| NOVOZYMES, INC. Patent applications |
| Patent application number | Title | Published |
|---|
| 20120135481 | Compositions and methods for 3-hydroxypropionic acid production - The present application discloses genetically modified yeast cells comprising an active 3-HP fermentation pathway, and the use of these cells to produce 3-HP. | 05-31-2012 |
| 20120122191 | Methods For Producing Secreted Polypeptides - The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a second nucleotide sequence encoding the polypeptide, wherein the first nucleotide sequence is foreign to the second nucleotide sequence and the 3′ end of the first nucleotide sequence is immediately upstream of the initiator codon of the second nucleotide sequence. The present invention also relates to the isolated signal peptide sequences and to constructs, vectors, and fungal host cells comprising the signal peptide sequences operably linked to nucleotide sequences encoding polypeptides. | 05-17-2012 |
| 20120096597 | Polypeptides having Beta-glucosidase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 04-19-2012 |
| 20120090054 | POLYPEPTIDES HAVING ENDOGLUCANASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 04-12-2012 |
| 20120088274 | Polypeptides having Beta-Glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 04-12-2012 |
| 20120070881 | Bacillus licheniformis chromosome - The present invention relates to an isolated polynucleotide of the complete chromosome of | 03-22-2012 |
| 20120058930 | POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 03-08-2012 |
| 20120023626 | Polypeptides Having Endoglucanase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 01-26-2012 |
| 20120023623 | Polypeptides having beta-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 01-26-2012 |
| 20120011619 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 01-12-2012 |
| 20110312047 | Polypeptides having C4 Dicarboxylic Acid Transporter Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having C4-dicarboxylic acid transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, and methods of producing C4-dicarboxylic acids, such as malic acid. | 12-22-2011 |
| 20110312046 | Methods for C4 Dicarboxylic Acid Production in Filamentous Fungi - The present invention relates to methods of producing C4-dicarboxylic acids, such as malic acid, comprising: (a) cultivating a host cell comprising a polynucleotide encoding a C4-dicarboxylic acid transporter; and (b) recovering the C4-dicarboxylic acid. The present invention also relates to methods for increasing C4-dicarboxylic acid production, as well as host cells comprising the polynucleotides. | 12-22-2011 |
| 20110296558 | Polypeptides having expansin Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having expansin activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 12-01-2011 |
| 20110296557 | Polypeptides Having Lipase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 12-01-2011 |
| 20110283423 | Polypeptides Having Carboxypeptidase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having carboxypeptidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 11-17-2011 |
| 20110283422 | Polypeptides Having Aspartic Endopeptidase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having aspartic endopeptidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 11-17-2011 |
| 20110283421 | Polypeptides having amylolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having amylolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 11-17-2011 |
| 20110271407 | Polypeptides Having Alpha-Mannosidase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having alpha-mannosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 11-03-2011 |
| 20110239333 | Polypeptides Having Xylanase Activity And Polynucleotides Thereof - The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 09-29-2011 |
| 20110236928 | Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum - The present invention relates to methods of producing a polypeptide, comprising: (a) cultivating a mutant of a parent | 09-29-2011 |
| 20110229936 | Polypeptides Having Beta-Glucosidase Activity And Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 09-22-2011 |
| 20110224123 | POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 09-15-2011 |
| 20110223671 | Methods for using positively and negatively selectable genes in a filamentous fungal cell - The present invention relates to methods for using positively and negatively selectable genes in a filamentous fungal cell to delete, disrupt, or insert a gene in a filamentous fungal cell. | 09-15-2011 |
| 20110189737 | Methods for producing hyaluronan in a recombinant host cell - The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a | 08-04-2011 |
| 20110185454 | Polypeptides having endoglucanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 07-28-2011 |
