Nihon University Patent applications |
Patent application number | Title | Published |
20160113970 | PERIODONTAL TISSUE REGENERATION MATERIAL - It is a problem of the present invention to provide a convenient and safe periodontal tissue regeneration material and provide a method of regenerating a periodontal tissue. The present invention provides a periodontal tissue regeneration material comprising dedifferentiated fat cells (DFAT) as the convenient and safe periodontal tissue regeneration material. The present invention provides a method of regenerating a periodontal tissue with the periodontal tissue regeneration material. | 04-28-2016 |
20160032057 | NOVEL PI POLYAMIDE - To provide a safe and stable medicine useful for prevention and treatment of prostate cancer. | 02-04-2016 |
20150175995 | THERAPEUTIC AGENT FOR EPITHELIAL AND ENDOTHELIAL INJURY - The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22. | 06-25-2015 |
20140357805 | Polyolefin Having Terminal Double Bond and Method of Producing the Same - The present disclosure relates to a novel polyolefin having a terminal double bond and a method of producing the same. A polyolefin having a terminal double bond includes a polyolefin having a terminal double bond at either end and a polyolefin having a terminal double bond at one end, which are thermal degradation products of a polyolefin. An average number of terminal vinylidene groups per molecule is 1.3 to 1.9, a number average molecular weight (Mn) is 50,000 to 5,000,000, and a polydispersity index (Mw/Mn) of a molecular weight distribution is less than or equal to 5.0. | 12-04-2014 |
20140212367 | HAIR OIL USING OIL-BASED GEL-LIKE COMPOSITION - Provided is a hair oil that spreads smoothly, gives a soft and light finish, and satisfactorily effectively imparts a moist feel, easiness of styling, and a glossy feel to the hair. The provided hair oil includes an oil-based gel-like composition including a gel-forming agent and an oil-phase component, | 07-31-2014 |
20140200253 | INDIRUBIN DERIVATIVE HAVING HIGHLY SELECTIVE CYTOTOXICITY FOR MALIGNANT TUMORS - An agent for treating malignant tumors based on a new mechanism is provided, which comprises an indirubin derivative represented by formula (1) or a salt thereof: | 07-17-2014 |
20140186464 | PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR SEPSIS - The present invention provides a sepsis therapeutic drug useful for prophylaxis and treatment of sepsis. A prophylactic agent and/or a therapeutic agent for sepsis containing 5-aminolevulinic acid (5-ALA) or a derivative thereof or a pharmacologically acceptable salt of 5-ALA or the derivative as an active ingredient is prepared. The prophylactic agent and/or the therapeutic agent preferably contains a metal-containing compound such as ferrous sodium citrate in addition to the ALAs. Preferred examples of the ALAs include ALA; various esters of ALA such as methyl, ethyl, propyl, butyl, and pentyl esters; and hydrochlorides, phosphates, sulfates of ALA and the esters. | 07-03-2014 |
20140094528 | OIL-BASED GEL-LIKE COMPOSITION - Provided is a gel-forming agent that is easy to prepare and has all the properties including high safety for the living body and the environment, satisfactory gel-forming capability, comfortable feeling upon use, and good handleability. The gel-forming agent includes a lecithin, and a polyglycerol fatty acid ester in an amount of from 30 to 150 parts by weight per 100 parts by weight of the lecithin. The polyglycerol fatty acid ester has a fatty acid residue having 14 or less carbon atoms, has an HLB of 15 or more as determined based on an organic conceptual diagram, and has a degree of glycerol polymerization of from 8 to 40. | 04-03-2014 |
20130340239 | SUBSTRATE JOINING METHOD USING RIVET, AND JOINING STRUCTURE - A joining method includes punching respective laminated plate materials by a rivet shaft portion of a SPR, forming a crimp portion at the front end of the rivet shaft portion, and fastening and joining the laminated plate materials between the rivet head portion and the crimp portion. Washers are laid on and brought into contact with respective opposite surfaces relative to joining surfaces of the laminated plate materials, the washers each having an inner hole through which the rivet shaft portion is allowed to pass, the washers are used as jigs at the time of the punching, the punching by means of the rivet shaft portion is performed along the inner holes of the washers, and the joining is performed so that the washers left between the rivet head and the crimp portion and the opposite surfaces. | 12-26-2013 |
