| NORTHEASTERN UNIVERSITY Patent applications |
| Patent application number | Title | Published |
|---|
| 20130089812 | HIGHLY STABLE PLATINUM ALLOY CATALYST FOR METHANOL ELECTROOXIDATION - A catalyst for use in at the anode of direct methanol fuel cells is made from nanoparticles having a core-shell structure. The core is an alloy of platinum and gold. The core is surrounded by a first shell of ruthenium and a second shell containing a ternary alloy of platinum, gold, and ruthenium. The catalyst can be made by a reverse-micelle method or by a single-phase scalable method. The catalyst is highly stable under conditions of use and resists dissolution of ruthenium or platinum. | 04-11-2013 |
| 20130079693 | Customizable Embedded Sensors - A method of constructing a sensor includes depositing a first material in a predetermined arrangement to form a structure. The depositing results in at least one void occurring within the structure. The method further includes depositing a second material within the voids. The second material may have electrical properties that vary according to deformation of the second material. The method also includes providing electrical access to the second material to enable observation of the one or more electrical properties. A sensor includes a structure that has one or more voids distributed within the structure. The sensor also includes a material deposited within the one or more voids. The material may be characterized by one or more electrical properties such as piezoresistivity. The sensor includes a first contact electrically coupled to a first location on the material, and a second contact electrically coupled to a second location on the material. | 03-28-2013 |
| 20130079495 | COLLAGEN FIBRILLAR CONSTRUCTION - Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering. | 03-28-2013 |
| 20130054204 | AUTOMATIC THREE-PHASE UNBALANCED LOAD COMPENSATION EXPERIMENTAL DEVICE AND ITS CONTROL METHOD - Disclosed are an automatic three-phase unbalanced load compensation experimental device and its control method. The experimental device comprises an automatic compensation device, a load simulation part, and detection, display and control parts. The automatic compensation device comprises power capacitors and intelligent grouping compound switches; the detection, display and control part comprises current transformers, molded case circuit breakers, a three-phase digital display ammeter, a three-phase electric power monitoring instrument, a protocol conversion module, 485 buses, Ethernet cables and an upper computer; the load simulation part comprises phase A, B and C loads which are in star connection and are same in component and circuit connection, an analog output module and a relay output module. Power monitoring instrument and digital ammeter are connected to the grid by circuit breaker and current transformer. The automatic compensation device and load simulation part are connected to the grid in parallel. | 02-28-2013 |
| 20130039852 | METHODS OF TARGETING CELLS FOR DIAGNOSIS AND THERAPY - Methods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and nanopolymers for detecting and treating cells. | 02-14-2013 |
| 20120323136 | ELECTRICAL IMPEDANCE MYOGRAPHY - Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM. | 12-20-2012 |
| 20120302653 | INITIATOR-TIGHTENED COMPOSITIONS - Disclosed herein are gel and plastic compositions comprising tightened layers of polymerized vinyl monomers, as well as methods of making the same, where the layers are tightened in having smaller pores. The tightened layers comprise tightened inner layers and exterior layers, and the compositions comprise polymer-attached (pendant) initiator or helper residues. | 11-29-2012 |
| 20120293023 | Voltage Tuning of Microwave Magnetic Devices Using Magnetoelectric Transducers - Tunable microwave magnetic devices that provide increased performance with reduced size, weight, and cost. The disclosed microwave magnetic devices are voltage-tunable devices that include ferrite substrates. To tune the devices, the magnetic permeability of the respective ferrite substrates is varied by external, voltage-tuned, magnetic fringe fields created by one or more magnetoelectric (ME) transducers. | 11-22-2012 |
| 20120267223 | BISTABLE NANOSWITCH - A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state. | 10-25-2012 |
| 20120264224 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 10-18-2012 |
| 20120252820 | METHODS OF TREATING FUNGAL INFECTIONS - Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators to treat fungal infections are disclosed. | 10-04-2012 |
| 20120232110 | Antimicrobial Compounds - This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections. | 09-13-2012 |
