NORTHEASTERN UNIVERSITY Patent applications |
Patent application number | Title | Published |
20160108016 | Novel Cannabinergic Compounds and Uses Thereof - Disclosed are compounds and compositions that modulate cannabinoid receptors, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. This disclosure is directed to methods of treating cannabinoid dependence, neuropathy, inflammation, glaucoma, a neurodegenerative disorder, a motor function disorder, a gastrointestinal disorder, hypothermia, emesis, loss of appetite, or anorexia associated with AIDS. | 04-21-2016 |
20160099701 | NANO- AND MICRO-ELECTROMECHANICAL RESONATORS - A resonator includes a piezoelectric plate and interdigitated electrode(s). The interdigitated electrode includes a plurality of conductive strips disposed over a top surface of the piezoelectric plate. A two-dimensional mode of mechanical vibration is excited in a cross sectional plane of the piezoelectric plate in response to an alternating voltage applied through the interdigitated electrode. The two-dimensional mode of mechanical vibration is a cross-sectional Lamé mode resonance (CLMR) or a degenerate cross-sectional Lamé mode resonance (dCLMR). | 04-07-2016 |
20160086047 | APPARATUS AND METHOD FOR EXTRACTING FEATURE OF IMAGE INCLUDING OBJECT - At least one example embodiment discloses a method of converting a vector corresponding to an input image. The method includes receiving first-dimensional vector data associated with an input image, the input image including an object and converting the received first-dimensional vector data to second-dimensional vector data based on a projection matrix with an associated rank. A first dimension of the first-dimensional vector data is higher than a second dimension of the second-dimensional vector data. | 03-24-2016 |
20160081577 | ELECTRIC FIELD ENCEPHALOGRAPHY: ELECTRIC FIELD BASED BRAIN SIGNAL DETECTION AND MONITORING - Systems and methods for measuring brain activity of a subject are disclosed, comprising: positioning a plurality of electric field sensors at multiple positions on the exterior of a skull of the subject; measuring one to three components of a plurality of instantaneous electric field vectors generated by a plurality of electric field sources, the electric field vectors being measured by the plurality of electric field sensors; and determining brain activity of the subject based on the measurement of the plurality of instantaneous electric field vectors. | 03-24-2016 |
20150367289 | FILTERING ARTICLE CONTAINING TITANIA NANOTUBES - Provided in one embodiment is a filtering article, comprising: powders comprising bundles of nanotubes, each bundle comprising hollow titania nanotubes. Embodiments of the methods of making and using the filtering articles are also provided. | 12-24-2015 |
20150328497 | VIRTUALLY-INTERFACED ROBOTIC ANKLE & BALANCE TRAINER - According to an aspect of the invention, a robotic ankle and balance training platform comprises a footplate to support a foot. The footplate is capable of rotation about an inversion/eversion axis and a plantar/dorsiflexion axis. The robotic platform further comprises an actuation system configured to apply an assistive inversion/eversion force and a resistive inversion/eversion force to the footplate and an assistive plantar/dorsiflexion force and a resistive plantar/dorsiflexion force to the footplate. | 11-19-2015 |
20150297088 | DISTRIBUTED PRESSURE SENSING SYSTEM FOR A MEDICAL DEVICE - The present disclosure describes a device and method for detecting distributed pressures along a medical device. The device includes an optical fiber that is helically wound around the flexible shaft of the medical device. Responsive to microbends caused by the application of a pressure to the optical fiber, attenuation occurs as light propagates down the optical fiber. The device detects the light attenuation and calculates the pressure exerted on the device. Accordingly, a physician can ensure pressure induced by the medical device does not surpass clinically safe levels. | 10-22-2015 |
20150238621 | Compounds and Methods for Targeted Immune System Delivery - Compounds and methods for targeted immune system delivery are disclosed. Pharmaceutical compositions including the disclosed compounds and a pharmaceutically acceptable excipient are also disclosed. Methods of targeted delivery to an antigen-presenting cell, and methods of treating or preventing a disease or condition susceptible to treatment by immunomodulation are disclosed. | 08-27-2015 |
20150196220 | ELECTRICAL IMPEDANCE MYOGRAPHY - Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM. | 07-16-2015 |
20150188361 | BYPASS TYPE 220V GRID VOLTAGE SAG PREVENTION DEVICE AND CONTROL METHOD THEREFOR - Provided are a bypass type 220V grid voltage sag prevention device and a control method therefor. The bypass type 220V grid voltage sag prevention device comprises an AC-to-DC energy storage unit, a Single Chip Microcomputer (SCM) control and display unit, and an inverter output unit. The AC-to-DC energy storage unit comprises a rectifier circuit, an energy storage control circuit and a quick tank circuit; the SCM control and display unit comprises an SCM, a DC step-down module circuit and an energy storage voltage detecting circuit; and the inverter output unit comprises a high-frequency PWM generating circuit, a high-frequency transformer output circuit, a transformer output full-bridge rectifier circuit, a PWM generating circuit, a PWM driving and full-bridge inverter circuit, a 220V grid zero-cross point detecting circuit, a 220V grid voltage detecting circuit, a 220V grid and inversion AC converting circuit, and a signal interface circuit. | 07-02-2015 |
20150111946 | METHODS FOR DELIVERY TO THE CENTRAL NERVOUS SYSTEM OF NUCLEIC ACID NANOPARTICLES TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS - Disclosed herein are methods and compositions for the treatment of diseases of the CNS with nucleic acid nanoparticles. Compositions are also disclosed herein that utilize nucleic acid nanoparticles to treat conditions such as Parkinson's Disease. Furthermore, methods of intranasally administering the compacted nucleic acid nanoparticles for therapeutic purposes in the brain are disclosed. | 04-23-2015 |
20150084443 | HIGH ENERGY DENSITY VIBRATION ENERGY HARVESTING DEVICE WITH HIGH-MU MATERIAL - The present disclosure describes a vibration energy harvester with increased output power density. The vibration energy harvester has two magnetic solenoids, each with cores that include multiple layers of high permeability materials. The two magnetic solenoids are fixed at two sides of a movably supported hard magnetic core, such as a magnet pair with anti-parallel magnetization, which produces a spatially inhomogeneous bias magnetic field for switching the flux inside the solenoids during vibration of the magnetic core. An output voltage of 2.52 V and a power density 20.84 mW/cm3 at 42 Hz, with a half peak working bandwidth of 6 Hz. | 03-26-2015 |
20150035522 | Device For Direct Microwave Measurement of Permeability as a Function of High DC Voltage - A sample holder and a coaxial method of measuring the permeability of magnetoelectric materials as a function of applied DC voltage are described. The sample holder reduces electromagnetic radiation losses as compared to conventional devices. The connections in the sample holder are electrically isolated from measuring equipment, preventing damage. A complementary algorithm to analyze the signal from the sample and calculate the permeability of the sample is described. | 02-05-2015 |
20150019155 | PHASE CORRECTION TO COMPENSATE FOR REFLECTIVE DISTORTIONS OF OPTICAL SPECTRA - Disclosed herein is a process and system to correct reflective distortions of an optical spectrum. In addition, a spectroscopy system that compensates for reflective distortions is disclosed. | 01-15-2015 |
20140377240 | METHODS AND COMPOSITIONS FOR EXPANDING IMMUNOSUPPRESSIVE T REGULATORY CELLS IN VITRO AND USES THEREOF - Disclosed herein are methods and compositions for expanding T-regulatory cells (“Treg” cells), resulting in “conditioned Treg cells.” Also disclosed herein are methods and compositions useful for modulating an autoimmune reaction and for treating or ameliorating immune-related diseases, disorders and conditions using the conditioned Treg cells. | 12-25-2014 |
20140372348 | REAL-TIME ANOMALY DETECTION OF CROWD BEHAVIOR USING MULTI-SENSOR INFORMATION - The present disclosure includes systems and methods for detecting an anomaly in crowd behavior. The method includes receiving sensor data representing a crowd, and partitioning the sensor data into local areas forming neighborhoods. The method further includes, for each local area, characterizing motion in the local area to determine real-time estimates of motion of sub-populations based on the sensor data, providing a crowd model for each local area, representing continuous functions describing expected motion near each local area, and determining parametric values of the crowd model based on the real-time estimates of the motion of the sub-populations. The method further includes learning and adapting auxiliary stochastic models characterizing normal evolution of the parametric values of the crowd model over time associated with each local area, and identifying a potential anomaly associated with the local area by comparing predictions from an auxiliary stochastic model with parametric values of the crowd model. | 12-18-2014 |