20130330319 | CELL MIGRATION MODULATOR - The present invention provides a cell migration regulator capable of promoting or inhibiting cell migration, a method for regulating cell migration, and a pharmaceutical composition comprising such a regulator, etc. The cell migration regulator of the present invention comprises a peptide, a derivative thereof, or a salt of the peptide or the derivative, wherein the peptide comprises the full-length blood coagulation factor IX, a segment derived from the full-length blood coagulation factor IX by removal of the trypsin domain, the light chain of blood coagulation factor IX, or the EGF1 domain of blood coagulation factor IX, or the EGF3 domain of the endothelial cell locus-1 protein. | 12-12-2013 |
20130288948 | ESTABLISHMENT OF MOTIF COMPRISING ACIDIC AMINO ACID, CAPABLE OF STABILIZING PROTEIN IN CELLS, AND APPLICABLE TO PROTEIN THERAPY, CONTROL OF DIFFERENTIATION/UNDIFFERENTIATION OF CELL AND ANTIBODY THERAPY - A motif is searched which can inhibit the proteolysis of a protein that has been administered to a cell or an individual. Thus, disclosed is a method for designing/producing a protein having resistance to proteolysis. Specifically disclosed is a motif capable of inhibiting proteolysis, which comprises an amino acid region lying between the 396 | 10-31-2013 |
20130281464 | BIGUANIDE DERIVATIVE COMPOUND - Provided is a novel compound which simultaneously inhibits both NMDA receptors and ASIC1a, which are associated with neurodegenerative disease and so on, and thus is useful for the prevention and treatment of various nervous system diseases. A biguanide derivative represented by the following general formula (1), a salt thereof, or a hydrate of the derivative or the salt: | 10-24-2013 |
20130232550 | AUTHENTICATION SERVER AND AUTHENTICATION METHOD BY AUTHENTICATION SERVER - An authentication server capable of determining securely and accurately whether an access source is a cellular phone or a computer when a content is accessed with being limited to cellular phone users. The authentication server including a transmission delay time measuring unit that measures a transmission delay time between the authentication server and a communication terminal over a plurality of times, a transmission delay time distribution property determining unit that determines whether or not a distribution property of the transmission delay time measured over the plurality of times is discrete, and a content access authentication unit recognizing that the communication terminal is a wireless communication terminal and approving the access to the contents when the distribution property of the transmission delay time is determined as being discrete and recognizing that the communication terminal is a wired communication terminal and denying the access to the contents when the distribution property of the transmission delay time is determined as not being discrete. | 09-05-2013 |
20130197000 | DRUG AND FOOD/DRINK FOR PREVENTING OR IMPROVING CEREBRAL DYSFUNCTION | 08-01-2013 |
20130116212 | OIL-BASED GEL-LIKE COMPOSITION - There is provided a gel-forming agent which is easily prepared and has all of high safety in the living body and the environment, good gel-forming capability, excellent use feeling, and good handleability. | 05-09-2013 |
20130078277 | INFECTIOUS HEPATITIS C VIRUS-HIGH PRODUCING HCV VARIANTS AND USE THEREOF - An objective of this invention is to provide an HCV strain with a high capacity for virus production in a cell culture system. This invention provides a nucleic acid encoding a polyprotein precursor of the hepatitis C virus JFH1 strain having one or more amino acid substitutions, wherein the polyprotein precursor comprises at least substitution of glutamine at position 862 with arginine, as determined with reference to the amino acid sequence as shown in SEQ ID NO: 2 in the Sequence Listing. | 03-28-2013 |
20130071804 | Adhesive for Teeth-Straightening Members - The present invention discloses an adhesive for orthodontic attachments, which contains (A) a polymerizable monomer, (B) a polymerization initiator and (C) a fluorescent dye and, when cured, exhibits a fluorescence spectrum having a peak at 400 to 800 nm. As the polymerization initiator (B), there is preferably used a compound which generates a radical through the transfer of hydrogen between two components, or a compound which generates a radical species through intramolecular cleavage. As the fluorescent dye (C), a coumarin type dye is used preferably. | 03-21-2013 |
20120264742 | PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE - A pharmaceutical composition for external use which is an organogel containing a fatty acid ester and a glycerolglycerin fatty acid ester, in particular, a novel transdermally absorbable pharmaceutical composition for external use which has a drug such as non-narcotic analgesics as an active ingredient made in organogel form containing a drug such as non-narcotic analgesics as an active ingredient, a fatty acid ester and a glycerolglycerin fatty acid ester, and a method for producing the composition. The pharmaceutical composition significantly improves skin permeability of drugs such as non-narcotic analgesics and allows a sufficient amount of drug to permeate the skin sustainably. Moreover, since the pharmaceutical composition is in organogel form, it can be easily applied to a preparation in practice. In addition, the pharmaceutical composition can provide efficient use and the like of drugs due to a high drug release rate and therefore is highly useful. | 10-18-2012 |
