUGATES AND USES THEREFOR - Described herein are conjugates of collagen peptides and metal binding agents and compositions resulting therefrom, useful in various tissue engineering and regeneration applications, in cell culture, cell adhesion, cosmetic surgery, construction of artificial skin substitutes, management of severe burns and burn surgery, reconstruction of bone and a wide variety of dental, orthopedic and surgical purposes, as drug delivery vehicles and in delivering populations of cells to a site of disease or injury. | 04-07-2011 |
| 20110071808 | GNSS Ephemeris with Graceful Degradation and Measurement Fusion - A method for providing an extended propagation ephemeris model for a satellite in Earth orbit, the method includes obtaining a satellite's orbital position over a first period of time, applying a least square estimation filter to determine coefficients defining osculating Keplarian orbital elements and harmonic perturbation parameters associated with a coordinate system defining an extended propagation ephemeris model that can be used to estimate the satellite's position during the first period, wherein the osculating Keplarian orbital elements include semi-major axis of the satellite (a), eccentricity of the satellite (e), inclination of the satellite (i), right ascension of ascending node of the satellite (Ω), true anomaly (θ*), and argument of periapsis (ω), applying the least square estimation filter to determine a dominant frequency of the true anomaly, and applying a Fourier transform to determine dominant frequencies of the harmonic perturbation parameters. | 03-24-2011 |
| 20110066385 | QUANTIFICATION OF DIFFERENCES BETWEEN MEASURED VALUES AND STATISTICAL VALIDATION BASED ON THE DIFFERENCES - A system and method of validating differences between measured values of fluorescence intensities obtained from a fluorescence-based instrument, including: generating calibration histograms for calibration beads run through the instrument; calibrating a distance function configured to measure distances between the histograms by: constructing a metric using the distance function, which includes a bin-to-bin dissimilarity matrix; and populating the dissimilarity matrix to maximize the following conditions: (A) the distance function of two histograms representing two sets of different beads equals the difference of their MESF values; and (B) the distance function of two histograms representing fluorescence of two sets of identical beads is zero; applying the metric to flow cytometry histograms generated for biological samples, to determine distances between the histograms; constructing a statistical test using the metric to determine a statistical significance of the distances; and determining whether the histogram results from the biological samples are reliable based on the statistical significance. | 03-17-2011 |
| 20110066241 | DEMINERALIZED CANCELLOUS BONE SCAFFOLDS - The present invention provides a cancellous bone scaffold to use in the replacement or repair of connective tissue such as ligaments and tendons. The cancellous bone scaffold has a fully demineralized segment with at least one adjacent mineralized end segment. | 03-17-2011 |
| 20110056369 | AXIAL SLIDING BEARING AND METHOD OF REDUCING POWER LOSSES THEREOF - A machine and method for a hydrostatic axial sliding bearing that has bearing and sealing functions and is capable of exhibiting reduced power losses. The hydrostatic axial sliding bearing of the machine is defined by axial sliding bearing surfaces that are separated by a fluid film and adapted for movement relative to each other during operation of the machine. The machine has first and second elements that define a first and a second of the axial sliding bearing surfaces. In combination, the first and second axial sliding bearing surfaces function as bearing and sealing surfaces for the hydrostatic axial sliding bearing. The machine is adapted so that the first and second axial sliding bearing surfaces move relative to each other in a first direction of motion, and at least the second axial sliding bearing surface has a surface profile with an oscillatory waveform in the first direction of motion. | 03-10-2011 |
| 20110048183 | MACHINING APPARATUS AND PROCESS - A machining process and apparatus capable of increasing removal rates achievable when machining titanium and its alloys. The process includes heating a portion of a workpiece with a laser beam, cryogenically cooling a cutting tool with a cryogenic fluid without flowing the cryogenic fluid onto the workpiece, and machining the heated portion of the workpiece with the cutting tool. The apparatus includes a cutting tool, a device for heating a portion of a workpiece with a laser beam prior to being machined with the cutting tool, and a device for cryogenically cooling the cutting tool with a cryogenic fluid without flowing the cryogenic fluid onto the workpiece. The cryogenic fluid is circulated around the cutting tool to achieve a temperature differential between the workpiece and the cutting tool that is capable of improving removal rates and extending tool life at cutting speeds of, for example, above 100 m/min. | 03-03-2011 |
| 20110046199 | SMALL MOLECULE INHIBITORS OF HIV PROTEASES - Described herein are compounds, compositions, and methods for treating HIV and related diseases. | 02-24-2011 |
| 20110042560 | LOW TEMPERATURE PLASMA PROBE AND METHODS OF USE THEREOF - The present invention generally relates to a low temperature plasma probe for desorbing and ionizing at least one analyte in a sample material and methods of use thereof. In one embodiment, the invention generally relates to a low temperature plasma probe including: a housing having a discharge gas inlet port, a probe tip, two electrodes, and a dielectric barrier, in which the two electrodes are separated by the dielectric barrier, in which application of voltage from a power supply generates a low temperature plasma, and in which the low temperature plasma is propelled out of the discharge region by the electric field and/or the discharge gas flow. | 02-24-2011 |
