OHMx Corporation Patent applications |
Patent application number | Title | Published |
20160097082 | PROSTATE SPECIFIC ANTIGEN PROTEOLYTIC ACTIVITY FOR CLINICAL USE - Methods for predicting the outcome of and monitoring prostate cancer patients using prostate specific antigen (PSA) proteolytic activity (PPA) in combination with other molecular biomarkers or other parameters are described. Methods of determining sets of parameters for use in predicting the outcome of and monitoring of prostate cancer patients are also described. | 04-07-2016 |
20150323484 | BIOELECTRONIC BINDING ASSAY USING PEAK PROFILING - In one aspect, a method for detection of a target in a sample based on the change of electrochemical cyclic voltammetry peak profile is provided. The method may involve at least two or more electroactive moieties (EAMs) comprising a transitional metal complex and an anchor group. Said transitional metal complex may be capable of reversibly or semi-reversibly transferring one or more electrons. Said anchor group may allow said EAMs to covalently attach to a solid support, forming a self-assembled monolayer (SAM) on the surface. At least one EAM may further comprises a capture ligand that can be recognized and bound by a target or a surrogate target. When a sample is introduced to an EAM, the interaction between said capture ligand and said target or surrogate target may lead to change of the properties of the SAM containing all EAMs involved. Said change can be detected by an electrochemical detection system. | 11-12-2015 |
20150198552 | NOVEL CHEMISTRY USED IN BIOSENSORS - The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. | 07-16-2015 |
20150192538 | NOVEL CHEMISTRY USED IN BIOSENSORS - The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes. | 07-09-2015 |
20140342383 | ELECTROCHEMICAL ASSAY FOR THE DETECTION OF ENZYMES - The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process. | 11-20-2014 |
20140322740 | PSA PEPTIDASE ACTIVITY (PPA) AS A PROSTATE CANCER BIOMARKER - The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples. | 10-30-2014 |
20140311922 | NOVEL CHEMISTRY USED IN BIOSENSORS - The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. | 10-23-2014 |
20140134658 | PSA ENZYMATIC ACTIVITY: A NEW BIOMARKER FOR ASSESSING PROSTATE CANCER AGGRESSIVENESS - The disclosure provides for methods to determine prognosis, aggressiveness, and progression of prostate cancer with the ability to differentiate between aggressive and non-aggressive prostate cancer. The method utilizes the differential enzymatic activity in patient samples, for example of enzymatically active prostate specific antigen (PSA) activity, in order to determine the aggressiveness and prognosis of prostate cancer, and monitor the progression of prostate cancer therapy. The invention also encompasses assay platforms (e.g., optical or electrochemical) that specifically detect PSA-triggered peptide cleavage events. | 05-15-2014 |
20130236909 | Enzyme Triggered Redox Altering Chemical Elimination (E-Trace) Immunoassay - The present invention is directed to electronic methods of detecting target analytes such that upon binding of the target analyte a shift in electrochemical potential is seen. This assay relies on the use of an electroactive moiety (“EAM”) that is attached to an electrode and comprises a self-immolative moiety, whose presence gives the EAM a first E0, and whose absence, upon irreversible cleavage gives the EAM a second E0. This difference is detected, and if such change occurs, it is an indication of the presence of a target analyte. | 09-12-2013 |
20130112572 | NOVEL CHEMISTRY USED IN BIOSENSORS - The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes. | 05-09-2013 |
20130098777 | Single, Direct Detection Of Hemoglobin A1C Percentage Using Enzyme Triggered Redox Altering Chemical Elimination (E-Trace) Immunoassay - The disclosure also relates to novel compositions and methods for the single, direct detection of Hemoglobin A1c percentage in a sample, using conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at two unique potentials, E | 04-25-2013 |
20120181186 | Enzyme Triggered Redox Altering Chemical Elimination (E-Trace) Immunoassay - Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E | 07-19-2012 |
20120156709 | Electrochemical Assay for the Detection of Enzymes - The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process. | 06-21-2012 |
20120012472 | NOVEL CHEMISTRY USED IN BIOSENSORS - The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes. | 01-19-2012 |
20110033869 | Enzyme Triggered Redox Altering Chemical Elimination (E-Trace) Immunoassay - The present invention is directed to electronic methods of detecting target analytes such that upon binding of the target analyte a shift in electrochemical potential is seen. This assay relies on the use of an electroactive moiety (“EAM”) that is attached to an electrode and comprises a self-immolative moiety, whose presence gives the EAM a first E0, and whose absence, upon irreversible cleavage gives the EAM a second E0. This difference is detected, and if such change occurs, it is an indication of the presence of a target analyte. | 02-10-2011 |
20100003710 | Electrochemical Assay for the Detection of Enzymes - The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process. | 01-07-2010 |
20090253149 | Novel Chemistry Used in Biosensors - The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process. | 10-08-2009 |