| NORTHWESTERN UNIVERSITY Patent applications |
| Patent application number | Title | Published |
|---|
| 20120129156 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 05-24-2012 |
| 20120128882 | GEL POLYMER PEN LITHOGRAPHY - The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible gel polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copies (e.g., greater than 15,000, or greater than 11 million) of a pattern can be made in a parallel fashion in as little as 40 minutes. | 05-24-2012 |
| 20120122799 | CYCLIC PEPTIDE ANTITUMOR AGENTS - Cyclic peptide compounds and derivatives thereof having antitumor activity as shown by treatment of human melanoma, pancreatic, breast, prostate cancer cells. | 05-17-2012 |
| 20120100571 | METHODS AND MATERIALS FOR NANOCRYSTALLINE SURFACE COATINGS AND ATTACHMENT OF PEPTIDE AMPHIPHILE NANOFIBERS THEREON - Biocompatible composites comprising peptide amphiphiles and surface modified substrates and related methods for attachment thereon. | 04-26-2012 |
| 20120100515 | Fluoroscopy Simulator - An apparatus and machine for more realistically simulating fluoroscopy is disclosed. The apparatus includes a light source, cameras, an artificial lumen, and an access port. The artificial lumen can be comprised of an anterior side and a posterior side. The anterior side of the artificial lumen is opaque to the light source such that light reflects off the anterior side of the artificial lumen to a camera to provide a real-time extra-luminal view of an artificial lumen. The posterior side of the artificial lumen is transparent to the light source such that light passes through it, reflects off the opaque anterior side of the artificial lumen, back through the transparent posterior side of the artificial lumen to a camera to provide a real-time intra-luminal view of an artificial lumen. The cameras can be in electronic communication with video monitors to display the real-time extra-luminal and intra-luminal views. | 04-26-2012 |
| 20120097058 | Multiplexed Biomolecule Arrays Made By Polymer Pen Lithography - Methods of patterning multiple biomolecules on a surface are disclosed. The method includes inking a polymer pen array, where tips are inked with selected inks comprising the biomolecules, and transferring the biomolecules to a surface using a polymer pen lithography technique. Methods of using the multiple patterned biomolecules on a surface are also disclosed. | 04-26-2012 |
| 20120093885 | THERAPEUTIC VESICLES - The present technology provides compositions of vesicles, uses of vesicles, and methods relating to vesicles. For example, provided herein are vesicles derived from stem cells for use in regenerative therapies. | 04-19-2012 |
| 20120093784 | COMPOSITIONS AND METHODS FOR CONTROLLING STEM CELL AND TUMOR CELL DIFFERENTIATION, GROWTH, AND FORMATION - The present invention relates to the use of self-assembling peptide amphiphiles to prevent tumor formation by transplanted stem cells. The present invention further relates to the use of self-assembling peptide amphiphiles to treat cancers. | 04-19-2012 |
| 20120093455 | ULTRA-SENSITIVE ELECTRIC FIELD DETECTION DEVICE - An electric field detection device. In one embodiment, the electric field detection device includes an interferometer having a reference arm and an active arm. The reference arm comprises a first electro-optic waveguide. The active arm comprises a first electrically conductive plate, a second electrically conductive plate spaced apart from the first electrically conductive plate defining a first gap therebetween, a third electrically conductive plate disposed in the first gap and vertically extending from the first electrically conductive plate to define a T-shape structure and a second gap between the third electrically conductive plate and the second electrically conductive plate, where the second gap is substantially smaller than the first gap; and a second electro-optic waveguide disposed in the second gap and being in electrical communication with the second and third electrically conductive plates. | 04-19-2012 |
| 20120071423 | Heterotricyclic AMPA Receptor Antagonists for Treatment of Epilepsy, Pain, and Other Neurological Disorders and Diseases - Disclosed are heterotricyclic compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a glutamate receptor. The pharmaceutical compositions may include and the methods may utilize heterotricyclic compounds that are glutamate analogues which have specificity for AMPA receptors. The pharmaceutical compositions may be utilized to treat or prevent neurological diseases or disorders. | 03-22-2012 |
| 20120059048 | METHODS FOR DIAGNOSING AND TREATING SQUAMOUS CELL CARCINOMA UTILIZING miRNA-205 AND INHIBITORS THEREOF - Disclosed are diagnostic and therapeutic methods related to squamous cell carcinoma. In particular, the diagnostic methods relate to detecting miRNA-205, thereby diagnosing an aggressive form of squamous cell carcinoma. The therapeutic methods relate to inhibiting the function of miRNA-205, thereby treating an aggressive form of squamous cell carcinoma. | 03-08-2012 |
| 20120046309 | PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to the identification of inventive pyrimidine-2,4,6-triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds. | 02-23-2012 |
| 20120024788 | DEVICES AND METHODS FOR FILTERING BLOOD PLASMA - The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input. | 02-02-2012 |
| 20120016493 | Passive ankle-foot prosthesis and orthosis capable of automatic adaptation to sloped walking surfaces and method of use - The present invention relates to an improved system for use in rehabilitation and/or physical therapy for the treatment of injury or disease to the lower limbs or extremities. The system can enable an amputee to proceed over any inclined or declined surface without overbalancing. The system is mechanically passive in that it does not utilize motors, force generating devices, batteries, or powered sources that may add undesirable weight or mass and that may require recharging. In particular the system is self-adapting to adjust the torque moment depending upon the motion, the extent of inclination, and the surface topography. An additional advantage of the improvement is that the system can be light and may also be simple to manufacture. | 01-19-2012 |
| 20120015350 | LATERAL FLOW STRIP AND USES THEREOF - The present invention relates to lateral flow strip assay system and uses thereof. In particular, the present invention relates to lateral flow assay systems for the simple and inexpensive detection of biomolecules. | 01-19-2012 |
| 20120013039 | Programmable soft lithography: solvent-assisted nanoscle embossing - A method of forming a nanoscale pattern on a substrate is provided, wherein the method increases or decreases the spacing of patterns on the substrate relative to a master, while keeping the pattern feature size constant. The method can alternatively reduce the pattern feature size of the substrate relative to a master, while keeping the spacing patterns constant. | 01-19-2012 |
| 20120006674 | ENERGY TRANSFER THROUGH SURFACE PLASMON RESONANCE EXCITATION ON MULTISEGMENTED NANOWIRES - Disclosed herein is energy transfer on multisegmented nanowires via surface plasmon resonance excitation of visible light, such as solar energy, absorbed by metals sensitive to visible light and transferred to metals insensitive to visible light. The nanowires are prepared with controllable gap sizes between different segments by on-wire lithography (OWL). | 01-12-2012 |
| 20120000780 | Physically Crosslinked Copolymer Compounds and Related Compositions and Methods for Electrophoretic Separation - Linear acrylamide copolymer compounds which can comprise monomeric components comprising at least one N-substituted moiety capable of physical cross-linking, and related compositions and methods of use. | 01-05-2012 |
| 20110313309 | Neurophysiological Central Auditory Processing Evaluation System and Method - A system and method of central auditory processing testing and evaluation provides for identifying clinically relevant neural synchrony in the auditory brainstem pathway. The system or method finds use as a tool to evaluate auditory processing disorders, and hence, potential auditory system and/or learning disabilities. The system or method may further find use in the selection and fitting of hearing corrective appliances such as hearing aid or cochlear implant devices and/or in the selection and implementation of auditory training regimens. | 12-22-2011 |
| 20110306904 | ABLATION DEVICES AND RELATED METHODS THEREOF - The present invention relates generally to devices for performing targeted tissue ablation in a subject. In particular, the present invention provides devices configured to deliver energy to a targeted tissue region without causing damage to untargeted tissue. | 12-15-2011 |
| 20110306109 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 12-15-2011 |
| 20110305996 | Beam Pen Lithography - The disclosure relates to methods of beam pen lithography using a tip array having a plurality of transparent, elastomeric, reversibly-deformable tips coated with a blocking layer and apertures defined in the blocking layer to expose tip ends of the tips in the array. The tip array can be used to perform a photolithography process in which the tips are illuminated with a radiation that is channeled through the tips and out the apertures to expose a photosensitive substrate. Also disclosed are tip arrays formed of polymers and gels, apparatus including the tip arrays and radiation sources, and related apparatus for selectively masking tips in the tip array from radiation emitted from the radiation source. | 12-15-2011 |
| 20110300166 | Vaccine Compositions for Inducing Immune Responses Against Components of Drusen - Disclosed are compositions and methods for treating or preventing the formation of drusen in a patient in need thereof. The compositions include an effective amount of at least one polypeptide present in drusen, or an immunogenic fragment or variant thereof that induces an immune response against the polypeptide, together with a pharmaceutical carrier, excipient, or diluent. The compositions are suitable as vaccines for treating or preventing drusen and diseases associated with drusen. | 12-08-2011 |
| 20110294160 | Cysteine Protease Autoprocessing of Fusion Proteins - Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably, the protease activity of the cysteine protease is inducible. Suitable autoproteolytic cysteine proteases for the fusion proteins include the cysteine protease of the | 12-01-2011 |
| 20110293631 | MAST CELL MARKERS AND PREVENTION, DIAGNOSIS, AND THERAPY FOR CHRONIC PELVIC PAIN SYNDROME - The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e g inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome. | 12-01-2011 |
| 20110282988 | GEOGRAPHIC LOCATION SYSTEM AND METHOD - A method for determining a derived geographic location of a target Internet host includes identifying plural landmark Internet hosts communicatively coupled with the target Internet host by a network. The method also includes measuring network latencies of probe packets transmitted to the target and landmark Internet hosts along different network pathways and calculating relative distances between the target Internet host and one or more of the landmark Internet hosts based on the network latencies. The method further includes comparing the relative distances to identify at least one of the landmark Internet hosts that is geographically closer to the target Internet host than one or more other landmark Internet hosts and determining the derived geographic location of the target Internet host based on a geographic location of the at least one of the landmark Internet hosts that is geographically closer to the target Internet host. | 11-17-2011 |