| 20110041224 | ATOMIC FORCE MICROSCOPE INCLUDING ACCELEROMETER - A microcantilever used in Atomic Force Microscopy (AFM) includes an elongated cantilevered body with a probe tip placed preferably near its free end and preferably along the cantilever's axis. Some embodiments of the present invention integrate into the microcantilever body an embedded or etched paddle that rotates rigidly about an axis parallel to that of the cantilever with hinges that connect the paddle to the cantilever body. In one embodiment the resonance frequency of this paddle resonator is higher than the fundamental resonance of the microcantilever so that the paddle rotation is proportional to the vertical microcantilever acceleration at the hinge location. The motion of the paddle can be detected using radiation irradiating the paddle; the reflected beam is centered onto a four quadrant photodiode as commonly found in AFM. The paddle's vertical motion is detected in the usual way by monitoring the vertical channel in the photodiode while its rotation is monitored from the lateral channel in the photodiode. By monitoring the vertical tip acceleration signal from the paddle rotation, it is possible to resolve the history of tip-sample force during oscillation cycles. A calibration method to convert the measured paddle rotation into vertical probe tip acceleration and instantaneous tip-sample force is also disclosed. | 02-17-2011 |
| 20110039280 | HYBRID MICROFLUIDIC SPR AND MOLECULAR IMAGING DEVICE - A hybrid microfluidic biochip designed to perform multiplexed detection of singled- celled pathogens using a combination of SPR and epi-fluorescence imaging. The device comprises an array of gold spots, each functionalized with a capture biomolecule targeting a specific pathogen. This biosensor array is enclosed by a polydimethylsiloxane (PDMS) microfluidic flow chamber that delivers a magnetically concentrated sample to be tested. The sample is imaged by surface plasmon resonance on the bottom of the biochip, and epi- fluorescence on the top. | 02-17-2011 |
| 20110020539 | PALLADIUM THIOLATE BONDING OF CARBON NANOTUBES - Carbon nanotube (CNT) arrays are attractive thermal interface materials with high compliance and conductance that can remain effective over a wide temperature range. Disclosed herein are CNT interface structures in which free CNT ends are bonded using palladium hexadecanethiolate Pd(SC | 01-27-2011 |
| 20110007477 | ENHANCEMENT OF THERMAL INTERFACE CONDUCTIVITIES WITH CARBON NANOTUBE ARRAYS - A method of forming a well-anchored carbon nanotube (CNT) array, as well as thermal interfaces that make use of CNT arrays to provide very high thermal contact conductance. A thermal interface is formed between two bodies by depositing a continuous array of carbon nanotubes on a first of the bodies so that, on mating the bodies, the continuous array is between surface portions of the first and second bodies. The thermal interface preferably includes a multilayer anchoring structure that promotes anchoring of the continuous array of carbon nanotubes to the first body. The anchoring structure includes a titanium bond layer contacting the surface portion of the first body, and an outermost layer with nickel or iron catalytic particles from which the continuous array of carbon nanotubes are nucleated and grown. Additional thermal interface materials (TIM's) can be used in combination with the continuous array of carbon nanotubes. | 01-13-2011 |
| 20100324008 | PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING - Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them. | 12-23-2010 |
| 20100322854 | POSITRON EMISSION TOMOGRAPHY IMAGING METHOD - Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are | 12-23-2010 |
| 20100311949 | ALIGNED COLLAGEN AND METHOD THEREFOR - Compositions and methods of preparing a graft construct comprising aligned collagen fibrils, wherein the construct is anisotropic, are described. The construct is prepared by application of an electrochemical field and a pH gradient to solutions containing collagen. In accordance with this method, collagen aligns at its isoelectric point to form anisotropic constructs. | 12-09-2010 |
| 20100303953 | SLOWLY FERMENTABLE SOLUBLE DIETARY FIBER - The embodiments described herein provide a method for improving bowel health by increasing short chain fatty acid concentration in the colon of a mammal including administering to the mammal a composition having from about 0.1 grams to about 50 grams of a treated bran product. After administration, the treated bran product results in an increased short chain fatty acid production during fermentation in the colon as compared to untreated bran fermented in the colon. | 12-02-2010 |
| 20100301209 | DISCONTINUOUS ATMOSPHERIC PRESSURE INTERFACE - A method of interfacing atmospheric pressure ion sources, including electrospray and desorption electrospray ionization sources, to mass spectrometers, for example miniature mass spectrometers, in which the ionized sample is discontinuously introduced into the mass spectrometer. Discontinuous introduction improves the match between the pumping capacity of the instrument and the volume of atmospheric pressure gas that contains the ionized sample. The reduced duty cycle of sample introduction is offset by operation of the mass spectrometer under higher performance conditions and by ion accumulation at atmospheric pressure. | 12-02-2010 |
| 20100298081 | POWER SPLIT TRANSMISSION WITH ENERGY RECOVERY - Power split drive (PSD) transmissions capable of energy recovery and suitable for use in automotive applications. Each PSD transmission includes a mechanical transmission system for mechanically transmitting mechanical power between a rotatable input shaft and a rotatable output shaft, and a hydraulic transmission system containing a fluid for hydraulically transmitting hydraulic power between the input shaft and the output shaft, and at least a third shaft operatively interconnected to one of the mechanical and hydraulic transmission systems. The hydraulic transmission system is operatively coupled by at least a first planetary gear train to the mechanical transmission system. According to the invention, the PSD further comprises means operatively associated with at least one of the mechanical and hydraulic transmission systems for storing and releasing energy within the PSD transmission, the energy storing and releasing means comprising a flywheel or an accumulator or a combination thereof. | 11-25-2010 |
