ONCOLYS BIOPHARMA, INC.
|ONCOLYS BIOPHARMA, INC. Patent applications|
|Patent application number||Title||Published|
|20110117644||DR5 gene promoter and SIAH-1 gene promoter - The inventors discovered for the first time the nucleotide sequence of the human DR5 gene promoter, the nucleotide sequence of the human Siah-1 gene promoter and what appear to be the core promoter regions thereof. The present invention further provides a screening method for substances which regulate promoter activity, comprising a step of bringing a test substance into contact with cells holding a vector which comprises this DNA together with a reporter gene ligated expressibly to this DNA, and a step of detecting changes in the expressed amount of the reporter gene due to contact with the test substance. This screening method is a method of very efficiently selecting anti-cancer drugs and the like.||05-19-2011|
|20110111480||Telomelysin/GFP-expressing recombinant virus - The present invention provides a reagent for cancer cell detection or cancer diagnosis. The present invention relates to a reagent for cancer cell detection, comprising a recombinant virus where a replication cassette comprising a promoter from human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order is integrated in E1 region of the viral genome and a labeling cassette comprising a gene encoding a labeling protein and a promoter capable of regulating the expression of the gene encoding the labeling protein is integrated in E3 region of the viral genome.||05-12-2011|
|20110044949||ONCOLYTIC VIRUS REPLICATING SELECTIVELY IN TUMOR CELLS - By using a virus having a gene sequence comprising a telomerase promoter and an E1 gene (preferably a sequence comprising E1A gene, IRES sequence and E1B gene) or by using an anticancer agent comprising the virus, the virus replicates in cancer cells to thereby produce an efficient anticancer effect.||02-24-2011|
|20100280235||METHOD FOR PRODUCING 4'ETHYNYL d4T - Disclosed is a method for mass-producing 4′-ethynyl d4T (4′-ethynyl-2′,3′-didehydro-3′-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4′-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.||11-04-2010|
|20100150884||Anticancer Agent to Be Combined with Telomelysin - The present invention relates to providing a pharmaceutical composition with a still more enhanced anticancer activity. Specifically, the present invention relates to a pharmaceutical composition for combination therapy for tumors, comprising a recombinant virus comprising a polynucleotide containing a promoter for human telomerase, an E1A gene, an IRES sequence and an E1B gene in this order, and a substance having an antitumor effect.||06-17-2010|
|20100130075||Female Electrical Contact Comprising Spring Contact Plates - The invention relates to a female electrical contact including a housing which is cut and folded from a metal strip and which includes at least one contact plate which extends along the longitudinal axis (A) of the housing and which is equipped with a section that is in contact with a complementary contact pin. According to the invention, the contact plate includes part for connecting to the housing and a free end. The invention also includes a spring element which is cut from the extension of the contact plate prior to folding, such as to form a counter plate after folding. The spring element and the plate are provided, for example, on either side of the above-mentioned connection part.||05-27-2010|
|20090181931||ANTIVIRAL ACTIVITY OF CIDOFOVIR AGAINST ONCOLYTIC VIRUSES - The present invention relates to pyrimidine compounds and their use as pharmacologically active agents capable of suppressing and inhibiting viruses (e.g., oncolytic viruses). The subject compounds and compositions are particularly useful in treating and suppressing human oncolytic adenovirus infection.||07-16-2009|
Patent applications by ONCOLYS BIOPHARMA, INC.