| 20110269190 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 11-03-2011 |
| 20110262492 | CATALYST AND BYPRODUCT-FREE NATIVE CHEMICAL LIGATION USING CYCLIC THIOESTER PRECURSORS - A method of synthesizing a biocompatible hydrogel by covalently cross-linking an effective amount of a first macromonomer including a cyclic thioester group with an effective amount of a second macromonomer including a terminal cysteine group is disclosed. In addition, the synthesis and use of the following specific cyclic thioester macromonomer that can be used in the method, as well as specific hydrogels made using this macromonomer are disclosed. The disclosed method produces a biocompatible hydrogel, while producing substantially no toxic free thiol by-product. Accordingly, the method can be used in making biomedical products, such as sutures and tissue replacement biomaterials, and for encapsulating therapeutic cells and pharmaceuticals. | 10-27-2011 |
| 20110248209 | THERMOELECTRIC FIGURE OF MERIT ENHANCEMENT BY MODIFICATION OF THE ELECTRONIC DENSITY OF STATES - A thermoelectric material and a method of using a thermoelectric material is provided. The thermoelectric material can include at least one compound. For example, the at least one compound may be a Group IV-VI compound such as lead telluride. The at least one compound may further include one or more dopants such as sodium, potassium, and thallium. The method of using a thermoelectric material can include exposing at least one portion of the at least one compound to a temperature greater than about 700 K. | 10-13-2011 |
| 20110238657 | METHOD AND SYSTEM FOR ASSESSING RELEVANT PROPERTIES OF WORK CONTEXTS FOR USE BY INFORMATION SERVICES - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system determines the relevance of a word to the context by utilizing an adaptive weighting system. The information retrieval system assigns varying weights to different attributes of a word and calculates an accumulated weight of the word by accumulating all weights assigned to the word. The attributes may include word size, style, location of the word, etc. The system then ranks the importance of words based on their respective accumulated weight, and chooses words that rank within a predetermined number from the top to form search terms to conduct an information search using various data sources. | 09-29-2011 |
| 20110237907 | TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided compounds. | 09-29-2011 |
| 20110230650 | Compositions and Methods for Solubilizing Membrane Proteins Without the Use of Detergent - Disclosed are compositions and methods for isolating proteins from lipids. The isolation methods may utilize derivatives of apolipoprotein A1 for isolating membrane proteins from membranes without the use of detergent. | 09-22-2011 |
| 20110223128 | REGULATION OF MICROVASCULATURE OCCLUSION - The present invention provides compositions and methods to regulate embolic occlusion of the microvasculature. In particular, the present invention inhibits extravasation of emboli from microvasculature resulting in increased occlusion (e.g., by administering a MMP 2/9 inhibitor locally to a subject). | 09-15-2011 |
| 20110218045 | PREDICTING GAME PLAYER MONETIZATION BASED ON PLAYER LOGS - A massively multiplayer online game (MMOG) monetization analysis computer system may include an electronic data processing system configured to electronically analyze data, including player behavioral logs, in accordance with one or more algorithms. Based on the analysis, the electronic data processing system may predict player changes that are relevant to monetization of the MMOG and generate a report relating to these predicted changes. The analysis may identify players whom are predicted to terminate their subscriptions to the MMOG, an amount of time each of several players is likely to spend playing the MMOG, and/or a number of transactions each of a several players is likely to engage in while playing the MMOG. | 09-08-2011 |
| 20110212482 | METHODS AND DEVICES FOR SAMPLE COLLECTION, TREATMENT AND DISPENSING - A device for collecting, treating and dispensing a biological sample is described. Use of the device permits integration of sample collection, sample treatment, and sample dispensing. | 09-01-2011 |
| 20110209150 | AUTOMATIC METHOD AND SYSTEM FOR FORMULATING AND TRANSFORMING REPRESENTATIONS OF CONTEXT USED BY INFORMATION SERVICES - An information retrieval system for automatically retrieving information related to the context of an active task being manipulated by a user. The system observes the operation of the active task and user interactions, and utilizes predetermined criteria to generate a context representation of the active task that are relevant to the context of the active task. The information retrieval system then processes the context representation to generate queries or search terms for conducting an information search. The information retrieval system reorders the terms in a query so that they occur in a meaningful order as they naturally occur in a document or active task being manipulated by the user. Furthermore, the information retrieval system may access a user profile to retrieve information related to the user, and the select information sources or transform search terms based on attributes related to the user, such as the user's occupation, position in a company, major in school, etc. | 08-25-2011 |
| 20110190161 | Methylation Profile of Cancer - The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides methods of identifying methylation patterns in genes associated with specific cancers. | 08-04-2011 |
| 20110177008 | PARAMAGNETIC METAL-NANODIAMOND CONJUGATES - The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes. | 07-21-2011 |
| 20110171531 | Multifunctional Nanocomposites of Carbon Nanotubes and Nanoparticles Formed Via Vacuum Filtration - In one aspect, the present invention provides a method of forming a film of nanocomposites of carbon nanotubes (CNTs) and platinum (Pt) nanoparticles. In one embodiment, the method includes the steps of (a) providing a first solution that contains a plurality of CNTs, (b) providing a second solution that contains a plurality of Pt nanoparticles, (c) combining the first solution and the second solution to form a third solution, and (d) filtering the third solution through a nanoporous membrane using vacuum filtration to obtain a film of nanocomposites of CNTs and Pt nanoparticles. | 07-14-2011 |
| 20110166153 | Protein Kinase Targeted Therapeutics - The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1δ, and upstream and downstream protein kinases). | 07-07-2011 |
| 20110165341 | BLOCK COPOLYMER-ASSISTED NANOLITHOGRAPHY - In accordance with an embodiment of the disclosure, a method for forming submicron size nanostructures on a substrate surface includes contacting a substrate with a tip coated with an ink comprising a block copolymer matrix and a nanostructure precursor to form a printed feature comprising the block copolymer matrix and the nanostructure precursor on the substrate, and reducing the nanostructure precursor of the printed feature to form a nanostructure having a diameter (or line width) of less than 1 μm. | 07-07-2011 |
| 20110165329 | Force Feedback Leveling of Tip Arrays for Nanolithography - A method of leveling a polymer pen array includes contacting a pen array with a surface and measuring a total force exerted on the surface by the pen array, the pen array being disposed at a first angle with respect to a first axis of the surface and a second angle with respect to a second axis of the surface; tilting one or both of the pen array and the surface to vary the first and second angles of the pen array with respect to the surface; measuring the total force exerted by the tilted pen array on the surface; and repeating the tilting and measuring steps until a global maximum of the total force exerted on the surface by the pen array is measured, thereby determining first and second angles which correspond to a leveled position of the pen array with respect to the surface. | 07-07-2011 |
| 20110151445 | ALLELIC DISORDERS CAUSED BY MUTATIONS IN TRPV4 - The present invention provides methods, kits, and compositions for detecting mutations in transient receptor potential cation channel, subfamily V, member 4 (TRPV4). In particular, mutations are detected in TRPV4 to detect diseases such as scapuloperoneal spinal muscular atrophy (SPSMA) and hereditary motor and sensory neuropathy type IIC (HMSN IIC) or Charcot-Marie-Tooth disease type 2C (CMT2C). | 06-23-2011 |
| 20110137284 | DEVICES FOR MATERIAL DELIVERY, ELECTROPORATION, AND MONITORING ELECTROPHYSIOLOGICAL ACTIVITY - The invention relates generally to devices for material delivery, electroporation and monitoring electrophysiological activity. In particular, the present invention provides devices and systems configured to deliver therapeutic compositions, to provide electroporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment. | 06-09-2011 |
| 20110132220 | POLYMER PEN LITHOGRAPHY - The disclosure relates to methods of printing indicia on a substrate using a tip array comprised of elastomeric, compressible polymers. The tip array can be prepared using conventional photolithographic methods and can be tailored to have any desired number and/or arrangement of tips. Numerous copies (e.g., greater than 15,000, or greater than 11 million) of a pattern can be made in a parallel fashion in as little as 40 minutes. | 06-09-2011 |
| 20110111974 | Short Duplex Probes for Enhanced Target Hybridization - The present disclosure is directed to compositions and methods for detecting or associating with a target polynucleotide. | 05-12-2011 |
| 20110105996 | METHODS FOR SCAR PREVENTION - Provided herein are compositions and methods for preventing or reducing scar formation (e.g., hypertrophic scars). For example, provided herein are methods of administrating HMG-CoA-inhibiting agents for preventing or reducing scar formation. | 05-05-2011 |
| 20110105585 | METHODS FOR DIAGNOSING AND TREATING SQUAMOUS CELL CARCINOMA UTILIZING miRNA-205 AND INHIBITORS THEREOF - Disclosed are diagnostic and therapeutic methods related to squamous cell carcinoma. In particular, the diagnostic methods relate to detecting miRNA-205, thereby diagnosing an aggressive form of squamous cell carcinoma. The therapeutic methods relate to inhibiting the function of miRNA-205, thereby treating an aggressive form of squamous cell carcinoma. | 05-05-2011 |
| 20110091493 | VACCINE COMPOSITIONS AND USES THEREOF - The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comprising an antigen and a dendritic cell-targeting peptide. Such compositions target vaccines to dendritic cells, resulting in a high level of humoral and acquired immunity, including both mucosal and systemic immunity. Such delivery systems find use in the specific delivery of a wide variety of oral vaccines to subjects. | 04-21-2011 |