| 20100295023 | FIELD EFFECT TRANSISTOR FABRICATION FROM CARBON NANOTUBES - Methods and apparatus for an electronic device such as a field effect transistor. One embodiment includes fabrication of an FET utilizing single walled carbon nanotubes as the semiconducting material. In one embodiment, the FETs are vertical arrangements of SWCNTs, and in some embodiments prepared within porous anodic alumina (PAA). Various embodiments pertain to different methods for fabricating the drains, sources, and gates. | 11-25-2010 |
| 20100286170 | (3-HYDROXY-4-AMINO-BUTAN-2-YL) -3- (2-THIAZOL-2-YL-PYRROLIDINE-1-CARBONYL) BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR TREATING - The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. | 11-11-2010 |
| 20100286145 | ISOPHTHALAMIDE DERIVATIVES INHIBITING BETA-SECRETASE ACTIVITY - The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating of Alzheimer's disease. | 11-11-2010 |
| 20100278325 | Annoying Telephone-Call Prediction and Prevention - A method for predicting whether a telephone call that is being set up will be considered annoying by the called party and, if so, for preventing it from being established. The illustrative embodiment predicts whether a telephone call will be considered annoying by the called party based on temporal characteristics of previous calls from the same caller. For example, when a called party receives an unwanted telephone solicitation, he or she will usually hang up within the first minute. If many telephone calls are made from the same caller, and all of these calls last under a minute, then it is reasonable to predict that future calls from this caller will be considered annoying. | 11-04-2010 |
| 20100273178 | Affinity selected signature peptides for protein identification and quantification - A method for protein identification in complex mixtures that utilizes affinity selection of constituent proteolytic peptide fragments unique to a protein analyte. These “signature peptides” function as analytical surrogates. Mass spectrometric analysis of the proteolyzed mixture permits identification of a protein in a complex sample without purifying the protein or obtaining its composite peptide signature. | 10-28-2010 |
| 20100249072 | PRODRUGS AND CONJUGATES OF PRENYLATION INHIBITORS - Described herein are neutral prodrugs of phosphorus-containing inhibitors of farnesyl transferase that include one or more phosphate fragments or analogs of phosphate fragments. Analogs of phosphate fragments include various linkers other than oxygen connecting the phosphate fragment to the remaining portion of the drug, such as but not limited to linkers forming phosphoramidates, phosphonates, difluorophosphonates, phosphordiamidates, and the like. | 09-30-2010 |
| 20100240137 | DERIVATIZATION-ENHANCED ANALYSIS OF AMINO ACIDS AND PEPTIDES - The present invention provides compositions and methods for enhanced detection and quantification of amino acids by derivatization. Also provided are compositions and methods for enhanced detection and quantification of peptides by derivatization. | 09-23-2010 |
| 20100226967 | IMAGING AND THERAPEUTIC METHOD USING PROGENITOR CELLS - The invention relates to a method of treating or diagnosing a disease state worsened by progenitor cells. The method utilizes a composition comprising a conjugate or complex of the general formula | 09-09-2010 |
| 20100222311 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS - Described herein are formulations of active pharmaceutical ingredients, where the active pharmaceutical ingredients or drugs are included in a solid suspension with one or more solid additives. The formulations described herein are useful for formulating any drug or active pharmaceutical ingredient, including those that have limited solubility in organic and/or aqueous solvent systems. | 09-02-2010 |
| 20100221836 | SOL-GEL MATERIALS FOR CELLULAR MODULATION - A modified sol-gel material and method of making the same is provided herein. More particularly, sol-gels disclosed herein have been modified to have one or more bioactive peptides covalently bound to the surface of the sol-gel. In one embodiment the peptide presenting sol-gels are prepared as thin film coatings and in a further embodiment the sol-gels are combined with living cells. The present disclosure is also directed to a novel one vessel reaction process for preparing the sol-gel-based peptide material. | 09-02-2010 |
| 20100211574 | Method and Apparatus for Obtaining Forensic Evidence from Personal Digital Technologies - A system and method for personal digital technology forensics. The system and method can provide for the forensic identification, preservation, acquisition, analysis, presentation, exportation, and correlation of evidence obtained personal digital technologies including that obtained from cellular phones, personal digital assistants (PDAs), and smart phones. | 08-19-2010 |
| 20100192266 | SYSTEM AND METHOD FOR IMPROVING THE PRECISION OF NANOSCALE FORCE AND DISPLACEMENT MEASUREMENTS - A self-calibrating apparatus comprises a primary device and a test structure fabricated on an integrated circuit chip. The primary device and the test structure have at least one unknown property due to a fabrication process of the integrated circuit chip. An electrical measurand sensor is configured to measure an electrical measurand of the test structure. A controller coupled to the primary device and electrical measurand sensor. The controller is configured to calculate the at least one unknown property of the test structure based on the measured electrical measurand and use the calculated at least one unknown property to calibrate the primary device. | 07-29-2010 |