20120245099 | APOPTOSIS INDUCER - The present invention provides an apoptosis-inducing agent capable of inducing apoptosis in various cells including tumor cells and other cells in a simple manner, etc. The apoptosis-inducing agent of the present invention comprises a peptide shown in (a) or (b) below, a derivative thereof, or a salt of the peptide or the derivative: (a) a peptide which comprises an amino acid sequence represented by the formula: C—X-D-X—X—X—X—Y—X—C—X—C (SEQ ID NO: 1)(I); or (b) a peptide which comprises an amino acid sequence with deletion, substitution or addition of one or several amino acids in the amino acid sequence represented by formula (I) and which has apoptosis-inducing activity. | 09-27-2012 |
20120071628 | TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE - Disclosed is a topical therapeutic agent for ophthalmic diseases, which comprises a compound capable of binding specifically to a DNA sequence. More preferably disclosed is a topical therapeutic agent for ophthalmic diseases, which comprise a pyrrole-imidazole polyamide having a specific structure. The topical therapeutic agent for ophthalmic diseases comprises a pyrrole-imidazole polyamide which can inhibit transforming growth factor-β gene and matrix metalloproteinase 9 gene. | 03-22-2012 |
20120039435 | X-ray imaging apparatus - In an X-ray imaging apparatus that performs X-ray CT imaging, an X-ray generator ( | 02-16-2012 |
20120012593 | STRUCTURE AND MANUFACTURING METHOD FOR PRESSURE VESSEL - A pressure vessel structure includes a vessel main body, and a grid layer provided on a periphery of the vessel main body and including a plurality of grid lines formed by intersecting strip-form raw materials so as to overlap alternately. Thus, a burst pressure of the pressure vessel is increased. | 01-19-2012 |
20110262150 | HIGH-SPEED PULSED HOMODYNE DETECTOR IN TELECOM BAND - [Object] It is to raise operational frequency and S/N ratio of the pulsed homodyne detector to measure the quadrature amplitude of the signal pulse light. | 10-27-2011 |
20110228219 | OPHTHALMIC SIMULATOR - A metamorphopsia simulator is capable of numerically simulating deformation of the retina of a metamorphopsia patient and irregularity in an arrangement of visual cells caused thereby. The metamorphopsia simulator of the present invention uses a method of digitizing a deformation amount of the retina according to an expression based on a probability density function, to find a movement amount of visual cells, and according to the movement amount of visual cells, find distortion of an image observed by the metamorphopsia patient. | 09-22-2011 |
20110213575 | MATERIAL HARDNESS DISTRIBUTION DISPLAY SYSTEM AND MATERIAL HARDNESS DISTRIBUTION DISPLAY METHOD - A material hardness distribution display system ( | 09-01-2011 |
20110189497 | PURE-ALUMINUM STRUCTURAL MATERIAL WITH HIGH SPECIFIC STRENGTH CONSOLIDATED BY GIANT-STRAIN PROCESSING METHOD - Disclosed is a structural material using novel, high-purity aluminum, which is produced by using fine aluminum powder as the material, as well as a method for manufacturing such structural material. A processed aluminum material having the properties of an aluminum structural material constituted by aluminum, aluminum carbide and unavoidable impurities except aluminum and aluminum carbide is characterized in that a material obtained by uniformly dispersing stearic acid in fine aluminum powder is filled in an L-shaped bent die, and pressures are applied to the material from one direction and the other direction of the die wherein the pressure applied to the material from the one direction of the die is greater than the pressure applied to the material from the other direction of the die, to cause the material to pass through a hole of the L-shaped bent die so that the material is given and accumulates giant strain, and this process is performed continuously. | 08-04-2011 |
20110178100 | APOPTOSIS INHIBITOR - It is directed to provide a novel apoptosis inhibitor. Specifically directed is an apoptosis inhibitor containing a biphenylcarboxamide compound represented by the following formula (1) as an active ingredient, wherein R | 07-21-2011 |
20110160399 | HISTONE MODIFICATION INHIBITOR SPECIFIC TO TARGET GENE - The present invention provides a target gene-specific histone modification regulator, which comprises a conjugate between a histone modification regulator and a polyamide capable of recognizing a regulatory region in a target gene. This enables the provision of a target gene-specific histone modification regulator. | 06-30-2011 |