| 20110172122 | Methods for monitoring multiple gene expression - The present invention relates to methods for monitoring differential expression of a plurality of genes in a first filamentous fungal cell relative to expression of the same genes in one or more second filamentous fungal cells using microarrays containing | 07-14-2011 |
| 20110171347 | Polypeptides having Alpha-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 07-14-2011 |
| 20110136167 | Variants of glycoside hydrolases - The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of SEQ ID NO: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of SEQ ID NO: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 06-09-2011 |
| 20110111453 | Compositions for saccharification of cellulosic material - The present invention relates to enzyme compositions for high temperature saccharification of cellulosic material and to uses thereof. | 05-12-2011 |
| 20110099671 | Cellobiohydrolase variants and polynucleotides encoding same - The present invention relates to variants of a parent cellobiohydrolase II. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants. | 04-28-2011 |
| 20110086407 | Bacillus licheniformis chromosome - The present invention relates to an isolated polynucleotide of the complete chromosome of | 04-14-2011 |
| 20110078831 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 03-31-2011 |
| 20110078830 | Polypeptides having xylanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 03-31-2011 |
| 20110078829 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 03-31-2011 |
| 20110072540 | Polypeptides having beta-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 03-24-2011 |
| 20110067148 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 03-17-2011 |
| 20110053822 | Polypeptides having lipase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 03-03-2011 |
| 20110053233 | Methods for improving malic acid production in filamentous fungi - The present invention relates to methods of producing a C4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a C4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the C4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the C4 dicarboxylic acid. The present invention also relates to methods for increasing C4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants. | 03-03-2011 |
| 20110047652 | Polypeptides having endoglucanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 02-24-2011 |
| 20110027857 | Methods of improving the introduction of DNA into bacterial cells - The present invention relates to methods of improving the introduction of DNA into bacterial host cells. | 02-03-2011 |
| 20110014707 | Polypeptides having endoglucanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 01-20-2011 |
| 20110014662 | Methods for producing hyaluronan in a recombinant host cell - The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a | 01-20-2011 |
| 20110010805 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 01-13-2011 |
| 20100330618 | Methods for producing biological substances in pigment-deficient mutants of bacillus cells - The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent | 12-30-2010 |
| 20100323448 | Methods For Producing Biological Substances In Enzyme-Deficient Mutants Of Aspergillus niger - The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent | 12-23-2010 |
| 20100306879 | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 12-02-2010 |
| 20100304437 | Methods for enhancing the degradation or conversion of cellulosic material - The present invention relates to methods for degrading or converting a cellulosic material, comprising: treating the cellulosic material with an enzyme composition in the presence of a polypeptide having cellulolytic enhancing activity. | 12-02-2010 |
| 20100281582 | Polypeptides having xylanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 11-04-2010 |
| 20100273227 | Detoxifying Pre-Treated Lignocellulose-Containing Materials - The invention relates to a process of detoxifying pre-treated lignocellulose-containing material comprising subjecting the pre-treated lignocellulose-containing material to one or more phenolic compound oxidizing enzymes. | 10-28-2010 |
| 20100267584 | Methods for monitoring multiple gene expression - The present invention relates to methods for monitoring differential expression of a plurality of genes in a first | 10-21-2010 |
| 20100263092 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 10-14-2010 |
| 20100197556 | Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 08-05-2010 |
| 20100196968 | Polypeptides having beta-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 08-05-2010 |
| 20100192260 | Polypeptides having alpha-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 07-29-2010 |