| 20100179449 | MINIATURE STENT-BASED IMPLANTABLE WIRELESS MONITORING DEVICES - A system is provided for the transmission of in vivo arterial pressure, the system comprising: an a pressure sensor whereby in vivo arterial pressure data is collected; a wireless transmitter, whereby the in vivo arterial pressure data is transmitted to be received disposed externally to a patient in which the system is disposed; a stent body, the stent body having an integral antenna, and a power source, whereby power is supplied to the system. | 07-15-2010 |
| 20100163258 | SYSTEM AND METHOD FOR BLADE LEVEL CONTROL OF EARTHMOVING MACHINES - A system for automatically controlling the position and level of an earthmoving implement on an earthmoving machine. The system includes at least one hydraulic actuator adapted to raise and lower the earthmoving implement, a device for delivering a pressurized fluid to and receiving pressurized fluid from the actuator, and an electronic control circuit that includes electronic sensors for sensing the absolute orientation of the machine and the position of the actuator, and a controller for receiving outputs of the sensors, calculating an amount of the pressurized fluid that must be delivered to or received from the actuator to achieve a desired position for the earthmoving implement, and control the delivering-receiving device to deliver or receive the amount of the pressurized fluid to achieve the desired position for the earthmoving implement. | 07-01-2010 |
| 20100162885 | SYSTEM AND METHOD FOR ENABLING FLOATING OF EARTHMOVING IMPLEMENTS - A system and method for performing a floating function in an earthmoving implement of an earthmoving machine without physically connecting chambers within a hydraulic actuator that is adapted to raise and lower the earthmoving implement. The system includes a device for delivering a pressurized fluid to and receiving pressurized fluid from the actuator, a valve for compensating for differences in volume between chambers of the actuator, and an electronic control circuit that includes electronic sensors for sensing the pressures in the chambers of the actuator, and a controller for receiving outputs of the sensors. The controller calculates an amount of the pressurized fluid that, when delivered to or received from the actuator, achieves a substantially constant pressures in the chambers of the actuator and enables the earthmoving implement to float regardless of motion of the actuator. | 07-01-2010 |
| 20100162593 | DISPLACEMENT-CONTROLLED HYDRAULIC SYSTEM FOR MULTI-FUNCTION MACHINES - A displacement-controlled hydraulic system for installation on a multi-function machine, and multi-function machines equipped with the hydraulic system and having devices for propelling the machine, at least a first implement, and multiple actuators that perform multiple functions of the machine. The multiple actuators include first actuators that control the first implement and second actuators that control the propelling devices. The hydraulic system comprises multiple pumps for controlling the first actuators and optionally the second actuators, and valves that enable at least one of the pumps to sequentially control two of the multiple actuators and a corresponding two functions of the multiple functions performed thereby. None of the pumps sequentially controls the second actuators in combination with any of the first actuators. | 07-01-2010 |
| 20100143345 | EPHA2 AGONISTIC MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF - The present invention relates to methods and compositions designed for the treatment, management, or prevention of cancer, particularly, metastatic cancer. The methods of the invention comprise the administration of an effective amount of one or more antibodies that bind to and agonize EphA2, thereby increasing EphA2 phosphorylation and decreasing EphA2 levels in cells which EphA2 has been agonized. The invention also encompasses antibodies that preferentially bind an EphA2 epitope exposed on cancer cells but not non-cancer cells. The invention also provides pharmaceutical compositions comprising one or more EphA2 antibodies of the invention either alone or in combination with one or more other agents useful for cancer therapy. | 06-10-2010 |
| 20100137694 | RADIO TRANSPARENT SENSOR IMPLANT PACKAGE - A system is provided for the packaging of wireless electronics in a mammalian body, the system comprising: a package configured in a shape suitable for implantation in that body; the package being configured from a biocompatible material; and that biocompatible material having a high degree of radio wave transparency. | 06-03-2010 |
| 20100135594 | METHOD AND APPARATUS FOR DETERMINING THE STRAY-LIGHT POINT-SPREAD FUNCTION OF AN IMAGING SYSTEM - A method of determining the point-spread function (PSF) of an imaging system includes the steps of capturing image data, establishing an idealized source spot, establishing a functional form model, subtracting the captured image from the estimated image equation and determining a metric that measures the fit of the estimated image to the captured image. The functional form model may include both diffraction and aberration and stray light. The functional form model may be optimized to reduce the metric to an acceptable level. | 06-03-2010 |
| 20100134898 | NEAR FIELD SUPER LENS EMPLOYING TUNABLE NEGATIVE INDEX MATERIALS - A tunable super-lens (TSL) for nanoscale optical sensing and imaging of bio-molecules and nano-manufacturing utilizes negative-index materials (NIMs) that operate in the visible or near infrared light. The NIMs can create a lens that will perform sub-wavelength imaging, enhanced resolution imaging, or flat lens imaging. This new TSL covers two different operation scales. For short distances between the object and its image, a near-field super-lens (NFSL) can create or enhance images of objects located at distances much less than the wavelength of light. For the far-zone, negative values are necessary for both the permittivity ε a permeability μ. While well-structured periodic meta-materials, which require delicate design and precise fabrication, can be used, metal-dielectric composites are also candidates for NIMs in the optical range. The negative-refraction in the composite films can be made by using frequency-selective photomodification. | 06-03-2010 |
