| 20110160431 | PRODUCTION OF PEPTIDES CONTAINING POLY-GLY SEQUENCES USING FMOC CHEMISTRY - A peptide containing a poly-Gly sequence, such as bivalirudin, can be prepared in a purified form in which low amounts of GIy deletion or GIy addition byproducts are present. A protected poly-Gly-containing peptide is attached to a resin using Fmoc-Gly-GIy-OH units for assembly of the poly-Gly segment. The protected peptide is then cleaved from the resin with an acidic composition to produce an unprotected or semi-protected crude peptide, which can then be isolated from acidic composition. | 06-30-2011 |