| 20100190680 | Polypeptides having lipase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 07-29-2010 |
| 20100159536 | Methods for increasing hydrolysis of cellulosic material in the presence of cellobiose dehydrogenase - The present invention relates to methods for degrading or converting a cellulosic material, methods for producing a fermentation product, and methods of fermenting a cellulosic material with an enzyme composition comprising one or more (several) cellulolytic enzymes, a cellobiose dehydrogenase, and a polypeptide having cellulolytic enhancing activity. | 06-24-2010 |
| 20100159535 | METHODS FOR INCREASING HYDROLYSIS OF CELLULOSIC MATERIAL - The present invention relates to methods for pretreating a cellulosic material, methods for degrading or converting a cellulosic material, methods for producing a fermentation product, and methods of fermenting a cellulosic material under anaerobic conditions. | 06-24-2010 |
| 20100159509 | Methods for increasing enzymatic hydrolysis of cellulosic material in the presence of a peroxidase - The present invention relates to methods for increasing hydrolysis of a cellulosic material, comprising: hydrolyzing the cellulosic material with an enzyme composition in the presence of a polypeptide having peroxidase activity. | 06-24-2010 |
| 20100159494 | Methods for determining cellulolytic enhancing activity of a polypeptide - The present invention relates to methods for determining cellulolytic enhancing activity of a polypeptide, comprising: (a) incubating a cellulosic material with an enzyme composition comprising a cellobiose dehydrogenase and one or more (several) cellulolytic enzymes in the presence and absence of the polypeptide; and (b) measuring the release of sugar from the cellulosic material in the presence and absence of the polypeptide. | 06-24-2010 |
| 20100151515 | Microbial trypsin mutants having chymotrypsin activity and nucleic acids encoding same - The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, S193A, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, (b) one or more deletions corresponding to positions 192, 197, and 226 of amino acids 25 to 248 of SEQ ID NO: 2; and (c) an insertion between positions corresponding to positions 224 and 225 of amino acids 25 to 248 of SEQ ID NO: 2. The present invention further relates to nucleotide sequences encoding microbial trypsin variants having chymotrypsin-like activity; nucleic acid constructs, expression vectors, and recombinant host cells comprising such nucleotide sequences; and methods of producing microbial trypsin variants having chymotrypsin-like activity or a precursor thereof. | 06-17-2010 |
| 20100143971 | POLYPEPTIDES HAVING CELLULOLYTIC ENHANCING ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 06-10-2010 |
| 20100143967 | Compositions and methods for enhancing the degradation or conversion of cellulose-containing material - The present invention relates to methods for degrading or converting a cellulose-containing material, comprising: treating the cellulose-containing material with an effective amount of a cellulolytic enzyme composition comprising a polypeptide having cellulolytic enhancing activity, and one or more (several) components selected from the group consisting of a CEL7 polypeptide having endoglucanase activity, a CEL12 polypeptide having endoglucanase activity, a CEL45 polypeptide having endoglucanase activity, a CEL7 polypeptide having cellobiohydrolase activity with a cellulose binding domain, and a CEL7 polypeptide having cellobiohydrolase activity without a cellulose binding domain. The present invention also relates to such cellulolytic enzyme compositions. | 06-10-2010 |
| 20100129860 | Methods of producing the cellulolytic enhancing activity of a polypeptide - The present invention relates to methods of increasing the activity of a polypeptide having cellulolytic enhancing activity, comprising: adding a soluble activating divalent metal cation to a composition comprising the polypeptide having cellulolytic enhancing activity, wherein the presence of the soluble activating divalent metal cation and the polypeptide having cellulolytic enhancing activity increases degradation or conversion of a cellulose-containing material by a cellulolytic enzyme composition compared to the polypeptide having cellulolytic enhancing activity without the soluble activating divalent metal cation. The present invention also relates to compositions, methods for degrading or converting a cellulose-containing material, and methods for producing a fermentation product. | 05-27-2010 |
| 20100124769 | Methods and compositions for degrading cellulosic material - The present invention relates to enzyme compositions comprising a polypeptide having cellobiohydrolase II activity, a polypeptide having xylanase activity, and one or more cellulolytic proteins and their use in the degradation or conversion of cellulosic material. | 05-20-2010 |