20140353873 | MICROPARTICLE ORGANIZATION - Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template. | 12-04-2014 |
20140331696 | METHODS AND SYSTEMS FOR MINIMIZATION OF MECHANICAL EFFECTS OF IMPACT VELOCITY DURING TISSUE PRESERVATION - Disclosed herein are methods and devices for preserving a sample for histological analysis, in particular embodiments, the disclosed methods and devices allow for contacting a surface with the sample at a contact velocity of between 0.05 cm/s to 10 cm/s. | 11-13-2014 |
20140297051 | ENERGY RESOURCE-GRID-LOAD AUTOMATIC CONTROL SYSTEM OF SMART MICROGRID AND CONTROL METHODS THEREOF - The present invention relates to an energy resource-grid-load automatic control system of smart microgrid and control methods thereof, which belong to the field of microgrid control and electrical technology. The energy resource-grid-load automatic control system comprises a distributed renewable energy power generation module, a distributed renewable energy inverter module, a conventional power generation module, a user load module, a bidirectional grid-connected control module, a distributed renewable energy intelligent optimizing power generation control module, an energy storage module, an intelligent energy storage unit adjuster and a storage battery pack. Compared with the conventional microgrid comprising a distributed renewable energy power generation system, the present invention guarantees the stability and the high energy utilization of the power generation system and effectively solves the problem of non-uniform frequency of use of storage batteries to unify the service life of the storage battery pack. | 10-02-2014 |
20140283536 | Systems, methods, and devices for frozen sample distribution - A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software. | 09-25-2014 |
20140279623 | SYSTEMS AND METHODS FOR SECURING ONLINE CONTENT RATINGS - Systems and methods are described for determining a weighted rating and a relative rating. In some embodiments, a receiving module and rating module are configured to receive an identity of a collector, a list of raters, and a social graph, determine for at least one rater a set of non-intersecting paths between the rater and the collector, calculate capacity values for non-intersecting paths, normalize path values, convert path values to a user weight, and apply the at least one rater's weight to the at least one rater's rating. In some embodiments, a receiving module and rating module are also configured to receive a rating for each of the items rated by the rater, calculate a transformed rating, calculate a relative rating, and assign a relative rating to an item. | 09-18-2014 |
20140277679 | Systems and Methods of using a Hieroglyphic Machine Interface Language for Communication with Auxiliary Robotics in Rapid Fabrication Environments - Disclosed are methods and systems for using hieroglyphs for communication in a rapid fabrication environment. The method includes receiving, by a control system for an articulated robotic arm, one or more images of a fabrication machine build space. The method includes identifying, by the control system, a hieroglyph present in the one or more images and translating the identified hieroglyph into one or more instructions for manipulation of the articulated robotic arm. The method includes causing the articulated robotic arm to carry out the instructions translated from the identified hieroglyph. Accordingly foreign objects are inserted into fabricated objects during an automated rapid fabrication process without extensive redesign of the rapid fabrication machine. In some implementations, an unmodified third-party stereolithographic rapid fabrication machine can be used. | 09-18-2014 |
20140273276 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 09-18-2014 |
20140213951 | ROBOTIC GAIT REHABILITATION TRAINING SYSTEM WITH ORTHOPEDIC LOWER BODY EXOSKELETON FOR TORQUE TRANSFER TO CONTROL ROTATION OF PELVIS DURING GAIT - A robotic gait rehabilitation (RGR) training system is provided to address secondary gait deviations such as hip-hiking. An actuation assembly follows the natural motions of a user's pelvis, while applying corrective moments to pelvic obliquity. A human-robot interface (HRI), in the form of a lower body exoskeleton, is provided to improve the transfer of corrective moments to the pelvis. The system includes an impedance control system incorporating backdrivability that is able to modulate the forces applied onto the body depending on the patient's efforts. Various protocols for use of the system are provided. | 07-31-2014 |
20140205172 | METHOD OF RECONSTITUTING CELLULAR SPECTRA USEFUL FOR DETECTING CELLULAR DISORDERS - Embodiments of the present disclosure provides improved methods for determining the presence of abnormalities in exfoliated cells. In one embodiment, the present disclosure provides methods for reconstructing cellular spectrum of a cell sample by creating a spectral map of the cellular sample, generating a binary mask of the spectral map, removing edge artifacts from each cell, and co-adding spectral data of each pixel corresponding to the cell to reconstruct the spectrum of each cell. | 07-24-2014 |
20140202964 | ANTIMICROBIAL POLYCATIONIC SAND FILTER FOR WATER DISINFECTION - A composition comprised of sand and a hydrophobic polycationic polymer covalently bonded to the sand is provided. Exemplary polycationic polymer are N,N-hexyl, methyl-PEI or N,N-dodecyl, methyl-PEI. This antimicrobial polycationic sand filter uses the antimicrobial properties of hydrophobic polycations (N-hexylated polyethylenimine). The sand filter inactivates microorganisms, as water is run through the sand. Preliminary sand washing methods can be used regenerate the inactivation efficacy. Unlike traditional water disinfectants, the polycationic sand filter does not create harmful disinfection byproducts and does not require large chemical and energy consumption. | 07-24-2014 |
20140202860 | System and method for integrating a single nanowire into a nanocircuit - A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state. | 07-24-2014 |
20140200458 | THREE DIMENSIONAL METAMATERIALS FROM CONFORMAL POLYMER COATING LAYERS - A manufacture for supporting propagation of terahertz waves includes a stack of layers made of a conformal protective polymer coating material; and an array of cells patterned on each of said layers, each cell including a metallic structure. | 07-17-2014 |
20140200241 | PRODRUGS FOR TREATING MICROBIAL INFECTIONS - Disclosed are methods of inhibiting the growth of pathogens using prodrug compounds as described herein. Also disclosed are methods of treating microbial infections using such compounds. | 07-17-2014 |
20140199372 | MICROBIAL GROWTH FACTORS - Disclosed are methods of cultivating or isolating a microorganism using one or more quinones as growth factors. Also disclosed are methods of treating a mammalian species with deficiency in symbionts using such compounds. | 07-17-2014 |
20140197046 | Chemical Sensor Based on Highly Organized Single Walled Carbon Nanotube Networks - A carbon nanotube-based micron scale chemical sensor or sensor array is provided that enables the remote detection of hydrogen sulfide and other chemicals in a gas stream. The sensor is suitable for use in harsh environments of high temperature and pressure such as those encountered during petrochemical exploration and recovery. Multiplex sensor devices detect two or more chemical agents simultaneously, or they can detect conditions such as pressure, salinity, humidity, pH, or scale-forming ions. Incorporation of read out electronics and an RF signal generator into the sensor device enables it to communicate to a relay station or receiver for 3D mapping or other analysis. Methods are also provided for fabricating the chemical sensor device and using the device for detection. | 07-17-2014 |
20140197042 | Saliva Glucose Monitoring System - A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided. The glucose sensor is highly sensitive and can detect glucose levels at least down to 5 ppm. Fabrication of the sensor involves depositing single-walled carbon nanotubes onto the surface of a working electrode in a 3 electrode electrochemical detector and functionalizing the nanotubes by depositing layers of polymers, metallic nanoparticles, and glucose oxidase enzyme onto the nanotubes. The sensor can be used as a disposable, single-use device or as part of an analytical system, such as a microfluidics system, for the analysis of multiple analytes. The sensor enables the diagnosis and monitoring of diabetes to be performed without pain or the need for finger pricks in a home or clinical setting. | 07-17-2014 |