| 20110076467 | High-Throughput Imaging of Graphene Based Sheets by Fluorescence Quenching Microscopy and Applications of Same - A method for imaging a graphene-based film. In one embodiment, the method includes the steps of providing a graphene-based film on a surface of a medium; forming a fluorescent coating over the graphene-based film to form a sample; illuminating the sample with light of a specific wavelength or wavelengths, which is absorbed by the fluorescent coating to cause the fluorescent coating to emit light of wavelengths longer than that of the absorbed light, which is quenched by the graphene-based film such that a visibility contrast is formed between the graphene-based film and the fluorescent coating; and imaging the graphene-based film from the visibility contrast. | 03-31-2011 |
| 20110064709 | USE OF ECDI-FIXED CELL TOLERANCE AS A METHOD FOR PREVENTING ALLOGRAFT REJECTION - The present invention provides methods, systems, and compositions for inducing donor-specific tolerance. In particular, the present invention provides methods of administering ECDI-treated cells before, during, and/or after administration of donor transplant cells or a donor allograft in order to induce tolerance for the cells and/or allograft in a recipient. | 03-17-2011 |
| 20110059431 | NON-ENZYMATIC DETECTION OF BACTERIAL GENOMIC DNA - The present invention relates to methods for detecting for the presence of one or more target analytes, e.g. biomolecules, in a sample. In particular, the present invention relates to a method that utilizes blocking strands to inhibit target rehybridization to detect double stranded genomic DNA. | 03-10-2011 |
| 20110059156 | Nanostructures Suitable for Sequestering Cholesterol and Other Molecules - Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. | 03-10-2011 |
| 20110054004 | METHOD FOR REDUCING SCARRING DURING WOUND HEALING USING ANTISENSE COMPOUNDS DIRECTED TO CTGF - This invention provides a method for reducing hypertropic scarring resulting from dermal wound healing in a subject in need which comprises administering to the subject an antisense oligonucleotide which inhibits expression of connective tissue growth factor (CTGF) in an amount effective to inhibit expression of CTGF and thereby reduce hypertrophic scarring. | 03-03-2011 |
| 20110052788 | ANTIFOULING HYDROGELS, COATINGS, AND METHODS OF SYNTHESIS AND USE THEREOF - The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one oxidizing reagent, wherein the at least one oxidizing reagent reacts with the modified antifouling polymer to provide a modified antifouling polymer comprising at least one oxidized catechol end group, wherein an antifouling hydrogel is provided. Methods of synthesis, methods of use and kits of the antifouling hydrogel are also provided. | 03-03-2011 |
| 20110038786 | Separation of Carbon Nanotubes in Density Gradients - The separation of single-walled carbon nanotubes (SWNTs), by chirality and/or diameter, using centrifugation of compositions of SWNTs in and surface active components in density gradient media. | 02-17-2011 |
| 20110033940 | CLICK CHEMISTRY, MOLECULAR TRANSPORT JUNCTIONS, AND COLORIMETRIC DETECTION OF COPPER - Click chemistry is used to construct molecular transport junctions (MTJs) through assembly of a molecular wire across a nanogap formed between two electrodes. Also disclosed are methods of using click chemistry and oligonucleotide-modified nanoparticles to detect the presence of copper in a sample. | 02-10-2011 |
| 20110030057 | MATCHING WITH A LARGE VULNERABILITY SIGNATURE RULESET FOR HIGH PERFORMANCE NETWORK DEFENSE - Systems, methods, and apparatus are provided for vulnerability signature based Network Intrusion Detection and/or Prevention which achieves high throughput comparable to that of the state-of-the-art regex-based systems while offering improved accuracy. A candidate selection algorithm efficiently matches thousands of vulnerability signatures simultaneously using a small amount of memory. A parsing transition state machine achieves fast protocol parsing. Certain examples provide a computer-implemented method for network intrusion detection. The method includes capturing a data message and invoking a protocol parser to parse the data message. The method also includes matching the parsed data message against a plurality of vulnerability signatures in parallel using a candidate selection algorithm and detecting an unwanted network intrusion based on an outcome of the matching. | 02-03-2011 |
| 20110029470 | SYSTEMS, METHODS, AND APPARATUS FOR RECONSTRUCTION OF 3-D OBJECT MORPHOLOGY, POSITION, ORIENTATION AND TEXTURE USING AN ARRAY OF TACTILE SENSORS - Systems, methods, and apparatus are provided using signals from a set of tactile sensors mounted on a surface to determine the three-dimensional morphology (e.g., size, shape, orientation, and/or position) and texture of objects of arbitrary shape. Analytical, numerical, and/or neural network approaches can be used to interpret the sensory data. | 02-03-2011 |
| 20110029111 | SYSTEMS, METHODS, AND APPARATUS FOR EQUALIZATION PREFERENCE LEARNING - Systems, methods, and apparatus are provided for equalization preference learning for digital audio modification. A method for listener calibration of an audio signal includes modifying a reference sound using at least one equalization curve; playing the modified reference sound for a listener; accepting listener feedback regarding the modified reference sound; and generating a weighting function based on listener feedback. A listener audio configuration system includes an output providing a sound for listener review; an interface accepting listener feedback regarding the sound; and a processor programming an audio device based on listener feedback. | 02-03-2011 |
| 20110027250 | Sealants for Fetal Membrane Repair - The present invention provides a method for preventing or repairing damage to a fetal membrane. In one embodiment, the method comprises contacting a fetal membrane with a composition comprising a four-armed catechol-terminated polyethylene glycol (cPEG) and a biocompatible oxidant. In one embodiment, the four-armed cPEG and the biocompatible oxidant are initially contained in separate solutions, and the solutions are mixed to form the composition just prior to or at the same time that the composition contacts the fetal membrane. | 02-03-2011 |
| 20110021608 | METHODS FOR NUCLEIC ACID TRANSFER INTO CELLS - The present invention provides methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in increasing gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications. | 01-27-2011 |
| 20110020230 | BIOMARKERS FOR PROSTATE CANCER - The present invention relates to compositions and methods for the detecting, treating, and empirically investigating the prostate. In particular, the present invention provides compositions and methods for using neuroligin biomarkers (e.g., NLGN-4Y) in the diagnosis, treatment, and empirical investigation of prostate disorders (e.g., prostate cancer, benign prostatic hypertrophy). | 01-27-2011 |
| 20110008890 | Self-Assembly of Peptide-Amphiphile Nanofibers Under Physiological Conditions - Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions. | 01-13-2011 |
| 20110008281 | CARDIOPROTECTIVE ROLE OF HEPATIC CELLS AND HEPATOCYTE SECRETORY FACTORS IN MYOCARDIAL ISCHEMIA - The present invention provides methods, compositions, and systems for treating a subject at risk for, with, or suspected of having, myocardial ischemia using hepatocyte secretory factors (e.g., AGP2, BMPER, FGF21, NRG4, and/or TFF3) or using factors that promote liver cell migration to ischemic myocardial tissue (e.g., IL-6 and/or MMP-2). | 01-13-2011 |
| 20110002391 | DIGITAL IMAGE COMPRESSION BY RESOLUTION-ADAPTIVE MACROBLOCK CODING - Disclosed is an image encoder that divides a digital image into a set of “macroblocks.” If appropriate, a macroblock is “downsampled” to a lower resolution. The lower-resolution macroblock is then encoded by applying spatial (and possibly temporal) prediction. The “residual” of the macroblock is calculated as the difference between the predicted and actual contents of the macroblock. The low-resolution residual is then either transmitted to an image decoder or stored for later use. In some embodiments, the encoder calculates the rate-distortion costs of encoding the original-resolution macroblock and the lower-resolution macroblock and then only encodes the lower-resolution macroblock if its cost is lower. When a decoder receives a lower-resolution residual, it recovers the lower-resolution macroblock using standard prediction techniques. Then, the macroblock is “upsampled” to its original resolution by interpolating the values left out by the encoder. The macroblocks are then joined to form the original digital image. | 01-06-2011 |
| 20100331263 | METHODS AND COMPOSITIONS FOR INHIBITING ANGIOGENESIS - The present invention relates to methods and compositions for modulating angiogenesis. In particular, the present invention relates to Pigment Epithelial-derived Factor (PEDF) fragments for use in modulating angiogenesis and treating angiogenesis mediated disease. | 12-30-2010 |
| 20100330025 | Surface Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof - The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface. | 12-30-2010 |
| 20100328410 | Metastable Nanoparticle Ink Compositions and Images Made Therefrom - Self-erasing inks in which both the printing and self-erasure of color images can be controlled by the dynamic/non-equilibrium aggregation of photoresponsive surface-coated nanoparticles contained in a carrier film are provided. The aggregation is a reversible aggregation that is triggered by a photo-induced transformation in ligands within the surface coating on the nanoparticles. Methods for forming images using the inks are also provided. | 12-30-2010 |
| 20100317738 | COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH NEURONAL DYSFUNCTION - The present invention relates to compositions and methods for the treating and empirically investigating conditions associated with neuronal dysfunction (e.g., chronic pain, epileptic neuronal activity). In particular, the present invention provides compositions and methods for using flufenamic acid in the treatment and empirical investigation of conditions associated with neuronal dysfunction (e.g., chronic pain, epileptic neuronal activity). | 12-16-2010 |
| 20100316614 | COMPOSITIONS AND METHODS FOR URINARY BLADDER REGENERATION - The present invention provides compositions and methods for the regeneration of tissue. In particular, the present invention provides mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) for bladder regeneration. | 12-16-2010 |
| 20100311067 | DETECTION OF MATERNAL ALCOHOL EXPOSURE - The present invention provides methods, compositions, and systems for detecting in utero alcohol exposure by detecting expression level changes in certain biomarkers (e.g., in placental tissue). In certain embodiments, the biomarkers are selected from glucocorticoid receptor (GR), thyroid hormone receptor alpha (TRα), iodothyronine deiodinase III (Dio3) and G-protein α-subunit (Gsα). | 12-09-2010 |
| 20100305309 | NANODIAMOND PARTICLE COMPLEXES - The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc. | 12-02-2010 |
| 20100304173 | Plasmonic-Driven Synthesis of Nanoprisms from Isotropic and Anisotropic Gold Cores - A nanoprism having a prismatic silver shell formed about a gold core and a process of forming the same are disclosed. The process includes irradiating a mixture of gold and silver nanoparticles with a narrow band of wavelengths capable of exciting the surface plasmon resonance of the gold. | 12-02-2010 |