| 20100122380 | Polypeptides having feruloyl esterase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having feruloyl esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 05-13-2010 |
| 20100120654 | Polypeptides having lipase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 05-13-2010 |
| 20100099146 | Variants of Beta-Glucosidases - The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 04-22-2010 |
| 20100064393 | Bacillus liceniformis chromosome - The present invention relates to an isolated polynucleotide of the complete chromosome of | 03-11-2010 |
| 20100055755 | Methods of Eliminating or Reducing Expression of Genes in Filamentous Fungal Strains by Transitive RNA Interference - The present invention relates to methods of reducing or eliminating expression of a target gene in a filamentous fungal strain by transitive RNA interference. | 03-04-2010 |
| 20100055739 | Methods of improving the introduction of DNA into bacterial cells - The present invention relates to methods of improving the introduction of DNA into bacterial host cells. | 03-04-2010 |
| 20100034797 | Lipase Variants for Pharmaceutical Use - The pharmaceutical use of lipases related to the | 02-11-2010 |
| 20100028944 | Methods of obtaining genetic competence in bacillus cells - The present invention relates to methods of obtaining genetic competence in non-competent | 02-04-2010 |
| 20100028943 | Modified Messenger RNA Stabilizing Sequences for Expressing Genes in Bacterial Cells - The present invention relates to methods of producing a polypeptide having biological activity in a bacterial cell, comprising: (a) cultivating a bacterial host cell in a medium conducive for production of the polypeptide, wherein the bacterial host cell comprises a nucleic acid construct comprising a promoter region operably linked to a polynucleotide sequence encoding the polypeptide and a modified mRNA processing/stabilizing sequence located downstream of the promoter region and upstream of the ribosome binding site of the polynucleotide sequence encoding the polypeptide, wherein the modified mRNA processing/stabilizing sequence promotes higher expression of the polynucleotide sequence compared to an unmodified mRNA processing/stabilizing sequence; and (b) isolating the polypeptide having biological activity from the cultivation medium. The present invention also relates to such modified mRNA processing/stabilizing sequences, nucleic acid constructs, and bacterial host cells and to methods of obtaining such bacterial host cells. | 02-04-2010 |
| 20090328259 | Polypeptides having endoglucanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 12-31-2009 |
| 20090317866 | Methods for Increasing Expression of Genes In a Fungal Cell - The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide comprising a nucleic acid sequence encoding the polypeptide operably linked to a copper-inducible promoter sequence comprising a copper-responsive upstream activation sequence activated by a copper-dependent trans-acting transcription factor and a second polynucleotide comprising one or more (several) additional copper-responsive upstream activation sequences operably linked upstream to the promoter sequence, wherein the promoter sequence is foreign to the nucleic acid sequence encoding the polypeptide and the copper-responsive upstream activation sequences are responsible for copper-induced transcription of the promoter sequence, and a third polynucleotide comprising at least one copy of a gene encoding the copper-dependent trans-acting transcription factor; and (b) isolating the polypeptide from the cultivation medium. | 12-24-2009 |
| 20090311755 | Methods for enhancing the degradation or conversion of cellulosic material - The present invention relates to methods for degrading or converting a cellulosic material and for producing a substance from a cellulosic material. | 12-17-2009 |
| 20090298126 | Methods of increasing secretion of polypeptides having biological activity - The present invention relates to methods for producing a secreted polypeptide having biological activity, comprising: (a) transforming a fungal host cell with a fusion protein construct encoding a fusion protein, which comprises: (i) a first polynucleotide encoding a signal peptide; (ii) a second polynucleotide encoding at least a catalytic domain of an endoglucanase or a portion thereof; and (iii) a third polynucleotide encoding at least a catalytic domain of a polypeptide having biological activity; wherein the signal peptide and at least the catalytic domain of the endoglucanase increases secretion of the polypeptide having biological activity compared to the absence of at least the catalytic domain of the endoglucanase; (b) cultivating the transformed fungal host cell under conditions suitable for production of the fusion protein; and (c) recovering the fusion protein, a component thereof, or a combination thereof, having biological activity, from the cultivation medium. | 12-03-2009 |