| 20100115936 | SYSTEM AND METHOD FOR PUMP-CONTROLLED CYLINDER CUSHIONING - A system and method for controlling the movement of an implement of an earthmoving machine. The system includes a hydraulic actuator adapted to move the implement. A variable displacement pump is coupled to the actuator for delivering a pressurized fluid to and receiving pressurized fluid from chambers within the actuator. A sensor generates an output based on the position of the actuator's piston or piston rod, and a controller controls the displacement of the variable displacement pump in response to the output of the sensor by executing an algorithm to reduce the flow rate of the fluid to and from the actuator's chambers and thereby reduce the velocity of the piston as it approaches an end of a piston stroke thereof and prevent the piston from impacting the actuator at the end of the piston stroke. | 05-13-2010 |
| 20100113610 | METHODS FOR CONTROLLING INFLAMMATORY AND IMMUNOLOGICAL DISEASES - The present invention provides methods for generating mucosal tissue homing immunosuppressive T-cells comprising treating naïve T-cells with retinoids and/or retinoid agonists. Methods are also provided for treating a mammal having an inflammatory or immunological disease by administering a therapeutically effective dose of retinoids and/or retinoid agonists. Additional methods are also provided for boosting the immune system of a mammal by inhibiting the generation of immunosuppressive T-cells by administering a therapeutically effective dose of a retinoid receptor antagonist to the mammal. | 05-06-2010 |
| 20100099755 | CHEMOTHERAPEUTIC FLAVONOIDS, AND SYNTHESES THEREOF - Substituted flavonoid compounds, and pharmaceutical formulations of flavonoid compounds are described. Also described are processes for preparing flavonid compounds, as are methods for treating cancer in mammals using the described flavonoid compounds or pharmaceutical formulations thereof. | 04-22-2010 |
| 20100093562 | METAL COATED VIRUS-BASED NANOELECTRODES AND METHOD OF ASSEMBLING OF SAME - The present invention relates to high content surface areas containing nickel and/or cobalt metallic compounds assembled on a modified Tobacco mosaic virus (TMV) template, wherein the modified TMV template is engineered to encode unique placement of cysteine residues that self-assemble onto gold patterned surfaces in a substantially aligned fashion, producing a >10 fold increase in surface area. Deposition of ionic metals onto the surface assembled virus templates produce uniform metal coatings for the fabrication of oriented high surface area materials. | 04-15-2010 |
| 20100075301 | Methods for Generation of Reporter Phages and Immobilization of Active Bacteriophages on a Polymer Surface - Novel reporter bacteriophages are provided. Provided are compositions and methods that allow bacteriophages that are used for specific detection or killing of | 03-25-2010 |
| 20100064395 | Monolithic Comb Drive System and method for Large-Deflection Multi-Dof Microtransduction - A scanning probe microscope includes a plate moveable in an x-axis direction, a y-axis direction, and a z-axis direction, and a probe tip coupled to the plate. A plurality of actuators cooperate to move the probe tip with three degrees of freedom of movement. | 03-11-2010 |
| 20100054394 | METHOD AND SYSTEM FOR IMAGE RECONSTRUCTION - A method and system for image reconstruction of data acquired by a device such as computed tomography is provided. The method and system use a multi-stage statistical iterative reconstruction techniques to provide a three dimensional representation of the scanned object. In one embodiment, the first stage uses a projection-based reconstruction technique, such as Ordered Subset (OS) to converge on a solution for low frequency portion of the image. A subsequent stage uses a voxel-based reconstruction technique, such as Iterative Coordinate Descent (ICD), to converge on a solution for high frequency portions of the image. Systems and methods for reconstructing images from incomplete or partial projection data is also provided. | 03-04-2010 |
| 20100047159 | METHOD FOR RELEASING HYDROGEN FROM AMMONIA BORANE - A method of releasing hydrogen from ammonia borane is disclosed. The method comprises heating an aqueous ammonia borane solution to between about 80-135° C. at between about 14.7 and 200 pounds per square inch absolute (psia) to release hydrogen by hydrothermolysis. | 02-25-2010 |
| 20100025221 | PROCESS FOR DISTILLATION OF MULTICOMPONENT MIXTURES INTO FIVE PRODUCT STREAMS - Novel distillation processes for reducing the heat duty requirement of petroleum crude distillation as compared to the conventional distillation process are described. These processes are also applicable for distillation of other multi-component mixtures similar to petroleum crude. | 02-04-2010 |
| 20100005547 | BACKBONE-FREE LOW TRANSGENE COPY TRANSGENIC PLANTS - Methods and compositions reduce copy number of transgenes and minimizing vector backbone sequences in plant transformation. Bacterial strains including | 01-07-2010 |
| 20100003753 | Multivalent rna nanoparticles for delivery of active agents to a cell - A polyvalent multimeric complex formed from a plurality of chimeric pRNA molecules, each carrying at least one biologically active moiety, detectable label, or other heterologous component. | 01-07-2010 |
| 20090324681 | Vascularization Enhanced Graft Constructs - A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided. | 12-31-2009 |
| 20090282728 | Crawling arthropod intercepting device and method - An intercepting device (e.g. a furniture coaster device) is placed under furniture (bed, sofa, chair. etc.), other climbable object, or the floor adjacent an object to intercept crawling arthropods and other crawling pests. The intercepting device can be used to monitor the presence of crawling arthropods and other crawling pests (such as bed bugs, ants, cockroaches, beetles, spiders, etc.), reduce pest numbers, and monitor efficacy of pest control procedures. The intercepting device includes pitfall trap surfaces that form multiple pitfall traps. | 11-19-2009 |