| 20100303719 | ANTI-CANCER COMPOUNDS - The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation. | 12-02-2010 |
| 20100298415 | TARGETED SCHIFF BASE COMPLEXES - The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof. | 11-25-2010 |
| 20100294952 | CONTROLLED AGENT RELEASE AND SEQUESTRATION - Disclosed are nanostructures having nanoprisms and agents, such as diagnostic and/or therapeutic agents. Nanoprisms with a surface plasmon resonance in the near-infrared convert irradiation, such as from a laser into heat selectively to allow the dissociation, such as dehybridization of oligonucleotide duplexes, of agents associated with the nanoprism surface. These nanostructures show morphological, chemical, and functional stability under hours of irradiation. Further disclosed are methods of selectively releasing agents from nanostructures after directed surface plasmon resonance mediated heating of the nanoprisms. Released agents, such as oligonucleotides, are unharmed by this process and can be repeatedly released and sequestered under spatiotemporal control. | 11-25-2010 |
| 20100292065 | NONLINEAR OPTIC GLASSY FIBER, METHODS OF MAKING AND APPLICATIONS OF THE SAME - A process for producing an optical glass fiber from crystal-glass phase material. In one embodiment, the process includes the step of providing a molten crystal-glass phase material in a container, wherein the temperature of the molten crystal-glass phase material is at or above the melting temperature of the molten crystal-glass phase material, T | 11-18-2010 |
| 20100291707 | Multiplexed Scanometric Assay for Target Molecules - The present invention is directed to compositions and methods of use of a functionalized nanoparticle having a catalytic metal deposit. | 11-18-2010 |
| 20100286039 | Use of SCF and G-CSF in the Treatment of Cerebral Ischemia and Neurological Disorders - The present invention relates to the use of stem cell factor (SCF) polypeptide, alone and in combination with granulocyte colony stimulating factor (G-CSF) polypeptide, in the prevention or treatment of injury to the brain after cerebral ischemia or neurological disorder. More particularly, the invention provides methods of improving neurological function and outcome after stroke by the administration of SCF polypeptide, alone and in combination with G-CSF polypeptide. This treatment can be used alone or in combination with other well-known methods of treatment of cerebral ischemia and neurological disorders in a mammal. | 11-11-2010 |
| 20100266557 | NOVEL PEPTIDE-BASED SCAFFOLDS FOR CARTILAGE REGENERATION AND METHODS FOR THEIR USE - Disclosed herein are novel peptide amphiphile molecules and compositions composed of a peptide sequence that non-covalently binds the growth factor TGF-β1. Also disclosed are methods of using these peptide amphiphiles to create a gel scaffold in situ that enhances articular cartilage regeneration when used in combination with microfracture. Significant improvement in tissue quality and overall O'Driscoll histological scores were observed in rabbits with full thickness articular cartilage defects treated with the TGF-binding peptide amphiphile. The gel can further serve as a delivery vehicle for recombinant TGF-β1 protein growth factor. Scaffolds that localize and retain chondrogenic growth factors may synergistically enhance cartilage repair when combined with microfracture, by inducing bone marrow mesenchymal stem cells into chondrogenic differentiation. This invention represents a promising new biomimetic approach to enhance current techniques of articular cartilage regeneration in the clinical setting. | 10-21-2010 |
| 20100262020 | PROBE APPARATUS FOR RECOGNIZING ABNORMAL TISSUE - The present invention relates to probe apparatuses and component combinations thereof that are used to recognize possibly abnormal living tissue using a detected early increase in microvascular blood supply and corresponding applications. In one embodiment there is disclosed an apparatus that emits broadband light obtained from a light source onto microvasculature of tissue disposed within a human body and receives interacted light that is obtained from interaction of the broadband light with the microvasculature for transmission to a receiver. Different further embodiments include combinations of optical fibers, polarizers and lenses that assist in the selection of a predetermined depth profile of interacted light. In another embodiment, a kit apparatus is described that has various probe tips and/or light transmission elements that provide for various combinations of predetermined depth profiles of interacted light. In a further embodiment, a method of making a spectral data probe for depth range detection selectivity for detection of blood within microvasculature of tissue is described. | 10-14-2010 |
| 20100258786 | SELF-ASSEMBLED ORGANIC MONOLAYERS ON GRAPHENE AND METHODS OF MAKING AND USING - Self-assembled organic monolayers on epitaxial graphene are described. The organic molecules are perylene derivatives including 3,4,9,10-perylene-tetracarboxylic dianhydride (PTCDA) molecules arranged in a herringbone phase and/or molecules are of the following formula: | 10-14-2010 |
| 20100252113 | ORGANIC PHOTOVOLTAIC DEVICE WITH INTERFACIAL LAYER AND METHOD OF FABRICATING SAME - An organic photovoltaic device and method of forming same. In one embodiment, the organic photovoltaic device has an anode, a cathode, an active layer disposed between the anode and the cathode; and an interfacial layer disposed between the anode and the active layer, the interfacial layer comprising 5,5′-bis [(p-trichlorosilylpropylphenyl) phenylamino]-2,2′-bithiophene (PABTSi | 10-07-2010 |
| 20100239869 | Method of forming a film of graphite oxide single layers, and applications of same - A method for forming a film of graphite oxide single layers. In one embodiment, the method includes the steps of preparing a solution of graphite oxide to allow a plurality of graphite oxide single layers to be formed and dispersed in the solution; and applying the solution of graphite oxide onto an air-water interface of water to form a film at the air-water interface, wherein the film comprises a plurality of graphite oxide single layers and is characterized by a packing density, wherein the film of graphite oxide single layers is formed with no presence of a surfactant or stabilizing agent. | 09-23-2010 |
| 20100239675 | PLASMON MEDIATED PHOTOINDUCED SYNTHESIS OF SILVER TRIANGULAR BIPYRAMIDS - A method of preparing silver triangular bipyramids having a high shape selectivity and low edge length variation is disclosed. Also disclosed are silver triangular bipyramids prepared by this method. | 09-23-2010 |
| 20100233270 | Delivery of Oligonucleotide-Functionalized Nanoparticles - The present invention relates to compositions and methods for delivering an oligonucleotide-functionalized nanoparticle. | 09-16-2010 |
| 20100230814 | NANOSCALE, SPATIALLY-CONTROLLED GA DOPING OF UNDOPED TRANSPARENT CONDUCTING OXIDE FILMS - An article of manufacture comprising a nanowire and methods of making the same. In one embodiment, the nanowire includes a Ga-doped trace formed on a surface of an indium oxide layer having a thickness in nano-scale, and wherein the Ga-doped trace is formed with a dimension that has a depth is less than a quarter of the thickness of the indium oxide layer. In one embodiment, the indium oxide layer, which is optically transparent and electrically insulating, comprises an In | 09-16-2010 |
| 20100221508 | METHODS OF FLASH REDUCTION AND PATTERNING OF GRAPHITE OXIDE AND ITS POLYMER COMPOSITES - A method of reducing a film of graphite oxide. In one embodiment, the method includes the steps of providing a film of graphite oxide with a thickness d | 09-02-2010 |
| 20100221224 | COMPOSITION AND METHOD FOR SELF-ASSEMBLY AND MINERALIZATION OF PEPTIDE-AMPHIPHILES - The present invention is directed to a composition useful for making homogeneously mineralized self assembled peptide-amphiphile nanofibers and nanofiber gels. The composition is generally a solution comprised of a positively or negatively charged peptide-amphiphile and a like signed ion from the mineral. Mixing this solution with a second solution containing a dissolved counter-ion of the mineral and/or a second oppositely charged peptide amphiphile, results in the rapid self assembly of the peptide-amphiphiles into a nanofiber gel and templated mineralization of the ions. Templated mineralization of the initially dissolved mineral cations and anions in the mixture occurs with preferential orientation of the mineral crystals along the fiber surfaces within the nanofiber gel. One advantage of the present invention is that it results in homogenous growth of the mineral throughout the nanofiber gel. Another advantage of the present invention is that the nanofiber gel formation and mineralization reactions occur in a single mixing step and under substantially neutral or physiological pH conditions. These homogeneous nanostructured composite materials are useful for medical applications especially the regeneration of damaged bone in mammals. This invention is directed to the synthesis of peptide-amphiphiles with more than one amphiphilic moment and to supramolecular compositions comprised of such multi-dimensional peptide-amphiphiles. Supramolecular compositions can be formed by self assembly of multi-dimensional peptide-amphiphiles by mixing them with a solution comprising a monovalent cation. | 09-02-2010 |
| 20100215663 | METHODS AND COMPOSITIONS FOR REGULATION OF NEUROLOGICAL CONDITIONS - The invention relates to methods and compositions for regulation of neurological conditions. In particular, methods and compositions for the modulation of the chemokine receptor 1 (CX3CR1) and its ligands are described. | 08-26-2010 |
| 20100210590 | COMPOSITIONS AND TREATMENTS FOR SEIZURE-RELATED DISORDERS - The present invention relates to therapeutic and/or prophylactic uses of pyridazine compounds and to pharmaceutical compositions containing one or more of these compounds as an active component for treating a disorder characterized by conduction disturbances, electroconvulsions and/or seizures, in particular epilepsy, more particularly pediatric epilepsy. In an aspect of the invention, the pyridnsine compound has the Formula (Ia) or (Ib) wherein R | 08-19-2010 |
| 20100184844 | Inhibition of Bacterial Protein Production by Polyvalent Oligonucleotide Modified Nanoparticle Conjugates - The present invention is directed to oligonucleotide-modified nanoparticle conjugates and methods of inhibiting bacterial protein production. | 07-22-2010 |
| 20100172961 | Encapsulated Peptide Amphiphile Nanostructures - The present invention provides compositions and methods for creating encapsulated peptide amphiphilic nanostructures useful in treating diseases. In particular, the present invention provides compositions and methods for preparing peptide amphiphile nanostructures that are encapsulated in liposomes by the application of light, and using such compositions in treating diseases, such as cancer. | 07-08-2010 |
| 20100160182 | Metal Ion-Based Immobilization - A method for immobilizing unmodified material using a metal-ion approach is provided wherein the material is immobilized on a surface in an active state on surface features coupled with metal-ions. | 06-24-2010 |