| 20090275104 | Bacillus licheniformis chromosone - The present invention relates to an isolated polynucleotide of the complete chromosome of | 11-05-2009 |
| 20090215128 | Methods for degrading lignocellulosic materials - The present invention relates to methods for degrading a lignocellulosic material, comprising: treating the lignocellulosic material with an effective amount of one or more cellulolytic enzymes in the presence of at least one surfactant selected from the group consisting of a secondary alcohol ethoxylate, fatty alcohol ethoxylate, nonylphenol ethoxylate, tridecyl ethoxylate, and polyoxyethylene ether, wherein the presence of the surfactant increases the degradation of lignocellulosic material compared to the absence of the surfactant. The present invention also relates to methods for producing an organic substance, comprising: (a) saccharifying a lignocellulosic material with an effective amount of one or more cellulolytic enzymes in the presence of at least one surfactant selected from the group consisting of a secondary alcohol ethoxylate, fatty alcohol ethoxylate, nonylphenol ethoxylate, tridecyl ethoxylate, and polyoxyethylene ether, wherein the presence of the surfactant increases the degradation of lignocellulosic material compared to the absence of the surfactant; (b) fermenting the saccharified lignocellulosic material of step (a) with one or more fermenting microorganisms; and (c) recovering the organic substance from the fermentation. | 08-27-2009 |
| 20090130707 | Methods of reducing the inhibitory effect of a redox active metal ion on the enzymatic hydrolysis of cellulosic material - The present invention relates to methods of producing a cellulosic material reduced in a redox active metal cation having a redox potential (E | 05-21-2009 |
| 20090123979 | Methods of reducing the inhibitory effect of a tannin on the enzymatic hydrolysis of cellulosic material - The present invention relates to methods of producing a cellulosic material reduced in a tannin, comprising treating the cellulosic material with an effective amount of a tannase to reduce the inhibitory effect of the tannin on enzymatically saccharifying the cellulosic material. The present invention also relates to methods of saccharifying a cellulosic material, comprising: treating the cellulosic material with an effective amount of a tannase and an effective amount of a cellulolytic enzyme composition, wherein the treating of the cellulosic material with the tannase reduces the inhibitory effect of a tannin on enzymatically saccharifying the cellulosic material with the cellulolytic enzyme composition. The present invention also relates to methods of producing a fermentation product, comprising: (a) saccharifying a cellulosic material with an effective amount of a cellulolytic enzyme composition; (b) fermenting the saccharified cellulosic material of step (a) with one or more fermenting microorganisms to produce a fermentation product; and (c) recovering the fermentation product, wherein the cellulosic material is treated with an effective amount of a tannase to reduce the inhibitory effect of a tannin on enzymatically saccharifying the cellulosic material. | 05-14-2009 |
| 20090098606 | Methods for producing biological substances in pigment-deficient mutants of bacillus cells - The present invention relates to methods of producing a heterologous biological substance, comprising: (a) cultivating a mutant of a parent | 04-16-2009 |
| 20090053765 | Variants of Beta-Glucosidase - The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 02-26-2009 |
| 20090035820 | Microbial Trypsin Mutants Having Chymotrypsin Activity And Nucleic Acids Encoding Same - The present invention relates to microbial trypsin variants having chymotrypsin-like activity, comprising: (a) a one or more substitutions corresponding to positions 144, S193A, 198, 201, 218, 223, 227, 228, 229, 230, and 231 of amino acids 25 to 248 of SEQ ID NO: 2, (b) one or more deletions corresponding to positions 192, 197, and 226 of amino acids 25 to 248 of SEQ ID NO: 2; and (c) an insertion between positions corresponding to positions 224 and 225 of amino acids 25 to 248 of SEQ ID NO: 2. The present invention further relates to nucleotide sequences encoding microbial trypsin variants having chymotrypsin-like activity; nucleic acid constructs, expression vectors, and recombinant host cells comprising such nucleotide sequences; and methods of producing microbial trypsin variants having chymotrypsin-like activity or a precursor thereof. | 02-05-2009 |
| 20090019608 | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides. | 01-15-2009 |
