| New York University Patent applications |
| Patent application number | Title | Published |
|---|
| 20130123885 | APPARATUS, SYSTEMS, COMPUTER-ACCESSIBLE MEDIUM AND METHODS FOR FACILITATING RADIO FREQUENCY HYPERTHERMIA AND THERMAL CONTRAST IN A MAGNETIC RESONANCE IMAGING SYSTEM - The present disclosure can provide exemplary apparatus, system, methods, and computer-accessible medium for generating a prediction model for at least one of an electromagnetic radiation absorption or a specific absorption rate (SAR). For example, according to certain exemplary embodiments, an exemplary method can include directing electromagnetic radiation at a subject using a plurality of transmit elements, obtaining electromagnetic radiation deposition information associated with a deposition of the at least one electromagnetic radiation within the subject using a sensing apparatus, and with a processor arrangement, generating the prediction model as a function of the electromagnetic radiation deposition information. | 05-16-2013 |
| 20130123306 | Inhibition of Mitogen-activated Protein Kinases in Cardiovascular Disease - The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic material with a mitogen-activated protein kinase (MAPK) pathway inhibitor. The present invention further relates to vascular devices comprising a MAPK pathway inhibitor. | 05-16-2013 |
| 20130123196 | THIOETHER-, ETHER-, AND ALKYLAMINE-LINKED HYDROGEN BOND SURROGATE PEPTIDOMIMETICS - Provided herein are peptidomimetics and their salts having a stable, internally constrained protein secondary structure containing a thioether-, ether-, or alkylamine-linked hydrogen bond surrogate; compositions containing at least one of these, and methods of making and using these. | 05-16-2013 |
| 20130121067 | HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER - A high speed, low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity and/or magnetization direction. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer. The fixed and free magnetic layers may have magnetization directions at a substantially non-zero angle relative to the layer normal. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to read out the information stored in the device. | 05-16-2013 |
| 20130097194 | APPARATUS, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR DISPLAYING VISUAL INFORMATION - A method for displaying visual information corresponding to at least one user can including receiving a selection of at least one attribute to be viewed, with a computer arrangement, tracking at least one user pose of the at least one user in real-time using a marker-less capture procedure to generate tracking information, matching the at least one user pose with at least one database pose provided in a database based on the tracking information, and displaying the at least one database pose in combination with the at least one attribute. | 04-18-2013 |
| 20130095115 | STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS, AND USES THEREOF - Disclosed herein are isolated and purified | 04-18-2013 |
| 20130090255 | Biological Markers of Chronic Wound Tissue and Methods of Using for Criteria in Surgical Debridement - The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds. | 04-11-2013 |
| 20130080101 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR EVALUATING A MALIGNANCY STATUS IN AT-RISK POPULATIONS AND DURING PATIENT TREATMENT MANAGEMENT - In accordance with certain exemplary embodiments of the present disclosure, exemplary visualization system, method, procedure and computer-accessible medium can be provided, which individually and/or collectively can be called, e.g., ImmunoRuler (IR). Certain exemplary embodiments of the exemplary IR in accordance with the present disclosure can be used for, e.g., comparing two groups of objects with specific and distinguished properties, such as a group of case subjects with a particular disease and a group of control subjects without that particular disease, and/or a group of subjects with a particular disease who are given a treatment and a group of subjects with the same disease but under another treatment or no treatment at all. | 03-28-2013 |
| 20130079385 | USP47 Inhibtors and Methods to Induce Apoptosis - The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. | 03-28-2013 |
| 20130071424 | PEPTIDES MIMICKING HIV-1 VIRAL EPITOPES IN THE V2 LOOP FOR THE GP120 SURFACE ENVELOPE GLYCOPROTEIN - The present invention relates to an isolated immunogenic peptide comprising a V2 loop fragment from HIV surface envelope glycoprotein gp120. This peptide binds specifically with antibodies in blood of patients vaccinated with a vaccine that has shown protection from HIV-1 infection, does not react with blood of matched patients who did not receive the vaccine, and can, therefore, elicit anti-HIV-1 antibodies which protect against HIV-1 infection. Other aspects of the present invention relate to an isolated immunogenic polypeptide comprising the peptide inserted into an immunogenic scaffold protein, a vaccine composition comprised of the immunogenic peptide and an immunologically or pharmaceutically acceptable vehicle or excipient as well as methods of inducing an immune response against HIV-1 and methods of detecting HIV-1. | 03-21-2013 |
| 20130063145 | APPARATUS, SYSTEMS AND METHODS FOR FACILITATING SIGNAL EXCITATION AND/OR RECEPTION IN A MAGNETIC RESONANCE SYSTEM - In accordance with certain exemplary embodiments of the present disclosure, provided herein are apparatus, systems and methods for, e.g., faciliatating signal excitation and/or reception in a magnetic resonance system, such as, e.g., a system configured for magnetic resonance imaging (MRI) and/or spectroscopy. For example, exemplary embodiments of a method for traveling wave imaging in an MRI system can include, e.g., a circular conductive structure lying in a transverse plane within the scanner bore. The exemplary structure can be concentric with the center of the scanner RF shield. The structure can be arranged to have a resonant mode at the MR frequency characterized by a current pattern which can be configured to excite and receive an exemplary waveguide mode. The exemplary current pattern can be further configured to facilitate traveling wave imaging, for example. | 03-14-2013 |
| 20130045918 | Methods for Treating Diabetic Wounds - The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment. | 02-21-2013 |
| 20130045879 | METHODS, COMPUTER-ACCESSIBLE MEDIUM, AND SYSTEMS FOR GENERATING A GENOME WIDE HAPLOTYPE SEQUENCE - Methods, computer-accessible medium, and systems for generating a genome wide probe map and/or a genome wide haplotype sequence are provided. In particular, a genome wide probe map can be generated by obtaining a plurality of detectable oligonucleotide probes hybridized to at least one double stranded nucleic acid molecule cleaved with at least one restriction enzyme, and detecting the location of the detectable oligonucleotide probes. For example, genome wide haplotype sequence can be generated by analyzing at least one genome wide restriction map in conjunction with at least one genome wide probe map to determine distances between restriction sites of the genome wide restriction map(s) and locations of detectable oligonucleotide probes of the genome wide probe map(s) and defining a consensus map indicating restriction sites based on the genome wide restriction map(s) and/or locations of detectable oligonucleotide probes based on each of the genome wide probe map(s). | 02-21-2013 |
| 20130045216 | Method for Treating Amyloid Disease - Disclosed herein are methods for treating amyloid disease in humans by clearing amyloid peptides from one or more bodily fluids such as, e.g., blood, of a patient. In particular, the methods are based on the administration of compounds capable of binding to amyloid-beta (Aβ) or on dialysis of blood or plasma exchange in order to remove Aβ peptides from the blood circulation, and/or brain or other affected organs. | 02-21-2013 |
| 20130042457 | Method and System Using Microscopic Building Blocks For Driving 3D Self-Assembly - A method and system for constructing structures by self-assembly of objects. The method and system include providing a first object having a first selected shape and providing a second object having a second selected shape, the shape of the first and second objects interacting to form an alignment which has only a simple stable state arising from minimization of interaction energy for the single stable state. | 02-21-2013 |
| 20130039885 | LEUKOTOXIN E/D AS A NEW ANTI-INFLAMMATORY AGENT AND MICROBICIDE - The present invention relates to methods for preventing or treating Human Immunodeficiency Virus (HIV) infection, inflammatory conditions, and graft-versus-host-disease (GVHD) in a subject. Therapeutic compositions of the present invention comprise Leukocidin E (LukE) and/or D proteins or polypeptides. The invention further relates to methods of treating | 02-14-2013 |
| 20130034586 | AVIRULENT ONCOLYTIC HERPES SIMPLEX VIRUS STRAINS ENGINEERED TO COUNTER THE INNATE HOST RESPONSE - The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ | 02-07-2013 |
| 20130030322 | TISSUE COLLECTION SYSTEM - The present invention relates to a tissue collection system. The system includes an outer housing, a first cylindrical fenestrated member within and immovable relative to the outer housing, a second cylindrical fenestrated member defining an inner tissue collection chamber and being positioned within and rotatable relative to the first cylindrical fenestrated member, a plunger axially movable within the second fenestrated member, an elongate rod being connected to the plunger, and one or more stop units attached to the outer housing. The present invention also relates to methods for separating components of a tissue sample using a system according to the present invention. | 01-31-2013 |
| 20130022612 | METHODS AND COMPOSITIONS FOR MALARIA PROPHYLAXIS - A composition for preventing malaria infection including a steric inhibitor of circumsporozoite protein cleavage. A pharmaceutical composition for preventing malaria infection including a steric inhibitor and a pharmaceutical carrier. A method of malaria infection prophylaxis including the step of administering an effective amount of the composition of the present invention. A method of malaria prophylaxis by sterically inhibiting circumsporozoite protein processing or by directly inhibiting a protease of a sporozoite from binding to its target. Methods of preventing sporozoite cell invasion or preventing circumsporozoite processing through steric or direct inhibition. | 01-24-2013 |
| 20130022544 | IMMUNOTHERAPEUTIC MODULATION OF AMYLOIDOGENIC DISEASE USING NON-FIBRILLOGENIC, NON-AMYLOIDOGENIC POLYMERIZED PROTEINS AND PEPTIDES - The present invention is directed to polymerized products and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease. | 01-24-2013 |
| 20130017203 | METHODS OF TREATING AND PREVENTING STAPHYLOCOCCUS AUREUS INFECTIONS AND ASSOCIATED CONDITIONS - The present invention relates to methods and compositions for preventing and treating | 01-17-2013 |
| 20120329861 | TREATMENT OF CANCER USING BENZOIC ACID DERIVATIVES - The present invention provides a method of treating cancer using benzoic acid derivatives, alone or in combination with standard treatments such as chemotherapy and radiotherapy. Also provided are methods of screening for benzoic derivatives based on their ability to inhibit the enzyme tyrosinase or to bind to and activate PXR/SXR xenobiotic receptors. | 12-27-2012 |
| 20120329828 | Cocaine Analogs and Methods of Preparation and Uses Thereof - The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8 positions of the tropane bicyclic scaffold. The invention further provides methods of providing anesthesia, blocking reuptake of a monoamine neurotransmitter, and treating depression, by administering to a subject in need of such treatment a pharmaceutical composition comprising a compound of the invention. | 12-27-2012 |
| 20120322743 | Compositions and Methods for Diagnosing and Treating Melanoma - Described herein are compositions and methods for the diagnosis, prognosis, prevention and treatment of melanoma or melanoma associated symptoms. The compositions are microRNA molecules associated with melanoma, as well as various nucleic acid molecules relating thereto or derived therefrom. | 12-20-2012 |
| 20120321594 | METHODS OF CONTROLLING AXON OR DENDRITE DEVELOPMENT OF NEURONAL CELLS - One aspect of the present invention relates to a method of controlling axon or dendrite development in a neuronal cell population. This method involves providing a neuronal cell population and contacting the neuronal cell population with a modulator of R-type Ca | 12-20-2012 |
| 20120303001 | System and Method for Correction of Intracerebral Chemical Imbalances - An osmotic pump includes a plurality of agent reservoirs; first and second solute chambers; a semi-permeable membrane separating the first and second solute chambers from one another; a flexible membrane separating a first one of the agent reservoirs from the first solute chamber; and a plurality of valves. Each of the valves is moveable between an open position in which a corresponding one of the agent reservoirs is open to an outlet of the pump and a closed position in which the corresponding one of the agent reservoirs is sealed with respect to the pump outlet. | 11-29-2012 |
| 20120301895 | METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING - The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras. | 11-29-2012 |
| 20120296199 | Apparatus and Method of Non-Contrast Magnetic Resonance Angiography of Abdominal and Pelvic Arteries - Exemplary method and apparatus can be provided for generating information regarding at least one tissue. Using such exemplary method and apparatus, it is possible to generate a plurality of inversion recovery (IR) radio frequency (RF) pulses that are configured to establish an identifier of an element associated with at least one portion of the tissue(s). It is also possible to determine an inversion time associated with at least one of the RF pulses. Further, it is possible to generate, e.g., with a computing arrangement, the information regarding the tissue(s) based on the inversion time. | 11-22-2012 |
| 20120294809 | LANTHANOID COMPLEX CAPSULE AND PARTICLE CONTRAST AGENTS, METHODS OF MAKING AND USING THEREOF - The invention relates to compositions of DOTA derivative compounds, lanthanoid-DOTA derivative molecular complex, and lanthanoid-complex encapsulated solid lipid particles or capsules, and methods of making and using the compositions. The solid lipid particles or capsules contain micelle cores stabilized by a hyperbranched polymer shell based from a crosslinked DOTA derivative compound or crosslinked lanthanoid-DOTA derivative complex. These solid lipid particles or capsules can be used in various applications, such as contrast agents or drug delivery vehicles. | 11-22-2012 |