| 20100151544 | SYSTEMS AND METHODS FOR SELECTIVE ALCOHOL PRODUCTION - The present invention relates to metabolic engineering issues related to flux determinism in core primary-metabolism pathways. In particular, the present invention relates to alcohol (e.g., butanol) production and selectivity, and related methods thereof. | 06-17-2010 |
| 20100143679 | NANOSCALE LAMELLAR PHOTOCONDUCTOR HYBRIDS AND METHODS OF MAKING SAME - An article of manufacture and methods of making same. In one embodiment, the article of manufacture has a plurality of zinc oxide layers substantially in parallel, wherein each zinc oxide layer has a thickness d | 06-10-2010 |
| 20100143666 | REDOX ACTIVATED PATTERNING - A method of forming a target pattern using a redox activated surface is disclosed. The method includes patterning a redox agent on a template layer formed on a substrate, the template layer having a first oxidation state, wherein upon contact with the redox agent, the contacted portion of the template layer changes to a second oxidation state different than the first oxidation state, and a template pattern is formed from the portion of the template layer having either the first oxidation state or the second oxidation state, and exposing the substrate having the template pattern to a target material, wherein the target material selectively binds to the template pattern to form a target pattern. | 06-10-2010 |
| 20100137700 | CATHETERS AND ELECTROPHYSIOLOGICAL DEVICES - The present invention provides systems and methods of use for catheters and electrophysiological devices. In particular, the present invention provides coronary catheters within which an extendable electrode array is housed. | 06-03-2010 |
| 20100137563 | Cysteine Protease Autoprocessing of Fusion Proteins - Disclosed are fusion proteins, polynucleotides that encode the disclosed fusion proteins, and methods for expressing and autoprocessing of the disclosed fusion proteins to obtain a target protein. The disclosed fusion proteins include an autoproteolytic cysteine protease fused to a heterologous polypeptide, which may be isolated as the target protein. Preferably, the protease activity of the cysteine protease is inducible. Suitable autoproteolytic cysteine proteases for the fusion proteins include the cysteine protease of the | 06-03-2010 |
| 20100137425 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS - The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4. | 06-03-2010 |
| 20100136682 | Polyvalent RNA-Nanoparticle Compositions - The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity. | 06-03-2010 |
| 20100133489 | Photoinduced phase separation of gold in two-component nanoparticles to form nanoprisms - Nanoprisms containing silver and gold are disclosed. The nanoprisms exhibit the properties of pure silver nanoprisms, but are less susceptible to silver modification or reaction by a surrounding environment than pure silver nanoprisms due to the presence of the gold. The gold surface of the nanoprisms can be further modified, using known gold-modification techniques. | 06-03-2010 |
| 20100129808 | PARTICLES FOR DETECTING INTRACELLULAR TARGETS - Methods describing the use of nanoparticles modified with binding moieties are provided. | 05-27-2010 |
| 20100129793 | COMPOSITE PARTICLES - Composite particles and methods of synthesizing a composite particle are disclosed, in particular, methods of synthesizing a composite particle comprising a dielectric component, a magnetic component, and a gold shell are disclosed. Further disclosed herein are methods of detecting a target compound using the composite particles of the present invention. Also disclosed are photonic crystals that can be manipulated with an external magnetic field comprising the composite particles of the present invention. | 05-27-2010 |
| 20100125281 | CARDIAC PACING LEAD AND DELIVERY SHEATH - The present invention provides compositions and methods related to epicardial pacing systems. In particular, the present invention provides a novel delivery sheath and cardiac pacing lead to be deployed in the pericardial space via a percutaneous approach. | 05-20-2010 |
| 20100125189 | SYSTEMS AND METHODS FOR CATHETER STABILITY - The present invention provides systems and methods for stabilizing catheters, such as decapolar coronary sinus catheters in veins. In particular, the present invention provides fixation elements for improved tissue contact and stability. | 05-20-2010 |
| 20100123120 | A SINGLE-PHOTON DETECTOR WITH A QUANTUM DOT AND A NANO-INJECTOR - A semiconductor photodetector for photon detection without the use of avalanche multiplication, and capable of operating at low bias voltage and without excess noise. In one embodiment, the photodetector comprises a plurality of InP/AlInGaAs/AlGaAsSb layers, capable of spatially separating the electron and the hole of an photo-generated electron-hole pair in one layer, transporting one of the electron and the hole of the photo-generated electron-hole pair into another layer, focalizing it into a desired volume and trapping it therein, the desired volume having a dimension in a scale of nanometers to reduce its capacitance and increase the change of potential for a trapped carrier, and a nano-injector, capable of injecting carriers into the plurality of InP/AlInGaAs/AlGaAsSb layers, where the carrier transit time in the nano-injector is much shorter than the carrier recombination time therein, thereby causing a very large carrier recycling effect. | 05-20-2010 |
| 20100120750 | METHODS FOR INDUCING POLYPLOIDIZATION OF MEGAKARYOCYTES AND FOR TREATING BLOOD AND BONE MARROW DISEASES AND DISORDERS - Disclosed are methods for inducing polyploidization of megakaryocyte cells and for promoting differentiation of megakaryocyte cells into platelet-producing cells. The methods may be utilized for treating blood and bone marrow diseases and disorders in a subject in need thereof and for identifying agents for treating blood and bone marrow diseases and disorders. | 05-13-2010 |
| 20100118386 | APPARATUS AND METHODS OF BROADBAND SECOND HARMONIC GENERATION - Apparatus and methods for second harmonic generation with a waveguide. In one embodiment, a method includes the steps of providing a waveguide, wherein the waveguide has a substrate, and a polydomain epitaxial thin film on the substrate, wherein the polydomain epitaxial thin film defines a plane and has a first surface and a second, opposite surface defining a body portion of the polydomain epitaxial thin film therebetween with a film thickness, l, and wherein the polydomain epitaxial thin film has a coherence length, l | 05-13-2010 |
| 20100115672 | SCANNING PROBE EPITAXY - A dual tip probe for scanning probe epitaxy and a method of forming the dual tip probe are disclosed. The dual tip probe includes first and second tips disposed on a cantilever arm. The first and second tips can be a reader tip and a synthesis tip, respectively. The first tip can remain in contact with a substrate during writing and provide in situ characterization of the substrate and or structures written, while the second tip can perform in non-contact mode to write and synthesis nanostructures. This feature can allow the dual tip probe to detect errors in a printed pattern using the first tip and correct the errors using the second tip. | 05-06-2010 |
| 20100106108 | FLUID CONTAINMENT APPARATUS - The invention relates to the treatment of wounds. In particular, the invention relates to systems, devices, and methods enabling pulse lavage irrigation of wounds in a non-controlled setting while providing containment of contaminated irrigation fluid, thereby preventing exposure of individuals and surfaces in proximity to the patient to infectious materials. | 04-29-2010 |
| 20100093834 | MANIPULATION OF NEURONAL ION CHANNELS - The present invention provides compositions and methods for the manipulation of ion channels. For example, the present invention relates to Parkinson's and other neurological diseases and conditions, and treatments thereof. In particular, the present invention provides methods of decreasing pathophysiological high frequency neuronal bursts of Parkinson's and other neurological diseases and conditions. Methods of the present invention comprise decreasing Kv3 ion channel activity in fast-spiking neurons, including by decreasing activity of a Kv3.4 protein and by specifically targeting a Kv3.4 protein with an inhibitor. | 04-15-2010 |
| 20100092979 | METHODS AND COMPOSITIONS FOR ISOLATING NUCLEIC ACID - The present invention relates to compositions and methods for isolating and purifying nucleic acid. In particular, the present invention relates to methods of isolating nucleic acid from cells for use in further analysis. | 04-15-2010 |
| 20100092747 | INFRARED-REFLECTING FILMS AND METHOD FOR MAKING THE SAME - There is provided single layer infrared-reflecting films and a method of making the same that provide enhanced reflectivity in an 800 nanometer to 2500 nanometer infrared waveband. The method comprises providing a substrate, depositing onto the substrate a mixture of an oxide matrix material and either a conductive metal dopant or a higher valence cation, and producing the infrared-reflecting film. | 04-15-2010 |
| 20100092372 | HALIDE ION CONTROL OF SEED MEDIATED GROWTH OF ANISOTROPIC GOLD NANOPARTICLES - Methods of forming nanoprisms or nanorods from gold seed particles by adding controlled amounts of iodide ion to the growth solution are disclosed. | 04-15-2010 |
| 20100091841 | SYSTEM AND METHOD OF OPTIMIZED BIT EXTRACTION FOR SCALABLE VIDEO CODING - A device for use with a frame generating portion that is arranged to receive picture data corresponding to a plurality of pictures and to generate encoded video data for transmission across a transmission channel having an available bandwidth. The frame generating portion can generate a frame for each of the plurality of pictures to create a plurality of frames. The encoded video data is based on the received picture data. The device includes a distortion estimating portion and inclusion determining portion and an extracting portion. The distortion estimating portion can estimate a distortion. The inclusion determining portion can establish an inclusion boundary based on the estimated distortion. The extracting portion can extract a frame from the plurality of frames based on the inclusion boundary. | 04-15-2010 |
| 20100087622 | Method of Synthesizing Acetonide-Protected Catechol-Containing Compounds and Intermediates Produced Therein - The inventors disclose here a novel, facile approach to the synthesis of acetonide-protected catechol-containing compounds having at least one amine group. In specific embodiments, the invention provides novel methods of synthesizing 3,4-dihydroxyphenylalanine (H-DOPA(acetonide)-OH (6)), Fmoc-protected H-DOPA(acetonide)-OH (Fmoc-DOPA(acetonide)-OH (7)), Fmoc-protected dopamine (Fmoc-dopamine(acetonide) (10)), TFA-protected dopamine (TFA-dopamine(acetonide) (13)) and acetonide-protected 4-(2-aminoethyl)benzene-1,2-diol (acetonide-protected dopamine (14)). | 04-08-2010 |
| 20100076072 | COMPOSITIONS AND METHODS OF VITAMIN E ADMINISTRATION - The present invention relates to compositions and methods of vitamin E administration. In particular, the present invention provides opposing effects, relative to inflammation, from the administration of two major forms of vitamin E (α-tocopherol and γ-tocopherol). | 03-25-2010 |
