| OTSUKA CHEMICAL CO., LTD. Patent applications |
| Patent application number | Title | Published |
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| 20120121496 | METHOD FOR STORING A HYDRAZINE RESIN - A hydrazine-fixing group such as a ketone group, a formyl group, a chlormethyl group or an amide group, which is capable of releasably fixing hydrazine, is introduced into a side chain of a synthetic resin, and hydrazine is fixed to the hydrazine-fixing group. Since a hydrazine storage resin of the present invention has a hydrazine-releasable group capable of releasing hydrazine, it is able to store hydrazine stably. In addition, hydrazine can be supplied by releasing hydrazine from the hydrazine-releasable group. Consequently, the hydrazine storage resin can be widely used in various industrial fields requiring supply of hydrazine. | 05-17-2012 |
| 20120114595 | SUGAR CHAIN-ADDED AILIM EXTRACELLULAR DOMAIN AND METHOD FOR PRODUCING SAME - Disclosed is a synthetic AILIM extracellular domain which has high ligand-binding ability and a quality sufficient for a pharmaceutical product. Also disclosed is a method for synthesizing the synthetic AILIM extracellular domain. Specifically disclosed is a sugar chaim-added AILIM extracellular domain wherein a sugar chain is bound at a position corresponding to the 69-position of the amino acid sequence of human AILIM extracellular domain, said amino acid sequence being depicted in SEQ ID NO: 7, and no sugar chain is added at positions corresponding to the 3-position and the 90-position of the amino acid sequence. | 05-10-2012 |
| 20120047586 | POLYPEPTIDE HAVING ENHANCED EFFECTOR FUNCTION - Disclosed is a polypeptide having an enhanced effector function. Specifically disclosed are: a polypeptide having a modified Fc region; a nucleic acid encoding the polypeptide; a vector carrying the nucleic acid; a host cell or a host organism harboring the vector; a pharmaceutical composition comprising the polypeptide; a method for producing the polypeptide; a method for enhancing the effector function of an antibody; and a method for producing a cell capable of producing an antibody having a high effector function. | 02-23-2012 |
| 20120035345 | PROCESS FOR PREPARING GLYCOPEPTIDES HAVING ASPARAGINE-LINKED OLIGOSACCHARIDES, AND THE GLYCOPEPTIDES - Glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain obtained by:
| 02-09-2012 |
| 20110313136 | IgG-Fc FRAGMENT AND PROCESS FOR PRODUCING THE SAME - A full-length IgG-Fc fragment having a substantially homogeneous sugar chain added thereto, and a process for producing the full-length IgG-Fc fragment. Specifically, an IgG-Fc fragment has a sugar chain added thereto, in which the sugar chain is added to the same position as that in a naturally occurring IgG-Fc fragment, any one amino acid residue selected from 1st to 30th amino acid residues from the sugar chain-added amino acid residue on the N-terminal side of the sugar chain-added amino acid residue is substituted by a Cys residue and at least one Met reside is substituted by an amino acid reside other than a Met residue. | 12-22-2011 |
| 20110306106 | HIGH EXPRESSION PROMOTER AND METHOD FOR PRODUCING GENE PRODUCT USING SAME - Disclosed is a promoter which enables the expression of a gene product in a large quantity in | 12-15-2011 |
| 20110281819 | LOW-MOLECULAR POLYSULFATED HYALURONIC ACID DERIVATIVE AND MEDICINE CONTAINING SAME - A low-molecular-weight polysulfated hyaluronic acid derivative useful for prevention and/or treatment of an allergic disease. An agent for prevention and/or treatment of an allergic disease selected from pollinosis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, and asthma, represented by the following general formula (IA) or (IB); | 11-17-2011 |
| 20110262945 | GLYCOPROTEIN PRODUCTION METHOD AND SCREENING METHOD - A method for producing a glycoprotein, which is uniform in terms of functions derived from a sugar chain (e.g., a blood half-life) and physiological activities, i.e., a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure and the higher-order structure; specifically, a method for producing a glycoprotein, which is uniform in terms of the amino acid sequence, the sugar chain structure, and the higher-order structure, includes the following steps (a) to (c): (a) folding a glycoprotein, which is uniform in terms of the amino acid sequence and the sugar chain structure; (b) fractionating the folded glycoprotein by column chromatography; and (c) collecting a fraction having a specified activity. | 10-27-2011 |