| 20120219489 | CARBON NANOSTRUCTURES FROM PYROLYSIS OF ORGANIC MATERIALS - Methods and apparatus to generate carbon nanostructures from organic materials are described. Certain embodiments provide solid waste materials into a furnace, that pyrolyzes the solid waste materials into gaseous decomposition products, which are then converted to carbon nanostructures. Methods and apparatuses described herein provide numerous advantages over conventional methods, such as cost savings, reducion of handling risks, optimization of process conditions, and the like. | 08-30-2012 |
| 20120177723 | SiRNA PHOSPHOLIPID CONJUGATE - siRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides in such cells, are described. | 07-12-2012 |
| 20120172339 | ANGIOGENIC RESORCINOL DERIVATIVES - Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid receptor distinct from CB1 and CB2. Thus, these compounds are specific ligands for one cannabinoid receptor distinct from CB1 and CB2. The invented compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response may be useful to treat a number of physiological conditions. | 07-05-2012 |
| 20120156499 | STABLE POLYELECTROLYTE COATED NANOPARTICLES - Stable nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics. | 06-21-2012 |
| 20120135064 | CONJUGATED NANODELIVERY VEHICLES - Anti-angiogenesis agent-linked liposomes and micelles, methods of making such liposomes and micelles, and methods of using such liposomes and micelles, such as for delivery of therapeutic and detection agents to tumor cells, are described. | 05-31-2012 |
| 20120109025 | MULTIPLE DEGREE OF FREEDOM REHABILITATION SYSTEM HAVING A SMART FLUID-BASED, MULTI-MODE ACTUATOR - A rehabilitation system that combines robotics and interactive gaming to facilitate performance of task-specific, repetitive, upper extremity/hand motor tasks, to enable individuals undergoing rehabilitation to improve the performance of coordinated movements of the forearm and hand is disclosed. More specifically, the rehabilitation system includes a two degree-of-freedom (DOF) robotic, upper limb rehabilitation system and interactive gaming hardware that is coupled to a computer, to provide a virtual reality-like environment. | 05-03-2012 |
| 20120082362 | Method for analyzing biological specimens by spectral imaging - A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components. | 04-05-2012 |
| 20120046461 | STEROIDAL ANTI-HORMONE HYBRIDS - Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer. | 02-23-2012 |
| 20120027681 | Low-Aspect Ratio Carbon Nanostructures - Low-aspect ratio nanostructures, such as nanocups, nanorings, and arrays of nanocups and nanorings, methods of fabrication of nanostructures, and methods of using nanostructures are disclosed. | 02-02-2012 |
| 20110248166 | TUNABLE LASER-BASED INFRARED IMAGING SYSTEM AND METHOD OF USE THEREOF - Methods, devices, and systems for imaging tissue and other samples or samples using infrared (IR) transmissions from coherent transmission sources, such as a wide range, tunable, quantum cascade laser (QCL) designed for the rapid collection of infrared microscopic data for medical diagnostics across a wide range of discrete spectral increments. The infrared transmissions are transmitted through, reflected from, and/or transreflected through a sample, and then magnified and/or focused prior to being detected by a detector. After detection, the sample related image data is used to assess the sample. Such methods, devices, and systems may be used to detect abnormalities in tissue, for example, before such abnormalities can be diagnosed using art cytopathological methods. The methods, devices and systems may also optionally include a visible light detection subsystem and/or a motion control subsystem to assist in control and processing of imaging. | 10-13-2011 |
| 20110244048 | MULTIFUNCTIONAL SELF-ASSEMBLING POLYMERIC NANOSYSTEMS - Libraries of nanoparticles comprising therapeutic agents and/or imaging agents are disclosed, as well as methods of making, customizing, and using such libraries of nanoparticles. | 10-06-2011 |
| 20110123711 | METHODS FOR FORMING METAL-POLYMER HYBRID TOOLING FOR FORMING PARTS HAVING MICRO FEATURES - A method for forming metal-polymer hybrid tooling includes patterning a surface of a member such as a silicon wafer, stainless steel, nickel or nickel alloy, engaging a polymer layer with the patterned features of the surface of the silicon wafer to form the polymer layer having a reverse of the patterned surface the silicon wafer, removing the patterned polymer layer to expose a patterned polymer layer surface, depositing a metallic layer on the patterned polymer layer surface, and wherein the deposited metallic layer on the patterned polymer layer is operable to form parts with features having a width dimension between about 0.01 microns and about 100 microns and a height dimension of between about 0.01 micron and about 800 microns (e.g., up to aspect ratio of 8). | 05-26-2011 |