| 20080299613 | Compositions for degrading cellulosic material - The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the compositions. | 12-04-2008 |
| 20080293109 | Methods for degrading or converting plant cell wall polysaccharides - The present invention relates to methods for converting plant cell wall polysaccharides into one or more products, comprising: treating the plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into the one or more products. The present invention also relates to methods for producing an organic substance, comprising: (a) saccharifying plant cell wall polysaccharides with an effective amount of a spent whole fermentation broth of a recombinant microorganism, wherein the recombinant microorganism expresses one or more heterologous genes encoding enzymes which degrade or convert the plant cell wall polysaccharides into saccharified material; (b) fermenting the saccharified material of step (a) with one or more fermenting microoganisms; and (c) recovering the organic substance from the fermentation. | 11-27-2008 |
| 20080289067 | Polypeptides having endoglucanase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 11-20-2008 |
| 20080274500 | Promoter variants for expressing genes in a fungal cell - The present invention relates to methods for producing a biological substance, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the biological substance, wherein the fungal host cell comprises a first nucleic acid sequence encoding the biological substance operably linked to a second nucleic acid sequence comprising a promoter variant selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, and SEQ ID NO: 12; and a subsequence thereof; and hybrid and tandem promoters thereof; and (b) isolating the biological substance from the cultivation medium. The present invention also relates to the isolated promoter variants and to constructs, vectors, and fungal host cells comprising the promoter variants operably linked to nucleic acid sequences encoding biological substances. | 11-06-2008 |
| 20080274499 | Polypeptides having alpha-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 11-06-2008 |
| 20080268526 | Methods for producing secreted polypeptides - The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a second nucleotide sequence encoding the polypeptide, wherein the first nucleotide sequence is foreign to the second nucleotide sequence and the 3′ end of the first nucleotide sequence is immediately upstream of the initiator codon of the second nucleotide sequence. The present invention also relates to the isolated signal peptide sequences and to constructs, vectors, and fungal host cells comprising the signal peptide sequences operably linked to nucleotide sequences encoding polypeptides. | 10-30-2008 |
| 20080241887 | Polypeptides With Starch Debranching Activity - Polypeptides comprising a catalytic starch debranching domain and a starch binding domain are disclosed. The polypeptides comprising the starch binding domain have an improved functionality in raw starch degradation compared with same catalytic unit in same amount but without the starch binding domain. | 10-02-2008 |
| 20080233613 | Polypeptides having beta-glucosidase activity and polynucleotides encoding same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 09-25-2008 |
| 20080213901 | Methods for producing heterologous polypeptides in trichothecene-deficient filamentous fungal mutant cells - The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a mutant of a parent filamentous fungal cell under conditions conducive for the production of the polypeptide, wherein (i) the mutant cell comprises a first nucleic acid sequence encoding the polypeptide and a second nucleic acid sequence comprising a modification of at least one of the genes involved in the production of a trichothecene and (ii) the mutant produces less of the trichothecene than the parent filamentous fungal cell when cultured under the same conditions; and (b) isolating the polypeptide from the cultivation medium. The present invention also relates to mutants of filamentous fungal cells and methods for obtaining the mutant cells. The present invention also relates to isolated trichodiene synthases and isolated nucleic acid sequences encoding the trichodiene synthases. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the trichodiene synthases. The present invention further relates to mutants cells comprising a marker-free modification of a gene, and methods for obtaining and using such mutant cells. | 09-04-2008 |
| 20080206815 | Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same - The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 08-28-2008 |
| 20080201805 | Polypeptides Having Beta-Glucosidase Activity and Polynucleotides Encoding Same - The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides. | 08-21-2008 |