20110086342 | Hepatocellular Carcinoma-Associated Gene - The present invention provides a method for evaluating cancer, which comprises the following steps of:
| 04-14-2011 |
20110076700 | ANTI-CRP ANTIBODY AND UTILIZATION OF THE SAME - It is intended to provide means capable of specifically recognizing CRP in a test sample and assaying it with high sensitivity. The present invention provides an anti-CRP antibody which reacts with a C-reactive protein (hereinafter referred to as CRP) and recognizes an epitope located at residues 147 to 172 in a CRP amino acid sequence represented by SEQ ID NO: 1. | 03-31-2011 |
20110028491 | APOPTOSIS INHIBITOR - It is directed to provide a novel apoptosis inhibitor. Specifically directed is an apoptosis inhibitor containing a biphenylcarboxamide compound represented by the following formula (1) as an active ingredient, wherein R | 02-03-2011 |
20110010407 | SIGNAL APPROXIMATION SYSTEM FOR MINIMIZING THE MEASURE OF WORST-CASE ERROR - The purpose of this invention is that the optimum approximation formula can be derived even if an analysis filter has non-linear characteristic in a discrete signal approximation system. The norm of source signal | 01-13-2011 |
20100237142 | PAPER CONTAINER - Provided is a paper container including four body portion panels ( | 09-23-2010 |
20100209738 | THIN FILM MATERIAL AND RECORDING MEDIUM - Disclosed is a thin film material including a substrate and an underlying layer formed on the substrate. A large number of recesses of an extremely small size are demonstrated in a surface of the underlying layer. On this surface of the underlying layer is formed a magnetic film or a non-magnetic film. | 08-19-2010 |
20100204191 | Function-Selective Vitamin D Receptor Agonist - The present invention provides a VDR ligand which does not induce hypercalcemia that is an adverse reaction of a vitamin D3 preparation; and a composition which comprises lithocholic acid propionate, a salt thereof, a solvate thereof, or a prodrug thereof. | 08-12-2010 |
20100195517 | PROPAGATION DELAY TIME MEASURING SYSTEM - A propagation delay time measuring system | 08-05-2010 |
20100186756 | MOUTH GUARD AND PROCESS FOR PRODUCING THE SAME - A mouth guard with a uniform shape adapts to occlusion shapes and fits closely to teeth at an occlusion position. The mouth guard is attached to a maxillary tooth row. The mouth guard is formed from a continuous pore high-polymer material to have a characteristic that includes a plateau region of a stress to a compression strain. The mouth guard utilizes the characteristic to fit closely to the tooth rows at the occlusion portion between upper and lower tooth rows, to apply even stress to the tooth rows contacting the occlusion portion. As this result, the mouth guard provides an excellently close-fitting degree and high safety owing to high impact absorption power. | 07-29-2010 |
20100184882 | ADHESIVE FOR TEETH-STRAIGHTENING MEMBERS - The present invention discloses an adhesive for orthodontic attachments, which contains (A) a polymerizable monomer, (B) a polymerization initiator and (C) a fluorescent dye and, when cured, exhibits a fluorescence spectrum having a peak at 400 to 800 nm. As the polymerization initiator (B), there is preferably used a compound which generates a radical through the transfer of hydrogen between two components, or a compound which generates a radical species through intramolecular cleavage. As the fluorescent dye (C), a coumarin type dye is used preferably. | 07-22-2010 |
20100136558 | CANINE CD20 GENE - It is intended to clarify the CD20 amino acid sequence and its gene sequence which are essentially required in constructing an anti-CD20 antibody useful in treating animal malignant lymphoma. It is also intended to provide a method of diagnosing canine malignant lymphoma by using the CD20 gene sequence. Using monocytes in canine blood as a sample, mRNA is obtained and the full base sequence of canine CD20 gene (SEQ ID NO:2) is determined. Based on this sequence, its amino acid sequence (SEQ ID NO:1) is determined. Comparing the homologies with human and mouse CD20 genes and amino acid sequences, it is identified as canine CD20 gene. Moreover, a primer specific to the canine CD20 gene is constructed and the expression of the CD20 gene in a sample is examined, thereby giving a method of diagnosing canine B lymphocyte-origin malignant lymphoma. | 06-03-2010 |
20100075940 | DENDRITIC POLYAMIDOAMINE PHTHALOCYANINE DERIVATIVE - The present invention is directed to a dendritic polyamidoamine phthalocyanine derivative which is useful as, for example, a fluorescent material or a photodynamic therapeutic drug for cancer. The derivative is represented by the following formula (1): | 03-25-2010 |