| 20110117582 | MULTI-BIOMARKER BIOSENSOR - Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described. | 05-19-2011 |
| 20110105608 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING - Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer. | 05-05-2011 |
| 20110097757 | Biomarkers for Diabetes, Obesity, and/or Hypertension - Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hypertension, and biomarkers identified by such methods. | 04-28-2011 |
| 20110071178 | Methods and Compounds for Modulating Cannabinoid Activity - Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. | 03-24-2011 |
| 20110046142 | ANTIBIOTIC COMPOUNDS - Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these compounds. | 02-24-2011 |
| 20110039874 | MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY - Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. | 02-17-2011 |
| 20110038939 | THERAPEUTIC STABLE NANOPARTICLES - Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics. | 02-17-2011 |
| 20100317614 | COMPOSITIONS AND METHODS FOR PEST CONTROL - Provided herein are compositions and kits comprising carbohydrate-based inhibitors that bind GNBP and/or inhibit β(1,3)-glucanase activity. Also provided are methods of using such inhibitors to protect against or treat pest infestation, as are compositions and kits comprising subparts of the carbohydrate-based inhibitors. | 12-16-2010 |
| 20100298084 | SEQUENTIAL PLANETARY STACK TRANSMISSION SYSTEM - A sequential planetary stack transmission system is provided. The system includes a stack of planetary gear sets, each gear set including a sun gear engageable with a rotatable central shaft, and freely rotatable concentrically about the central input or output shaft when not engaged with the central shaft. A plurality of planet gears engage with the sun gear, and a ring gear engages with the planet gears. The ring gears form a ring gear barrel rotatable as a unit concentrically with respect to the central shaft. A shifting assembly within the hollow central shaft engages sequentially with the sun gears to provide a desired gear ratio. The planetary stack assembly and the shifting assembly are disposed within a case. The system is suitable for a variety of applications, and is particularly suitable for bicycles. | 11-25-2010 |
| 20100292603 | Electrical Impedance Myography - Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM. | 11-18-2010 |
| 20100285111 | SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY - Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG-lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor. | 11-11-2010 |
| 20100260676 | PRECISION-GUIDED NANOPARTICLE SYSTEMS FOR DRUG DELIVERY - A method of preparing multifunctionalized nanoparticles involves using a modular system of half-linkers to attach functional moieties that serve to deliver the nanoparticles to a desired target, exert an effect at the target, or track the nanoparticles within a cell or an animal. The modular chemistry of the half-linker system permits the custom design and synthesis of functionalized nanoparticles bearing multiple groups and therefore results in precise delivery to desired cell types and intracellular locations. The functionalized nanoparticles can be used to treat or diagnose a variety of medical conditions, including neoplastic diseases, infectious diseases, and chronic diseases. | 10-14-2010 |
| 20100178299 | METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSES - The present invention relates to compositions and methods for enhancing an immune response, for example to a vaccine, by combining the administration of oxygen (O | 07-15-2010 |
| 20100173101 | METHOD OF MANUFACTURING THICK-FILM, LOW MICROWAVE LOSS, SELF-BIASED BARIUM-HEXAFERRITE HAVING PERPENDICULAR MAGNETIC ANISOTROPY - A method of producing a relatively-thick film of a magnetic material on a substrate for use in microwave and millimeter wave devices is disclosed. The method includes preparing a wet paste comprising a binder material, glass frit, and a finely-grained magnetic material; applying the wet paste over a stencil, template or mask disposed on the substrate, to form a film on a surface of the substrate; drying the wet paste within an applied magnetic field, to vaporize fluid and organic compounds in the binder material and to produce a desired magnetic orientation in the magnetic film; and sintering the magnetic film. Hot pressing the magnetic film during sintering by adding weight on the film improves density. | 07-08-2010 |
| 20100166726 | COMPOSITIONS FOR IMPROVING CELLULAR UPTAKE OF A CHEMOTHERAPEUTIC AGENT IN A CELL EXHIBITING MUCIN DEREGULATION - Methods and compositions that increase the cellular uptake of a chemotherapeutic agent are provided. Also provided are methods of increasing access to the cell surface by antibodies and ligands. The methods are useful in treating any mucinous carcinoma characterized by an increased expression and/or secretion of mucins. In addition, these methods provide an improvement in existing methods of chemotherapy. | 07-01-2010 |
