| 20090037116 | SYSTEMS, DEVICES, AND METHODS FOR ANALYZING MACROMOLECULES, BIOMOLECULES, AND THE LIKE - Systems, devices, and methods for analyzing hybridization of target molecules to probes on substrate-bound oligonucleotide, peptide, or protein arrays. In one aspect, the system includes a computer-readable memory medium and a controller. The system may further include a computer-readable memory medium including thermodynamic data configured as a data structure for use in analyzing biological samples. In some embodiments, the data structure comprises a thermodynamic data section having: thermodynamic data representative of dangling ends of two or more bases; thermodynamic data representative of unpaired single strands of two or more bases adjacent to a Watson-Crick base pairing; thermodynamic data representative of unpaired single strands of one or more bases adjacent to a non-Watson-Crick base pairing; thermodynamic data representative of tandem base pair mismatches of two or more bases; thermodynamic data representative of length-dependent terminal mismatches of nucleic acid bases; thermodynamic data representative of terminal base pair mismatches, or combinations thereof. | 02-05-2009 |
