Pharming Intellectual Property B.V. Patent applications |
Patent application number | Title | Published |
20140373786 | MILKING DEVICE - A milking device includes a vessel and cover plate. The vessel and the cover plate form a sealed volume that is internally divided into a collecting chamber, a vacuum chamber and an air intake chamber. The collecting chamber is arranged between the vacuum chamber and the air intake chamber. The vessel has a first internal wall that separates the collecting chamber from the air intake chamber, with a first passage between the collecting chamber and the air intake chamber arranged at the first internal wall. The vessel has a second internal wall that separates the collecting chamber from the vacuum chamber, with a second passage between the collecting chamber and the vacuum chamber arranged at the second internal wall. | 12-25-2014 |
20130244941 | Use Of C1 Inhibitor For The Prevention Of Ischemia-Reperfusion Injury - The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke. | 09-19-2013 |
20130053546 | Use of Anticoagulants in the Production of Recombinant Proteins in the Milk of Transgenic Animals - The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin. | 02-28-2013 |
20120088728 | USE OF C1 INHIBITOR FOR THE PREVENTION OF ISCHEMIA-REPERFUSION INJURY - The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke. | 04-12-2012 |
20110263503 | TREATMENT OF BLEEDING WITH LOW HALF-LIFE FIBRINOGEN - The invention provides low-half life fibrinogen as a result of recombinant expression or enzymatic and chemical removal. The low-half life fibrinogen is useful in treating or effecting prophylaxis of bleeding particularly in situations of an acute nature in which a high initial dose and rapid decline to normal or below normal levels is desirable. | 10-27-2011 |
20100305039 | Production of collagen in the milk of transgenic mammals - The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided. | 12-02-2010 |
20080305993 | Use of C1 Inhibitor for the Prevention of Ischemia-Reperfusion Injury - The present invention relates to the therapeutic and prophylactic use of C1 inhibitor for preventing, reducing and treating ischemia and reperfusion injury. The C1 inhibitor of the present invention is still therapeutically effective when administered after an ischemic period and reperfusion and therefore particularly useful for unforeseen occurrences of ischemic reperfusion such as e.g. a stroke. | 12-11-2008 |