20140195984 | ANALYTIC FRAMEWORKS FOR PERSONS OF INTEREST - The present systems and methods relate to frameworks for identifying persons of interest identified through datasets collected from law-enforcement agencies, financial institutions, or other public resources. The present systems represent network data regarding individuals and explicit connections between them as a network graph. The present systems determine a statistical model representing the network graph, the statistical model generating hidden parameters for decomposing and projecting the network graph onto a space of baseline communities. The present systems categorize cliques of nodes in the network graph as the space of baseline communities and infer a category for a received potential person of interest by determining a node corresponding to the received potential person of interest, and associating a clique from the categorized cliques to the node corresponding to the received potential person of interest, where the inferred category for the potential person of interest identifies the potential person of interest as suspicious. | 07-10-2014 |
20140195034 | COIL SCHEDULING METHOD AND SYSTEM FOR ELECTROGALVANIZING LINE IN STEEL INDUSTRY - A coil scheduling system and a method for electrogalvanizing line in steel industry are disclosed. In addition to considering the minimum changeover of physical parameters such as post-processing mode, width, thickness between every two adjacent steel coils, the method of the present invention further considers the influence of selecting coils on the production system stability due to the changeover of post-processing mode, width and thickness, and, thereby less adjusting the production equipment. Thus, the coils are smoothly produced, and more reasonable production process is obtained. The result of comparing the coil production schedule controlled by coil scheduling system for electrogalvanizing line in steel industry of the present invention with that of the production schedule determined manually shows that the number of changeover is reduced by 31.51%, and the adjustment of the production equipment is effectively reduced. Thus, the product quality is improved, and the enterprise benefit is increased. | 07-10-2014 |
20140175800 | Non-Rotating Wind Energy Generator - In an embodiment of the invention, a non-rotating wind energy generator uses the fluid flow principles of vortex shedding and transverse galloping to generate oscillatory, linear motion of a beam, and linear alternators, optionally located near both ends of the beam, generate electrical power when the beam is in motion. | 06-26-2014 |
20140128689 | JOINT SENSOR DEVICES AND METHODS - Joint sensor devices, bracing members, and methods of use are provided. A joint sensor device includes a bracing member contoured to fit over a joint on a limb of a human subject, such that the bracing member allows the limb to pivot; at least a first sensor operably connected to the bracing member, such that the first sensor is configured to detect an angle of the joint; at least a second sensor operably connected to the bracing member, such that the second sensor is configured to detect a vibration caused by joint movement; and a data communication device operably connected to the sensors, wherein the data communication device communicates signals from the sensors to an external device. The devices can also include temperature sensors. Bracing members and methods of monitoring joint health of subjects are also disclosed. | 05-08-2014 |
20140109545 | METHOD AND DEVICE FOR FUEL AND POWER GENERATION BY CLEAN COMBUSTION OF ORGANIC WASTE MATERIAL - Disclosed herein are systems and methods for the conversion of solid organic waste material, such as waste plastics, into fuel for the generation of heat and power. In addition, embodiments of the systems and methods disclosed herein relate to converting solid organic waste material into a gasified material for mixing with an oxidizing gas to allow for clean combustion of the fuel, thereby minimizing emissions of pollutants. | 04-24-2014 |
20140093769 | Carbon Nanotube-Based Electrode and Rechargeable Battery - Carbon nanotube-based electrode materials for rechargeable batteries have a vastly increased power density and charging rate compared to conventional lithium ion batteries. The electrodes are based on a carbon nanotube scaffold that is coated with a thin layer of electrochemically active material in the form of nanoparticles. Alternating layers of carbon nanotubes and electrochemically active nanoparticles further increases the power density of the batteries. Rechargeable batteries made with the electrodes have a 100 to 10000 times increased power density compared to conventional lithium-ion rechargeable batteries and a charging rate increased by up to 100 times. | 04-03-2014 |
20140085693 | METASURFACE NANOANTENNAS FOR LIGHT PROCESSING - A birefringent reflectarray having a planar metasurface containing metallic patches of subwavelength dimension is provided. The reflectarray is capable of simultaneously reflecting, concentrating, and splitting incident infrared light into two orthogonal linearly polarized reflections, and transforms the phase front of an incoming polarized light to a desired phase for the two reflections. Also provided is an optical modulator having a metasurface containing layers of nanoantennas of subwavelength dimension, and capable of modulating the phase and amplitude of light scattered from the modulator. The optical modulator has ability to perform computation through processing of light. | 03-27-2014 |
20140070935 | REAL-TIME WIRELESS DYNAMIC TIRE PRESSURE SENSOR AND ENERGY HARVESTING SYSTEM - An instantaneous/real-time wireless dynamic tire pressure sensor (DTPS) for characterizing pavement qualities and for detecting surface and subsurface pavement defects under normal driving conditions. Signal processing provides quantitative assessment of surface conditions. DTPS includes a vehicle tire valve stem-mounted pressure sensor and wheel hub-mounted signal conditioning, amplification, and transmitting circuitry. A signal processing computer within the vehicle is wirelessly coupled to the hub-mounted circuitry. Tire pressure changes caused by ground vibration excitation from the interaction between the tire and pavement at normal driving speeds are detected. When acoustic radiation from a surface wave is significantly stronger than acoustic noise, subsurface information can be extracted. An energy harvester based on strong magnetostatic coupling between a high permeability core solenoid, fixed proximate a vehicle wheel, and a bias magnet array, fixedly mounted in conjunction with a dust shield, can provide power the DIPS. | 03-13-2014 |
20140070111 | SIGNAL PROCESSING METHODS AND SYSTEMS FOR EXPLOSIVE DETECTION AND IDENTIFICATION USING ELECTROMAGNETIC RADIATION - In some aspects, the disclosure is directed to signal processing methods and systems for identifying a material on a body of a person using electromagnetic radiation. A radar system may measure a first reflection of radiation incident on a body of a person. The first reflection may be from a surface of the body. The radar system may measure a second reflection of the radiation. The second reflection may be from a first material residing on or proximate to the surface of the body. An analyzer may determine, relative to the first reflection, a delay in the second reflection due to propagation of a portion of the radiation through the first material. The analyzer may determine, based on the delay, at least one of: the first material and a dielectric constant of the first material. | 03-13-2014 |
20140065688 | METHODS AND COMPOSITIONS FOR MAGNETOPHORETIC SEPARATION OF BIOLOGICAL MATERIALS - Disclosed herein are devices for the magnetophoretic separation of target biological materials including a separation chamber that has a plurality of channels, and one or more wires carrying a current, the wires generating a magnetic force that deflects magnetically-labeled target biological materials into a buffer stream. In addition, methods of separating target biological materials from non-target biological materials in a sample are disclosed. Finally, methods for constructing a magnetophoretic separation device are disclosed. | 03-06-2014 |
20140061061 | ELECTROLYTIC TRANSFORMATION OF WATER CONTAMINANTS - Methods and apparatuses to transform contaminants in water by electrolytic processes are described. In some embodiments, the apparatuses and electrolytic processes couple an anode comprising iron and a high specific surface area cathode. Methods and apparatuses described herein provide advantages over conventional apparatuses and methods such as, for example, cost savings, efficiency, environmentally benign impact and versality for a variety contaminants. | 03-06-2014 |
20140057280 | METHODS AND COMPOSITIONS FOR HIGHLY SPECIFIC CAPTURE AND RELEASE OF BIOLOGICAL MATERIALS - Disclosed herein are hydrogel compositions and methods of making hydrogel compositions. Furthermore, methods of specifically capturing and releasing biological materials from a sample using the disclosed hydrogel compositions are disclosed, including methods of utilizing the compositions in microfluidic devices. | 02-27-2014 |
