| PHASERX, INC. Patent applications |
| Patent application number | Title | Published |
|---|
| 20120021514 | HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY - Compositions comprising a heterogeneous polymeric micelle and an agent (e.g., a polynucleotide) associated with the micelle are disclosed, together with methods for intracellular delivery of such agent. | 01-26-2012 |
| 20110305660 | OMEGA-FUNCTIONALIZED POLYMERS, JUNCTION-FUNCTIONALIZED BLOCK COPOLYMERS, POLYMER BIOCONJUGATES, AND RADICAL CHAIN EXTENSION POLYMERIZATION - Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective co-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization. | 12-15-2011 |
| 20110286957 | MULTIBLOCK COPOLYMERS - Provided herein are multiblock copolymers, as well as micelles and therapeutic compositions thereof. | 11-24-2011 |
| 20110281934 | MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS - Provided herein are micelles comprising a plurality of copolymers. In certain instances, micelles provided herein are pH sensitive particles. | 11-17-2011 |
| 20110281354 | BISPECIFIC INTRACELLULAR DELIVERY VEHICLES - A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target. | 11-17-2011 |
| 20110143435 | POLYMERIC CARRIER - Provided herein are polymeric carriers suitable for the delivery of polynucleotides (e.g. oligonucleotides) and/or other therapeutic agents into a living cell. | 06-16-2011 |
| 20110143434 | DIBLOCK COPOLYMERS AND POLYNUCLEOTIDE COMPLEXES THEREOF FOR DELIVERY INTO CELLS - Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one unit with a group that is anionic at about physiologic pH. The described copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the copolymer is endosomolytic. | 06-16-2011 |
| 20110142951 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS - Composition comprising a polymeric micelle and an associated polynucleotide. | 06-16-2011 |
| 20110129921 | TARGETED POLYMER BIOCONJUGATES - Polymer bioconjugate having a RNAi agent covalently coupled to the alpha or omega end of a pH-dependent membrane-destabilizing polymer. | 06-02-2011 |
| 20110123636 | MICELLIC ASSEMBLIES - Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instances, micellic assemblies provided herein are pH sensitive particles. | 05-26-2011 |