| 20120290278 | PROCESS, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEM FOR OBTAINING DIAGNOSIS, PROGNOSIS, RISK EVALUATION, THERAPEUTIC AND/OR PREVENTIVE CONTROL BASED ON CANCER HALLMARK AUTOMATA - The present disclosure relates to exemplary embodiments of method, computer-accessible medium, system and software arrangements for, e.g., Cancer Hallmark Automata, a formalism to model the progression of cancers through discrete phenotypes (so-called hallmarks). The precise computational model described herein includes the automatic verification of progression models (e.g., consistency, causal connections, etc.), classification of unreachable or unstable states (e.g., “anti-hallmarks”) and computer-generated (individualized or universal) therapy plans. Exemplary embodiments abstractly model transition timings between hallmarks as well as the effects of drugs and clinical tests, and thus allows formalization of temporal statements about the progression as well as notions of timed therapies. Certain exemplary models discussed herein can be based on hybrid automata (e.g., with multiple clocks), for which relevant verification and planning algorithms exist. | 11-15-2012 |
| 20120289463 | Compositions and Methods for Promoting Epithelialization and Wound Closure - Compositions for antagonizing phosphorylation and subsequent degradation of glycogen synthase kinase 3 beta (GSK3β) in epidermal cells are disclosed. GSK3β phosphorylation antagonists include molecules that function to inhibit or reduce the binding activity or enzymatic activity of an upstream signaling molecule leading to GSK3β phosphorylation, or by downregulating the expression of one or more upstream signaling molecules involved in regulating GSK3β phosphorylation. Methods of using the GSK3β phosphorylation antagonists to inhibit or reduce the phosphorylation and degradation of GSK3β in epidermal cells are provided. The methods are useful to promote epithelialization and closure of wounds, such as chronic non-healing wounds. | 11-15-2012 |
| 20120288886 | INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA - The present invention is directed to a method of treating hypophosphatemia in a subject. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed. | 11-15-2012 |
| 20120284577 | ARCHITECTURE, SYSTEM, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR ELIMINATING SCAN PERFORMANCE PENALTY - Exemplary apparatus, methods, and computer-accessible medium can be provided for transforming a circuit. For example, it is possible to select, from the circuit, at least one scan cell which includes a first multiplexer coupled to a first flip-flop. A second flip-flop and a second multiplexer can be inserted in the circuit. The first multiplexer can be coupled as an input to the second flip-flop, and the second multiplexer can be coupled to the output of the first flip-flop and the second flip-flop. | 11-08-2012 |
| 20120278672 | ARCHITECTURE, SYSTEM, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR TOGGLE-BASED MASKING - Exemplary embodiments of the present disclosure include apparatus, methods, and computer-accessible medium for a toggle-masking procedure configured to mask, e.g., most or all the unknown x's and minimizing the over-masked known bits for clustered distribution of unknown bits. According to certain exemplary embodiments, it is possible to obtain previous masking information regarding the scan chain(s) associated with a previous cycle, and mask the scan chain(s) for a present cycle based on the previous masking information. | 11-01-2012 |
| 20120277287 | Modulating the CDC14B-CDH1-PLK1 Axis and Methods for Sensitizing Target Cells to Apoptosis - The invention relates to modulating Cdc14B levels (cell division cycle 14 homolog B) and/or Cdh1 (Fzr1 protein, CDC20-like 1b, or fizzy-related protein) levels to sensitize cells to DNA damage by increasing the abundance of Plk1 (polo-like kinase 1) in a target cell. In certain embodiments, the invention relates to modulating Plk1 levels, and in particular to increasing Plk1 levels, to sensitize target cells such as cancer cells to cell death or apoptosis. In certain embodiments, the invention relates to inhibitors of Cdc14B and Cdh1 that sensitize tumor cells to chemotherapy or radiation induced cell death or apoptosis. In addition to applications relating to cancer therapies and diagnostics, the Plk1 modulators and assays will be employed for identifying novel drugs or drug candidates useful for various proliferative and/or differentiative disorders such as major opportunistic infections, immune disorders, cardiovascular diseases and inflammatory disorders. | 11-01-2012 |
| 20120271147 | APPARATUS, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR B1-INSENSITIVE HIGH RESOLUTION 2D T1 MAPPING IN MAGNETIC RESONANCE IMAGING - Exemplary systems, methods and computer-accessible mediums can be provided for imaging at least one anatomical structure. For example, it is possible to direct a saturation-recovery (SR) pulse sequence having fast spin echo (FSE) to or at the anatomical structure(s). At least one T | 10-25-2012 |
| 20120265789 | ARCHITECTURES, SYSTEMS, APPARATUS, METHODS, AND COMPUTER-READABLE MEDIUM FOR PROVIDING RECOMMENDATIONS TO USERS AND APPLICATIONS USING MULTIDIMENSIONAL DATA - Exemplary non-transitory computer-readable medium, method and system for providing at least one recommendation to users and applications using multidimensional data. The multidimensional data can define a multidimensional space defined by a Cartesian product of the dimensions. The multidimensional space can have at least three dimensions, and each of the dimensions can be capable of (i) providing variable information, and (ii) having a type that is different from a type of another one of the dimensions. The exemplary non-transitory computer-readable medium, method and system can retrieve information from data associated with the multidimensional space. Further, the exemplary non-transitory computer-readable medium, method and system can generate the at least one recommendation based on the retrieved information. Further, at least one of the dimensions can include profiles. | 10-18-2012 |
| 20120253960 | METHODS, SOFTWARE ARRANGEMENTS, STORAGE MEDIA, AND SYSTEMS FOR PROVIDING A SHRINKAGE-BASED SIMILARITY METRIC - The present invention relates to systems, methods, and software arrangements for determining associations between two or more datasets. The systems, methods, and software arrangements used to determine such associations include a determination of a correlation coefficient that incorporates both prior assumptions regarding such datasets and actual information regarding the datasets. The systems, methods, and software arrangements of the present invention can be useful in an analysis of microarray data, including gene expression arrays, to determine correlations between genotypes and phenotypes. Accordingly, the systems, methods, and software arrangements of the present invention may be utilized to determine a genetic basis of complex genetic disorder (e.g. those characterized by the involvement of more than one gene). | 10-04-2012 |
| 20120221284 | ARCHITECTURE, SYSTEM, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR PARTIAL-SCAN TESTING - Exemplary method, computer-accessible medium, test architecture, and system can be provided for a partial-scan test of at least one integrated circuit. For example, it is possible to obtain a plurality of test cubes using a first combinational automatic test pattern generation (ATPG) and identify at least one flip-flop of the integrated circuit using the test cubes to convert to a non-scan flip-flop and facilitate the partial-scan test to utilize the cubes without a utilization of a sequential ATPG or a second combinational ATPG. | 08-30-2012 |
| 20120217989 | ARCHITECTURE, SYSTEM, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR EXPEDITED-COMPACTION FOR SCAN POWER REDUCTION - Exemplary method, computer-accessible medium, and test configuration can be provided for testing at least one flip-flop. For example, the exemplary test configuration can include at least one scan-out channel having a plurality of regions and a plurality of compactors associated with the plurality of regions. | 08-30-2012 |
| 20120203051 | TREATMENT OF CANCER USING THE SODIUM SALT OF A BENZOIC ACID DERIVATIVE - The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy. | 08-09-2012 |
| 20120196919 | EX-VIVO TREATMENT OF IMMUNOLOGICAL DISORDERS WITH PKC-THETA INHIBITORS - Disclosed is a method for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and atherosclerosis. Specifically, the invention relates to a method of treating an immunological disorder or atherosclerosis in a patient comprising treating blood from the patient, or a defined component of said blood, with an inhibitor of PKC-theta ex vivo and then re-administering the treated blood to the patient. | 08-02-2012 |
| 20120172995 | IMPLANTS FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE - A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end conforming to the shape of the tibia, and is made of a metal alloy or a ceramic. The upper surface is dished while the lower surface is planar and can be parallel or sloped relative to the upper surface. The femoral implant for implementation in a femoral condyle is rounded such that, when implemented, the femoral implant is flush at the anterior and posterior sides and protruding away from the femur between the anterior and posterior ends. The femoral implant can have an elongated keel for extending into the femur, and can be made from a highly cross-linked polyethylene. | 07-05-2012 |
| 20120172292 | METHOD FOR PROTECTION OF ANTIMICROBIAL AND ANTICANCER DRUGS FROM INACTIVATION BY NITRIC OXIDE - This invention discloses a method for enhancing the efficacy of antimicrobial, anti-protozoa and anti-cancer treatments by co-administering an inhibitor of endogenous NO production and/or NO scavenger. | 07-05-2012 |
| 20120171193 | Diagnostic and Treatment Methods for Characterizing Bacterial Microbiota in Skin Conditions - The present invention relates to methods for characterization of bacterial skin microbiota to provide diagnostic, therapeutic, and preventive measures for alleviating skin conditions. In certain embodiments, the invention relates to characterization of bacterial skin microbiota associated with psoriasis and related diagnostic, therapeutic, and preventive measures for alleviating psoriasis. These methods will be useful for detecting, diagnosing, and monitoring individuals who have or are at risk of certain skin conditions. | 07-05-2012 |
| 20120157522 | B. Anthracis Prevention and Treatment: Mutant B. Anthracis Lacking Luxs Activity and Furanone Inhibition of Growth, AI-2 Quorum Sensing, and Toxin Production - The present invention pertains to the discovery that | 06-21-2012 |
| 20120157507 | USP47 Inhibtors and Methods to Induce Apoptosis - The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. | 06-21-2012 |
| 20120150458 | APPARATUS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR NONINVASIVE DETERMINATION OF ELECTRICAL PROPERTIES OF TISSUES AND MATERIALS - Apparatus, method, and computer-accessible medium embodiments for a noninvasive mapping of electrical properties of tissues or materials. For example, it is possible to apply a plurality of stimulations to a target. It is possible to receive at least one signal from the target in response to the applied stimulations. Further, it is possible to process the at least one signal to determine electromagnetic-field-related quantities associated with the stimulations and the target response. Also, it is possible to supply the electromagnetic-field-related quantities to a system of equations relating these quantities to a plurality of electrical property values and residual field-related unknown values of the at least one target. It is also possible to determine a solution to the system of equations, including determining at least one electrical property of the at least one target. | 06-14-2012 |
| 20120146637 | APPARATUS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINATION OF ELECTRICAL PROPERTIES OF TISSUES AND MATERIALS USING MULTIPLE RADIO FREQUENCY MEASUREMENTS - An assembly for determining at least one electrical property of an object. The assembly includes at least one transmitter that can generate a plurality of electromagnetic field distribution patterns directed at an object. The assembly also includes a data apparatus with an MRI apparatus and a data processor. The MRI apparatus can produce at least one image of the object using a magnitude or a phase modulated by the electromagnetic field distribution patterns. The processor can then process data associated with the object to determine the at least one electrical property the object. | 06-14-2012 |
| 20120142100 | HEAT SHOCK RNA FROM VARIOUS SPECIES AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR, IN TREATMENT OF VARIOUS DISEASES IN ANIMALS AND IN GENERATION OF STRESS-RESISTANT PLANTS - The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of various diseases in animals and for generation of stress-resistant plants. | 06-07-2012 |
| 20120134964 | HUMAN MATRIX METALLOPROTEINASE-8 GENE DELIVERY ENHANCES THE ONCOLYTIC ACTIVITY OF A REPLICATING ADENOVIRUS - The present invention discloses a method of treating cancer in a subject. This involves co-administering a replicating virus and a matrix metalloproteinase to the subject under conditions effective to treat cancer. It also relates to a method of enhancing the delivery to and distribution within a tumor mass of therapeutic viruses. This involves co-administering a replicating virus and a matrix metalloproteinase to the tumor mass under conditions effective to enhance the delivery to and distribution within the tumor mass of therapeutic viruses. Another aspect relates to a cancer therapeutic. This involves a replicating virus and a matrix metalloproteinase. | 05-31-2012 |