20140055314 | DOUBLY SHAPED REFLECTOR TRANSMITTING ANTENNA FOR MILLIMETER-WAVE SECURITY SCANNING SYSTEM - In some aspects, the disclosure is directed methods and systems for focusing millimeter-wave radiation to a line for scanning a target object. A source may provide millimeter-wave radiation, and may include a substantially point source. A reflector may include a surface with an elliptical cross-section within a first plane and a curved cross-section within a second plane perpendicular to the first plane. The curved cross-section may be shaped differently from the elliptical cross-section within their respective planes. The surface may focus the millimeter-wave radiation from the source at a line on a third plane parallel to or coinciding with the second plane. The line may be located at an approximate location where a target object is expected to be positioned. At least one sensor may measure the millimeter-wave radiation from the reflector scattered off the target object. | 02-27-2014 |
20140033804 | NARROW BORE POROUS LAYER OPEN TUBE CAPILLARY COLUMN AND USES THEREOF - A polymer-based PLOT capillary column prepared by in situ copolymerization of a functional monomer and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Also disclosed is a system comprising the polymer-based PLOT column coupled to a mass flow or concentration sensitive detector, for carrying out a chemical analysis method on samples separated by liquid chromatography using the column, and a process for using the system. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power and high column-to-column reproducibility. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems are capable of detecting the component parts of complex proteomic samples down to the low attomole to sub-attomole level. | 02-06-2014 |
20140031275 | METHODS OF ERADICATING BACTERIAL CELL POPULATIONS - Disclosed herein are methods and compositions for the eradication of bacterial infections. In particular, methods and compositions are disclosed for the eradication of persister and slow growing bacterial cell populations. In particular embodiments, the methods and compositions disclosed herein are useful for eradication of biofilms. | 01-30-2014 |
20140012520 | PHOTOVOLTAIC STRING MONITOR - A photovoltaic string monitor that provides PV-string level monitoring to detect abnormal operating conditions. The photovoltaic string monitor includes an indicator unit for indicating normal conditions, existing abnormal conditions or past occurrence of abnormal conditions. In one embodiment, the photovoltaic string monitor includes a plurality of lights and an LCD display. | 01-09-2014 |
20130333451 | GAS DELIVERY SYSTEM TO PROVIDE INDUCED PARTIAL SATURATION THROUGH SOLUTE TRANSPORT AND REACTIVITY FOR LIQUEFACTION MITIGATION - A system and method for providing a partial level of saturation to a mass of sand, through generation of gas bubbles, as a way to prevent liquefaction during earthquakes. The system includes a solution that is operable to generate gas bubbles and a solution generator that prepares the solution. A conduit delivers the solution to the sand, so that the solution generates the gas bubbles during and after being delivered to the sand. A probe may be used to determine whether the sand is susceptible to liquefaction before the solution is delivered and to assess a change in degree of partial saturation after the solution has been delivered. | 12-19-2013 |
20130333399 | Systems, methods, and devices for frozen sample distribution - A drilling system including a motor that produces a sonic, linear oscillatory motion is provided for removing a frozen biological sample from a stored frozen specimen and methods of use thereof without thawing the remainder of the specimen. The stator and slider assembly is operated by a servo controller which can communicate and be programmed through a port of a PC equipped with software. | 12-19-2013 |
20130330747 | MULTI-BIOMARKER BIOSENSOR - Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described. | 12-12-2013 |
20130323165 | Magnetic Nanoplatforms for Theranostic and Multi-Modal Imaging Applications - Disclosed are nanoparticle compositions comprising paramagnetic particles, radiolabels, fluorophores, and/or positron emission tomography agents encapsulated within a biocompatible vehicle. In addition, methods of multi-modal diagnostic imaging and treating diseased tissues are disclosed, wherein the methods comprises administering a nanoparticle composition to a subject in which the nanoparticle composition comprises paramagnetic particles, radiolabels, fluorophores, and positron emission tomography agents encapsulated within a biocompatible vehicle. | 12-05-2013 |
20130314828 | FAULT CURRENT LIMITER - A fault current limiter (FCL) for limiting a fault current in a power line during a fault condition. The FCL includes a magnetic coupling circuit for monitoring current in the power line through magnetic coupling; a sensing circuit for sensing the current in the power line and providing a signal indicative of the sensed current; a control circuit receiving the signal indicative of the sensed current in the power line and determining whether the sensed current indicates that the fault condition exists; and high and low impedance paths that are connected in parallel. The high impedance path includes a discharging impedance circuit for limiting the fault current. The low impedance path includes a reactor circuit and a switching unit having an ON state for conducting current through the low impedance path and an OFF state for conducting current through the high impedance path. | 11-28-2013 |
20130313198 | CAGED BAGS OF POROUS MATERIALS - Systems and methods employing beds of bagged and caged absorbent and adsorbent materials are disclosed. These inventions are useful in the area of solid phase extraction. | 11-28-2013 |
20130310717 | CUSTOMIZED, MECHANICALLY-ASSISTIVE REHABILITATION APPARATUS AND METHOD FOR DISTAL EXTREMITIES OF THE UPPER AND LOWER REGIONS - An apparatus for distal extremity rehabilitation includes a mechanical ground subassembly for disposition on a dorsal side of a patient's distal extremity, at or near a joint of the patient. The distal extremity may include the hand/wrist complex or the ankle/foot complex. The mechanical ground assembly may be constructed to match contours of the patient's distal extremity. The apparatus further includes a distal effector subassembly for disposition upon one or more distal appendages of the patient, the distal effector subassembly coupled to the mechanical ground subassembly. The apparatus also includes an LED thimble subassembly for disposition on one or more finger tips of the patient, and an LED object subassembly with which the patient interacts by manipulating the LED thimble with respect to the LED object. | 11-21-2013 |
20130289896 | REAL-TIME PAVEMENT PROFILE SENSING SYSTEM USING AIR-COUPLED SURFACE WAVE - A non-contact testing system and method using acoustic sensors and a mobile sensing system using this system and method is disclosed. The leaky surface wave is recorded with directional microphones. A fast inversion analysis algorithm is introduced to estimate the shear velocity profile and elastic modulus for the subsurface layers of pavement structures, using the dispersion curves obtained from the acoustic signals. An electrical hammer is used to produce impact impulses automatically. A mobile sensing system is integrated on a mobile cart to perform the mobile subsurface sensing for pavement structures. | 10-31-2013 |
20130287999 | Interfacial Convective Assembly for High Aspect Ratio Structures Without Surface Treatment - A method for assembling colloidal particles onto a substrate surface through fluid transport. The method comprises placing a first fluid placed adjacent to the substrate surface, applying a colloidal dispersion on top of the first fluid layer and removal of the first fluid layer. The method is extremely versatile, and is especially useful in depositing colloidal materials in high aspect ratio channels and vias without the need for prior treatment of the surface. | 10-31-2013 |
20130284606 | ELECTROCHEMICAL PROCESS FOR CONVERSION OF BIODIESEL TO AVIATION FUELS - Methods for the conversion of a biofuel such as biodiesel into an alkane composition such as an aviation fuel, kerosine, or liquified petroleum gas product involve a series of electrochemical reactions. The reactions include oxidation of methanol to carbon dioxide, reduction of fatty acid esters, and cleavage of fatty acid chains at C═C double bonds. The methods are carried out by systems of two or more electrochemical reactors. | 10-31-2013 |
20130281525 | ARYL HYDROCARBON RECEPTOR (AhR) MODIFIERS AS NOVEL CANCER THERAPEUTICS - Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness. | 10-24-2013 |
20130268249 | RE-MATCHING METHOD OF SLAB-ORDER FOR IMPROVING SLAB UTILIZATION IN IRON AND STEEL PLANTS - A re-matching method of slab-order for improving slab utilization in iron and steel plants, comprising the steps of Step 1: formulating a mathematical model according to information of slabs and orders, so as to quantitatively describe the optimization problem of slab-order matching; Step 2: dividing the slabs and orders into groups; Step 3: generating a new slab-order matching relationship for each group of slabs and orders by using a multiple neighborhoods based tabu search algorithm on the basis of the formulated mathematical model, tries to re-optimize the matching relationship with consideration of the original slab-order matching relationship and the load balance of all equipment units, so as to improve the slab-order matching relationship, decrease the slab cutting loss, reduce the redundant slab weight of each order, and improve the integrity of an order, thus improving slab utilization, ensuring to deliver an urgent order on time, and improving the customer satisfaction. | 10-10-2013 |
