| OSLO UNIVERSITETSSYKEHUS HF Patent applications |
| Patent application number | Title | Published |
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| 20120301434 | ANTIBACTERIAL POLYPEPTIDES AND USE THEREOF - The present invention discloses polypeptides with antibacterial properties and use said polypeptides and/or polynucleotides encoding said polypeptides in the preparation of medicament for the treatment of infectious diseases. The inventors also provide vectors encoding and adapted for expression of the polypeptides and polynucleotides of the invention. The vectors may be used in the preparation of a medicament for the treatment of bacterial infections. Further, the vector of the invention may be used to reduce the load of bacteria in food and/or feed. | 11-29-2012 |
| 20120172242 | CANCER SPECIFIC TRANSCRIPT VARIANTS - The present inventors here present a novel strategy for identification of RNA transcript variants and demonstrate that these can be correlated to disease states in mammals such as cancer. In particular, the transcript variants show prevalence and specificity to cancer, and thus also show clinical applicability in e.g. cancer diagnostics and prognostics, treatment and therapeutics. The present inventors have identified RNA transcript variants of VNN1 that can be used as biomarkers. The RNA transcript variant may also be used as biomarkers for diagnosing, prognosing, and/or monitoring a cancer. | 07-05-2012 |
| 20110257519 | ESTIMATING AND CORRECTING FOR CONTRAST AGENT EXTRAVASATION IN TISSUE PERFUSION IMAGING - The invention provides a method, an image analysis software product, and a system for medical imaging analysis for estimating contrast agent extravasation in contrast agent based perfusion imaging such as MRI dynamic contrast enhanced (DCE) imaging, and in particular correction, compensation, or visualization of extravascular leakage of contrast agent in tumors. According to the invention, the effect of extravasation is directly manifested in the tail part of an observed, apparent residue function, R′(t), obtained directly by de-convoluting the expression C(t)=R′(t) | 10-20-2011 |
| 20110170759 | VESSEL SEGMENTATION IN DCE MR IMAGING - The invention relates to segmenting blood vessels in perfusion MR images, more particularly, the invention relates to automated vessel removal in identified tumor regions prior to tumor grading. Pixels from a perfusion related map from dynamic contrast enhancement (DCE) MR images are clustered into arterial pixels and venous pixels by e.g. a k-means class cluster analysis. The analysis applies parameters representing the degree to which the tissue entirely consists of blood (such as relative blood volume (rBV), peak enhancement (ΔR | 07-14-2011 |
| 20110046488 | AUTOMATED MONITORING OF MYOCARDIAL FUNCTION BY ULTRASONIC TRANSDUCERS POSITIONED ON THE HEART - The invention relates to a method and a post-operative care unit for analysing and quantifying an ultrasound tissue Doppler imaging (TDI) signal from a transducer fastened on the myocardium to obtain a parameter indicating regional cardiac ischaemia or correlates with global hypokinetic heart function. This has the advantage over manually operated probes that it can be automated and used continuously over long time. According to the method, a TDI signal trace corresponding to at least one of tissue velocity, strain or strain rate is extracted and correlated with an electrocardiogram to define subsections within a cardiac cycle in the extracted trace corresponding to the early systolic phase and the post-systolic phase. Then, a velocity, strain or strain rate is read in at least the post-systolic phase of the extracted trace, and a parameter which is a function of one of these readings and which indicates ischaemia or global hypokinetic function is generated. | 02-24-2011 |
| 20100279890 | FUSION GENE MICROARRAY - The present invention relates to a microarray comprising a chimeric probe for an intergenic exon-to-exon junction of a fusion gene and at least two intragenic probes for a fusion gene partner of the fusion gene. The invention further relates to a method of detecting a fusion gene and a kit suitable for detecting fusion genes. | 11-04-2010 |
| 20100062440 | MARKERS FOR CANCER - The present invention relates to novel markers for hypermethylation of gene promoters in cancers. In particular the present invention relates to a method of determining whether a tumour is developing in the aero-digestive system, or whether a subject is relapsing after treatment of such a tumour. The method comprises determining the methylation level, the number of methylated CpG sites or the methylation state of CpG sites in a nucleic acid sequence in the promoter region, first exon or intron, of one or more genes selected from the group consisting of CNRIP1, MAL, FBN1, SPG20, SNCA, and INA. The method further relates to a diagnostic kit for detecting tumours in the aero-digestive tract. | 03-11-2010 |