| 20120116688 | METHOD, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEM FOR BASE-CALLING AND ALIGNMENT - Exemplary methods, procedures, computer-accessible medium, and systems for base-calling, aligning and polymorphism detection and analysis using raw output from a sequencing platform can be provided. A set of raw outputs can be used to detect polymorphisms in an individual by obtaining a plurality of sequence read data from one or more technologies (e.g., using sequencing-by-synthesis, sequencing-by-ligation, sequencing-by-hybridization, Sanger sequencing, etc.). For example, provided herein are exemplary methods, procedures, computer-accessible medium and systems, which can include and/or be configured for obtaining raw output from a sequencing platform configured to be used for reading fragment(s) of genomes, obtaining reference sequences for the genomes obtained independently from the raw output, and generating a base-call interpretation and/or alignment using the raw output and the reference sequences. For example, a score function can be determined based on information associated with the sequencing platform that can be used to analyze polymorphisms based on the base-call interpretation and/or alignment. | 05-10-2012 |
| 20120116524 | EARLY INTERVENTION KNEE IMPLANT DEVICE AND METHODS - A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end conforming to the shape of the tibia, and is made of a metal alloy or a ceramic. The upper surface is dished while the lower surface is planar and can be parallel or sloped relative to the upper surface, and can have a keel for fixation. The femoral implant for implementation in a femoral condyle is rounded such that, when implemented, the femoral implant is flush at the anterior and posterior sides and protruding away from the femur between the anterior and posterior ends. The femoral implant can have an elongated keel for extending into the femur, and can be made from a highly cross-linked polyethylene. | 05-10-2012 |
| 20120095700 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR DETERMINING MEMBRANE PROPERTIES RELATING TO DIFFUSION - Exemplary embodiments of a methodology, procedure, system, method and computer-accessible medium can be provided to obtain particular information relating to at least one transport property of a material containing at least one membrane, and to determine, e.g., a permeability of the membrane of the material and/or a surface area of the membrane of the material, as a function of, e.g., the obtained particular information. | 04-19-2012 |
| 20120095328 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR UTILIZING CARDIAC OUTPUT TO IMPROVE MEASUREMENT OF TRACER INPUT FUNCTION IN DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING - Exemplary embodiments of method, system and computer-accessible medium according to the present disclosure can be provided for converting magnetic resonance (MR) arterial signal intensity versus time curves to arterial input functions (AIF) with less susceptibility to artifacts such as flow-related enhancement. Exemplary methods, systems and computer-accessible medium can be used to constrain AIF to satisfies the indicator dilution principle, according to which the area under an initial pass component of AIF can be equal to the injected dose divided by the cardiac output. For example, Monte Carlo simulations of MR renography and tumor perfusion protocols can be performed for comparison with conventional methods. | 04-19-2012 |
| 20120066782 | QUANTITATIVE ASSAY FOR MEMBRANE ASSOCIATION OF PROTEINS - The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a first nucleic acid construct comprising a first nucleic acid molecule encoding a first fusion protein comprising a peripheral cellular membrane binding protein or membrane binding domain thereof operatively coupled to DNA binding and transactivation domains of a naturally occurring or chimeric transcription factor and a first promoter operatively associated with the first nucleic acid molecule. A second nucleic acid construct comprises a second nucleic acid molecule encoding a reporter protein and a second promoter responsive to the DNA binding and transactivation domains of the first fusion protein. The second promoter is operatively associated with the second nucleic acid molecule. Activation of the second promoter results in expression of the reporter protein. Also disclosed is a transgenic non-human animal. | 03-15-2012 |
| 20120065094 | METHODS AND KITS FOR DIAGNOSING OSTEOARTHRITIS AND PREDICTING PROGRESSION - This disclosure relates to methods and kits for diagnosing osteoarthritis and for determining the progression of osteoarthritis in a subject. | 03-15-2012 |
| 20120062220 | AGGREGATED SPIN-TORQUE NANO-OSCILLATORS - A nano-oscillator magnetic wave propagation system has a group of aggregated spin-torque nano-oscillators (ASTNOs), which share a magnetic propagation material. Each of the group of ASTNOs is disposed about an emanating point in the magnetic propagation material. During a non-wave propagation state of the nano-oscillator magnetic wave propagation system, the magnetic propagation material receives a polarizing magnetic field. During a wave propagation state of the nano-oscillator magnetic wave propagation system, each of the group of ASTNOs initiates spin waves through the magnetic propagation material, such that a portion of the spin waves initiated from each of the group of ASTNOs combine to produce an aggregation of spin waves emanating from the emanating point. The aggregation of spin waves may provide a sharper wave front than wave fronts of the individual spin waves initiated from each of the group of ASTNOs. | 03-15-2012 |
| 20120058094 | COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS BY CHARACTERIZING AND RESTORING MAMMALIAN BACTERIAL MICROBIOTA - The present invention relates to characterizing changes in mammalian intestinal microbiota associated with associated with high-fat and low-fat diets and with diets containing hydroxypropylmethylcellulose (HPMC) and related methods for diagnosing, preventing and treating obesity and related conditions such as metabolic syndrome and diabetes mellitus. Therapeutic methods of the invention involve the use of probiotics, and/or prebiotics, and/or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial intestinal microbiota. | 03-08-2012 |
| 20120041727 | METHOD, COMPUTER-ACCESSIBLE MEDIUM AND SYSTEMS FOR SCORE-DRIVEN WHOLE-GENOME SHOTGUN SEQUENCE ASSEMBLE - Exemplary embodiments of the present disclosure relate generally to methods, computer-accessible medium and systems for assembling haplotype and/or genotype sequences of at least one genome, which can be based upon, e.g., consistent layouts of short sequence reads and long-range genome related data. For example, a processing arrangement can be configured to perform a procedure including, e.g., obtaining randomly located short sequence reads, using at least one score function in combination with constraints based on, e.g., the long range data, generating a layout of randomly located short sequence reads such that the layout is globally optimal with respect to the score function, obtained through searching coupled with score and constraint dependent pruning to determine the globally optimal layout substantially satisfying the constraints, generating a whole and/or a part of a genome wide haplotype sequence and/or genotype sequence, and converting a globally optimal layout into one or more consensus sequences. | 02-16-2012 |
| 20120040992 | OLIGOOXOPIPERAZINES AND METHODS OF MAKING AND USING THEM - The present invention relates to oligooxopiperazines and their use. Methods for preparing oligooxopiperazines are also disclosed. | 02-16-2012 |
| 20120028369 | QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS - This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the medium with a fluid sample from a subject with an inflammatory condition, where the fluid sample comprises proteins or proteoglycans and a transfer agent; incubating the fluid sample with the medium under conditions effective for the transfer agent in the fluid sample to mediate transfer of heavy chains from the proteins or proteoglycans to the hyaluronan or a fragment thereof to form a complex; detecting, using an antibody, occurrence levels of the complex; and comparing occurrence levels of the complex from said detecting to a reference standard to predict progression of an inflammatory condition in the subject. Also disclosed are methods of tailoring treatment of an inflammatory condition and quantifying local inflammatory activity in a body fluid. | 02-02-2012 |
| 20120021002 | GENETICALLY ENGINEERED CLOSTRIDIAL GENES, PROTEINS ENCODED BY THE ENGINEERED GENES, AND USES THEREOF - The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed. | 01-26-2012 |
| 20120010519 | System and Method for Diagnosis and Treatment of Obstructive Sleep Apnea - A system for diagnosis and treatment of breathing disorders in a patient, comprises a flow generator supplying an air flow to an airway of a patient via a flow path, a venting arrangement moveable between (i) a closed position in which the flow path is substantially sealed between the flow generator and the patient's airway and (ii) an open position in which the flow path is open to an ambient atmosphere, a sensor detecting data corresponding to flow through the patient's airway, and a processing arrangement controlling operation of the venting arrangement and the flow generator, wherein, in a diagnostic mode, the processing arrangement maintains the venting arrangement in the open position and in a therapeutic mode, the processing arrangement maintains the venting arrangement in the closed position and controls the flow generator to supply to the patient's airway via the flow path a calculated therapeutic pressure. | 01-12-2012 |
| 20120004498 | DEVICE AND METHOD FOR REDUCING TENSION AND STRESS IN A SUBJECT - The present invention relates to a sensory device for reducing tension in a subject. The device includes an elastic covering, a filling material inside the elastic covering, an openable sealed reservoir located within the filling, an absorbent material surrounding the reservoir, and a calming odor releasing substance sealed within the reservoir. The present invention also relates to a method of reducing tension in a subject. This method involves providing a subject in need of tension relief with the device of the present invention. The device is manipulated to break open the reservoir and release the calming odor releasing substance. The released calming odor is inhaled in an amount sufficient to lower salivary cortisol levels in the subject and thereby reduce tension in the subject. | 01-05-2012 |
| 20120002851 | System, Method and Computer Accessible Medium for Providing Real-Time Diffusional Kurtosis Imaging and for Facilitating Estimation of Tensors and Tensor- Derived Measures in Diffusional Kurtosis Imaging - Exemplary method, system, and computer-accessible medium can be provided for determining a measure of diffusional kurtosis by receiving data relating to at least one diffusion weighted image, and determining a measure of a diffusional kurtosis as a function of the received data using a closed form solution procedure. In accordance with certain exemplary embodiments of the present disclosure, provided herein are computer-accessible medium, systems and methods for, e.g., imaging in an MRI system, and, more particularly for facilitating estimation of tensors and tensor-derived measures in diffusional kurtosis imaging (DKI). For example, DKI can facilitate a characterization of non-Gaussian diffusion of water molecules in biological tissues. The diffusion and kurtosis tensors parameterizing the DKI model can typically be estimated via unconstrained least squares (LS) methods. In the presence of noise, motion, and imaging artifacts, these methods can be prone to producing physically and/or biologically implausible tensor estimates. The exemplary embodiments of the present disclosure can address at least this deficiency by formulating an exemplary estimation problem, e.g., as linearly constrained linear LS, where the constraints can ensure acceptable tensor estimates. | 01-05-2012 |
| 20120000466 | System and Method for Improved Treatment of Sleeping Disorders using Therapeutic Positive Airway Pressure - Described is a method and system providing therapeutic positive airway pressure to a particular area of patient's airways. The system may include a flow generator and a processing arrangement. The flow generator supplies an airflow to an airway of the patient. The processing arrangement is connected to the flow generator to control a supply pressure at which the airflow is generated by the flow generator. The processing arrangement continuously adjusts the supply pressure to maintain a pressure in a predetermined portion of the patient's airway substantially constant. The predetermined portion of the patient's airway includes a collapsible portion of an upper airway of the patient. The processing arrangement also controls the supply pressure to maintain the pressure in the collapsible portion of the patient's airway at a value at least as great as a tissue pressure below which the collapsible portion collapses. | 01-05-2012 |
| 20110318430 | TUMOR THERAPY WITH ANTITUMOR AGENTS IN COMBINATION WITH SINDBIS VIRUS-BASED VECTORS - A method for treating malignant tumors with Sindbis viral based vectors in combination with antitumor agents and pharmaceutical formulations for use in such treatment. | 12-29-2011 |
| 20110318358 | IMMUNOTHERAPY FOR CLEARING PATHOLOGICAL TAU CONFORMERS - The present invention relates to methods of treating and preventing Alzheimer's Disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies recognizing the tau protein or its immunogenic epitopes under conditions effective to treat or prevent Alzheimer's Disease of other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tangle-related behavioral phenotype in a subject. | 12-29-2011 |
| 20110301057 | IN SITU ORIENTED IMMOBILIZATION OF PROTEINS ON A SUPPORT - The present invention relates to a method of directing in situ oriented immobilization of a protein on a support. This method involves providing a support and contacting the support with a solution. The solution comprises (a) a protein comprising a coupling moiety and (b) a molecule comprising a first group reactive with the support and a second group reactive with the coupling moiety. The molecule binds (i) the support at the first group and (ii) the coupling moiety at the second group, thereby immobilizing and orienting, in situ, the protein on the support. Also described are a protein array and a method of screening compounds for protein interaction. | 12-08-2011 |