| 20110224351 | METHOD FOR PRODUCING GRAFT COPOLYMER, GRAFT COPOLYMER OBTAINED BY THE METHOD, RUBBER COMPOSITION CONTAINING THE GRAFT COPOLYMER, AND TIRE - Provided are a method of producing a graft copolymer, the method involving subjecting a radically polymerizable monomer to living radical graft polymerization with a rubber component formed of a natural rubber and/or a synthetic diene-based rubber in an aqueous medium in the presence of a polymerization control agent, a rubber composition containing the graft copolymer obtained by the method, and a tire obtained by using the rubber composition in any one of its tire members. Further provided are a method of efficiently producing a graft copolymer, the method involving subjecting a radically polymerizable monomer, in particular, a functional group-containing radically polymerizable monomer to living radical graft polymerization with the natural rubber and/or the synthetic diene-based rubber, a rubber composition containing the graft copolymer obtained by the method and excellent in, for example, low heat generating property, wear resistance, and fracture characteristic, and a tire obtained by using the rubber composition in any one of its tire members and having the above-mentioned properties. | 09-15-2011 |
| 20110218171 | TREHALOSE COMPOUND, METHOD FOR PRODUCING SAME, AND PHARMACEUTICAL PRODUCT CONTAINING THE COMPOUND - A trehalose compound having high immunopotentiating activity and low toxicity is represented by formula (1). (In the formula, X and X′ each represents a phenyl, a naphthyl, R | 09-08-2011 |
| 20110195897 | GLYCOSYLATED GLP-1 PEPTIDE - Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers. | 08-11-2011 |
| 20110172392 | METHOD FOR PRODUCING PEPTIDE - The present invention provides a method for producing a peptide, characterized in that it comprises converting an —SH group of a peptide comprising an amino acid residue having the —SH group to an —OH group, wherein said method comprises the following steps (a) to (c): (a) allowing an —SH group in a peptide to react with a methylating agent to convert the —SH group to an —SMe group; (b) allowing the —SMe group obtained in the step (a) to react with a cyanizing agent to produce a reaction intermediate; and (c) converting the reaction intermediate obtained in the step (b) to a peptide comprising an amino acid residue having an —OH group under more basic conditions than the conditions in the step (b). | 07-14-2011 |
| 20110052906 | POROUS ALUMINUM TITANATE, SINTERED BODY OF THE SAME, AND METHOD FOR PRODUCING THE SAME - To obtain novel porous aluminum titanate in which aluminum titanate itself is porous, a sintered body of the porous aluminum titanate and a method for producing the porous aluminum titanate. Porous aluminum titanate is composed of porous particles having a form in which a plurality of particles of amoeba-like shape having a plurality of projections extending in random directions are fused together. For example, its pore volume within the pore diameter range of 0.0036 to 10 μm in a pore size distribution as measured by a mercury porosimeter is 0.05 ml/g or more. | 03-03-2011 |
| 20110038785 | METHOD FOR MANUFACTURING CARBON NANOTUBE - To efficiently and easily manufacture carbon nanotubes oriented in one direction. A method for manufacturing carbon nanotubes is characterized by including the steps of: bringing crystalline metal oxide particles into contact with a solution containing metal ions serving as a catalyst for forming carbon nanotubes, thereby attaching the catalyst to the surfaces of the metal oxide particles; subjecting the surfaces of the metal oxide particles to which the catalyst is attached to a CVD method or a combustion method, thereby forming carbon nanotubes on the surface of each of the metal oxide particles and resulting in producing metal oxide particles each supporting carbon nanotubes grown substantially perpendicularly to the surface of the metal oxide particle and in parallel with each other; and removing metal oxide particles from the metal oxide particles supporting carbon nanotubes. | 02-17-2011 |
| 20100306864 | POLYPEPTIDE HAVING ENHANCED EFFECTOR FUNCTION - Disclosed is a polypeptide having an enhanced effector function. Specifically disclosed are: a polypeptide having a modified Fc region; a nucleic acid encoding the polypeptide; a vector carrying the nucleic acid; a host cell or a host organism harboring the vector; a pharmaceutical composition comprising the polypeptide; a method for producing the polypeptide; a method for enhancing the effector function of an antibody; and a method for producing a cell capable of producing an antibody having a high effector function. | 12-02-2010 |
| 20100261920 | AMIDE COMPOUND AND BACTERIAL DISEASE CONTROL AGENT FOR AGRICULTURAL AND HORTICULTURAL USE - The present invention provides an amide compound having antibacterial activity, and a bacterial infection control agent for agricultural and horticultural use that contains the amide compound. The novel amide compound of the present invention is represented by General Formula (1): | 10-14-2010 |
| 20100249057 | TREHALOSE COMPOUND AND PHARMACEUTICAL COMPRISING THE COMPOUND - The object of the present invention is to provide a novel trehalose compound having a high affinity for an adenosine A3 receptor. The trehalose compound of the present invention is represented by General Formula (1): | 09-30-2010 |
| 20100137582 | N-PYRIDYLPIPERIDINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND PEST CONTROL AGENT - The N-pyridylpiperidine compound of the invention is represented by Formula (1) | 06-03-2010 |
| 20100113769 | METHOD FOR PRODUCING 6-HYDROXYETHYLPENAM COMPOUND - The present invention provides a method by which a 6-hydroxyethyl penam compound represented by General Formula (2) below can be produced with a high selectivity: | 05-06-2010 |