| 20100076057 | TARGET DNA INTERFERENCE WITH crRNA - The present invention provides methods, systems, and compositions for interfering with the function and/or presence of a target DNA sequence in a eukaryotic cell (e.g., located in vitro or in a subject) using crRNA and CRISPR-associated (cas) proteins or cas encoding nucleic acids. The present invention also relates to a method for interfering with horizontal gene transfer based on the use of clustered, regularly interspaced short palindromic repeat (CRISPR) sequences. | 03-25-2010 |
| 20100075424 | METHODS AND COMPOSITIONS FOR GENETICALLY ENGINEERING CLOSTRIDIA SPECIES - The present invention relates to methods and compositions for engineering Clostridia species. In particular, embodiments of the present invention relate to the expression of recombinant resolvase proteins in Clostridia species. | 03-25-2010 |
| 20100075365 | PERINUCLEOLAR COMPARTMENT AS A CANCER MARKER - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 03-25-2010 |
| 20100071098 | SCANNING PROBE EPITAXY - A dual tip probe for scanning probe epitaxy is disclosed. The dual tip probe includes first and second tips disposed on a cantilever arm. The first and second tips can be a reader tip and a synthesis tip, respectively. The dual tip probe further includes a rib disposed on the cantilever arm between the first and second tips. The dual tip probe can also include a strain gauge disposed along the length of the cantilever arm. | 03-18-2010 |
| 20100068817 | COLORIMETRIC DETECTION OF METALLIC IONS IN AQUEOUS MEDIA USING FUNCTIONALIZED NANOPARTICLES - Disclosed herein are methods of detecting metal ions in a sample using functionalized nanoparticles. More specifically, functionalized nanoparticles are used to selectively detect metal ions in a sample using changes in melting temperature of hybridized oligonucleotides on functionalized nanoparticles. The melting temperature can be detected using absorbance, color change, or both. In some cases, the concentration of the metal ion in the sample can be determined. Concentrations of metal ion of as little as 20 ppb (about 100 nM) can be detected using the disclosed methods. | 03-18-2010 |
| 20100059475 | METHOD OF NANOSCALE PATTERNING USING BLOCK COPOLYMER PHASE SEPARATED NANOSTRUCTURE TEMPLATES - A method of forming nanostructures using block copolymer nanostructure templates is disclosed herein. The method includes forming a nanostructure template by patterning a block copolymer on a substrate and allowing the block copolymer to phase separate to form the nanostructure template. The nanostructure template can then be loaded with a nanostructure precursor material. The nanostructure template is removed to form the nanostructure. | 03-11-2010 |
| 20100055702 | Pathogenecity Islands of Pseudomonas Aeruginosa - Disclosed are | 03-04-2010 |
| 20100047890 | METHODS AND COMPOSITIONS FOR GENERATING SPORULATION DEFICIENT BACTERIA - The present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class | 02-25-2010 |
| 20100040672 | DELIVERY OF THERAPEUTICS - The present invention provides materials and devices for the controlled release of therapeutics, and methods for uses thereof. | 02-18-2010 |
| 20100034897 | Method for Removal or Inactivation of Heparin - The present invention relates to the use of immobilized RAGE or portions thereof for removal of heparin and low molecular weight heparin from a fluid sample or from a patient in need of neutralization of anticoagulant activity. The invention provides a method for removal or inactivation of heparin and low molecular weight heparin, as well as a device which utilizes this method. | 02-11-2010 |
| 20100029909 | COMPOSITIONS AND METHODS COMPRISING MAGNETIC RESONANCE CONTRAST AGENTS - The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging. | 02-04-2010 |
| 20100025616 | MECHANICAL STRENGTH & THERMOELECTRIC PERFORMANCE IN METAL CHALCOGENIDE MQ (M=Ge,Sn,Pb and Q=S, Se, Te) BASED COMPOSITIONS - Thermoelectric eutectic and off-eutectic compositions comprising a minor phase in a thermoelectric matrix phase are provided. These compositions include eutectic and near eutectic compositions where the matrix phase is a chalcogenide (S, Se, Te) of Ge, Sn, or Pb or an appropriate alloy of these compounds and at least one of Ge, Ge | 02-04-2010 |
| 20100021894 | Nanoparticle-Based Colorimetric Detection Of Cysteine - The invention provides methods to detect cysteine which employ oligonucleotide functionalized nanoparticles. | 01-28-2010 |
| 20100016587 | Protein Kinase Targeted Therapeutics - The present invention relates to compositions and methods useful in treating diseases and disorders related to protein kinases. In particular, the present invention relates to compositions and methods useful for targeting protein kinases related to mitogen activated protein kinase (MAPK) pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or casein kinase (CK) pathways (e.g., CK1δ, and upstream and downstream protein kinases), and diseases and disorders related to MAPK pathways (e.g., p38 MAPK, JNK, ERK, and upstream and downstream protein kinases) and/or CK pathways (e.g., CK1δ, and upstream and downstream protein kinases). | 01-21-2010 |
| 20090325859 | CITRIC ACID POLYMERS - The present invention provides polymers (e.g., elastomeric citric acid polymers) and methods of making and using these polymers (e.g., as a biologically active molecule delivery platform). In certain embodiments, the polymer has adsorbed biologically active molecules. In particular embodiments, the polymer comprises pores that are between about 7 and 15 nanometers in diameter. In other embodiments, the polymer comprises poly(1,8 octanediol-co-ctric acid). In certain embodiments, the polymers are made by employing polyethylene glycol dimethyl ether (PEGDM). | 12-31-2009 |
| 20090324706 | Nanostructures Suitable for Sequestering Cholesterol and Other Molecules - Articles, compositions, kits, and methods relating to nanostructures, including those that can sequester molecules such as cholesterol, are provided. Certain embodiments described herein include structures having a core-shell type arrangement; for instance, a nanoparticle core may be surrounded by a shell including a material, such as a lipid bilayer, that can interact with cholesterol and/or other lipids. In some embodiments, the structures, when introduced into a subject, can sequester cholesterol and/or other lipids and remove them from circulation. Accordingly, the structures described herein may be used to diagnose, prevent, treat or manage certain diseases or bodily conditions, especially those associated with abnormal lipid levels. | 12-31-2009 |
| 20090308202 | METHODS OF MAKING NANOPRISMS - The invention is a novel photo-induced method for converting large quantities of silver nanospheres into nanoprisms, the nanoprisms formed by this method and applications in which the nanoprisms are useful. Significantly, this light driven process results in a colloid with a unique set of optical properties that directly relate to the nanoprism shape of the particles. Theoretical calculations coupled with experimental observations allow for the assignment of the nanoprism plasmon bands and the first identification of two distinct quadrupole plasmon resonances for a nanoparticle. Finally, unlike the spherical particles from which they derive and which Rayleigh light scatter in the blue, these nanoprisms exhibit-scattering in the red, permitting multicolor diagnostic labels based not only on nanoparticle composition and size but also on shape. | 12-17-2009 |
| 20090298999 | Modified Acrylic Block Copolymers For Hydrogels and Pressure Sensitive Wet Adhesives - A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate). | 12-03-2009 |
| 20090281019 | COMPOSITIONS AND METHODS FOR TREATING ATRIAL FIBRILLATION - The present invention provides compositions and methods for treating heart conditions. In particular, the present invention provides compositions and methods that block G protein coupled receptor mediated signaling for treating atrial fibrillation. | 11-12-2009 |
| 20090280188 | ASYMMETRIC FUNCTIONALIZATED NANOPARTICLES AND METHODS OF USE - Disclosed herein are asymmetrically functionalized nanoparticles. Further disclosed herein are methods of preparing asymmetrically functionalized nanoparticles. Asymmetrically functionalized nanoparticles can be used in various therapeutic methods. | 11-12-2009 |
| 20090269847 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES AND RELATED METHODS FOR GROWTH FACTOR DELIVERY - Amphiphilic peptide compounds comprising one or more epitope sequences for binding interaction with one or more corresponding growth factors, micellar assemblies of such compounds and related methods of use. | 10-29-2009 |
| 20090269284 | CONTRAST AGENTS - The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T | 10-29-2009 |
| 20090263363 | Compositions and Methods For Treating Bone Formation Disorders - The present invention relates to compositions and methods for the detecting, treating, and empirically investigating disorders associated with bone formation (e.g., osteoporosis). In particular, the present invention provides compositions and methods for using maspin and targets of maspin in the diagnosis, treatment, and empirical investigation of disorders associated with bone formation (e.g., osteoporosis). | 10-22-2009 |
| 20090263331 | MULTIFUNCTION NANOCONJUGATES FOR IMAGING APPLICATIONS AND TARGETED TREATMENT - The present invention relates to nanoconjugates. In particular, the present invention provides nanoconjugates for diagnostic (e.g., imaging), research, and clinical (e.g., targeted treatment) applications. | 10-22-2009 |
| 20090258928 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND MODULATING HUMAN PAPILLOMAVIRUS (HPV) - The present invention concerns methods and compositions for treating a patient having, suspected of having, or at risk of obtaining a HPV infection. | 10-15-2009 |
| 20090250688 | MOLECULAR QUANTUM INTERFERENCE APPARATUS AND APPLICATIONS OF SAME - A molecular quantum interference device for use in molecular electronics. In one embodiment, the device includes a molecular quantum interference unit having a first terminal group and a second terminal group between which quantum interference affects electrical conduction, a molecular spacer having a first terminal group and a second terminal group and coupled to the molecular quantum interference unit through a chemical bonding between the first terminal group of the molecular spacer and the second terminal group of the molecular quantum interference unit, a first electrode electrically coupled to the molecular quantum interference unit and configured to supply charge carriers to or receive charge carriers from the molecular quantum interference unit, and a second electrode electrically coupled to the molecular spacer and configured to receive charge carriers from or supply charge carriers to the molecular spacer. | 10-08-2009 |
| 20090247704 | Modified Acrylic Block Copolymers For Hydrogels and Pressure Sensitive Wet Adhesives - A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate). | 10-01-2009 |
| 20090246782 | BARRIERS FOR FACILITATING BIOLOGICAL REACTIONS - The present invention relates to systems, devices, and methods for performing biological reactions. In particular, the present invention relates to the use of lipophilic, water immiscible, or hydrophobic barriers in sample separation, purification, modification, and analysis processes. | 10-01-2009 |