| 20110292216 | METHOD, COMPUTER-ACCESSIBLE, MEDIUM AND SYSTEMS FOR FACILITATING DARK FLASH PHOTOGRAPHY - Exemplary embodiments of the present disclosure relate generally to methods, computer-accessible medium and systems for dark flash photography. For example, described herein is an exemplary embodiment of an apparatus for providing illumination and obtaining an image, which can include, e.g., a first arrangement configured to emit a flash of light including ultra-violet light and/or infra-red light to illuminate a scene and/or one or more subjects, and a second arrangement configured to obtain an image of the illuminated scene and/or one or more subject. A duration of time and/or an intensity level of the flash can be selected, e.g., so that wavelengths of the flash can be substantially invisible to a human eye. For example, the visibility of the flash perceived by the human eye can be, e.g., approximately 200 times less than the visibility of a standard flash of light having substantially the same amount of energy as the flash. | 12-01-2011 |
| 20110288083 | METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE - The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases. | 11-24-2011 |
| 20110280840 | COMPOSITIONS AND METHODS FOR TREATING OBESITY AND RELATED DISORDERS BY CHARACTERIZING AND RESTORING MAMMALIAN BACTERIAL MICROBIOTA - The present invention relates to characterizing changes in mammalian gastrointestinal microbiota associated with antibiotic treatment and various disease conditions (such as obesity, metabolic syndrome, insulin-deficiency or insulin-resistance related disorders, glucose intolerance, diabetes, non-alcoholic fatty liver, abnormal lipid metabolism, short stature, osteoporosis, and other disorders of bone formation and mineralization, etc.) and related diagnostic and therapeutic methods. Therapeutic methods of the invention involve the use of probiotics, prebiotics, or narrow spectrum antibiotics/anti-bacterial agents that are capable of restoring healthy mammalian bacterial gastrointestinal microbiota. | 11-17-2011 |
| 20110279641 | APPARATUS, SYSTEMS, COMPUTER-ACCESSIBLE MEDIUM AND METHODS FOR VIDEO CROPPING, TEMPORALLY-COHERENT WARPING AND RETARGETING - A method for warping a video is provided. The method for warping a video, comprising steps of (a) receiving a video having at least a frame having a specific area; (b) defining a target video cube having a predetermined warping ratio and including the specific area; and (c) warping the frame so that the warped frame conforms to an aspect ratio of the target video cube. | 11-17-2011 |
| 20110274693 | STAPHYLOCOCCUS AUREUS LEUKOCIDINS, THERAPEUTIC COMPOSITIONS, AND USES THEREOF - Disclosed herein are isolated and purified | 11-10-2011 |
| 20110251072 | ASSEMBLY OF QUASICRYSTALLINE PHOTONIC HETEROSTRUCTURES - A method and system for assembling a quasicrystalline heterostructure. A plurality of particles is provided with desirable predetermined character. The particles are suspended in a medium, and holographic optical traps are used to position the particles in a way to achieve an arrangement which provides a desired property. | 10-13-2011 |
| 20110245175 | INHIBITING INTERACTION BETWEEN THE HIF-1ALPHA AND p300/CBP WITH HYDROGEN BOND SURROGATE-BASED - The present invention relates to peptides having one or more stable, internally constrained α-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300. | 10-06-2011 |
| 20110236415 | VIRULENT ONCOLYTIC HERPES SIMPLEX VIRUS STRAINS ENGINEERED TO COUNTER THE INNATE HOST RESPONSE - The present invention relates to an avirulent, oncolytic herpes simplex virus modified from a wild-type herpes simplex virus so that both γ | 09-29-2011 |
| 20110223179 | METHODS AND COMPOSITIONS FOR MALARIA PROPHYLAXIS - A composition for preventing malaria infection including a steric inhibitor of circumsporozoite protein cleavage. A pharmaceutical composition for preventing malaria infection including a steric inhibitor and a pharmaceutical carrier. A method of malaria infection prophylaxis including the step of administering an effective amount of the composition of the present invention. A method of malaria prophylaxis by sterically inhibiting circumsporozoite protein processing or by directly inhibiting a protease of a sporozoite from binding to its target. Methods of preventing sporozoite cell invasion or preventing circumsporozoite processing through steric or direct inhibition. | 09-15-2011 |
| 20110218950 | METHOD, SYSTEM, AND COMPUTER-ACCESSIBLE MEDIUM FOR CLASSIFICATION OF AT LEAST ONE ICTAL STATE - An exemplary methodology, procedure, system, method and computer-accessible medium can be provided for receiving physiological data for the subject, extracting one or more patterns of features from the physiological data, and classifying the at least one state of the subject using a spatial structure and a temporal structure of the one or more patterns of features, wherein at least one of the at least one state is an ictal state. | 09-08-2011 |
| 20110218592 | Cochlear Implant Fitting System - A method comprises adjusting baseline auditory stimulation parameters of a cochlear implant on a living body and providing auditory electrical stimulation to a living body via electrodes of the cochlear implant in combination with adjusting the auditory stimulation parameters of the cochlear implant to the living body in real time, retaining a database of used auditory stimulation parameters for a patient and selecting, in real time, from the database a desired one of the stimulation parameters that produces desired hearing percepts in a patient. | 09-08-2011 |
| 20110209708 | Ventilation Interface Device - A device comprises a harness configured to secure a mask over a respiratory orifice of a head of a patient; an inflatable cushion, at least a portion of the first inflatable cushion being adjoined to portion of the harness, the first inflatable cushion being positioned over a predetermined area including a portion of a buccinator muscle of a cheek of a patient; and an inflation lumen having a first end and a second end, the first end receiving pressurized air, the second end connected to the first inflatable cushion to provide pressurized air. When pressurized air is provided to the respiratory orifice via the mask, (a) the inflatable cushion is inflated with the pressurized air, (b) a tension between the mask and the head is increased and (c) the pressurized air in the inflatable cushion counters a bowing of the cheeks during inspiration. | 09-01-2011 |
| 20110206616 | RECOMBINANT DERIVATIVES OF BOTULINUM NEUROTOXINS ENGINEERED FOR TRAFFICKING STUDIES AND NEURONAL DELIVERY - This invention relates to isolated | 08-25-2011 |
| 20110195063 | Methods of Treating Ankylosing Spondylitis Using Anti-TNF Antibodies and Peptides of Human Tumor Necrosis Factor - Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided. | 08-11-2011 |
| 20110194737 | METHOD, SYSTEM, AND COMPUTER-ACCESSIBLE MEDIUM FOR AUTHENTICATION OF PAPER USING A SPECKLE PATTERN - An exemplary methodology, procedure, system, method and computer-accessible medium can be provided for authenticating a portion of a non-digital medium for a document, by receiving at least one image of at least one first marked portion of the non-digital medium for the document, extracting at least one first speckle pattern of the at least one first marked portion, and comparing the first speckle pattern of the at least one first marked portion with at least one second speckle pattern relating to the non-digital medium to determine if a similarity between the first and second speckle patterns equals or exceeds a predetermined amount. | 08-11-2011 |
| 20110190372 | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS - Compositions and methods for antagonizing miRNAs that are overexpressed in chronic, non-healing wounds, as compared to healthy tissue, are disclosed. The miRNA antagonists are oligonucleotides that hybridize to selected pre-miRNA or mature miRNAs and prevent the miRNAs from binding to and downregulating their target mRNAs. Methods of using the miRNA antagonists to treat inflammatory disorders, including to promote healing of chronic, non-healing wounds and acute wounds are provided. | 08-04-2011 |
| 20110190207 | INHIBITING BINDING OF FGF23 TO THE BINARY FGFR-KLOTHO COMPLEX FOR THE TREATMENT OF HYPOPHOSPHATEMIA - The present invention is directed to a method of treating hypophosphatemia in a subject. This method involves selecting a subject with hypophosphatemia associated with elevated or normal FGF23 and administering to the selected subject an inhibitor of FGF23-Klotho-FGF receptor complex formation under conditions effective to treat the hypophosphatemia. The present invention is also directed to a method of screening for compounds suitable for treatment of hypophosphatemia associated with elevated or normal FGF23. This method involves providing FGF23, FGFR-Klotho complex, and one or more candidate compounds. The FGF23, the FGFR-Klotho complex, and the candidate compounds are combined under conditions effective for the FGF23 and the binary FGFR-Klotho complex to form a ternary complex if present by themselves. This method also involves identifying the candidate compounds, which prevent formation of the complex as being potentially suitable in treating hypophosphatemic conditions associated with elevated or normal FGF23. A method of screening the specificity of compounds which prevent formation of the FGF23-Klotho-FGFR complex is also disclosed. | 08-04-2011 |
| 20110167031 | METHOD, SYSTEM, AND COMPUTER-ACCESSIBLE MEDIUM FOR INFERRING AND/OR DETERMINING CAUSATION IN TIME COURSE DATA WITH TEMPORAL LOGIC - Time-course data with an underlying causal structure may appear in a variety of domains, including, e.g., neural spike trains, stock price movements, and gene expression levels. Provided and described herein are methods, procedures, systems, and computer-accessible medium for inferring and/or determining causation in time course data based on temporal logic and algorithms for model checking. For example, according to one exemplary embodiment, the exemplary method can include receiving data associated with particular causal relationships, for each causal relationship, determining average characteristics associated with cause and effects of the causal relationships, and identifying the causal relationships that meet predetermined requirement(s) as a function of the average characteristics so as to generate a causal relationship. The exemplary characteristics associated with cause and effects of the causal relationships can include an associated average difference that a cause can make to an effect in relation to each other cause of that effect. | 07-07-2011 |
| 20110166470 | System and Method for Diagnosis and Treatment of a Breathing Pattern of a Patient - Described is a system including a sensor and a processing arrangement. The sensor measures data corresponding to a patient's breathing patterns. The processing arrangement analyzes the breathing patterns to determine whether the breathing patterns are indicative of a REM sleep state. In another embodiment, the processing arrangement analyzes the breathing patterns to determine whether the breathing patterns are indicative of one of the following states: (i) a wake state and (ii) a sleep state. In another embodiment, a neural network analyzes the data to determine whether the breathing patterns are indicative of one of the following states: (i) a REM sleep state, (ii) a wake state and (iii) a sleep state. In another embodiment, the processing arrangement analyzes the data to determine whether the breathing pattern is indicative of an arousal. | 07-07-2011 |
| 20110163748 | METHOD, SYSTEM AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING MULTIPLE-QUANTUM-FILTERED IMAGING - The present disclosure describes exemplary embodiments of process, system, computer-accessible medium and processing arrangement which can be used to provide multiple-quantum-filtered imaging. For example, provided herein is an exemplary system that can include an arrangement which can be configured to extract and/or determine at least one Nuclear Magnetic Resonance (NMR) signal provided from an anatomical sample utilizing differences of phases of excitation pulses provided from an apparatus. The NMR signal(s) can relate to at least one multiple-quantum coherence in a presence of B | 07-07-2011 |
| 20110162645 | System and Method for Guidance of Anesthesia, Analgesia and Amnesia - Described is a method and system which includes a first set of digital data generated by amplifying and digitizing brain waves of a patient before and after administration of initial doses of interventional agents to the patient and a second set of digital data generated by amplifying and digitizing brain waves of the patient during a medical procedure. In addition, the system includes a microprocessor computing separate trajectories for at least two different indices of an anesthetic state of the patient during the medical procedure as a function of a comparison of the first and second sets of digital data, the indices including a Depth Index (DI), a Memory Index (MI) and Pain Index (PI), the DI corresponding to a depth of anesthesia of the patient, the PI corresponding to a sensitivity of the patient to pain and the MI corresponding to an ability of the patient to form and store memories. The system also includes a display outputting the trajectories for the at least two different indices of anesthetic state of the patient to a user for consideration in formulating subsequent dosages of the interventional agents to be administered to the patient. | 07-07-2011 |
| 20110161011 | COMPUTER-ACCESSIBLE MEDIUM, SYSTEM AND METHOD FOR ASSESSING EFFECT OF A STIMULUS USING INTERSUBJECT CORRELATION - Exemplary embodiments of a system and method can be provided for measuring a level and/or details of how engaging, effective or memorable a stimulus that may be based on information associated with one or more subjects' neuronal, physiological and/or behavioral responses to the stimulus. In addition, an exemplary embodiment of a computer-accessible medium containing executable instructions thereon can also be provided which can be executed by a processing arrangement. For example, when the processing arrangement executes the instructions, the processing arrangement can be configured to, e.g., receive neuronal, physiological and/or behavioral data one or more subjects being presented with stimuli, determine further data associated with a measure of inter-subject similarity of the neuronal, physiological and/or behavioral data, and identify particular portions of the stimuli that meet a pre-determined criteria relating to the further data associated with the measure of inter-subject similarity. In addition, the processing arrangement can be further configured to display and/or store identifiers of the particular portions of the stimuli in a storage arrangement in a user-accessible format and/or a user-readable format. | 06-30-2011 |