| 20090268840 | MULTIPLE ANTENNA COMMUNICATION SYSTEM INCLUDING ADAPTIVE UPDATING AND CHANGING OF CODEBOOKS - Communication between a base station with multiple transmission antennas and a mobile station is provided. The base station and the mobile station may recognize or estimate, respectively, a channel between the base station and the mobile station, and update a previous codebook with a new codebook based on a variation of the channel. In this instance, the mobile station may provide feedback information to the base station using the new codebook, and the base station may generate a transmission signal for the mobile station using the new codebook and the feedback information. | 10-29-2009 |
| 20090246857 | STABLE RECOMBINANT YEASTS FOR FERMENTING XYLOSE TO ETHANOL - Described are recombinant yeast which ferment xylose to ethanol and which maintain their ability to do so when cultured for numerous generations in non-selective media. The preferred yeast contain multiple copies of integrated genes encoding xylose reductase, xylitol dehydrogenase, and xylulokinase fused to promoters which are non-glucose inhibited and which do not require xylose for induction. Also described are preferred methods for integrating multiple copies of exogenous DNA into host cells by transforming cells with replicative/integrative vectors, and then replicating the cells a number of times under selective pressure to promote retention of the vector in subsequent generations. The replicated vectors thus serve to integrate multiple copies of the exogenous DNA into the host cells throughout the replication/selection phase. Thereafter the selective pressure can be removed to promote loss of the vector in subsequent generations, leaving stable integrants of the exogenous DNA. | 10-01-2009 |
| 20090219154 | Fingerprint acquisition system and method using force measurements - An apparatus and method of optimizing performance of a fingerprint sensor includes determining whether a force applied to a sensing portion of the sensor is within an optimal force range for the fingerprint sensor and capturing at least one fingerprint image with the fingerprint sensor after the applied force is in the optimal force range. | 09-03-2009 |
| 20090214848 | FABRICATION OF NANOWIRE ARRAY COMPOSITES FOR THERMOELECTRIC POWER GENERATORS AND MICROCOOLERS - Methods for fabricating a nanowire array epoxy composite with high structural integrity and low effective thermal conductivity to achieve a power conversion efficiency goal of approximately 20% and power density of about 10 | 08-27-2009 |
| 20090189616 | POLYMERIC STRUCTURES AND METHODS FOR PRODUCING AND MONITORING POLYMERIC STRUCTURES - A method for monitoring a component formed of a polymer material, and the polymer component. The component includes an electrically-conductive polymer sensing element integrally incorporated into the component. An electric potential is applied to the polymer sensing element, and an electric signal generated by the polymer sensing element is sensed in response to the polymer sensing element physically responding to a transitory or permanent distortion of the component. A signal can then be generated if the electric signal exceeds a predetermined threshold value for the component. | 07-30-2009 |
| 20090149389 | Kinase Inhibitors And Uses Thereof - The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population. | 06-11-2009 |
| 20090148952 | Materials and methods for controlling isotope effects during fractionation of analytes - Compositions and methods for controlling or eliminating isotope effects during fractionation of chemically equivalent but isotopically distinct compounds. Isotope coding agents contain heavy isotopes other than deuterium. The invention facilitates intelligent data acquisition. After sample fractionation, isotope abundance ratios are calculated using mass spectrometry, and analytes of interest are identified in real time. | 06-11-2009 |
| 20090138115 | INTELLIGENT OPTIMIZATION METHOD AND SYSTEM THEREFOR - A method and system of optimizing a complex manufacturing process performed by an apparatus on a subject to achieve at least one processing objective. The system includes a graphical user interface, a process module, and an optimization module. The process module includes a training module, an empirical relationships database, an analytical equations database, a heuristic knowledge database, and a process models database. The graphical user interface is used to input at least one processing variable and constraints for the processing objective of the complex manufacturing process. The training module generates empirical relationships from the processing variable and empirical data obtained from the complex manufacturing process. The process module generates a process model that takes into consideration heuristic knowledge of the complex manufacturing process stored in the heuristic knowledge database, empirical relationships stored in the empirical relationships database, and optionally analytical equations stored in the analytical equations database and relating to the complex manufacturing process. The optimization module employs the process model to optimize the complex manufacturing process. | 05-28-2009 |
| 20090132003 | Wireless Electrical Stimulation of Neural Injury - An apparatus for wireless electrical stimulation of a neural injury includes a first electronic implant ( | 05-21-2009 |
| 20090123511 | BIOMATERIAL DERIVED FROM VERTEBRATE LIVER TISSUE - A tissue graft composition comprising liver basement membrane is described. The graft composition can be implanted to replace or induce the repair of damaged or diseased tissues. | 05-14-2009 |