| 20090240000 | Modified Acrylic Block Copolymers For Hydrogels and Pressure Sensitive Wet Adhesives - A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate). | 09-24-2009 |
| 20090238879 | DELIVERY SCAFFOLDS AND RELATED METHODS OF USE - The present invention relates to delivery systems. In particular, the present invention provides microporous scaffolds having thereon agents (e.g., extracellular matrix proteins, exendin-4) and biological material (e.g., pancreatic islet cells). In some embodiments, the scaffolds are used for transplanting biological material into a subject. In some embodiments, the scaffolds are used in the treatment of diseases (e.g., type 1 diabetes), and related methods (e.g., diagnostic methods, research methods, drug screening). | 09-24-2009 |
| 20090232836 | Vaccine Compositions for Inducing Immune Responses Against Components of Drusen - Disclosed are compositions and methods for treating or preventing the formation of drusen in a patient in need thereof. The compositions include an effective amount of at least one polypeptide present in drusen, or an immunogenic fragment or variant thereof that induces an immune response against the polypeptide, together with a pharmaceutical carrier, excipient, or diluent. The compositions are suitable as vaccines for treating or preventing drusen and diseases associated with drusen. | 09-17-2009 |
| 20090221095 | Colorimetric Screening of DNA Binding/Intercalating Agents with Gold Nanoparticle Probes - Methods are provided to identify and characterize compounds that bind with duplex and triplex polynucleotides. | 09-03-2009 |
| 20090215721 | DIETARY COMPOSITIONS AND RELATED METHODS OF USE - The present invention provides dietary compositions for mammalian consumption. In particular, the present invention provides compositions comprising pectin, a component comprising electrolytes, thickening agents, a sweetening agent, and water, and methods for making such compositions. In some embodiments, the dietary compositions are used for preventing and/or treating malabsorption dysfunction and associated disorders (e.g., short bowel syndrome, Crohn's disease). In some embodiments, the dietary compositions are used for preventing and/or treating colonic disorders (e.g., ulcerative colitis). The dietary compositions further find use in subjects with diarrhea, regardless of cause, subject suffering from gastric dumping syndrome, and obese patients or patients seeking to lose weight, as the composition delays gastric emptying (e.g., creating feeling of early satiety). In some embodiments, the dietary composition is a prebiotic food supplement. | 08-27-2009 |
| 20090211445 | AMORPHOUS INFINITE COORDINATION POLYMER MICROPARTICLES AND USE FOR HYDROGEN STORAGE - Infinite coordination polymeric (ICP) materials are disclosed. One ICP material has a formula | 08-27-2009 |
| 20090209629 | Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications - Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided. | 08-20-2009 |
| 20090197920 | METHODS AND COMPOSITIONS FOR MODULATING CALCIUM CHANNELS - The present invention relates to methods and compositions for modulating calcium channels. In particular, the present invention provides methods and compositions for modulating (e.g., disrupting) Cav1.3a calcium channels for research and therapeutic methods (e.g., treating dopaminergic diseases and conditions). | 08-06-2009 |
| 20090196829 | MRI CONTRAST AGENTS AND RELATED METHODS OF USE - The present invention relates to contrast agents for MRI and related methods of use. | 08-06-2009 |
| 20090175757 | Titanium dioxide, single-walled carbon nanotube composites - The present invention provides titanium dioxide/single-walled carbon nanotube composites (TiO | 07-09-2009 |
| 20090166222 | ELECTRICAL NANOTRAPS FOR SPECTROSCOPICALLY CHARACTERIZING BIOMOLECULES WITHIN - A method that combines on-wire-lithography (OWL) nanogaps, an electric field concentrating technique, and surface enhanced Raman spectroscopy (SERS) is disclosed for sensitive detection of analytes with small sample sizes in a chip format. | 07-02-2009 |
| 20090163661 | Modified Acrylic Block Copolymers For Hydrogels and Pressure Sensitive Wet Adhesives - A method of producing an acrylic block copolymer comprising hydrophobic poly (lower alkyl methoacrylate), hydrophilic poly (lower alkyl methacrylic acid), and hydrophobic poly (lower alkyl methacrylate). | 06-25-2009 |
| 20090156672 | Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities - Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia. | 06-18-2009 |
| 20090156505 | SELF-ASSEMBLY AND MINERALIZATION OF PEPTIDE-AMPHIPHILE NANOFIBERS - Peptide-amphiphilic compositions capable of self-assembly into useful nanostructures. | 06-18-2009 |
| 20090155785 | REAL-TIME COLORIMETRIC SCREENING INHIBITORS OF ENDONUCLEASE WITH GOLD NANOPARTICLE SUBSTRATE - The invention provides methods for screening a compound for its effect on endonuclease activity. The methods comprise providing a compound to be screened utilizing a gold nanoparticle aggregate as the substrate for the endonuclease. The gold nanoparticle aggregate is formed by the hybridization of oligonucleotides attached to the nanoparticles, with or without the presence of a third linker oligonucleotide. The hybridized oligonucleotide duplex serves as a substrate for the endonuclease. A detectable change is brought about in the presence of the endonuclease activity. A decrease in the detectable change reflects the reduced levels of endonuclease activities as a result of the effects of endonuclease inhibitors. The present invention also provides kits for screening an endonuclease inhibitor. | 06-18-2009 |
| 20090155587 | Multicomponent Nanorods - Multicomponent nanorods having segments with differing electronic and/or chemical properties are disclosed. The nanorods can be tailored with high precision to create controlled gaps within the nanorods or to produce diodes or resistors, based upon the identities of the components making up the segments of the nanorods. Macrostructural composites of these nanorods also are disclosed. | 06-18-2009 |
| 20090148945 | Novel Biodegradable Elastomeric Scaffold for Tissue Engineering and Light Scattering Fingerprinting Methods for Testing the Same - The present invention is directed to a novel biocompatible polymer that may be used in tissue engineering. More specifically, the specification describes methods and compositions for making and using a citric acid copolymers. | 06-11-2009 |
| 20090145742 | ENERGY TRANSFER THROUGH SURFACE PLASMON RESONANCE EXCITATION ON MULTISEGMENTED NANOWIRES - Disclosed herein is energy transfer on multisegmented nanowires via surface plasmon resonance excitation of visible light, such as solar energy, absorbed by metals sensitive to visible light and transferred to metals insensitive to visible light. The nanowires are prepared with controllable gap sizes between different segments by on-wire lithography (OWL). | 06-11-2009 |
| 20090136529 | Compositions And Methods For Treatment, Research And Therapeutic Applications For Malaria - The present invention provides anti- | 05-28-2009 |
| 20090130455 | UNIVERSAL PHOSPHORAMIDITE FOR PREPARATION OF MODIFIED BIOMOLECULES AND SURFACES - Reagents useful for attaching biomolecules (e.g., proteins, oligonucleotides, and other biomolecules) to a surface, processes of attaching molecules to a surface to form modified surfaces using these reagents, and methods of detecting a target compound using these modified surfaces are disclosed. | 05-21-2009 |
| 20090124569 | INHIBITION AND TREATMENT OF PROSTATE CANCER METASTASIS - The present invention provides compounds and methods of inhibiting and treating metastatic prostate cancer. The compounds include MEK4 inhibitors. In another aspect the invention provides methods of identifying inhibitors of metastatic prostate cancer by screening for inhibitors of MEK4. | 05-14-2009 |
| 20090123652 | Substrate-Independent Layer-by-Layer Assembly Using Catechol-Functionalized Polymers - The present invention provides a simple, non-destructive and versatile method that enables layer-by-layer (LbL) assembly to be performed on virtually any substrate. A novel catechol-functionalized polymer which adsorbs to virtually all surfaces and can serve as a platform for LbL assembly in a surface-independent fashion is also provided. | 05-14-2009 |
| 20090119037 | SYSTEM AND METHODS FOR DYNAMIC POWER ESTIMATION FOR A DIGITAL CIRCUIT - A method for dynamic timing-dependent power estimation for a digital circuit having coupled interconnects and at least two gates. In one embodiment, the method includes the steps of capturing information on relative switching activities and timing dependence for the coupled interconnects in the digital circuit, estimating the probabilities associated with switching activities and timing dependence for each gate in the digital circuit from the captured information, and obtaining dynamic power estimation of the digital circuit from the estimations of the probabilities. | 05-07-2009 |
| 20090118605 | Surface-enhanced raman nanobiosensor - The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose. | 05-07-2009 |
| 20090118358 | Kainate Receptor-Selective Epimeric Analogs of Dysiherbaine - Disclosed are compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a GluR5 receptor, a GluR6 receptor, or both receptors. The pharmaceutical compositions include and the methods utilize compounds that are analogs and stereoisomers of dysiherbaine and neodysiherbaine which have specificity for kainate receptors. | 05-07-2009 |
| 20090118191 | Anti-Antiogenic Fragments of Pigment Epithelium-Derived Factor (PEDF) - The present invention provides anti-angiogenic derived from pigment epithelium-derived factor (PEDF) pharmaceutical compositions comprising the peptides, and methods of preventing angiogenesis. Such methods are useful in treating angiogenesis-associated disorders and diseases. | 05-07-2009 |
| 20090098652 | SELF ASSEMBLING PEPTIDE SYSTEMS AND METHODS - The present invention provides a self-assembling peptide system which utilizes a bioactive sequence which enhances transfection efficiency. In particular, the present invention provides compositions and methods for transfecting aggregates of cells at a higher efficiency. | 04-16-2009 |
| 20090098366 | Methods of coating surfaces with nanoparticles and nanoparticle coated surfaces - Solutions containing oppositely-charged nanoparticles (NPs) deposit “patchy” coatings of alternating charge distribution on various types of materials, including polymers, elastomers, and semiconductors. Surface adsorption of the NPs is driven by cooperative electrostatic interactions and does not require chemical ligation or layer-by-layer schemes. The composition and the quality of the coatings can be regulated by the types, charges, and the relative concentrations of the NPs used and by the pH. Dense coatings can be formed on flat, curvilinear, or micropatterned surfaces. The coatings are stable against common chemicals for prolonged periods of time, and can be used in applications ranging from bacterial protection to plasmonics. | 04-16-2009 |