| 20110160607 | QEED-Guided Selection and Titration of Psychotropic Medications - Data corresponding to brain electrical activity of a patient from a QEEG is processed to determine which brain activity data deviates from that of a normative profile. The deviant brain activity data is used to determine a brain state vector (BSV) in a multidimensional brain electrical signal space, wherein the orientation of the BSV indicates the nature of the deviation from a normal state and may be used to prescribe a medicine to the patient and wherein the length of the BSV quantifies the degree of abnormality exhibited by the patient and may indicate the dosage of the medicine to be prescribed to the patient. | 06-30-2011 |
| 20110142973 | Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus - The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of HIV, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from PPARγ2, LPL and αP2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual. The invention further provides for screening for novel oleuropein analogues. | 06-16-2011 |
| 20110142814 | Methods for Using Protein Kinase C-Theta Inhibitors in Adoptive Immunotherapy - The present invention provides methods for reducing tumor necrosis factor activation of regulatory T cells (Tregs), restoring the activity of defective Tregs, and enhancing the function of Tregs using Protein Kinase C theta (PKC-θ) inhibitors. The enhancement in Treg function is of use in facilitating adoptive immunotherapy in the treatment of immunological disorders. | 06-16-2011 |
| 20110119221 | Method, system and software arrangement for reconstructing formal descriptive models of processes from functional/modal data using suitable ontology - A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc. | 05-19-2011 |
| 20110118618 | Electronic Identity Card - A method comprises the steps of obtaining a baseline measurement corresponding to a representation of brain activity from a living body and storing the baseline measurements on a storage device configured to be wearable on the living body in combination with obtaining, at a time subsequent to the baseline measurement, a second measurement representing brain activity from the living body, reading the baseline measurement from the storage device and evaluating the living body based on a comparison of the second measurement to the baseline measurement. A system for analyzing electrical brain activity, the system comprises a component for reading, from a storage medium, data corresponding to a baseline measurement of brain activity of a living body and a component for determining data representing a current brain activity of the living body in combination with a component for evaluating the living body by comparing the baseline measurement data and the current brain activity data. | 05-19-2011 |
| 20110109626 | METHOD AND APPARATUS FOR SEGMENTING AN IMAGE IN ORDER TO LOCATE A PART THEREOF - A method is disclosed to automatically segment 3D and higher-dimensional images into two subsets without user intervention, with no topological restriction on the solution, and in such a way that the solution is an optimal in a precisely defined optimization criterion, including an exactly defined degree of smoothness. A minimum-cut algorithm is used on a graph devised so that the optimization criterion translates into the minimization of the graph cut. The minimum cut thus found is interpreted as the segmentation with desired property | 05-12-2011 |
| 20110098719 | COCHLEAR IMPLANT WITH IMPROVED ELECTRODE ARRAY AND CONTROLLER - A cochlear implant device includes a deformable and stretchable flexible strip composed of a biological compatible material and positioned about a longitudinal axis so as to form a spiral. The implant device has a plurality of conductive strips with electrode windows formed so as to expose a segment of each conductive strip. A density of the electrode windows is sufficient to monitor a distance of the flexible strip from a non-conductive tissue of a patient in a 360 degree field of view about the longitudinal axis. A method of inserting a cochlear implant includes providing a multi-joint robot comprised of a series of actuator units, guiding the multi-joint robot into an inner ear of a patient, monitoring the position of the multi-joint robot relative to a non-conductive portion of the patient; and applying current to the multi-joint robot so as to adjust the position of the actuator units. | 04-28-2011 |
| 20110098252 | Treatment of Spinal Mechanical Pain - The invention is directed to a method of treating chronic spinal mechanical pain by intravenous administration to a subject in need of chronic spinal mechanical pain relief of an effective amount of bisphosphonate. | 04-28-2011 |
| 20110087437 | PROCESS, SOFTWARE ARRANGEMENT AND COMPUTER-ACCESSIBLE MEDIUM FOR OBTAINING INFORMATION ASSOCIATED WITH A HAPLOTYPE - The present invention relates to a method, system and software arrangement for determining the co-associations of allele types across consecutive loci and hence for reconstructing two haplotypes of a diploid individual from genotype data generated by mapping experiments with single molecules, families or populations. The haplotype reconstruction system, method and software arrangement of the present invention can utilize a procedure that is nearly linear in the number of polymorphic markers examined, and is therefore quicker, more accurate, and more efficient than other population-based approaches. The system, method, and software arrangement of the present invention may be useful to assist with the diagnosis and treatment of any disease, which has a genetic component. | 04-14-2011 |
| 20110082930 | METHOD AND APPARATUS FOR MONITOR AND NOTIFICATION IN A NETWORK - A user specifies one or more monitoring/probing rules on a client station. These rules specify user instructions for monitoring and probing conditions, events and data on monitored sites on the Internet. The client station transfers the monitor/probing rules to the monitoring site which also processes and interprets the monitoring/probing rules. When the monitoring site processes these rules, it results in (1) an allocation of space and (2) the creation or initialization of agent programs, such that these agent programs will affect periodic monitoring of Internet sites and send data therefrom back to monitoring site. If the retrieved information at the monitoring site satisfies the user specified conditions, the monitoring site will conduct further exploration to gather more information which may help determine the causes of these conditions. The results of such a probe may be obtained from the monitoring site or the Internet, and are communicated by the monitoring site to the client station for display on a display device. | 04-07-2011 |
| 20110060035 | PREVENTING AND TREATING AMYLOID-BETA DEPOSITION BY STIMULATION OF INNATE IMMUNITY - The present invention is directed to a method of preventing or reducing amyloid deposition in a subject. This method involves selecting a subject with amyloid deposits and stimulating the innate immune system of the selected subject under conditions effective to reduce the amyloid deposits. Also disclosed is a method of preventing or treating cerebral amyloidosis and Alzheimer's Disease in a subject by administering to the selected subject an agent that stimulates the innate immune system. In addition, a composition useful for the stimulation of the innate immune system of a subject exhibiting symptoms associated with amyloid deposition is disclosed. | 03-10-2011 |
| 20110052594 | AGENTS THAT DISSOLVE ARTERIAL THROMBI - Agents that induce platelet fragmentation include an IgG antibody that reacts with platelet epitope GPIIIA49-66 on platelet membrane, recombinant AMANTS-18, phorbol 12-myristate 13-acetate (PMA) and A23817. | 03-03-2011 |
| 20110045008 | THERAPEUTIC AGENTS FOR INDUCING PLATELET FRAGMENTATION AND TREATING THROMBOEMBOLIC DISORDERS - The present invention is directed to a therapeutic agent comprising a GPIIIa(49-66) specific targeting agent and a thrombi-specific homing agent. Also disclosed is the use of the therapeutic agent in carrying out a method of treating thromboembolic disorders and a method of inducing platelet fragmentation. | 02-24-2011 |
| 20110038198 | ELECTRONIC DEVICES BASED ON CURRENT INDUCED MAGNETIZATION DYNAMICS IN SINGLE MAGNETIC LAYERS - The present invention generally relates to magnetic devices used in memory and information processing applications, such as giant magneto-resistance (GMR) devices and tunneling magneto-resistance devices. More specifically, the present invention is directed to a single ferromagnetic layer device in which an electrical current is used to control and change magnetic configurations as well as induce high frequency magnetization dynamics. The magnetic layer includes full spin-polarized magnetic material, which may also have non-uniform magnetization. The non-uniform magnetization is achieved by varying the shape or roughness of the magnetic material. The present invention may be used in memory cells, as well as high frequency electronics, such as compact microwave sources, detectors, mixers and phase shifters. | 02-17-2011 |
| 20110030078 | TRYPANOSOME RESISTANT NON-HUMAN TRANSGENIC ANIMAL - The present invention is directed to a Trypanosome-resistant, non-human transgenic animal whose somatic and germ cells comprise a nucleic acid which encodes an apolipoprotein L-I polypeptide (apoL-I). The apoL-I protein has the amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4, and SEQ ID NO: 5. The first nucleic acid transgene is operatively associated with at least one expression regulatory sequence. Methods of producing and raising such transgenic animals as well as transgenic eggs and sperm are also disclosed. | 02-03-2011 |
| 20110021444 | COMPOSITIONS FOR CONTROLLING HAIR GROWTH - FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1 are provided. In addition, methods of isolating follicular papilla cells and methods of modulating hair growth are also disclosed. | 01-27-2011 |
| 20110014228 | IL23 MODIFIED VIRAL VECTOR FOR RECOMBINANT VACCINES AND TUMOR TREATMENT - The present invention relates to recombinant replicable viral vectors and viruses which are modified with IL23. This IL23 modified virus is highly immunogenic and attenuated for neurotropic pathology found in the wild type viruses. These viruses and vectors can be used for treatment of a variety of cancers and for vaccination against many viral, bacterial, or parasitic diseases. | 01-20-2011 |
| 20110011916 | ANASTOMOSIS DEVICE - The present invention is directed to a circular anastomosis surgical stapler and methods of use. The circular anastomosis surgical stapler includes an operator control assembly, a tubular shaft having a distal end that is associated with a head portion, and an actuating head portion. The actuating head portion includes a detachable anvil portion with an axially extending stem portion. The anvil portion is engagable with the remainder of the head portion, which receives an array of staples. The head portion also includes an associated stapling portion with a stapling mechanism for firing an array of staples against the anvil portion. The anvil portion and the head portion matingly engage along a mating edge. The mating edge is defined by locations around the stem portion spaced from a particular position on the axis of the stem portion at axially and/or radially varying distances. | 01-20-2011 |
| 20100323002 | INHIBITION OF MELANOGENESIS AND MELANOMA METASTASIS WITH P-AMINO BENZOIC ACID (PABA) - The present invention relates to the inhibition of melanogenesis with para-aminobenzoic acid (PABA) and its use in treating melanotic cancer. | 12-23-2010 |
| 20100317594 | Methods for treating breast cancer using NRIF3 related molecules - Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer. | 12-16-2010 |
| 20100316564 | IMMUNOLOGICAL TARGETING OF PATHOLOGICAL TAU PROTEINS - The present invention relates to methods and compositions for treating, preventing, and diagnosing Alzheimer's Disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose Alzheimer's Disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject. | 12-16-2010 |
| 20100305044 | PEPTIDE ANTI-TUMOR AGENT - Disclosed herein are isolated, purified peptides, biologically active fragments and analogs of the peptides having anti-tumor activity in mammals, pharmaceutical formulations comprising the peptides, fragments and analogs and methods of treating mammals suffering from tumors using such materials. | 12-02-2010 |
| 20100301860 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING BREATH-HOLD MULTI-ECHO FAST SPIN-ECHO PULSE SEQUENCE FOR ACCURATE R2 MEASUREMENT - Exemplary embodiments of system, method and computer-accessible medium can be provided in accordance with the present disclosure can be provided for generating a plurality of images associated with at least one anatomical structure using magnetic resonance imaging (MRI) data. For example, using such exemplary embodiments, it is possible to obtain at least one multi-echo fast spin-echo (FSE) pulse sequence based on the MRI data, which can include, e.g., hardware specifications of the MRI system. Further, it is possible to generate each of the images based on a particular arrangement of multiple echoes produced by the multi-echo FSE pulse sequence(s). | 12-02-2010 |
| 20100293124 | Method and System for Data Classification in the Presence of a Temporal Non-Stationarity - A method and system for determining a feature of a particular pattern are provided. In particular, data records are received, and predetermined patterns that are associated with at least some of the data records are obtained. Using the system and method, particular information is extracted from at least a subset of the received data records, the particular information being indicative of the particular pattern in at least some of the data records. Then, it is determined whether the particular pattern is an unexpected pattern based on the obtained predetermined patterns. In addition, it is possible to classify and reduce data and/or parameters provided in the data records. First, the data records are received. Then, the data records which have at least one particular pattern are classified using a Multivariate Adaptive Regression Splines technique. Thereafter, the data and/or parameters of the classified data records are shrunk using a Stein's Estimator Rule technique. | 11-18-2010 |
| 20100292344 | Methods and Compositions for Treating Thalamocortical Dysrhythmia - This invention relates to methods of inhibiting a Ca | 11-18-2010 |
| 20100291133 | RECOMBINANT PROTEIN CONTAINING A C-TERMINAL FRAGMENT OF PLASMODIUM MSP-1 - The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of the | 11-18-2010 |