| 20090084666 | NOVEL INTEGRATED GASIFICATION - PYROLYSIS PROCESS - In at least one embodiment of the present invention, a method for producing liquid hydrocarbons from biomass is provided. The method comprises hydropyrolizing biomass with a gaseous exhaust stream formed from one of gasification and reforming of carbon containing moiety (CCM). The gaseous exhaust stream includes hydrogen (H | 04-02-2009 |
| 20090082604 | NOVEL PROCESS FOR PRODUCING LIQUID HYDROCARBON BY PYROLYSIS OF BIOMASS IN PRESENCE OF HYDROGEN FROM A CARBON-FREE ENERGY SOURCE - In at least one embodiment of the present invention, a method for producing liquid hydrocarbons from biomass is provided. The method comprises pyrolizing the biomass with hydrogen (H | 03-26-2009 |
| 20090081710 | Method for Cancer Prognosis Using Cellular Folate Vitamin Receptor Quantification - The invention relates to a method for determining a prognosis for a cancer by quantifying vitamin receptor expression on the cancer cells. The method comprises the steps of quantifying vitamin receptor expression on the cancer cells, and determining a prognosis for the cancer. The invention also relates to methods and kits for determining the presence of vitamin receptors on cancer cells to select patients that should be treated with a therapy that utilizes vitamin receptor targeting and to develop a treatment regimen for such patients. The invention further relates to kits for performing the methods. | 03-26-2009 |
| 20090069648 | INTRA-OCCULAR PRESSURE SENSOR - A system is provided for monitoring intraocular pressure, the system comprising: a sensor package configured to be disposed in the suprachoroidal space of a patient's eye; a pressure sensor; a wireless transceiver disposed within the sensor package and coupled to the pressure sensor; an external transceiver, the external receiver being wirelessly coupled to the wireless transceiver when the transceiver is disposed proximate to the patient's eye. | 03-12-2009 |
| 20090042344 | InP-Based Transistor Fabrication - Methods of forming structures that include InP-based materials, such as a transistor operating as an inversion-type, enhancement-mode device. A dielectric layer may be deposited by ALD over a semiconductor layer including In and P. A channel layer may be formed above a buffer layer having a lattice constant similar to a lattice constant of InP, the buffer layer being formed over a substrate having a lattice constant different from a lattice constant of InP. | 02-12-2009 |
| 20090030025 | TRANS-FUSED CHROMENOISOQUINOLINES SYNTHESIS AND METHODS FOR USE - Optionally substituted chromenoisoquinolines and analogs and derivatives thereof are described herein. In addition, syntheses of these compounds are described herein. In addition, uses of these compounds as dopamine receptor binding compounds are described herein. | 01-29-2009 |
| 20090022402 | Image-resolution-improvement apparatus and method - Provided is an image-resolution-improvement apparatus and method which can increase the resolution of an input image at a high magnification to thereby obtain a high-quality final image. The apparatus includes a textured-region-detection unit to detect a texture region in an input image; and a final-image-generation unit to synthesize a first intermediate image and a second intermediate image, which are obtained by applying different interpolation techniques to the texture region and a non-texture region excluding the texture region and generating a final image. | 01-22-2009 |
| 20090022226 | Method and apparatus for enhancing resolution of video image - Provided is a technology which can prevent deterioration of image quality when enhancing resolution of a predetermined key frame in a video sequence. Specifically, an apparatus to enhance resolution of a video frame is provided. The apparatus includes a frame extraction unit which extracts a key frame and one or more neighboring frames of the key frame from a video sequence; an upsampling unit which upsamples the key frame and the neighboring frames; a motion-vector search unit which calculates a motion vector of the upsampled key frame using the upsampled neighboring frames as reference frames; and a key-frame estimation unit which enhances quality of the upsampled key frame using temporal information obtained from the motion vector and spatial information in the key frame. | 01-22-2009 |
| 20090012745 | NUCLEAR DETECTION VIA A SYSTEM OF WIDELY DISTRIBUTED LOW COST DETECTORS - A radiation detection system includes many receivers to continuously receive radiation emission data from at least some of a sufficient density of dispersed detectors capable of communicating geo-positions and photon emission counts over a network; the data includes gamma intensities, time stamps, and geo-positions. A processor builds digital image data of the received radiation data for a geographic area by treating gamma-ray proton data from each dispersed detector as a pixel in a low-light image. The processor continuously executes a plurality of statistical computational analyses on the digital image data to separate detected radiation signals from random, undesired signal noise, and known signal noise or sources. The statistical computational analyses include match-filter and/or other convolution techniques. An interface reports to a user when the computational analyses result in detection of a radiation signal and reports a location of one or more of the dispersed detectors that contribute to the detection. | 01-08-2009 |
| 20090012369 | ENDOSCOPIC IMAGING DEVICE - An endoscopic imaging device for endoscopy in a body vessel is disclosed. The device comprises an annular illumination tube comprising an annular illumination fiber for illuminating a body vessel during endoscopy. The device further includes a first imaging tube comprising a first imaging fiber for gross examination and navigation through the body vessel. The first imaging fiber is disposed within the annular illumination tube. The device further comprises a second imaging tube comprising a second imaging fiber for cellular imaging. The second illumination fiber is disposed adjacent the first imaging tube and within the annular illumination tube. | 01-08-2009 |