| 20100105931 | BIS(TETRAHYDROFURAN) COMPOUND, METHOD FOR PRODUCTION OF THE COMPOUND, AND USE OF THE COMPOUND - The present invention provides a new bis(tetrahydrofuran) compound having an excellent neurotrophic factor activity-enhancing effect, and a process for producing the same. The bis(tetrahydrofuran) compound of the present invention is represented by formula (1): | 04-29-2010 |
| 20100099881 | SPHINGOSINE COMPOUND, METHOD FOR PRODUCING THE SAME, AND SPHINGOMYELINASE INHIBITOR - An object of the invention is to provide a novel sphingosine compound with an inhibitory activity against sphingomyelinase, and a method for producing the sphingosine compound. | 04-22-2010 |
| 20100093993 | TREHALOSE COMPOUND, PROCESS FOR PRODUCTION OF THE COMPOUND, AND IMMUNO-STIMULATIVE AGENT COMPRISING THE COMPOUND - An object of the present invention is to provide a novel trehalose compound that exhibits excellent immunostimulating activity and that can be supplied in a large quantity in an industrial scale, and a method for producing the trehalose compound, wherein the trehalose compound of the present invention exhibits excellent immunostimulating activity, and is represented by general formula (1) below: | 04-15-2010 |
| 20090318662 | Hydrazine storage resin - A hydrazine-fixing group such as a ketone group, a formyl group, a chlormethyl group or an amide group, which is capable of releasably fixing hydrazine, is introduced into a side chain of a synthetic resin, and hydrazine is fixed to the hydrazine-fixing group. Since a hydrazine storage resin of the present invention has a hydrazine-releasable group capable of releasing hydrazine, it is able to store hydrazine stably. In addition, hydrazine can be supplied by releasing hydrazine from the hydrazine-releasable group. Consequently, the hydrazine storage resin can be widely used in various industrial fields requiring supply of hydrazine. | 12-24-2009 |
| 20090317670 | Hydrazine supply device, fuel cell system utilizing the same, vehicle carrying the fuel cell system, and method of supplying hydrazine - Hydrazine supply device ( | 12-24-2009 |
| 20090299008 | Organic antimony compound, process for producing the same, living radical polymerization initiator, process for producing polymer using the same, and polymer - An organoantimony compound represented by the formula (1), processes for producing polymers with use of the compound, and polymers | 12-03-2009 |
| 20090215100 | Process for producing sugar chain derivative, structure analysis method, and sugar chain derivative - A process for preparing an oligosaccharide derivative from an oligosaccharide mixture, the process being characterized in that the process comprises the steps of (a) introducing a lipophilic group into oligosaccharides of the mixture to obtain a mixture of oligosaccharide derivatives, and (b) treating the oligosaccharide derivative mixture by serotonin affinity column chromatography. | 08-27-2009 |
| 20090159847 | Resin Composition And Flexible Printed Circuit Board - A resin composition characterized as containing (A) a synthetic resin having a melting temperature of 300° C. or above and (B) a platy inorganic filler incorporated in the resin and having the following properties;
| 06-25-2009 |
| 20090137780 | METHOD FOR PRODUCTION OF PEPTIDE THIOESTER COMPOUND - The present invention provides a process for producing a peptide thioester compound, characterized by comprising: (A) forming a peptide by a solid-phase synthesis method using a resin modified with a linker represented by the formula (1) as a solid phase; (B) cleaving a bond between the solid phase and the peptide with at least one acid selected from dilute hydrochloric acid, dilute sulfuric acid, formic acid, and acetic acid to produce a peptide having a carboxyl group at the C-terminus; and (C) reacting a thiol compound with the peptide at −100 to 0° C. in the presence of a condensing agent in a solvent: (1) wherein R | 05-28-2009 |
| 20090111739 | SUGAR CHAIN ADDED GLP-1 PEPTIDE - The present invention relates to an oligosaccharide chain added GLP-1 peptide that has higher stability in blood than that of GLP-1 and, preferably, exhibits higher activity of controlling blood-sugar levels than that of GLP-1. The present invention relates to an oligosaccharide chain added GLP-1 peptide having GLP-1 activity, wherein at least one amino acid is substituted with an oligosaccharide chain added amino acid, in: (a) GLP-1; (b) a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or (c) a GLP-1 analog. | 04-30-2009 |
| 20080249222 | Potassium titanate, method for manufacturing the same, friction material and resin composition - Potassium titanate is obtained which has a novel configuration, exhibits excellent wear resistance when incorporated in a friction material and shows an excellent reinforcement performance when incorporated in a resin composition. A manufacturing method of the potassium titanate, a friction material using the potassium titanate and a resin composition using the potassium titanate are also obtained. The potassium titanate is represented by K | 10-09-2008 |