| 20100286549 | System and Method for Assessing Efficacy of Therapeutic Agents - A method for assessing an effect of a therapeutic agent, comprises the steps of detecting brain electrical activity of a subject to generate a first set of brain wave data and extracting from the first set of brain wave data first data features sensitive to a neurological disorder in combination with the steps of comparing the first data features to control data to define a baseline profile of brain electropathophysiology and computing one of a first classifying score and a first discriminant score based on the baseline profile to estimate a probability that the baseline profile corresponds to a predetermined pathophysiological condition. | 11-11-2010 |
| 20100285020 | LEUKEMIC CELL CNS INFILTRATION CONTROLLED BY NOTCH-INDUCED CHEMOTAXIS - The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-CCL19 signaling and methods of identifying additional therapeutic agents useful in the methods of the present invention are also disclosed. | 11-11-2010 |
| 20100284909 | IMMUNOTHERAPY TARGETING OF THE SHARED ABNORMAL CONFORMATIONAL STATE OF AMYLOIDOGENIC PEPTIDES/PROTEINS - The present invention is directed to pharmaceutical agents and compositions useful for the treatment and prevention of amyloid disease in a subject. The invention further relates to isolated antibodies that recognize a common conformational epitope of amyloidogenic proteins or peptides that are useful for the diagnosis, treatment, and prevention of amyloid disease. | 11-11-2010 |
| 20100281003 | SYSTEM AND USES FOR GENERATING DATABASES OF PROTEIN SECONDARY STRUCTURES INVOLVED IN INTER-CHAIN PROTEIN INTERACTIONS - The present invention relates to methods and systems for generating a database of protein secondary structures that are at an interface of a two-chain inter-protein interaction. Collections of secondary structures identified according to the methods disclosed herein, and their use in identifying therapeutic drug candidates potentially effective in modulating a two-chain inter-protein interaction having a secondary structure at its interface, are also disclosed. | 11-04-2010 |
| 20100278853 | CONSTRAINED HIV V3 LOOP PEPTIDES AS NOVEL IMMUNOGENS AND RECEPTOR ANTAGONISTS - The present invention provides constrained peptides and other organic molecules, that mimic the three dimensional characteristics of the HIV-1 V3 loop peptide when bound by a highly potent human neutralizing monoclonal antibody specific for a V3 conformational epitope, which structure is determined by NMR. Methods for screening for, and designing such molecules are disclosed. These molecules are useful as immunogens for inducing broadly-neutralizing antibodies against HIV-1 as well as antagonists for inhibiting the binding of HIV-1 to the relevant co-receptors, and may therefore be used in method of preventing or treating HIV-1 infection and disease. | 11-04-2010 |
| 20100269827 | System and Method for Circuits to Allow CPAP to Provide Zero Pressure - A system comprises a respiratory delivery arrangement adapted to cover at least one respiratory orifice of a patient. The system also comprises a first conduit having a first end and a second end, the second end connected to the respiratory delivery arrangement. A positive pressure is provided to the respiratory orifice via the first conduit and a second conduit having a third end and a fourth end, the fourth end connected to the respiratory delivery arrangement. An exhaled gas is extracted from the respiratory orifice by one or both of a valve configured to redirect flow through the respiratory delivery arrangement and a venturi opening. | 10-28-2010 |
| 20100253348 | RADIO FREQUENCY COIL ARRANGEMENT FOR HIGH FIELD MAGNETIC RESONANCE IMAGING WITH OPTIMIZED TRANSMIT AND RECEIVE EFFICIENCY FOR A SPECIFIED REGION OF INTEREST, AND RELATED SYSTEM AND METHOD - For example, the present disclosure provides exemplary embodiments of a coil arrangement that can include, e.g., a plurality of elements which can be provided at an angle from one another. The angle can be selected to effectuate an imaging of a target region of interest at least one of a predetermined depth or range of depths, for example. In certain exemplary embodiments according to the present disclosure, the angle can be selected to effectuate an exemplary predetermined transmit efficiency for at least one of the elements. Additionally, the exemplary angle can be selected to effectuate a predetermined receive sensitivity for at least one of the elements. Further, according to certain exemplary embodiments of a coil arrangement in according to the present disclosure, the angle can be adjusted manually and/or automatically. | 10-07-2010 |
| 20100253343 | SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR PROVIDING HYBRID ADIABATIC-RECTANGULAR PULSE TRAIN FOR EFFECTIVELY COMPLETE SATURATION OF MAGNETIZATION WITHIN AN ANATOMICAL STRUCTURE - According to exemplary embodiments of the present disclosure, it is possible to provide system, method and computer-accessible medium to facilitate a hybrid adiabatic-rectangular pulse train for saturation of magnetization within an anatomical structure. Using such exemplary embodiments, it is possible to determine information by combining a first information associated with a first nonselective rectangular radio frequency (RF) pulse, a second information associated with a second nonselective rectangular RF pulse, and a third information associated with a nonselective adiabatic half-passage pulse. Further, it is possible to rotate the longitudinal magnetization onto a particular plane (e.g., the transverse plane) based on the information. In addition, it is possible to minimize and/or achieve the residual longitudinal magnetization to be less than a predetermined threshold value (e.g., 2% of equilibrium magnetization) within the anatomical structure using a configuration of RF pulses. | 10-07-2010 |
| 20100233207 | C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE - The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants. | 09-16-2010 |
| 20100226852 | CLK-PEPTIDE AND SLK-PEPTIDE - The invention describes methods for inhibiting angiogenesis in a tissue by administering an antagonist that specifically binds to a proteolyzed or denatured collagen type-IV with substantially greater affinity than to the native triple helical form of collagen type-IV. Methods utilizing such antagonists for therapeutic treatment of tumor growth, tumor metastasis or of restenosis also are described, as are methods to use such antagonists as diagnostic markers of angiogenesis in normal or diseased tissues both in vivo and ex vivo. The invention further describes methods for treating tumors using said antagonists in combination with radiation therapy and therapies comprising the antagonists and radiation treatment. | 09-09-2010 |
| 20100224188 | System and Method for Guidance of Anesthesia, Analgesia and Amnesia - A system and method includes administering interventional agents to Patient until Patient attains a predetermined plane of anesthesia; amplifying and digitizing brain waves of Patient before and after administering step to generate first set of digital data; amplifying and digitizing brain waves of Patient during a medical procedure to generate second set of digital data; computing separate trajectories for at least two different indices of an anesthetic state of Patient during the medical procedure using a comparison of first and second sets (the indices including Depth Index (DI)—a depth of anesthesia, Memory Index (MI)—an ability to form and store memories, and Pain Index (PI)—sensitivity to pain); and determining an amount of at least one of the interventional agents to be delivered to Patient as a function of the trajectories, the interventional agents include anesthetic, analgesic and/or amnesic agents corresponding to DI, MI and/or PI trajectories. | 09-09-2010 |
| 20100216703 | Inhibitors of PDE4 and Methods of Use - The inventors have succeeded in discovering that the p75 neurotrophin receptor (p75NTR) is directly involved in the degradation of cAMP via interaction of its intracellular domain with phosphodiesterase 4A4/5 (PDE4A4/5). Provided herein are methods and compositions for the treatment of conditions of PDE4A4/5 and p75NTR expression (such as pulmonary disease and nerve regeneration) by blocking the interaction of PDE4A4/5 and p75NTR, as well as methods for the screening of agents useful in such applications. | 08-26-2010 |
| 20100210004 | PLASMODIUM AXENIC LIVER STAGES AS A NONINFECTIOUS WHOLE ORGANISM MALARIA VACCINE - The present invention relates to the treatment and prevention of malaria infection. In particular, the present invention provides novel noninfectious, whole organism vaccines for malaria, which vaccines comprise a | 08-19-2010 |
| 20100207626 | METHOD, SYSTEM AND SOFTWARE ARRANGEMENT FOR MEASURING MAGNETIC FIELD CORRELATION - Methods, systems, software arrangements and storage medium for measuring the magnetic field correlation function (“MFC”), and more particularly, to methods for measuring the magnetic field correlation function utilizing asymmetric spin echoes. Asymmetric Dual Spin Echo Sequences (“ADSE”) and Echo Planar Imaging Asymmetric Dual Spin Echo Sequences (“EPI-ADSE”) may be employed to apply multiple echoes to a sample and acquire data from which the MFC may be determined. | 08-19-2010 |
| 20100204801 | IMPLANTS FOR THE TREATMENT OF OSTEOARTHRITIS OF THE KNEE - A replacement knee implant has a femoral implant and a tibial implant, each of which are inset in a bone surface. The tibial implant is generally elongated with one end rounded and an opposite end conforming to the shape of the tibia, and is made of a metal alloy or a ceramic. The upper surface is dished while the lower surface is planar and can be parallel or sloped relative to the upper surface. The femoral implant for implementation in a femoral condyle is rounded such that, when implemented, the femoral implant is flush at the anterior and posterior sides and protruding away from the femur between the anterior and posterior ends. The femoral implant can have an elongated keel for extending into the femur, and can be made from a highly cross-linked polyethylene. | 08-12-2010 |
| 20100204122 | TREATMENT OF OSTEOPOROSIS IN PERI- AND POST- MENOPAUSAL WOMEN WITH HEPCIDIN - The present invention is directed to a method of treating, preventing, or reducing the risk of bone deterioration or osteoporosis in a peri- or post-menopausal female subject. The method involves selecting a peri- or post-menopausal female subject in need of treating, preventing, or reducing the risk of bone deterioration or osteoporosis and administering hepcidin to the selected subject under conditions effective to treat, prevent, or reduce the risk of bone deterioration or osteoporosis. | 08-12-2010 |
| 20100196421 | GENETICALLY ENGINEERED CLOSTRIDIAL GENES, PROTEINS ENCODED BY THE ENGINEERED GENES, AND USES THEREOF - The present invention relates to an isolated Clostridial neurotoxin propeptide having a light chain region, a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond, and an intermediate region connecting the light and heavy chain regions. An isolated nucleic acid molecule encoding a Clostridial neurotoxin propeptide is also disclosed. Also disclosed is an isolated, physiologically active Clostridial neurotoxin produced by cleaving a Clostridial neurotoxin propeptide, a vaccine or antidote thereof, and methods of immunizing against or treating for toxic effects of Clostridial neurotoxins. Methods of expressing recombinant physiologically active Clostridial neurotoxins are also disclosed. Also disclosed is a chimeric protein having a heavy chain region of a Clostridial neurotoxin and a protein with therapeutic functionality. A treatment method is also disclosed. | 08-05-2010 |
| 20100191123 | ULTRASONIC PROBE DEVICE AND SYSTEM AND METHODS OF GENERATING ULTRASONIC IMAGES - The present invention relates to an ultrasonic probe device comprising an elongated body having a proximal end and a distal end, where the body has a channel that extends from the proximal end to the distal end. A cord passes through the channel and is extendable and retractable relative to the distal end of the elongated body. An ultrasonic probe head is connected to the cord and has a proximal end adjacent the distal end of the elongated body. The proximal end of the probe head is detachably connected to the distal end of the elongated body. The present invention is also directed to an ultrasound imaging system and a method of generating an ultrasonic image. | 07-29-2010 |
| 20100185185 | System and Method for Correction of Intracerebral Chemical Imbalances - A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient's body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient's CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit. A system for treating disorders of the central nervous system (CNS), comprises first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient's CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS and a first reservoir imlpantable within the patient's body and holding material to be introduced to the CNS in combination with a first pump coupled to the first reservoir and the first conduit for introducing the material to the CNS via the first conduit and a brain wave detection unit for detecting and analyzing brain waves of the patient. | 07-22-2010 |
| 20100179518 | Microelectrode-Equipped Subdural Therapeutic Agent Delivery Strip - An apparatus for treating the brain, comprises a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the brain, the first fluid delivery device including a first fluid lumen extending to a first outlet port in the distal end to deliver fluids to a first target location and a first microelectrode mounted within the distal end of the first fluid delivery device for movement between an insertion position in which a first distal tip of the first microelectrode is received within the first fluid delivery device and a deployed position in which the first microelectrode extends out of the first fluid delivery device with the first distal tip thereof penetrating the pia mater to a first electrode target position in the cerebral cortex. | 07-15-2010 |
| 20100136016 | HEAT SHOCK PROTEINS FROM MYCOBACTERIUM LEPRAE AND USES THEREOF - The present invention is directed to heat shock proteins from | 06-03-2010 |
| 20100136000 | TREATMENT OF FOLLICULAR LYMPHOMAS USING INHIBITORS OF THE LT PATHWAY - Therapeutic uses of inhibitors of the lymphotoxin pathway to treat tumors, specifically to treat follicular lymphomas. | 06-03-2010 |