20130256013 | High Rate Electric Field Driven Nanoelement Assembly on an Insulated Surface - A method for high rate assembly of nanoelements into two-dimensional void patterns on a non-conductive substrate surface utilizes an applied electric field to stabilize against forces resulting from pulling the substrate through the surface of a nanoelement suspension. The electric field contours emanating from a conductive layer in the substrate, covered by an insulating layer, are modified by a patterned photoresist layer, resulting in an increased driving force for nanoelements to migrate from a liquid suspension to voids on a patterned substrate having a non-conductive surface. The method can be used for the production of micro scale and nanoscale circuits, sensors, and other electronic devices. | 10-03-2013 |
20130246107 | Method and Device for Assigning Surplus Slabs in the Slab Yard before Hot Rolling Process - The present invention provides a method and device for assigning surplus slabs in the slab yard to orders before hot rolling process, the method comprises steps of: S | 09-19-2013 |
20130236720 | RARE-EARTH-FREE OR NOBLE METAL-FREE LARGE MAGNETIC COERCIVITY NANOSTRUCTURED FILMS - Rare-earth-free, noble-metal-free nanostructured magnetic material thin films and methods of synthesis are described. Magnetocrystalline, ferrimagnetic thin films with islands of aligned single magnetic domains possess large coercivity. In particular, Mn | 09-12-2013 |
20130224120 | MULTIMODAL DIAGNOSTIC TECHNOLOGY FOR EARLY STAGE CANCER LESIONS - Disclosed herein are compositions of a multimodal detection agent and methods of fabricating the same. The multimodal detection agent comprises a plurality of metallic nanoparticles attached to a surface of a polymeric carrier. The detection agent further comprising one or more target-specific binding agents attached to the metallic nanoparticles or the polymeric carrier. | 08-29-2013 |
20130209991 | WIRELESS SWNT SENSOR INTEGRATED WITH MICROFLUIDIC SYSTEM FOR VARIOUS LIQUID SENSING APPLICATIONS - Sensors based on single-walled carbon nanotubes (SWNT) are integrated into a microfluidic system outfitted with data processing and wireless transmission capability. The sensors combine the sensitivity, specificity, and miniature size of SWNT-based nanosensors with the flexible fluid handling power of microfluidic “lab on a chip” analytical systems. Methods of integrating the SWNT-based sensor into a microfluidic system are compatible with the delicate nature of the SWNT sensor elements. The sensor devices are capable of continuously and autonomously monitoring and analyzing liquid samples in remote locations, and are applicable to real time water quality monitoring and monitoring of fluids in living systems and environments. The sensor devices and fabrication methods of the invention constitute a platform technology, because the devices can be designed to specifically detect a large number of distinct chemical agents based on the functionalization of the SWNT. The sensors can be combined into a multiplex format that detects desired combinations of chemical agents simultaneously. | 08-15-2013 |
20130197326 | Compositions And Methods For Measurement of Analytes - Disclosed herein are compositions comprising an oblong optode sensing agent. The oblong optode sensing agent comprises a core and a semipermeable membrane, wherein the core comprises one or more sensors configured to bind to an analyte. In addition, methods of making and detecting the oblong optode sensing agents are disclosed. | 08-01-2013 |
20130180861 | PHOTOCATALYST WITH ENHANCED STABILITY FOR HYDROGEN PRODUCTION AND OXIDATIVE REACTIONS | 07-18-2013 |
20130110422 | FAULT DETECTOR FOR OPERATING PROCESS OF ELECTRIC ARC FURNACE AND METHOD THEREOF | 05-02-2013 |
20130106206 | HIGH ENERGY DENSITY VIBRATION ENERGY HARVESTING DEVICE WITH HIGH-MU MATERIAL | 05-02-2013 |
20130089812 | HIGHLY STABLE PLATINUM ALLOY CATALYST FOR METHANOL ELECTROOXIDATION - A catalyst for use in at the anode of direct methanol fuel cells is made from nanoparticles having a core-shell structure. The core is an alloy of platinum and gold. The core is surrounded by a first shell of ruthenium and a second shell containing a ternary alloy of platinum, gold, and ruthenium. The catalyst can be made by a reverse-micelle method or by a single-phase scalable method. The catalyst is highly stable under conditions of use and resists dissolution of ruthenium or platinum. | 04-11-2013 |
20130079693 | Customizable Embedded Sensors - A method of constructing a sensor includes depositing a first material in a predetermined arrangement to form a structure. The depositing results in at least one void occurring within the structure. The method further includes depositing a second material within the voids. The second material may have electrical properties that vary according to deformation of the second material. The method also includes providing electrical access to the second material to enable observation of the one or more electrical properties. A sensor includes a structure that has one or more voids distributed within the structure. The sensor also includes a material deposited within the one or more voids. The material may be characterized by one or more electrical properties such as piezoresistivity. The sensor includes a first contact electrically coupled to a first location on the material, and a second contact electrically coupled to a second location on the material. | 03-28-2013 |
20130079495 | COLLAGEN FIBRILLAR CONSTRUCTION - Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering. | 03-28-2013 |
20130054204 | AUTOMATIC THREE-PHASE UNBALANCED LOAD COMPENSATION EXPERIMENTAL DEVICE AND ITS CONTROL METHOD - Disclosed are an automatic three-phase unbalanced load compensation experimental device and its control method. The experimental device comprises an automatic compensation device, a load simulation part, and detection, display and control parts. The automatic compensation device comprises power capacitors and intelligent grouping compound switches; the detection, display and control part comprises current transformers, molded case circuit breakers, a three-phase digital display ammeter, a three-phase electric power monitoring instrument, a protocol conversion module, 485 buses, Ethernet cables and an upper computer; the load simulation part comprises phase A, B and C loads which are in star connection and are same in component and circuit connection, an analog output module and a relay output module. Power monitoring instrument and digital ammeter are connected to the grid by circuit breaker and current transformer. The automatic compensation device and load simulation part are connected to the grid in parallel. | 02-28-2013 |
20130039852 | METHODS OF TARGETING CELLS FOR DIAGNOSIS AND THERAPY - Methods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and nanopolymers for detecting and treating cells. | 02-14-2013 |
20120323136 | ELECTRICAL IMPEDANCE MYOGRAPHY - Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM. | 12-20-2012 |
20120302653 | INITIATOR-TIGHTENED COMPOSITIONS - Disclosed herein are gel and plastic compositions comprising tightened layers of polymerized vinyl monomers, as well as methods of making the same, where the layers are tightened in having smaller pores. The tightened layers comprise tightened inner layers and exterior layers, and the compositions comprise polymer-attached (pendant) initiator or helper residues. | 11-29-2012 |
20120293023 | Voltage Tuning of Microwave Magnetic Devices Using Magnetoelectric Transducers - Tunable microwave magnetic devices that provide increased performance with reduced size, weight, and cost. The disclosed microwave magnetic devices are voltage-tunable devices that include ferrite substrates. To tune the devices, the magnetic permeability of the respective ferrite substrates is varied by external, voltage-tuned, magnetic fringe fields created by one or more magnetoelectric (ME) transducers. | 11-22-2012 |
20120267223 | BISTABLE NANOSWITCH - A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state. | 10-25-2012 |
20120264224 | SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER - Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel. | 10-18-2012 |
20120252820 | METHODS OF TREATING FUNGAL INFECTIONS - Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators to treat fungal infections are disclosed. | 10-04-2012 |
20120232110 | Antimicrobial Compounds - This disclosure relates to compositions including certain compounds identified by a quantitative, high throughput assay to be effective in inhibiting the ability of a bacterium to kill a host organism, as well as methods for using these compounds for treating bacterial infections. | 09-13-2012 |
