| Pola Chemical Industries Inc. Patent applications |
| Patent application number | Title | Published |
|---|
| 20110243865 | MELANIN PRODUCTION INHIBITOR - Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C | 10-06-2011 |
| 20110021619 | EXTERNAL PREPARATION FOR SKIN CONTAINING FLAVANONE DERIVATIVE - To increase a tissue regeneration ability of a living body such as a collagens production ability of fibroblast in the dermis in a skin defect area typified by a large wrinkle or wound, a flavanone derivative such as farrerol is used as an active ingredient of an external preparation for skin. Further, to efficiently screen a substance having an excellent effect on promoting wound healing, the remodeling action of collagen fiber bundle is tested by using skin wound model. | 01-27-2011 |
| 20100172964 | VESICLE USEFUL FOR EXTERNAL PREPARATION FOR SKIN, AND EXTERNAL PREPARATION FOR SKIN COMPRISING THE VESICLE - Disclosed is a technique for allowing an active ingredient as an agent for improving or maintaining the dermal environment to reach a dermis. Specifically disclosed is a vesicle comprising the following components 1) to 3): 1) an α,ε-bis(γ-N—(C | 07-08-2010 |
| 20100137489 | ORGANIC INORGANIC COMPOSITE POWDER, METHOD OF PRODUCING THE SAME, AND COMPOSITION CONTAINING THE POWDER - The present invention provides an organic inorganic composite powder which has a specific particle shape in accordance with a washing solvent, which contains fine inorganic particles, and which easily disperses in water by: precipitating a metal salt from the reaction solvent through neutralization or reduction in the presence of a polymer or monomer dissolved in the reaction solvent; polymerizing the monomer after precipitation of the metal salt in the case where the monomer forms no composite with the metal salt during precipitation in the presence of the monomer; washing the obtained precipitate with a specific washing solvent; and drying the resultant. | 06-03-2010 |
| 20100081162 | METHOD OF EVALUATING ANTIWRINKLE SUBSTANCE AND METHOD OF ASSESSING THE SKIN - It is intended to provide a method whereby the skin conditions (for example, loss in the skin elasticity, wrinkle formation possibility, insufficient tightness in dermal collagen fiber bundles, or the like) can be exactly and conveniently assessed. It is also intended to provide a method whereby the wrinkle-improvement effect of a test substance can be exactly and conveniently evaluated. The skin conditions are assessed by using the expression amount of an adhesion factor in skin cells as an indication. The wrinkle reducing effect of a test substance is evaluated by using the expression amount of an adhesion factor in skin cells in the presence of the test substance as an indication. | 04-01-2010 |
| 20100068309 | METHOD OF EVALUATING SKIN BARRIER FUNCTION, METHOD OF SCREENING MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION USING THE EVALUATING METHOD, THE MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION, AND COSMETIC CONTAINING THE MATERIAL FOR ENHANCING SKIN BARRIER FUNCTION - A method for developing an excellent material for enhancing skin barrier function, and providing a cosmetic which is developed based on the method and has excellent ability to enhance skin barrier function is described. The method evaluates skin barrier function by the steps of 1) culturing normal human epidermal cells in wells having a semipermeable membrane with two sides, in presence and absence of a test substance; 2) adding a medium not containing metal ions to a first side of the semipermeable membrane in each well and a medium containing the metal ions to a second side of the semipermeable membrane in each well, provided that the cells are adhered to the first side of the semipermeable membrane; 3) culturing the cells; 4) measuring the concentration of the metal ions in each medium; and 5) calculating permeability of the metal ions in the epidermal cell layer based on the measured concentrations of the metal ions in each media. The test substance is effective for enhancing skin barrier function when the permeability is reduced in the medium in which the test substance is added compared to the permeability in the medium in which no test substance is added. The larger the level of reduced permeability, the higher the suitability of the test substance as a material for enhancing skin barrier function. | 03-18-2010 |
| 20100055220 | SKIN EXTERNAL PREPARATION IN THE FORM OF WATER-IN-OIL EMULSION COMPRISING CERAMIDE - A technology for delivering a ceramide across the horny layer of skin to sufficiently exert the effects of the ceramide is disclosed. Specifically, an external preparation for skin containing a ceramide delivers the ceramide across the horny layer to near the dermis when the skin preparation is applied on the skin surface. The described skin external preparation contains a ceramide, an organically modified clay mineral, a diester of N-acylglutamic acid, and a phytosterol as components in the form of water-in-oil emulsion. | 03-04-2010 |
| 20100003210 | EXTERNAL SKIN AGENT COMPRISING MODIFIED CLAY FOR PREVENTING INFLAMMATION - To provide An external skin agent that prevents onset of atopic skin inflammations and is low irritant to skin, which is characterized by including: 1) clay modified by a compound having a quaternary amino group; and 2) a polymer or copolymer that has a side chain including a structure similar to a biological component. | 01-07-2010 |
| 20090162302 | ORGANIC INORGANIC COMPOSITE POWDER, METHOD OF PRODUCING THE SAME, AND COMPOSITION CONTAINING THE POWDER - The present invention provides an organic inorganic composite powder which has a specific particle shape in accordance with to a washing solvent, which contains fine inorganic particles, and which easily disperses in water by: precipitating a metal salt dissolved in a reaction solvent from the reaction solvent through neutralization or reduction in the presence of a polymer or monomer dissolved in the reaction solvent; polymerizing the monomer after precipitation of the metal salt in the case where the monomer forms no composite with the metal salt during precipitation in the presence of the monomer; washing the obtained precipitate with a specific washing solvent; and drying the resultant. | 06-25-2009 |
| 20090075946 | NOVEL TRITERPENIC ACID DERIVATIVE AND PREPARATION FOR EXTERNAL APPLICATION FOR SKIN COMPRISING THE SAME - In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug. | 03-19-2009 |
| 20090054515 | SKIN-WHITENING COSMETIC - Disclosed are: a novel skin-whitening agent; and a skin-whitening cosmetic or quasi-drug which is highly effective for prevention/amelioration of melanopathy and is prepared using the skin-whitening agent. The cosmetic contains a compound represented by the general formula (I) and/or a salt thereof as an active ingredient. In the general formula (I), R | 02-26-2009 |
| 20080304736 | METHOD OF ESTIMATING A VISUAL EVALUATION VALUE OF SKIN BEAUTY - A method of estimating a visual evaluation value of beauty of a skin, and a device and a program for calculating a visual evaluation value of beauty of a skin are provided. Anybody can easily estimate a visual evaluation value of beauty of a skin objectively and quantitatively. A visual evaluation value of beauty of the skin is estimated by using a correlation between a visual evaluation value of beauty of the skin and a fractal dimension of a distribution of a color system signal of an image of the skin or a 3-dimensional skin surface relief value of a skin surface. | 12-11-2008 |