| 20100131673 | SYSTEM AND METHOD FOR DISTRIBUTING FOVEATED DATA IN A NETWORK - A system and method for executing a computer program in a network. The system includes a surrogate proxy processor which, when executing the computer program, is programmed to receive at least one foveated image from at least one of the foveating proxy server and a further device that is connected to the foveating proxy server, wherein the foveating proxy server generates the at least one foveated image, and transmit the foveated image to at least one of the client computer and a another device. In addition, a system is provided which includes a foveating proxy server, and at least two surrogate proxy servers communicating with one another. At least one of the at least two surrogate proxy servers communicates with the foveating proxy server, and another one of the at least two proxy servers communicates with at least one of the client computer and a further device, wherein the at least two surrogate proxy servers are cascaded along a multi-hop portion of the network. | 05-27-2010 |
| 20100129798 | DETECTING GENETIC PREDISPOSITION TO OSTEOARTHRITIS ASSOCIATED CONDITIONS - This application relates to methods and kits for detecting predisposition to increased risk for osteoarthritis associated conditions. | 05-27-2010 |
| 20100120897 | NOVEL HELPER PLASMID, DEFECTIVE SINDBIS VIRAL VECTORS AND METHODS OF USE THEREOF - Disclosed herein are new defective Sindbis viral vectors made from a novel Helper plasmid, with differences in envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are vectors produced using the plasmid, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods. | 05-13-2010 |
| 20100106259 | Conducting polymer nanowire brain-machine interface systems and methods - The present invention relates to conducting polymer nanowires and their use in a brain-machine interface which is secure, robust and minimally invasive. In accordance with a first aspect of the present invention, a vascular-based brain-machine interface comprising conducting polymer nanowires is disclosed. | 04-29-2010 |
| 20100105064 | METHOD OF SCREENING TEST SUBSTANCES FOR TREATING OR PREVENTING A DISEASE MEDIATED BY PLASMA CELLS - The present invention relates to a method of screening a compound for potential effectiveness in treating or preventing a mammalian disease mediated by plasma cells or a mammalian disease caused by virus infection of mammalian cells. Compounds are tested for their ability to inhibit IRE1-mediated processing of untranslatable XBP-1 mRNA into translatable XBP-1 mRNA. Drugs that are useful in treating or preventing a mammalian disease mediated by plasma cells and a method for detecting XBP-1 activity in living cells are also described. | 04-29-2010 |
| 20100104018 | SYSTEM, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING BODY SIGNATURE RECOGNITION - Provided and described herein are, e.g., exemplary embodiments of systems, methods, procedures, devices, computer-accessible media, computing arrangements and processing arrangements in accordance with the present disclosure related to body signature recognition and acoustic speaker verification utilizing body language features. For example, certain exemplary embodiments can include a computer-accessible medium containing executable instructions thereon. When one or more computing arrangements executes the instructions, the computing arrangement(s) can be configured to perform certain exemplary procedures, including (i) receiving first information relating to one or more visual features from a video, (ii) determining second information relating to motion vectors as a function of the first information, and (iii) computing a statistical representation of a plurality of frames of the video based on the second information. Further, the computing arrangement(s) can be configured to provide the statistical representation to a display device and/or recording the statistical representation on a computer-accessible medium, for example. | 04-29-2010 |
| 20100094155 | System and Method for Prediction of Cognitive Decline - A system and method for prediction of cognitive decline, comprises an input receiving input data corresponding to brain activity of an individual and a processor coupled to the input for analyzing the input data to obtain a selected set of features, the processor comparing the selected set of features to at least a portion of entries in a database corresponding to brain activity of a plurality of individuals, wherein entries in the database have been separated into a plurality of categories corresponding to one of a degree of cognitive decline and a propensity for future cognitive decline of individuals relating to the entries, the processor determining, based on the comparison, a category most closely corresponding to the selected set of features. | 04-15-2010 |
| 20100092916 | METHOD AND DEVICES TO INCREASE CRANIOFACIAL BONE DENSITY - The present invention relates to a method for increasing bone growth in teeth and/or other craniofacial regions of a subject. This method includes administering to the jaw and/or teeth of the subject a mechanical vibration having a frequency of 10 to 1000 Hz with an acceleration peak of 0.1 to 2.00 g and that can produce a low magnitude strain of 1 to 50 microstrain in the jaw and/or teeth. The present invention also relates to devices that deliver high frequency, low magnitude force to the teeth. | 04-15-2010 |
| 20100092046 | LOGIC ARRANGEMENT, DATA STRUCTURE, SYSTEM AND METHOD FOR MULTILINEAR REPRESENTATION OF MULTIMODAL DATA ENSEMBLES FOR SYNTHESIS, RECOGNITION AND COMPRESSION - A data structure, method, storage medium and logic arrangement are provided for use in collecting and analyzing multilinear data describing various characteristics of different objects. In particular it is possible to recognize an unknown individual, an unknown object, an unknown action being performed by an individual, an unknown expression being formed by an individual, as well as synthesize a known action never before recorded as being performed by an individual, synthesize an expression never before recorded as being formed by an individual, and reduce the amount of stored data describing an object or action by using dimensionality reduction techniques, and the like. | 04-15-2010 |
| 20100074872 | COMPOSITIONS AND METHODS FOR CHARACTERIZING AND RESTORING GASTROINTESTINAL, SKIN, AND NASAL MICROBIOTA - The present invention relates to characterizing changes in mammalian bacterial gastrointestinal, cutaneous and nasal microbiota associated with antibiotic treatment and various disease conditions (such as asthma, allergy, obesity, metabolic syndrome, gastrointestinal reflux disease (GERD), eosinophilic esophagitis, gastro-esophageal junction adenocarcinomas (GEJAC), infections due to bacteria that are resistant to antibiotics, including Methicillin-resistant | 03-25-2010 |
| 20100048484 | METHODS FOR TREATING DIABETIC WOUNDS - The present invention relates to a method of treating chronic wounds using calreticulin. In particular, the invention relates to the treatment of chronic diabetic wounds using topical application of calreticulin to a patient in need of such treatment. | 02-25-2010 |
| 20100020040 | MULTI-TOUCH SENSING LIGHT EMITTING DIODE DISPLAY AND METHOD FOR USING THE SAME - Apparatus and method for both displaying graphical output and for sensing, e.g., multi-touch input are provided. A light-emitting diode (“LED”) matrix-array may be configured to both emit and sense light. The array may be driven in such a way so as to enable the array itself to act as the illumination source preferable for either reflective or scattering optical touch sensing. The need for additional opto-electronic components, or an external illumination source, is thus eliminated or at least reduced, and sensing accuracy is likely improved. Additionally, the method is practical for large dimensions. | 01-28-2010 |
| 20100016408 | MODULATING THE CDC14B-CDH1-PLK1 AXIS AND METHODS FOR SENSITIZING TARGET CELLS TO APOPTOSIS - The invention relates to modulating Cdc14B levels (cell division cycle 14 homolog B) and/or Cdh1 (Fzr1 protein, CDC20-like 1b, or fizzy-related protein) levels to sensitize cells to DNA damage by increasing the abundance of Plk1 (polo-like kinase 1) in a target cell. In certain embodiments, the invention relates to modulating Plk1 levels, and in particular to increasing Plk1 levels, to sensitize target cells such as cancer cells to cell death or apoptosis. In certain embodiments, the invention relates to inhibitors of Cdc14B and Cdh1 that sensitize tumor cells to chemotherapy or radiation induced cell death or apoptosis. In addition to applications relating to cancer therapies and diagnostics, the Plk1 modulators and assays will be employed for identifying novel drugs or drug candidates useful for various proliferative and/or differentiative disorders such as major opportunistic infections, immune disorders, cardiovascular diseases and inflammatory disorders. | 01-21-2010 |
| 20090327197 | SYSTEM AND METHOD FOR DYNAMIC PROFILING OF USER IN ONE-TO-ONE APPLICATIONS AND FOR VALIDATION OF USER RULES - A system and method for generating and validating a user profile ( | 12-31-2009 |
| 20090318535 | BETA -TrCP1, BETA -TrCP2 AND RSK1 OR RSK2 INHIBITORS AND METHODS FOR SENSITIZING TARGET CELLS TO APOPTOSIS - The invention relates to modulating BimEL levels (Bcl-2-Interacting Mediator of cell death, Extra Long isoform) to sensitize cancer cells to cell death or apoptosis. In certain embodiments, the invention relates to increasing BimEL levels. In certain embodiments, the invention relates to inhibitors of at least one of β-TrCP1/2 or RSK1/2 proteins that sensitize tumor cells to chemotherapy-induced death or apoptosis. Additionally, the invention relates to cancer therapies, diagnostics, and methods for identifying novel drugs or drug candidates for increasing BimEL levels. | 12-24-2009 |
| 20090312663 | System and Method for Neurometric Analysis - A system, comprises a plurality of neurometric analyzing software modules operating on electroencephalogram (EEG) data, each module performing a defined task with respect to neurometric analysis of the EEG data and a database including normative neurometric data in combination with a server including an authorization module, the authorization module comparing data received from a remote user to determine whether the user is authorized to utilize any of the plurality of analyzing software modules and an analysis module configured to receive input data from a patient and select one of the neurometric analyzing modules based on the input data, wherein the selected one of the neurometric analyzing modules compares the input data to the normative neurometric data to generate an output, the analysis module selecting the one of neurometric analyzing modules from a set of subscribed neurometric analyzing modules. | 12-17-2009 |
| 20090296462 | HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER - A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity and/or magnetization direction. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer. The fixed and free magnetic layers may have magnetization directions at a substantially non-zero angle relative to the layer normal. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to read out the information stored in the device. | 12-03-2009 |
| 20090286252 | NRIF3, NOVEL CO-ACTIVATOR FOR NUCLEAR HORMONE RECEPTORS - Nucleic acids encoding NRIF3 are described. Polypeptides having amino acid sequences of NRIF3 proteins are also provided. A method is also provided for isolating and cloning NRIF3 cDNA. NRIF3 is useful in development/implementation of high throughput screens to identify novel thyroid hormone receptor (TR) and retinoid X receptor (RXR) agonists and antagonists. Methods are also provided for identifying compounds that directly interfere with the interaction of NRIF3 and TR or RXR. Finally, therapies based on modulation of NRIF3 activity are disclosed. | 11-19-2009 |
| 20090281446 | SYSTEM AND DEVICE FOR SEIZURE DETECTION - A device comprises a head mounting arrangement sized and shaped to be worn on a user's head and a plurality of electrodes disposed on the arrangement so that, when the arrangement is worn on the user's head, the electrodes contact target portions of a scalp to detect electrical activity of a brain of the user in combination with an image capture device disposed on the arrangement so that, when the arrangement is worn on the user's head, a field of view of the image capture device includes a portion of an anatomy of the user and a processing unit generating EEG data from the electrical activity, wherein, when the EEG data is indicative of an epileptic event, the processing unit activates the image capture device to capture video data of the user and may store the EEG and/or the video data with transmission of warning signals to one or more remote displaying and/or computing arrangements. | 11-12-2009 |
| 20090275639 | USP47 INHIBTORS AND METHODS TO INDUCE APOPTOSIS - The present invention relates to USP47 (ubiquitin specific protease 47) inhibitors and methods for inducing apoptosis or cell death in a target cell. In certain embodiments, the invention relates to methods and kits to screen for related agents that induce apoptosis. Additionally, the invention relates to assays for screening compounds capable of acting as USP47 inhibitors. | 11-05-2009 |
| 20090233933 | Prostaglandin Transporter Inhibitors - Provided are methods of inhibiting prostaglandin transporter (PGT) activity in mammals. Also provided are methods of determining whether a test compound is an inhibitor of a prostaglandin transporter. Additionally provided are compounds that inhibit prostaglandin transporter activity, and pharmaceutical compositions of those compounds. Methods of inhibiting COX-2 in a mammal are also provided. Additionally, methods of treating pain or inflammation in a mammal are provided. | 09-17-2009 |
| 20090214425 | TUMOR THERAPY WITH REPLICATION COMPETENT SINDBIS VIRAL VECTORS - Disclosed herein are methods for treating a mammal harboring a solid tumor which expresses higher levels of High Affinity Laminin Receptors (LAMR) than normal cells of the same lineage comprising systematically administering to a mammal in need of such treatment a therapeutically effective amount of a Replication Competent (RC) Sindbis virus vector, wherein said vector encodes a suicide gene. | 08-27-2009 |
| 20090192569 | CORTICAL ELECTRODE ARRAY AND METHOD FOR STIMULATING AND RECORDING BRAIN ACTIVITY - An electrode device and a method of installing the electrode device in the vicinity of the brain. The electrode device includes a plurality of electrode assemblies, each with at least one electrode lead, extending from a common base. The base is configured to be positioned on an outside of the patient's cranium with each electrode assembly projecting individually through a hole in the patient's cranium such that the electrode lead is in the vicinity of the brain. The method of installation includes carving a recess out of the patient's cranium and inserting the base therein. Each of the electrode assemblies are placed in their respective holes in order to stimulate, monitor or record neurological activity. The electrode device may be used over long periods of time for chronic treatment or recording. | 07-30-2009 |