20100003083 | DIVING EQUIPMENT - Diving equipment easily operable by disabled persons, aged persons, etc. and wearable by oneself. The diving equipment such as buoyancy controlling device (BCD) has the function to hold a tank on the shoulder of a wearer and the function as a life jacket providing buoyancy to the wearer. In the diving equipment (BCD) of which the overall is formed in a vest-like shape, a tank holding part ( | 01-07-2010 |
20090286239 | Method of Detecting Individual Encapsulated Influenza Viruses, Primer Set for the Detection and Kit for the Detection - The present invention provides a method of rapidly, simply and accurately detecting capsular serotype | 11-19-2009 |
20090264608 | METHOD FOR PRODUCING NORBORNENE BASED ADDITION (CO)POLYMER - By specifying a catalyst system (combination of catalyst and cocatalyst) which has high polymerization activity, a norbornene based addition (co)polymer is efficiently produced. Specifically, C | 10-22-2009 |
20090259441 | COMMUNICATION NETWORK DESIGNING METHOD, COMMUNICATION DESIGNING APPARATUS, AND RECORDING MEDIUM - The present invention is to provide a communication network designing method based on an actual condition of social network structured on a communication network, a communication network designing program, and a recording medium on which the program is recorded. | 10-15-2009 |
20090258966 | Dental Composition - An object of the present invention is to provide a dental composition having excellent adhesive effect and simultaneously not causing microleakage. | 10-15-2009 |
20090215641 | Gene involved in occurrence/recurrence of hcv-positive hepatocelluar carcinoma - The present invention relates to a method for screening a gene involved in early recurrence of HCV-positive hepatocellular carcinoma associated with chronic hepatitis, comprising: determining an expression level of a gene in a noncancerous site from each of early and late recurrent cases of HCV-positive hepatocellular carcinoma associated with chronic hepatitis; and selecting a gene whose expression is increased in the early recurrent case compared with that in the late recurrent case. The present invention can provide a gene involved in recurrence of hepatocellular carcinoma. | 08-27-2009 |
20090211366 | Fatigue life estimating method for spot welded structure - A fatigue life estimating method for a spot welded structure is provided comprising the steps of providing a shell model of a spot welded structure for a finite element method analyzing process, calculating the nominal structural stress on a nugget as the center of the spot welded structure using a disk bending theory and a two-dimensional elastic theory of the elastodynamics with the partial loads exerted on the nugget and the deflection on the circumference of a circle, D in diameter, in which the nugget is located, which have been calculated by the finite element method analyzing process of the shell model, and estimating the fatigue life of the spot welded structure from the nominal structure stress. | 08-27-2009 |
20090170053 | Cutting Bar for Dental Use - Provided is a cutting bar for dental use that can cut both dentin and enamel with a single bar unanesthetically and efficiently without causing any pain or unpleasant sensation in a patient, in particular, a cutting bar for dental use that can fundamentally solve the problem in that a cutting blade of a cutting bar rotating at low speed comes into contact with hard enamel present in a surface layer of a tooth during cutting of carious dentin to cause unpleasant sensation in a patient. A cutting bar for dental use includes a head in which a cutting blade is formed; a neck leading to the head; and a handle joined to the neck through an intermediation of a joint portion, wherein diamond abrasive grains are electrodeposited in a predetermined range extending from a substantially maximum diameter portion of the head to the neck. | 07-02-2009 |
20090117410 | Thin Film Material and Recording Medium - Disclosed is a thin film material including a substrate ( | 05-07-2009 |
20090087837 | Method Of Detecting Streptococcus Pneumoniae, Primer Set For The Detection And Kit For The Detection - A method of detecting | 04-02-2009 |
20090078206 | AUTOMATIC MILKING APPARATUS FOR LABORATORY ANIMALS - An automatic milking apparatus for laboratory animals that can facilitate and stabilize the positioning of a teat cup | 03-26-2009 |
20090061386 | IMPLANTER - An implanter is provided, which enables rebuilding of an interdental papilla with a simple method. An implanter | 03-05-2009 |