20120219489 | CARBON NANOSTRUCTURES FROM PYROLYSIS OF ORGANIC MATERIALS - Methods and apparatus to generate carbon nanostructures from organic materials are described. Certain embodiments provide solid waste materials into a furnace, that pyrolyzes the solid waste materials into gaseous decomposition products, which are then converted to carbon nanostructures. Methods and apparatuses described herein provide numerous advantages over conventional methods, such as cost savings, reducion of handling risks, optimization of process conditions, and the like. | 08-30-2012 |
20120177723 | SiRNA PHOSPHOLIPID CONJUGATE - siRNA-conjugated liposomes and micelles, methods of making such conjugates, and methods of using such conjugates, such as for the delivery of siRNA to cells to reduce expression of target polypeptides in such cells, are described. | 07-12-2012 |
20120172339 | ANGIOGENIC RESORCINOL DERIVATIVES - Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid receptor distinct from CB1 and CB2. Thus, these compounds are specific ligands for one cannabinoid receptor distinct from CB1 and CB2. The invented compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response may be useful to treat a number of physiological conditions. | 07-05-2012 |
20120156499 | STABLE POLYELECTROLYTE COATED NANOPARTICLES - Stable nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics. | 06-21-2012 |
20120135064 | CONJUGATED NANODELIVERY VEHICLES - Anti-angiogenesis agent-linked liposomes and micelles, methods of making such liposomes and micelles, and methods of using such liposomes and micelles, such as for delivery of therapeutic and detection agents to tumor cells, are described. | 05-31-2012 |
20120109025 | MULTIPLE DEGREE OF FREEDOM REHABILITATION SYSTEM HAVING A SMART FLUID-BASED, MULTI-MODE ACTUATOR - A rehabilitation system that combines robotics and interactive gaming to facilitate performance of task-specific, repetitive, upper extremity/hand motor tasks, to enable individuals undergoing rehabilitation to improve the performance of coordinated movements of the forearm and hand is disclosed. More specifically, the rehabilitation system includes a two degree-of-freedom (DOF) robotic, upper limb rehabilitation system and interactive gaming hardware that is coupled to a computer, to provide a virtual reality-like environment. | 05-03-2012 |
20120082362 | Method for analyzing biological specimens by spectral imaging - A method for analyzing biological specimens by spectral imaging to provide a medical diagnosis includes obtaining spectral and visual images of biological specimens and registering the images to detect cell abnormalities, pre-cancerous cells, and cancerous cells. This method eliminates the bias and unreliability of diagnoses that is inherent in standard histopathological and other spectral methods. In addition, a method for correcting confounding spectral contributions that are frequently observed in microscopically acquired infrared spectra of cells and tissue includes performing a phase correction on the spectral data. This phase correction method may be used to correct various types of absorption spectra that are contaminated by reflective components. | 04-05-2012 |
20120046461 | STEROIDAL ANTI-HORMONE HYBRIDS - Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer. | 02-23-2012 |
20120027681 | Low-Aspect Ratio Carbon Nanostructures - Low-aspect ratio nanostructures, such as nanocups, nanorings, and arrays of nanocups and nanorings, methods of fabrication of nanostructures, and methods of using nanostructures are disclosed. | 02-02-2012 |
20110248166 | TUNABLE LASER-BASED INFRARED IMAGING SYSTEM AND METHOD OF USE THEREOF - Methods, devices, and systems for imaging tissue and other samples or samples using infrared (IR) transmissions from coherent transmission sources, such as a wide range, tunable, quantum cascade laser (QCL) designed for the rapid collection of infrared microscopic data for medical diagnostics across a wide range of discrete spectral increments. The infrared transmissions are transmitted through, reflected from, and/or transreflected through a sample, and then magnified and/or focused prior to being detected by a detector. After detection, the sample related image data is used to assess the sample. Such methods, devices, and systems may be used to detect abnormalities in tissue, for example, before such abnormalities can be diagnosed using art cytopathological methods. The methods, devices and systems may also optionally include a visible light detection subsystem and/or a motion control subsystem to assist in control and processing of imaging. | 10-13-2011 |
20110244048 | MULTIFUNCTIONAL SELF-ASSEMBLING POLYMERIC NANOSYSTEMS - Libraries of nanoparticles comprising therapeutic agents and/or imaging agents are disclosed, as well as methods of making, customizing, and using such libraries of nanoparticles. | 10-06-2011 |
20110123711 | METHODS FOR FORMING METAL-POLYMER HYBRID TOOLING FOR FORMING PARTS HAVING MICRO FEATURES - A method for forming metal-polymer hybrid tooling includes patterning a surface of a member such as a silicon wafer, stainless steel, nickel or nickel alloy, engaging a polymer layer with the patterned features of the surface of the silicon wafer to form the polymer layer having a reverse of the patterned surface the silicon wafer, removing the patterned polymer layer to expose a patterned polymer layer surface, depositing a metallic layer on the patterned polymer layer surface, and wherein the deposited metallic layer on the patterned polymer layer is operable to form parts with features having a width dimension between about 0.01 microns and about 100 microns and a height dimension of between about 0.01 micron and about 800 microns (e.g., up to aspect ratio of 8). | 05-26-2011 |
20110117582 | MULTI-BIOMARKER BIOSENSOR - Nanosubstrates as biosensors, methods of making such nanosubstrates, and methods of using such nanosubstrates to detect biomarkers are described. | 05-19-2011 |
20110105608 | MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING - Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer. | 05-05-2011 |
20110097757 | Biomarkers for Diabetes, Obesity, and/or Hypertension - Methods of identifying subjects having, or at risk of developing, diabetes, obesity, and/or hypertension are disclosed, as well as methods of identifying biomarkers for diabetes, obesity, and/or hypertension, and biomarkers identified by such methods. | 04-28-2011 |
20110071178 | Methods and Compounds for Modulating Cannabinoid Activity - Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. | 03-24-2011 |
20110046142 | ANTIBIOTIC COMPOUNDS - Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these compounds. | 02-24-2011 |
20110039874 | MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY - Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors. | 02-17-2011 |
20110038939 | THERAPEUTIC STABLE NANOPARTICLES - Stable colloid nanoparticles comprising poorly soluble drugs are disclosed, as well as methods of making and methods of using such nanoparticles, e.g., as therapeutics and diagnostics. | 02-17-2011 |
20100317614 | COMPOSITIONS AND METHODS FOR PEST CONTROL - Provided herein are compositions and kits comprising carbohydrate-based inhibitors that bind GNBP and/or inhibit β(1,3)-glucanase activity. Also provided are methods of using such inhibitors to protect against or treat pest infestation, as are compositions and kits comprising subparts of the carbohydrate-based inhibitors. | 12-16-2010 |
20100298084 | SEQUENTIAL PLANETARY STACK TRANSMISSION SYSTEM - A sequential planetary stack transmission system is provided. The system includes a stack of planetary gear sets, each gear set including a sun gear engageable with a rotatable central shaft, and freely rotatable concentrically about the central input or output shaft when not engaged with the central shaft. A plurality of planet gears engage with the sun gear, and a ring gear engages with the planet gears. The ring gears form a ring gear barrel rotatable as a unit concentrically with respect to the central shaft. A shifting assembly within the hollow central shaft engages sequentially with the sun gears to provide a desired gear ratio. The planetary stack assembly and the shifting assembly are disposed within a case. The system is suitable for a variety of applications, and is particularly suitable for bicycles. | 11-25-2010 |
20100292603 | Electrical Impedance Myography - Electrical impedance myography (EIM) can be used for the assessment and diagnosis of muscular disorders. EIM includes applying an electrical signal to a region of tissue and measuring a resulting signal. A characteristic of the region of tissue is determined based on the measurement. Performing EIM at different frequencies and/or different angular orientations with respect to a muscle can aid in the assessment and diagnosis. Devices are described that facilitate assessment and diagnosis using EIM. | 11-18-2010 |