| 20100147678 | ALUMINUM ELECTROLYTIC CELLS HAVING HETEROTYPIC STRUCTURED CATHODE CARBON BLOCKS - Disclosed is an aluminum electrolytic cell having profiled cathode carbon blocks structures, comprising a cell case, a refractory material installed on the bottom, an anodes and a cathode. The cathode carbon blocks include a profiled structure having projections on the top surface of the carbon blocks, that is, a plurality of projections are formed on a surface of the cathode carbon blocks. The aluminum electrolytic cell having the cathode structure according to the present invention can reduce the velocity of the flow and the fluctuation of the level of the cathodal molten aluminum within the electrolytic cell, so as to increase the stability of the surface of molten aluminum, reduce the molten lose of the aluminum, increase the current efficiency, reduce the inter electrode distance, and reduce the energy consumption of the production of aluminum by electrolysis. With the above configuration, compounds or precipitates of viscous cryolite molten alumina can be formed on the lower portion between walls protruding on the upper surface of the cathode, which can prohibit the molten aluminum from flowing into the cell bottom through the cracks and apertures on cathodes, so that the life of the electrolytic cell can be extended. | 06-17-2010 |
| 20100130450 | Methods of Treating Fungal Infections - Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed. | 05-27-2010 |
| 20100120163 | ULTRA-SENSITIVE TEMPERATURE SENSING AND CALORIMETRY - Methods and apparatus for ultra-sensitive temperature sensing and calorimetry. Radiation is directed at a thin electrically conductive film having one or more small apertures. The incident radiation excites surface plasmons on a first surface of the electrically conductive film, and energy associated with the surface plasmons couples to an opposite surface of the electrically conductive film, where surface plasmon-enhanced radiation (SPER) is emitted from the aperture(s). A temperature-sensitive fluid or solid dielectric material is disposed contiguous with at least a portion of the electrically conductive film, such that a temperature change in the dielectric material alters a resonance condition for the SPER. Measureable changes in the SPER due to altered resonance conditions provide for an ultrasensitive temperature sensor that can detect small temperature changes in the dielectric material. The disclosed methods and apparatus may be used for a variety of applications including, but not limited to, nanoscale to microscale calorimetry for pharmaceutical and biotechnology products, combustion sensing, explosive detection, and biotoxin monitoring. | 05-13-2010 |
| 20100116631 | BISTABLE NANOSWITCH - A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state. | 05-13-2010 |
| 20100107775 | System, Method, And Device For Measuring Parameters Of A Two-Phase Flow - A capacitive sensor for measuring flow parameters of a two-phase flow, a device for measuring phase concentration of a two-phase flow, and a system and method for measuring flow parameters of a two-phase flow is disclosed. In the capacitive sensor, at least one pair of electrodes is twisted by 180° in a common direction into a spiral shape. Edge guard electrodes are twisted in the common direction and are formed between adjacent electrode edges. Problems of non-homogeneous sensitivity distribution of a measuring field and soft field effect can be effectively addressed, thereby allowing reliable and accurate measurement of phase concentration of a two-phase flow. The system for measuring flow parameters of the two-phase flow can output signals with a current of 4˜20 mA to a PLC system or communicate with an industrial process control computer or with a remote control computer system in a operating room. | 05-06-2010 |
| 20100067263 | DUAL INTERLEAVED FLYBACK CONVERTER FOR HIGH INPUT VOLTAGE - An integrated magnetic flyback converter includes interleaved phases that can be connected in series for an input stage and in parallel for an output stage. An integrated magnetic core has legs with gaps that may weaken a coupling between a primary and secondary of the associated transformer. The primary and secondary of the transformer may be inversely coupled for each phase. The transformer leg gaps permit each phase to be operated with a duty cycle ratio greater than 50%. The interleaved converter has reduced output current ripple, reduced input component voltage stress, reduced magnetizing inductance, reduced magnetic component physical size and reduced common integrated magnetic core current spikes. | 03-18-2010 |