20090047685 | ULTRAHIGHLY SENSITIVE DETERMINATION REAGENT FOR C-REACTIVE PROTEIN AND DETERMINATION METHOD - The present invention is related to an ultrahighly sensitive determination reagent for C-reactive protein (CRP) for use in determination of CRP in a test sample with high sensitivity; and a CRP determination method using the reagent. A reagent for determining C-reactive protein containing an insoluble carrier particle loading an antibody directed to the C-reactive protein via an amino acid; and a method for determining a C-reactive protein including the steps of reacting the reagent with an antigenic substance in a test sample, and determining a resulting aggregate. | 02-19-2009 |
20090039237 | HIGH-SPEED SINGLE-PHOTON DETECTOR IN TELECOMMUNICATION WAVELENGTH BAND - In order to operate a single photon detector in communication wavelength band at a high speed, a DC bias voltage | 02-12-2009 |
20080299546 | Canine Cd20 Gene - It is intended to clarify the CD20 amino acid sequence and its gene sequence which are essentially required in constructing an anti-CD20 antibody useful in treating animal malignant lymphoma. It is also intended to provide a method of diagnosing canine malignant lymphoma by using the gene sequence. Using monocytes in canine blood as a sample, mRNA is obtained and the full base sequence of canine CD20 gene (SEQ ID NO:2) is determined. Based on this sequence, its amino acid sequence (SEQ ID NO:1) is determined. Comparing the homologies with human and mouse CD20 genes and amino acid sequences, it is identified as canine CD20 gene. Moreover, a primer specific to the canine gene is constructed and the expression of the CD20 gene in a sample is examined, thereby giving a method of diagnosing canine B lymphocyte-origin malignant lymphoma. | 12-04-2008 |
20080260565 | PROCESS FOR PRODUCING CONCENTRIC-CIRCULAR-GRADIENT FUNCTIONAL MATERIAL FOR BIOGENIC USE AND APPARATUS FOR PRODUCING THE SAME - A concentric-circular-gradient functional material for biogenic use is produced using first, second, third and forth cylindrical partitions, and a cylindrical dice which are concentrically stood on a supporting stand. Ti powder (A) fills the first cylindrical partition. A first mixed powder including Ti powder (A) and biogenic material powder (B) fills between the first and second cylindrical partitions. A second mixed powder including a smaller amount of Ti powder (A) than the first mixed powder fills between the second and third cylindrical partitions. A third mixed powder including a smaller amount of Ti powder (A) than the second mixed powder fills between the third and fourth cylindrical partitions. The biogenic material powder (B) fills between the fourth cylindrical partition and the dice. The first to fourth partitions are pulled out. The dice is capped using a punch. The powders are sintered using a discharge plasma sintering machine. | 10-23-2008 |
20080255368 | Tgf-ß Gene Expression Inhibitor - A TGF-β gene expression inhibitor containing a pyrrole-immidazole polyamide comprising an N-methylpyrrole unit (hereinafter also referred to as Py), an N-methylimidazole unit (hereinafter also referred to as Im) and a γ-aminobutyric acid unit which can be folded into an U-shaped conformation at the above-described γ-aminobutyric acid unit site in a minor groove of a double-stranded region (hereinafter referred to as the target region) containing a part or the whole of the following base sequence (SEQ ID NO: 2) corresponding to −450 to −310 of human transforming growth factor β1 (hereinafter also referred to as h TGF-β1) promoter and a strand complementary thereto and in which a Py/Im pair, an Im/Py pair and a PY/Py pair correspond respectively to a C-G base pair, a G-C base pair and an A-T base pair and a T-A base pair. | 10-16-2008 |
20080246178 | Method For Dividing Ceramic Cylindrical Body and Shape of Notched Portions Thereof - There are provided a method for dividing a ceramic cylindrical body, involving forming first and second notched portions in an inner periphery surface of the ceramic cylindrical body at positions confronting each other in the diametrical direction and subsequently applying a compressive load in the diametrical direction to divide the cylindrical body along the first and second notches, thereby making it possible to afford divided surfaces having such a concave and a convex as prevent axial displacement when re-joining divided sections, as well as a shape of the notched portions. Bisected cylindrical body portions can be joined together closely without axial displacement of the joined cylindrical body. | 10-09-2008 |
20080208080 | Human Body Backbone Measuring/Displaying System - The invention provides a human spinal column measuring and displaying system for calculating a measured data of three-dimensional coordinates and a circumflex angle of the spinal column by scanning a predetermined probe along the spinal column, and simulating a shape of the spinal column from the measured data to be able to display a three-dimensional pseudonymous spinal column image by utilizing a computer graphics. | 08-28-2008 |