| 20090095882 | NEAR-FIELD NANO-IMAGER - An imaging device. In one embodiment, the imaging device includes a plurality of first electrode strips in parallel to each other along a first direction x, wherein each first electrode strip has an elongated body with a first surface and an opposite, second surface and a thickness n | 04-16-2009 |
| 20090095684 | Chalcogenide compounds with a clay-like cation-exchange capacity and methods of use - Chalcogenide compounds with cation exchange capability and methods of using the compounds are described. Compounds of the general formula A | 04-16-2009 |
| 20090092817 | MAGNETIC MATERIAL WITH LARGE MAGNETIC-FIELD-INDUCED DEFORMATION - A magnetic materials construct and a method to produce the construct are disclosed. The construct exhibits large magnetic-field-induced deformation through the magnetic-field-induced motion of crystallographic interfaces. The construct is a porous, polycrystalline composite structure of nodes connected by struts wherein the struts may be monocrystalline or polycrystalline. If the struts are polycrystalline, they have a “bamboo” microstructure wherein the grain boundaries traverse the entire width of the strut. The material from which the construct is made is preferably a magnetic shape memory alloy, including polycrystalline Ni—Mn—Ga. The construct is preferably an open-pore foam. The foam is preferably produced with a space-holder technique. Space holders may be dissolvable ceramics and salts including NaAlO | 04-09-2009 |
| 20090085258 | SYSTEM AND METHODS OF LASER ASSISTED FIELD INDUCED OXIDE NANOPATTERNING - A method of forming a nanoscale pattern on a substrate surface. In one embodiment, the method includes the steps of providing a substrate having a surface; providing a nanoscale pattern forming device, comprising an elongated cantilever that has a tip portion proximate an end of the elongated cantilever; and controllably illuminating at least the tip portion of the cantilever with a beam of substantially coherent monoenergetic particles when the cantilever moves relative to the substrate to form a nanoscale pattern on the surface, wherein the tip portion of the cantilever is made from lightly doped silicon. | 04-02-2009 |
| 20090082304 | Methods of Treating Hematological Malignancies with Nucleoside Analog Drugs - The present invention provides methods of treating hematological malignancies, including multi-drug resistant malignancies, with 8-amino-adenosine and variants thereof. Also encompassed by the present invention is a method of predicting the response of a patient diagnosed with a hematological malignancy to treatment with a nucleoside analog and a method of screening candidate drugs for efficacy in treating hematological malignancies. | 03-26-2009 |
| 20090075836 | SCREENING FOR MODULATORS OF METALATION PATHWAYS FOR METALLOPROTEINS - The present invention is directed to compositions and methods for screening of metalation pathways for the metalation of metalloproteins. | 03-19-2009 |
| 20090074719 | Peptides, Peptidomimetics and Small Molecule Inhibitors of the Epstein-Barr Virus Mediated Fusion and Entry Process - Disclosed are compositions and methods for modulating Epstein-Barr virus (EBV) infection in a patient. The compositions may include peptides or peptidomimetics that are related to gp42 and function to inhibit EBV-mediated membrane fusion. | 03-19-2009 |
| 20090069266 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID TRANSFER INTO CELLS - The present invention provides compositions and methods for increasing the transfer of nucleic acids into cells. In particular, the present invention provides for the use of inhibitors of HDAC6, a cytoplasmic histone deacetylase present in mammalian cells by, for example, small molecules or siRNA treatment, in increasing gene transfer and/or expression in cells in vitro and in vivo for research and gene therapy applications. | 03-12-2009 |
| 20090057652 | Multilayer structure with zirconium-oxide tunnel barriers and applications of same - A multilayer structure with zirconium-oxide tunnel barriers. In one embodiment, the multilayer structure includes a first niobium (Nb) layer, a second niobium (Nb) layer, and a plurality of zirconium-oxide tunnel barriers sandwiched between the first niobium (Nb) layer and the second niobium (Nb) layer, wherein the plurality of zirconium-oxide tunnel barriers is formed with N layers of zirconium-oxide, N being an integer greater than 1, and M layers of zirconium, M being an integer no less than N, such that between any two neighboring layers of zirconium-oxide, a layer of zirconium is sandwiched therebetween. | 03-05-2009 |
| 20090056810 | TFB:TPDSi2 INTERFACIAL LAYER USABLE IN ORGANIC PHOTOVOLTAIC CELLS - The present invention, in one aspect, relates to a solar cell. In one embodiment, the solar cell includes an anode; an active organic layer comprising an electron-donating organic material and an electron-accepting organic material; and an interfacial layer formed between the anode and active organic layer, where the interfacial layer comprises a hole-transporting polymer characterized with a hole-mobility higher than that of the electron-donating organic material in the active organic layer, and a small molecule that has a high hole-mobility and is capable of crosslinking on contact with air. | 03-05-2009 |
| 20090053141 | COMPOSITIONS AND METHODS FOR MAGNETIC RESONANCE IMAGING CONTRAST AGENTS - The present application provides for compositions and methods of creating and applying contrast agents that find use in magnetic resonance imaging (MRI). In particular, contrast agents that comprise monodisperse, protein polymer backbones capable of chelating multiple paramagnetic ions resulting in high relaxivity for use in enhancing MRI signal intensity. | 02-26-2009 |
| 20090048198 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID DELIVERY SYSTEMS - The present invention relates to compositions and methods for use in delivering nucleic acids and other agents into cells and tissues. In particular, the present invention provides lipid mixtures at the gel-liquid crystalline phase transition providing superior lipofection activity for transferring materials into cells and tissues. | 02-19-2009 |
| 20090044855 | p-Type Semiconducting Nickel Oxide as an Efficiency-Enhancing Anodal Interfacial Layer in Bulk Heterojunction Solar Cells - The present invention, in one aspect, relates to a solar cell. In one embodiment, the solar cell includes an anode, a p-type semiconductor layer formed on the anode, and an active organic layer formed on the p-type semiconductor layer, where the active organic layer has an electron-donating organic material and an electron-accepting organic material. | 02-19-2009 |
| 20090025556 | Metal-Organic Framework Materials Based on Icosahedral Boranes and Carboranes - Disclosed herein are metal-organic frameworks of metals and boron rich ligands, such as carboranes and icosahedral boranes. Methods of synthesizing and using these materials in gas uptake are disclosed. | 01-29-2009 |
| 20090011420 | SPARSELY CROSS-LINKED NANOGELS: A NOVEL POLYMER STRUCTURE FOR MICROCHANNEL DNA SEQUENCING - The present invention is generally directed to novel polymeric materials for use in the electrophoretic separation of nucleic acids. In particular, the novel polymer materials are sparsely crosslinked nanogels, dissolved in an aqueous buffer to form solutions with moderate to high viscosity. The present invention further provides methods for generating such novel polymers, and related methods of their use. | 01-08-2009 |
| 20090004241 | POLYMER NANOFILM COATINGS - Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications. | 01-01-2009 |
| 20080317840 | COMPOSITIONS AND METHODS FOR POLYMER-CAGED LIPOSOMES - The present invention provides liposomal compositions and methods of using such compositions in vitro and in vivo. In particular, the present invention provides stable, polymer-caged liposomes comprising a pH responsive delivery mechanism for delivery of nucleic acids, peptides, small molecules, drugs, etc. in vitro and in vivo. | 12-25-2008 |
| 20080313130 | Method and System for Retrieving, Selecting, and Presenting Compelling Stories form Online Sources - The invention provides a method and system for automatically retrieving, selecting, and presenting compelling stories from online sources. The system mines the online sources and collects texts that are likely to contain compelling stories. The system then extracts candidate stories from them and transforms these candidate stories to make them appropriate for presentation. The candidate stories are then passed through a set of filters to focus the system on stories with a heightened emotional state. Techniques are used to ensure retrieval of appropriate and meaningful content for the performance of the stories. The modified and filtered stories are then prepared for presentation, including marked up with speech and animation cues, gender classification, and dramatic Adaptive Retrieval Charts (or ARCs). These ARCs allow for various performance types from an ongoing performance of multiple actors in a physical installation to single actor performance of a single story for an online system. | 12-18-2008 |
| 20080311669 | SCREENING SEQUENCE SELECTIVITY OF OLIGONUCLEOTIDE-BINDING MOLECULES USING NANOPARTICLE BASED COLORIMETRIC ASSAY - Disclosed herein are methods of screening sequence selectivity of oligonucleotide-binding molecules using a gold nanoparticle based calorimetric assay. | 12-18-2008 |
| 20080306016 | Nucleic Acid Functionalized Nanoparticles for Therapeutic Applications - Materials and Methods for modulating cellular uptake of functionalized nanoparticles are provided. Also provided are materials and methods for modulating the effectiveness of a therapeutic agent with a functionalized nanoparticle. | 12-11-2008 |
| 20080299657 | ALIGNED NANOFIBERS AND RELATED METHODS OF USE - The present invention relates to nanofibers. In particular, the present invention provides aligned nanofiber bundle assemblies. In some embodiments, the aligned nanofiber bundle assemblies are used for tissue regeneration, controlled growth of cells, and related methods (e.g., diagnostic methods, research methods, drug screening). | 12-04-2008 |
| 20080293588 | NANODISK CODES - The invention relates to nanodisk codes and methods of using the nanodisk codes in encoding and detection schemes. In one aspect, the invention relates to nanodisk codes having a binary encoding scheme and functionalized such that the encoding of the nanodisk codes is detectable. | 11-27-2008 |
| 20080274461 | Perinucleolar Compartment Markers for Cancer - The present invention relates to compositions and methods for cancer diagnostics, prognostics and predictions, including but not limited to, cancer markers. In particular, the present invention provides perinucleolar compartments and their resident molecules as cancer markers. | 11-06-2008 |
| 20080248569 | SELF-ASSEMBLING PEPTIDE AMPHIPHILES FOR TISSUE ENGINEERING - The present invention provides for compositions and methods for creating self-assembled peptide amphiphile (PA) structures. In particular, the present invention provides for two and three-dimensional structures of crosslinked PA microtexture structures useful for tissue engineering and drug discovery. | 10-09-2008 |
| 20080247984 | DOPA-FUNCTIONALIZED, BRANCHED, POLY(AKLYLENE OXIDE) ADHESIVES - The invention describes DOPA functionalized, branched, polyalkylene oxide materials that are useful as adhesives. | 10-09-2008 |