| 20090011021 | Engineered Extracellular Matrices - The invention relates to engineered matrices comprising collagen fibrils with specific characteristics, including, but not limited to, a specific fibril area fraction (i.e., density) and/or a specific elastic or linear modulus (i.e., stiffness). The invention also relates to methods of preparation and use of the matrices. | 01-08-2009 |
| 20080317706 | Targeted Conjugates and Radiation - The invention relates to a method for enhancing an endogenous immune response-mediated elimination of a population of cancer cells in a host. The method comprises the steps of administering to the host a composition comprising an immunogen conjugated to a vitamin receptor-binding ligand selected from the group consisting of a vitamin, or an analog or a derivative thereof, and administering to the host a therapeutically effective amount of radiation wherein the amount of radiation can range from about 0.5 to about 10 Gy per dose. | 12-25-2008 |
| 20080300288 | Alkenyldiarylmethanes, Fused Analogs And Syntheses Thereof - Non-nucleoside inhibitors of HIV-1 reverse transcriptase are described. Such inhibitors may be used as part of a combination therapy to treat HIV infection. Compounds described herein exhibit antiviral potency. In addition, compounds described herein exhibit metabolic stability. Also described herein are processes for preparing Non-nucleoside inhibitors of HIV-1 reverse transcriptase. | 12-04-2008 |
| 20080261277 | pRNA chimera - A circularly permuted chimeric pRNA molecule carrying a stabilized biologically active RNA, such as a ribozyme. | 10-23-2008 |
| 20080256163 | APPARATUS AND METHOD OF GENERATING CODEBOOK FOR MULTIPLE INPUT MULTIPLE OUTPUT COMMUNICATION SYSTEM - An apparatus and method of generating a codebook. The codebook generation apparatus includes a matrix extender to generate a candidate matrix set by multiplying a base matrix and at least one diagonal matrix, wherein the at least one diagonal matrix includes elements of a constrained set as diagonal elements; and a codebook generator to generate the codebook where a minimum distance between the elements is maximized, based on the candidate matrix set. According to aspects of the present invention, it is possible to provide a precoding codebook that can reduce an amount of feedback from a terminal. | 10-16-2008 |
| 20080251975 | MOLDING PROCESSES AND TOOL THEREFOR - A molding process and apparatus suitable for use in molding processes, including rapid prototyping processes and short run production processes. The molding process and apparatus entail the use of a reconfigurable screen tool having a housing defining a manifold cavity and a plurality of substantially parallel pins, each having a head protruding from the housing and a shank protruding into the housing. The heads of the pins define a screen surface through which air is able to flow, for example, through gaps between adjacent heads or through internal passages within the pins. The process further includes axially moving the pins to configure the screen surface, preventing further axial movement of the pins relative to each other, and then drawing a vacuum within the manifold cavity and creating a vacuum at the screen surface. | 10-16-2008 |
| 20080247475 | METHOD FOR CODEBOOK DESIGN AND BEAMFORMING VECTOR SELECTION IN PER-USER UNITARY RATE CONTROL (PU2RC) SYSTEM - A base station includes a storage unit to store a codebook, wherein the codebook includes a plurality of matrices; a control unit to perform beamforming using the codebook to generate a signal; and a multi-antenna to transmit the signal. For all of the plurality of matrices, all column vectors of a same matrix of the plurality of matrices are orthogonal to each other. For all columns of the plurality of matrices, all column vectors of a same column of all of the plurality of matrices satisfy a Grassmannian line packing (GLP) criterion. | 10-09-2008 |
| 20080245140 | System and method for improving the precision of nanoscale force and displacement measurements - An apparatus and method for improving the precision of nanoscale force and/or displacement measurements using electro micro metrology (EMM). | 10-09-2008 |
| 20080242332 | DECENTRALIZED CONTROL OF FEEDBACK FOR MULTI-USER DIVERSITY - A communication apparatus includes a mobile terminal to measure a downlink channel state of a downlink between a base station and the mobile terminal, and to determine whether to transmit feedback information about the downlink channel state to the base station based on the measured downlink channel state. | 10-02-2008 |
| 20080212980 | METHODS AND SYSTEMS FOR POLARIZATION CONTROL AND POLARIZATION MODE DISPERSION COMPENSATION FOR WIDEBAND OPTICAL SIGNALS - An optical processing method includes: receiving an optical signal from an optical system, wherein the optical signal is distorted by frequency-dependent polarization effects in the optical system; spatially dispersing frequency components of the distorted optical signal on a spatial light modulator (SLM); and independently adjusting the polarization transfer matrix of multiple regions of the SLM to reduce the distortion of the optical signal. A related optical processing method includes: providing a precompensation signal indicative of frequency-dependent polarization effects in a downstream optical system; spatially dispersing frequency components of an optical signal on a spatial light modulator (SLM); and independently adjusting the polarization transfer matrix of multiple regions of the SLM to at least partially precompensate the optical signal for distortions caused by the frequency-dependent polarization effects in the downstream optical system. Another related optical processing method includes: providing a model of the frequency-dependent polarization effects; spatially dispersing frequency components of the optical signal on a spatial light modulator (SLM); and independently adjusting the polarization transfer matrix of multiple regions of the SLM based on the model to emulate the optical signal transmission. | 09-04-2008 |
