| Oriental Yeast Co., LTD. Patent applications |
| Patent application number | Title | Published |
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| 20110195902 | Fusion Protein Composed of Matrix Metalloproteinase-2 Inhibitor Peptide Derived From Amyloid-B Precursor Protein and Tissue Inhibitor of Metalloproteinase-2 - The present invention provides an agent capable of inhibiting MMP-2 specifically. Disclosed is a fusion molecule composed of a β-amyloid precursor protein molecule-derived domain having an activity of selectively inhibiting matrix metalloproteinase-2 and a tissue inhibitor of metalloproteinase capable of binding to latent matrix metalloproteinase. Also disclosed are a pharmaceutical composition, a cancer metastasis and/or angiogenesis inhibitor, a therapeutic and/or prophylactic for cardiovascular diseases, and a matrix metal loproteinase-2 inhibitor, each of which comprises the fusion molecule. | 08-11-2011 |
| 20110154514 | Polynucleotide used for releasing recombinant protein to the outside of eukaryotic cell - This invention provides a method for efficiently producing a recombinant protein by allowing the recombinant protein to express in a eukaryotic cell and releasing the expressed recombinant protein to the outside of the cell. The invention provides a polynucleotide used for producing a recombinant protein in a host cell comprising a polynucleotide encoding a glycosylation sequence comprising a transitional endoplasmic reticulum signal sequence and the sequence represented by: Asn-X-(Thr/Ser) (wherein X is an amino acid other than proline) and a polynucleotide encoding a target protein, which would not be efficiently released to the outside of the cell even when a transitional endoplasmic reticulum signal sequence is fused. The polynucleotide releases the target protein to the outside of the host cell via sugar chain modification. | 06-23-2011 |
| 20110117645 | METHOD FOR PROLIFERATION OF PLURIPOTENT STEM CELLS - For efficient proliferation of pluripotent stem cells in a system free from any animal-derived material such as feeder cells or serum, the present invention provides a method for proliferation of pluripotent stem cells, which comprises culturing the pluripotent stem cells in a medium free from both feeder cells and serum in a system containing laminin-5. | 05-19-2011 |
| 20100310721 | YEAST HAVING IMMUNOPOTENTIATING CAPABILITY AND FOOD OR FEED - A yeast including a cell wall having a low mannan content, wherein the yeast has an immunopotentiating capability, and is able to grow in a YPD liquid medium with an osmotic pressure of 300 mOsm, and wherein, when a part of a pre-culture of the yeast grown in a YPDS liquid medium is added to the YPD liquid medium so that OD | 12-09-2010 |
| 20100260680 | NOVEL BONE MASS INCREASING AGENT - The present invention provides an osteogenesis enhancer comprising a molecule capable of acting on RANKL that enhances differentiation, proliferation, maturation, or calcification of osteoblasts or cells capable of differentiating into osteoblasts. A pharmaceutical composition for treatment or prevention of bone metabolism diseases associated with osteopenia, which comprising, as an active ingredient, a compound that acts on RANKL located on osteoblasts or cells capable of differentiating into osteoblasts and promotes differentiation, proliferation, maturation, or calcification of osteoblasts or cells capable of differentiating into osteoblasts is provided. | 10-14-2010 |
| 20100209566 | METHOD OF SEPARATING AND DISTINGUISHING WALNUT FROM PECAN NUT - [Object] To newly develop a method whereby walnut can be simply, rapidly and accurately separated and distinguished from pecan nut. | 08-19-2010 |
| 20100105612 | AGENT CONTAINING FUSED PROTEIN OF SOLUBLE RANKL WITH EPITOPE TAG - The present invention provides a reagent containing a fused protein of RANKL with an epitope tag that has improved effects of differentiating and activating osteoclasts and improved preservation stability compared with the case of using RANKL alone, and an agent for differentiating and activating osteoclasts that can be used in vitro or in vivo, containing, as an active ingredient, a fused protein of soluble RANKL with an epitope tag peptide. | 04-29-2010 |
| 20100086939 | DETERMINATION METHOD FOR ALLERGIC DISEASE - It is to provide a method for determining allergic diseases with a high sensitivity and accuracy which enables multilateral and global analysis with a minute amount of sample, even using body fluid other than blood such as saliva, nasal discharge and tears as a sample, particularly by suppressing nonspecific reaction as much as possible. A chemically modified diamond/DLC (Diamond-like Carbon) chip is activated with a reacting reagent, a coupling reaction with a peptide comprising allergen or allergen epitope is conducted, and a sample such as saliva, tears, and nasal discharge which has undergone pressure filtration with a low protein-adsorbing filter, is contacted with an allergen determination chip to which washing and blocking operations have been performed on unreacted active groups, and an allergen recognizing antibody in the sample captured by the allergen determination chip is detected by immunoassay using a labeled secondary antibody, wherein a glycine-containing solution is used for a washing solution and/or blocking solution used in the washing and blocking operations, is used. | 04-08-2010 |
| 20100086489 | OSTEOPENIA ANIMAL MODEL - The present invention provides a method for producing an osteopenia animal model by RANKL administration and an osteopenia animal model. | 04-08-2010 |
| 20090275045 | METHOD FOR DETECTING MAMMARY CANCER CELLS - The present invention provides a novel method for detecting mammary cancer cells which uses, as an index, an expression level of a specific gene in human mammary cancer tissue (or cells). The method is characterized by including (1) measuring an expression level of a gene having a specific nucleotide sequence in human mammary cancer tissue (or cells), (2) measuring an expression level of the gene in human normal mammary gland tissue (or cells), and (3) detecting mammary cancer cells on the basis of the difference between measurement values obtained in (1) and (2). | 11-05-2009 |
| 20090053202 | Peptide fragment of LYVE-1 and antibody against the same - It is intended to provide a specific peptide fragment of LYVE-1 which can serve as an epitope of a lymphatic vessel-specific antibody, and an antibody recognizing the above peptide fragment. A peptide fragment comprising an amino acid sequence:
| 02-26-2009 |
| 20090011423 | GENES FOR PROGNOSIS OF CANCER - To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes between metastatic breast cancer tissue (or cell) and non-metastatic breast cancer tissue (or cell). The method involves ( | 01-08-2009 |