| 20100041529 | VARIABLE RESISTANCE HAND REHABILITATION DEVICE WITH LINEAR SMART FLUID DAMPER AND DYNOMETER CAPABILITIES - A variable resistance hand rehabilitation device and corresponding system. Improvements over the prior art include: a new damping system or damper design, to reduce friction and increase maximum force output; a dynometer feature that enables converting the dynamic device to a static grip force measuring device; a closed-loop controller; and a new graphic user interface for the medical practitioner and new virtual reality game software that allow accurate and smooth operation of the device and increased patient motivation. | 02-18-2010 |
| 20100038794 | THREE DIMENSIONAL NANOSCALE CIRCUIT INTERCONNECT AND METHOD OF ASSEMBLY BY DIELECTROPHORESIS - An assembly of nanoelements forms a three-dimensional nanoscale circuit interconnect for use in microelectronic devices. A process for producing the circuit interconnect includes using dielectrophoresis by applying an electrical field across a gap between vertically displaced non-coplanar microelectrodes in the presence of a liquid suspension of nanoelements such as nanoparticles or single-walled carbon nanotubes to form a nanoelement bridge connecting the microelectrodes. The assembly process can be carried out at room temperature, is compatible with conventional semiconductor fabrication, and has a high yield. The current-voltage curves obtained from the nanoelement bridge demonstrate that the assembly is functional with a resistance of −40 ohms for gold nanoparticles. The method is suitable for making high density three-dimensional circuit interconnects, vertically integrated nanosensors, and for in-line testing of manufactured conductive nanoelements. | 02-18-2010 |
| 20100024879 | TITANIA NANOTUBES PREPARED BY ANODIZATION IN CHLORIDE-CONTAINING ELECTROLYTES - A method of preparing titania nanotubes involves anodization of titanium in the presence of chloride ions and at low pH (1-7) in the absence of fluoride. The method leads to rapid production of titania nanotubes of about 25 nm diameter and high aspect ratio. The nanotubes can be organized into bundles and tightly packed parallel arrays. Inclusion of organic acids in the electrolyte solution leads to the incorporation into the nanotubes of up to 50 atom percent of carbon. In a two-stage method, a titanium anode is pre-patterned using a fluoride ion containing electrolyte and subsequently anodized in a chloride ion containing electrolyte to provide more evenly distributed nanotube arrays. The titania nanotubes have uses in composite materials, solar cells, hydrogen production, and as hydrogen sensors. | 02-04-2010 |
| 20100003158 | VIBRATORY POWDER CONSOLIDATION - A vibratory powder consolidation process is provided in which a powder material is subjected to vibratory energy while under static compressive loading. The process provides rapid, full-density powder consolidation with minimum or no structural degradation. | 01-07-2010 |
| 20090306801 | PATIENT SPECIFIC ANKLE-FOOT ORTHOTIC DEVICE - The unique advantages of computer-controlled fabrication of a patient-specific orthotic device using an automated fabrication machine capable of following computer instructions to create 3D surface contours and new developments in non-invasive three-dimensional (3D) scanning have made it possible to acquire digital models of freeform surfaces such as the surface anatomy of the human body and to then fabricate such a patient-specific device with high precision. Such a patient-specific device brings significant improvement in patient-specific fit, comfort, and function of medical devices (and, in particular, to orthoses that require a close fit to the wearer's body to act effectively). The combination of these two technologies is ideally suited for the development of patient-specific orthotic devices. | 12-10-2009 |
| 20090285757 | METHODS OF TARGETING CELLS FOR DIAGNOSIS AND THERAPY - Methods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and nanopolymers for detecting and treating cells. | 11-19-2009 |
| 20090242756 | INTENSIFIED NEUTRAL LOSS TAGS AND USE THEREOF IN MASS SPECTROMETRY - Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer. | 10-01-2009 |
| 20090221430 | Proteomic Methods For The Identification And Use Of Putative Biomarkers Associated With The Dysplastic State In Cervical Cells Or Other Cell Types - The invention relates to methods for detecting and identifying potential biomarkers of high-grade cervical dysplasia in an individual human subject. The invention also relates to newly discovered biomarkers, as set forth in Tables 1-4 herein, which are associated with the dysplastic state of cervical cells. It has been discovered that a differential level of expression of any of these markers or combination of these markers correlates with a dysplastic condition in a human subject, e.g., a patient. | 09-03-2009 |