20100285111 | SELF-ASSEMBLING MICELLE-LIKE NANOPARTICLES FOR SYSTEMIC GENE DELIVERY - Nanoparticles containing nucleic acid and suitable for use as in vivo delivery agents for nucleic acids are provided. The nanoparticles use a covalent conjugate of a polycation such as polyethylenimine and phospholipids. The final DNA-containing nanoparticle has a vesicular structure with a polyplex core surrounded by a mixed lipid/PEG-lipid monolayer envelope and offers simple preparation, high loading capacity, and in vivo stability. The nanoparticles have good in vivo stability and a prolonged blood circulation time and can effectively deliver a gene to a biological target such as a tumor. | 11-11-2010 |
20100260676 | PRECISION-GUIDED NANOPARTICLE SYSTEMS FOR DRUG DELIVERY - A method of preparing multifunctionalized nanoparticles involves using a modular system of half-linkers to attach functional moieties that serve to deliver the nanoparticles to a desired target, exert an effect at the target, or track the nanoparticles within a cell or an animal. The modular chemistry of the half-linker system permits the custom design and synthesis of functionalized nanoparticles bearing multiple groups and therefore results in precise delivery to desired cell types and intracellular locations. The functionalized nanoparticles can be used to treat or diagnose a variety of medical conditions, including neoplastic diseases, infectious diseases, and chronic diseases. | 10-14-2010 |
20100178299 | METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSES - The present invention relates to compositions and methods for enhancing an immune response, for example to a vaccine, by combining the administration of oxygen (O | 07-15-2010 |
20100173101 | METHOD OF MANUFACTURING THICK-FILM, LOW MICROWAVE LOSS, SELF-BIASED BARIUM-HEXAFERRITE HAVING PERPENDICULAR MAGNETIC ANISOTROPY - A method of producing a relatively-thick film of a magnetic material on a substrate for use in microwave and millimeter wave devices is disclosed. The method includes preparing a wet paste comprising a binder material, glass frit, and a finely-grained magnetic material; applying the wet paste over a stencil, template or mask disposed on the substrate, to form a film on a surface of the substrate; drying the wet paste within an applied magnetic field, to vaporize fluid and organic compounds in the binder material and to produce a desired magnetic orientation in the magnetic film; and sintering the magnetic film. Hot pressing the magnetic film during sintering by adding weight on the film improves density. | 07-08-2010 |
20100166726 | COMPOSITIONS FOR IMPROVING CELLULAR UPTAKE OF A CHEMOTHERAPEUTIC AGENT IN A CELL EXHIBITING MUCIN DEREGULATION - Methods and compositions that increase the cellular uptake of a chemotherapeutic agent are provided. Also provided are methods of increasing access to the cell surface by antibodies and ligands. The methods are useful in treating any mucinous carcinoma characterized by an increased expression and/or secretion of mucins. In addition, these methods provide an improvement in existing methods of chemotherapy. | 07-01-2010 |
20100147678 | ALUMINUM ELECTROLYTIC CELLS HAVING HETEROTYPIC STRUCTURED CATHODE CARBON BLOCKS - Disclosed is an aluminum electrolytic cell having profiled cathode carbon blocks structures, comprising a cell case, a refractory material installed on the bottom, an anodes and a cathode. The cathode carbon blocks include a profiled structure having projections on the top surface of the carbon blocks, that is, a plurality of projections are formed on a surface of the cathode carbon blocks. The aluminum electrolytic cell having the cathode structure according to the present invention can reduce the velocity of the flow and the fluctuation of the level of the cathodal molten aluminum within the electrolytic cell, so as to increase the stability of the surface of molten aluminum, reduce the molten lose of the aluminum, increase the current efficiency, reduce the inter electrode distance, and reduce the energy consumption of the production of aluminum by electrolysis. With the above configuration, compounds or precipitates of viscous cryolite molten alumina can be formed on the lower portion between walls protruding on the upper surface of the cathode, which can prohibit the molten aluminum from flowing into the cell bottom through the cracks and apertures on cathodes, so that the life of the electrolytic cell can be extended. | 06-17-2010 |
20100130450 | Methods of Treating Fungal Infections - Methods of identifying compounds that potentiate the activity of antifungal agents, potentiators identified by these methods, and methods of using potentiators are disclosed. | 05-27-2010 |
20100120163 | ULTRA-SENSITIVE TEMPERATURE SENSING AND CALORIMETRY - Methods and apparatus for ultra-sensitive temperature sensing and calorimetry. Radiation is directed at a thin electrically conductive film having one or more small apertures. The incident radiation excites surface plasmons on a first surface of the electrically conductive film, and energy associated with the surface plasmons couples to an opposite surface of the electrically conductive film, where surface plasmon-enhanced radiation (SPER) is emitted from the aperture(s). A temperature-sensitive fluid or solid dielectric material is disposed contiguous with at least a portion of the electrically conductive film, such that a temperature change in the dielectric material alters a resonance condition for the SPER. Measureable changes in the SPER due to altered resonance conditions provide for an ultrasensitive temperature sensor that can detect small temperature changes in the dielectric material. The disclosed methods and apparatus may be used for a variety of applications including, but not limited to, nanoscale to microscale calorimetry for pharmaceutical and biotechnology products, combustion sensing, explosive detection, and biotoxin monitoring. | 05-13-2010 |
20100116631 | BISTABLE NANOSWITCH - A non-volatile bistable nano-electromechanical switch is provided for use in memory devices and microprocessors. The switch employs carbon nanotubes as the actuation element. A method has been developed for fabricating nanoswitches having one single-walled carbon nanotube as the actuator. The actuation of two different states can be achieved using the same low voltage for each state. | 05-13-2010 |
20100107775 | System, Method, And Device For Measuring Parameters Of A Two-Phase Flow - A capacitive sensor for measuring flow parameters of a two-phase flow, a device for measuring phase concentration of a two-phase flow, and a system and method for measuring flow parameters of a two-phase flow is disclosed. In the capacitive sensor, at least one pair of electrodes is twisted by 180° in a common direction into a spiral shape. Edge guard electrodes are twisted in the common direction and are formed between adjacent electrode edges. Problems of non-homogeneous sensitivity distribution of a measuring field and soft field effect can be effectively addressed, thereby allowing reliable and accurate measurement of phase concentration of a two-phase flow. The system for measuring flow parameters of the two-phase flow can output signals with a current of 4˜20 mA to a PLC system or communicate with an industrial process control computer or with a remote control computer system in a operating room. | 05-06-2010 |
20100067263 | DUAL INTERLEAVED FLYBACK CONVERTER FOR HIGH INPUT VOLTAGE - An integrated magnetic flyback converter includes interleaved phases that can be connected in series for an input stage and in parallel for an output stage. An integrated magnetic core has legs with gaps that may weaken a coupling between a primary and secondary of the associated transformer. The primary and secondary of the transformer may be inversely coupled for each phase. The transformer leg gaps permit each phase to be operated with a duty cycle ratio greater than 50%. The interleaved converter has reduced output current ripple, reduced input component voltage stress, reduced magnetizing inductance, reduced magnetic component physical size and reduced common integrated magnetic core current spikes. | 03-18-2010 |
20100041529 | VARIABLE RESISTANCE HAND REHABILITATION DEVICE WITH LINEAR SMART FLUID DAMPER AND DYNOMETER CAPABILITIES - A variable resistance hand rehabilitation device and corresponding system. Improvements over the prior art include: a new damping system or damper design, to reduce friction and increase maximum force output; a dynometer feature that enables converting the dynamic device to a static grip force measuring device; a closed-loop controller; and a new graphic user interface for the medical practitioner and new virtual reality game software that allow accurate and smooth operation of the device and increased patient motivation. | 02-18-2010 |
20100038794 | THREE DIMENSIONAL NANOSCALE CIRCUIT INTERCONNECT AND METHOD OF ASSEMBLY BY DIELECTROPHORESIS - An assembly of nanoelements forms a three-dimensional nanoscale circuit interconnect for use in microelectronic devices. A process for producing the circuit interconnect includes using dielectrophoresis by applying an electrical field across a gap between vertically displaced non-coplanar microelectrodes in the presence of a liquid suspension of nanoelements such as nanoparticles or single-walled carbon nanotubes to form a nanoelement bridge connecting the microelectrodes. The assembly process can be carried out at room temperature, is compatible with conventional semiconductor fabrication, and has a high yield. The current-voltage curves obtained from the nanoelement bridge demonstrate that the assembly is functional with a resistance of −40 ohms for gold nanoparticles. The method is suitable for making high density three-dimensional circuit interconnects, vertically integrated nanosensors, and for in-line testing of manufactured conductive nanoelements. | 02-18-2010 |
20100024879 | TITANIA NANOTUBES PREPARED BY ANODIZATION IN CHLORIDE-CONTAINING ELECTROLYTES - A method of preparing titania nanotubes involves anodization of titanium in the presence of chloride ions and at low pH (1-7) in the absence of fluoride. The method leads to rapid production of titania nanotubes of about 25 nm diameter and high aspect ratio. The nanotubes can be organized into bundles and tightly packed parallel arrays. Inclusion of organic acids in the electrolyte solution leads to the incorporation into the nanotubes of up to 50 atom percent of carbon. In a two-stage method, a titanium anode is pre-patterned using a fluoride ion containing electrolyte and subsequently anodized in a chloride ion containing electrolyte to provide more evenly distributed nanotube arrays. The titania nanotubes have uses in composite materials, solar cells, hydrogen production, and as hydrogen sensors. | 02-04-2010 |
20100003158 | VIBRATORY POWDER CONSOLIDATION - A vibratory powder consolidation process is provided in which a powder material is subjected to vibratory energy while under static compressive loading. The process provides rapid, full-density powder consolidation with minimum or no structural degradation. | 01-07-2010 |
20090306801 | PATIENT SPECIFIC ANKLE-FOOT ORTHOTIC DEVICE - The unique advantages of computer-controlled fabrication of a patient-specific orthotic device using an automated fabrication machine capable of following computer instructions to create 3D surface contours and new developments in non-invasive three-dimensional (3D) scanning have made it possible to acquire digital models of freeform surfaces such as the surface anatomy of the human body and to then fabricate such a patient-specific device with high precision. Such a patient-specific device brings significant improvement in patient-specific fit, comfort, and function of medical devices (and, in particular, to orthoses that require a close fit to the wearer's body to act effectively). The combination of these two technologies is ideally suited for the development of patient-specific orthotic devices. | 12-10-2009 |
20090285757 | METHODS OF TARGETING CELLS FOR DIAGNOSIS AND THERAPY - Methods of making bispecific binding complexes and nanopolymers coupled to detection and/or therapeutic agents are disclosed. Also disclosed are methods of using such bispecific binding complexes and nanopolymers for detecting and treating cells. | 11-19-2009 |
20090242756 | INTENSIFIED NEUTRAL LOSS TAGS AND USE THEREOF IN MASS SPECTROMETRY - Ultrasensitive detection of a chemical substance (analyte) by mass spectrometry is achieved by employing a molecular tag that yields an intense parent ion and then an intense daughter ion in a multi-stage mass spectrometer. | 10-01-2009 |
20090221430 | Proteomic Methods For The Identification And Use Of Putative Biomarkers Associated With The Dysplastic State In Cervical Cells Or Other Cell Types - The invention relates to methods for detecting and identifying potential biomarkers of high-grade cervical dysplasia in an individual human subject. The invention also relates to newly discovered biomarkers, as set forth in Tables 1-4 herein, which are associated with the dysplastic state of cervical cells. It has been discovered that a differential level of expression of any of these markers or combination of these markers correlates with a dysplastic condition in a human subject, e.g., a patient. | 09-03-2009 |
20090203146 | NARROW BORE LAYER OPEN TUBE CAPILLARY COLUMN AND USES THEREOF - A polymer-based PLOT column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Styrenic based monomers such as styrene and divinylbenzene or meth/acrylic based monomers such as butyl or stearyl methacrylate and ethylene glycol dimethacrylate, are preferred. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC/MS proteomic analysis. Columns according to the invention are characterized by high resolving power, high column-to-column reproducibility and relatively high loading capacity. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems provide high sensitivity for analysis of complex proteomic samples, even down to the low attomole to sub-attomole level. | 08-13-2009 |
20090198817 | SYSTEM AND METHOD FOR VIRTUAL SERVER MIGRATION ACROSS NETWORKS USING DNS AND ROUTE TRIANGULATION - A first virtual server is moved from a first network location to a second network location without interrupting service to users of the first virtual server. The state and data of the first virtual server are copied and transmitted to the second network location to create a copy of the first virtual server. The first virtual server copy is then updated to duplicate the first virtual server and all connections or packets directed to the first virtual server are intercepted and directed to the first virtual server copy at the second network location. A DNS entry for the symbolic name of the first virtual server is updated to reflect a shortened TTL value and then the address field of the DNS entry is set to the address of the first virtual server copy after the changeover and subsequent connections are directed to the first virtual server copy. | 08-06-2009 |
20090188999 | DEVICES, METHODS AND APPLICATIONS FOR EXTRACTION OF MOLECULES FROM POLYMERIC GEL ELECTROPHORETIC MEDIA - A device and method to provide a simplified wash process and controlled disintegration of a soft substance, such as a gel, are disclosed. In use, a block of, e.g., gel matrix is placed in the device and washed with a series of appropriate solutions to remove interfering contaminants. The washing liquid is removed through a deformable narrow opening in the bottom of the device, and, subsequently, the gel block is extruded through the deformable narrow opening, by a physical force, such as centrifugal force, a vacuum or positive pressure from a gas or liquid, etc., resulting in fragmentation of the gel block into a series of particles of similar size. The fragmentation of the gel results from shear forces exerted onto the gel block traveling through the deformable narrow opening in the device. The rate of such fragmentation and resulting fragment size can be controlled by extruding the gel block using a predefined level of force as well as by controlling the dimensions and shape of the narrow opening (s) in the device. | 07-30-2009 |
20090086322 | Photonic Crystal Devices Using Negative Refraction - Negative refraction in photonic crystals and diffraction grating is used to design plano-concave lenses to focus plane waves. Microwave experiments are carried out to demonstrate negative refraction and the performance of these lenses. Demonstration of negative refraction of visible light is also performed for the grism. These lenses can be used in optical circuits, astronomical applications, etc. | 04-02-2009 |
20090040132 | Anisotropic metal-dielectric metamaterials for broadband all-angle negative refraction and superlens imaging - A metamaterial comprises a plurality of metallic nanowires embedded in a dielectric matrix. The metamaterial composite media provide broadband all-angle negative refraction and flat lens, superlens and curved hyperlens imaging in specific spectral regions over a wide range of frequencies including, for example, from deep infrared to ultraviolet frequencies. | 02-12-2009 |
20090040131 | Dielectric and magnetic particles based metamaterials - RF-optical metamaterials with (±ε, ±μ) figures-of-merit of interest are constructed from coupled magnetic and dielectric multi-resonant multi-disks (finite-size cylinders) or multi-sphere lattices arranged in a periodic or a random fashion to offer tailored magnetic and electric dipole moments. The present metamaterials include embedded particles arrays that provide coupled magnetic and electronic modes equivalent to L (inductor) and C (capacitor) circuit models. Novel arrangements of these dipole modes (L and C) tailor the transfer function to the physics of interest. | 02-12-2009 |
20080280317 | Comprehensive Characterization Of Complex Proteins At Trace Levels - A combination of “bottom up” and “top down” MS analysis of posttranslational modifications in complex proteins is described. The method comprises digestion of the protein with an enzyme that forms larger peptide fragments than trypsin (>3000 D), performing HPLC with the fragments and applying a new data acquisition strategy using on-line coupling with e.g. LTQ-FTMS, a hybrid mass spectrometer that couples a linear ion trap with a Fourier transform ion cyclotron resonance (FTICR) cell. The method is applied to analysis of posttranslational modifications of protein isoforms. | 11-13-2008 |