| 20090203146 | NARROW BORE LAYER OPEN TUBE CAPILLARY COLUMN AND USES THEREOF - A polymer-based PLOT column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Styrenic based monomers such as styrene and divinylbenzene or meth/acrylic based monomers such as butyl or stearyl methacrylate and ethylene glycol dimethacrylate, are preferred. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power, high column-to-column reproducibility and relatively high loading capacity. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems provide high sensitivity for analysis of complex proteomic samples, even down to the low attomole to sub-attomole level. | 08-13-2009 |
| 20090198817 | SYSTEM AND METHOD FOR VIRTUAL SERVER MIGRATION ACROSS NETWORKS USING DNS AND ROUTE TRIANGULATION - A first virtual server is moved from a first network location to a second network location without interrupting service to users of the first virtual server. The state and data of the first virtual server are copied and transmitted to the second network location to create a copy of the first virtual server. The first virtual server copy is then updated to duplicate the first virtual server and all connections or packets directed to the first virtual server are intercepted and directed to the first virtual server copy at the second network location. A DNS entry for the symbolic name of the first virtual server is updated to reflect a shortened TTL value and then the address field of the DNS entry is set to the address of the first virtual server copy after the changeover and subsequent connections are directed to the first virtual server copy. | 08-06-2009 |
| 20090188999 | DEVICES, METHODS AND APPLICATIONS FOR EXTRACTION OF MOLECULES FROM POLYMERIC GEL ELECTROPHORETIC MEDIA - A device and method to provide a simplified wash process and controlled disintegration of a soft substance, such as a gel, are disclosed. In use, a block of, e.g., gel matrix is placed in the device and washed with a series of appropriate solutions to remove interfering contaminants. The washing liquid is removed through a deformable narrow opening in the bottom of the device, and, subsequently, the gel block is extruded through the deformable narrow opening, by a physical force, such as centrifugal force, a vacuum or positive pressure from a gas or liquid, etc., resulting in fragmentation of the gel block into a series of particles of similar size. The fragmentation of the gel results from shear forces exerted onto the gel block traveling through the deformable narrow opening in the device. The rate of such fragmentation and resulting fragment size can be controlled by extruding the gel block using a predefined level of force as well as by controlling the dimensions and shape of the narrow opening (s) in the device. | 07-30-2009 |
| 20090086322 | Photonic Crystal Devices Using Negative Refraction - Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also performed for the grism. These lenses can be used in optical circuits, astronomical applications, etc. | 04-02-2009 |
| 20090040132 | Anisotropic metal-dielectric metamaterials for broadband all-angle negative refraction and superlens imaging - A metamaterial comprises a plurality of metallic nanowires embedded in a dielectric matrix. The metamaterial composite media provide broadband all-angle negative refraction and flat lens, superlens and curved hyperlens imaging in specific spectral regions over a wide range of frequencies including, for example, from deep infrared to ultraviolet frequencies. | 02-12-2009 |
| 20090040131 | Dielectric and magnetic particles based metamaterials - RF-optical metamaterials with (±ε, ±μ) figures-of-merit of interest are constructed from coupled magnetic and dielectric multi-resonant multi-disks (finite-size cylinders) or multi-sphere lattices arranged in a periodic or a random fashion to offer tailored magnetic and electric dipole moments. The present metamaterials include embedded particles arrays that provide coupled magnetic and electronic modes equivalent to L (inductor) and C (capacitor) circuit models. Novel arrangements of these dipole modes (L and C) tailor the transfer function to the physics of interest. | 02-12-2009 |
| 20080280317 | Comprehensive Characterization Of Complex Proteins At Trace Levels - A combination of “bottom up” and “top down” MS analysis of posttranslational modifications in complex proteins is described. The method comprises digestion of the protein with an enzyme that forms larger peptide fragments than trypsin (>3000 D), performing HPLC with the fragments and applying a new data acquisition strategy using on-line coupling with e.g. LTQ-FTMS, a hybrid mass spectrometer that couples a linear ion trap with a Fourier transform ion cyclotron resonance (FTICR) cell. The method is applied to analysis of posttranslational modifications of protein isoforms. | 11-13-2008 |