| 20090188009 | HEAT SHOCK RNA FROM VARIOUS SPECIES AND ITS USE IN ACTIVATION OF HEAT SHOCK TRANSCRIPTION FACTOR, IN TREATMENT OF VARIOUS DISEASES IN ANIMALS AND IN GENERATION OF STRESS-RESISTANT PLANTS - The present invention provides a novel RNA, designated herein as the “HSR1” (Heat Shock RNA), and its use together with translation elongation factor eEF1A in activation of heat shock transcription factor HSF. The invention further provides the use of HSR1 for generation of novel therapeutics for the treatment of various diseases in animals and for generation of stress-resistant plants. | 07-23-2009 |
| 20090186829 | Nitrosation-Inducible Inhibitors Biological Macromolecules - Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: | 07-23-2009 |
| 20090177246 | Cochlear Implant Fitting System - A method comprises adjusting baseline auditory stimulation parameters of a cochlear implant on a living body and providing auditory electrical stimulation to a living body via electrodes of the cochlear implant in combination with adjusting the auditory stimulation parameters of the cochlear implant to the living body in real time, retaining a database of used auditory stimulation parameters for a patient and selecting, in real time, from the database a desired one of the stimulation parameters that produces desired hearing percepts in a patient. | 07-09-2009 |
| 20090175853 | METHOD FOR TREATING AMYLOID DISEASE - Disclosed herein are methods for treating amyloid disease in humans by clearing amyloid peptides from one or more bodily fluids such as, e.g. blood, of a patient. In particular, the methods are based on the administration of compounds capable of binding to amyloid-beta (Aβ) or on dialysis of blood or plasma exchange in order to remove Aβ peptides from the blood circulation, and/or brain or other affected organs. | 07-09-2009 |
| 20090163420 | SYNTHETIC IMMUNOGENIC BUT NON-DEPOSIT-FORMING POLYPEPTIDES AND PEPTIDES HOMOLOGOUS TO AMYLOID BETA, PRION PROTEIN, AMYLIN, ALPHA-SYNUCLEIN, OR POLYGLUTAMINE REPEATS FOR INDUCTION OF AN IMMUNE RESPONSE THERETO - The present invention relates to immunogenic but non-depositing-forming polypeptides or peptides homologous to amyloid β, prion, amylin or α-synuclein which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid β peptides and amyloid deposits, to prion protein and prion deposits, to amylin and amylin deposits, to α-synuclein and deposits containing α-synuclein, or to polyglutamine repeats and deposits of proteins containing polyglutamine repeats. Described are also antibodies directed against such peptides, their generation, and their use in methods of passive immunization to such peptides and deposits. | 06-25-2009 |
| 20090162275 | CONTRAST AGENTS ANCHORED BY THIOLS ON NANOPARTICLES - The present invention is directed toward a multivalent product including a nanoparticle with a metal, metal alloy, or metal oxide core, a plurality of non-polymerizing ligands bound to the nanoparticle, and a plurality of paramagnetic ions coupled to the nanoparticle by the ligands. Methods of making and using the multivalent product are also disclosed. | 06-25-2009 |
| 20090137738 | LADDER COPOLYMERS - The present invention relates to a copolymer termed a ladder copolymer because it has two backbones that serve as legs/sides of a ladder structure. These two backbones, one of which is a nucleic acid or nucleic acid-like polymer, are linked together as the legs/sides of a ladder are linked together by the rungs. | 05-28-2009 |
| 20090137654 | METHODS OF MODULATING BINDING OF SON OF SEVENLESS TO PHOSPHATIDIC ACID AND IDENTIFYING COMPOUNDS THAT MODULATE SUCH BINDING - The present invention relates to methods of modulating binding of Son of sevenless to phosphatidic acid and identifying compounds that modulate such binding. In particular, the present invention relates to a method of controlling pleckstrin homology domain-dependent membrane recruitment of Son of sevenless or histone folds domain-dependent membrane recruitment of Son of sevenless. Also disclosed are methods of controlling Ras and treating a subject for a condition mediated by Ras. The present invention also relates to a method of identifying compounds potentially effective in treating a condition mediated by Ras. | 05-28-2009 |
| 20090124967 | DEVICES AND METHODS FOR REMOVAL OF LEUKOCYTES FROM BREAST MILK - The present invention relates to a nipple shield device or baby bottle nipple for removing leukocytes from breast milk with a filter attached to the nipple shield or baby bottle nipple at a location permitting removal of leukocytes from breast milk. A method of removing leukocytes from breast milk involving filtering breast milk with a filter that removes leukocytes is also disclosed. | 05-14-2009 |
| 20090124507 | SYSTEM AND METHOD FOR RAPID SEARCHING OF HIGHLY SIMILAR PROTEIN-CODING SEQUENCES USING BIPARTITE GRAPH MATCHING - An exemplary embodiment of system, computer-accessible medium and method for comparing a first genome to a second genome. For example, a first genome may be compared to a second genome by building a first library for the first genome and a second library for the second genome, providing a plurality of matches between elements in the first library common to elements in the second library, ranking each match to determine a likelihood of similarity between the common elements in the first and second libraries; and associating matches having a predetermined likelihood. The association may be performed efficiently by a stable marriage procedure. | 05-14-2009 |
| 20090117577 | METHODS TO IDENTIFY COMPOUNDS USEFUL FOR TUMOR SENSITIZATION TO DNA DAMAGE - Cdc25A is herein identified as a substrate for β-TrCP1- or β-TrCP2-mediated ubiquitination and subsequent degradation via the ubiquitin-proteasome pathway. In particular, it has been found that interfering with β-TrCP expression or function, or increasing β-TrCP degradation, leads to accumulation of Cdc25A in a cell. Since degradation of Cdc25A is a key feature of the response to DNA damage, leading to a stall in the cell cycle during which the cell can repair the damage, Cdc25A accumulation can abolish this response, thereby sensitizing the cell to DNA damage. Described herein are assays for identifying β-TrCP inhibitors, and method of using such inhibitors for modulating Cdc25A degradation, sensitization of tumor cells, and as adjuvants in cancer therapy based on DNA damaging agents. | 05-07-2009 |
| 20090104623 | COMPOSITIONS FOR CONTROLLING HAIR GROWTH - FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1 are provided. In addition, methods of isolating follicular papilla cells and methods of modulating hair growth are also disclosed. | 04-23-2009 |
| 20090099351 | NYLON POLYRIBONUCLEOSIDES - The present invention provides a polyribonucleoside ladder copolymer molecule of general formula (I) | 04-16-2009 |
| 20090098148 | HIGH EFFICIENCY TISSUE-SPECIFIC COMPOUND DELIVERY SYSTEM USING STREPTAVADIN-PROTEIN A FUSION PROTEIN - The present invention relates to methods and compositions that can be employed to introduce toxins and nucleic acids into the cytoplasm or nucleus of a eukaryotic cell, particularly a cell of a higher vertebrate. The invention particularly concerns the use of a fusion protein of streptavidin and protein A sequences to form a non-covalent complex of a toxin or nucleic acid and an antibody. | 04-16-2009 |
| 20090098144 | IMMUNOGEN PRESENTING HIV GP120 V3 LOOP IN A CONFORMATION THAT INDUCES BROADLY NEUTRALIZING ANTIBODIES - Insertion of HIV-1 V3 loop peptides from the viral glycoprotein gp120 into selected, immunogenic scaffold proteins results in a recombinant polypeptide that is a potent V3 immunogen. V3 immunogens include natural and consensus V3 sequences and cyclic and reverse peptides. Preferred scaffold proteins are Cholera Toxin subunit B and homologues thereof including closely related | 04-16-2009 |
| 20090085564 | SYSTEM, METHOD AND COMPUTER ACCESSIBLE MEDIUM FOR MAGNETIC RESONANCE SPECTROCOPIC IMAGING - An exemplary embodiment of system, method, and computer accessible medium for magnetic resonance spectroscopic imaging for improving signal-to-noise ratio per unit time and optimizing duty cycle in MRSI and/or for reducing chemical-shift artifacts can be provided. One exemplary embodiment includes forwarding an excitation pulse to the target and acquiring a signal from the target by multiplexing in time and space. Multiplexing in time may involve segmenting a field of view of the at least one portion of the target into a predetermined number of slabs that are acquired sequentially during each repetition time. Multiplexing in space may involve acquiring multiple voxels. Data may be generated based on the acquired signal. A further exemplary embodiment includes providing an excitation pulse to the target and acquiring a signal from the target. The excitation pulse can be a series of cascaded Hadamard pulse components. Data may be generated based on the acquires signal. | 04-02-2009 |
| 20090081283 | TUMOR THERAPY WITH NON-VIRAL-BASED HIGH AFFINITIY LAMININ RECEPTOR-TARGETED VECTORS - The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to alphavirus-based, preferably Sindbis virus-based, vectors and to non-alphavirus-based vectors, which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and have the ability to cause tumor necrosis. | 03-26-2009 |
| 20090081204 | SYNTHETIC IMMUNOGENIC BUT NON-AMYLOIDOGENIC PEPTIDES HOMOLOGOUS TO AMYLOID BETA FOR INDUCTION OF AN IMMUNE RESPONSE TO AMYLOID BETA AND AMYLOID DEPOSITS - The present invention relates to synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid β which can be used alone or conjugated to an immunostimulatory molecule in an immunizing composition for inducing an immune response to amyloid β peptides and amyloid deposits. | 03-26-2009 |
| 20090081131 | TUMOR THERAPY WITH HIGH AFFINITY LAMININ RECEPTOR-TARGETED VECTORS AND COMPOUNDS - The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to alphavirus-based, preferably Sindbis virus-based, vectors and to non-alphavirus-based vectors, which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and have the ability to cause tumor necrosis. | 03-26-2009 |
| 20090076735 | Method, system and software arrangement for comparative analysis and phylogeny with whole-genome optical maps - The present invention provides a method for organizing genomic information from multiple organisms. In one embodiment of the invention, phylogenetic trees can be constructed for the organisms. The method of the present invention is termed CAPO, Comparative Analysis and Phylogeny with Optical-Maps. Optical maps of organisms are obtained and phylogeny between the organisms is determined by optical map comparison and bipartite graph matching between the organisms, as, for example, computed by a stable marriage algorithm. | 03-19-2009 |
| 20090041726 | TUMOR THERAPY WITH HIGH AFFINITY LAMININ RECEPTOR-TARGET VECTORS AND COMBINATIONS WITH CHEMOTHERAPEUTIC AGENTS - The present invention relates to methods and compositions for treating tumors using vectors that preferentially target tumor cells. In particular, the invention relates to alphavirus-based, preferably Sindbis virus-based, vectors and to non-alphavirus-based vectors, which have a preferential affinity for high affinity laminin receptors (HALR). These vectors are efficiently targeted to tumors and have the ability to cause tumor necrosis. | 02-12-2009 |
| 20090035329 | DIAGNOSTIC AND TREATMENT METHODS FOR CHARACTERIZING BACTERIAL MICROBIOTA IN SKIN CONDITIONS - The present invention relates to methods for characterization of bacterial skin microbiota to provide diagnostic, therapeutic, and preventive measures for alleviating skin conditions. In certain embodiments, the invention relates to characterization of bacterial skin microbiota associated with psoriasis and related diagnostic, therapeutic, and preventive measures for alleviating psoriasis. These methods will be useful for detecting, diagnosing, and monitoring individuals who have or are at risk of certain skin conditions. | 02-05-2009 |
| 20090022718 | Methods of treating a blood pathology using anti-TNF antibodies and fragments thereof - Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided. | 01-22-2009 |
| 20090005329 | NUCLEIC ACID BASED LADDER COPOLYMERS - The present invention relates to a copolymer termed a ladder copolymer because it has two backbones that serve as legs/sides of a ladder structure. These two backbones, one of which is a nucleic acid or nucleic acid-like polymer, are linked together as the legs/sides of a ladder are linked together by the rungs. | 01-01-2009 |
| 20080300394 | DEFECTIVE SINDBIS VIRAL VECTORS - Disclosed herein are new defective Sindbis viral vectors made from wild type Ar-339 Sindbis virus, with differences in replicase and envelope proteins between JT vectors and consensus Sindbis virus sequences, and also between JT and Ar-339 vectors. Also disclosed are plasmids used for the production of the vectors, methods for producing the vectors, methods for treating mammals suffering from tumors and pharmaceutical formulations for use in the treatment methods. | 12-04-2008 |
| 20080299153 | B. ANTHRACIS PREVENTION AND TREATMENT: MUTANT B. ANTHRACIS LACKING LUXS ACTIVITY AND FURANONE INHIBITION OF GROWTH, AI-2 QUORUM SENSING, AND TOXIN PRODUCTION - The present invention pertains to the discovery that | 12-04-2008 |
| 20080279879 | INDUCTION OF BROADLY REACTIVE NEUTRALIZING ANTIBODIES BY FOCUSING THE IMMUNE RESPONSE ON V3 EPITOPES OF THE HIV-1 gp120 ENVELOPE - Compositions, kits and methods for boosting, or for priming and boosting, high titer broadly neutralizing cross-clade antibody responses focused on single HIV-1 neutralizing epitopes are disclosed. gp120 DNA plasmids comprising HIV env genes are used to prime the antibody response. Primed subjects are immunized with recombinant fusion proteins that comprise a “carrier” protein fusion partner, preferably a truncated form of the MuLV gp70 Env protein, and a desired HIV neutralizing epitopes. Preferred epitopes are epitopes of V3 from one or more HIV clades. Immune sera from such immunized subjects neutralized primary isolates from virus strains heterologous to those from which the immunogens were constructed. Neutralizing activity was primarily due to V3-specific antibodies and cross-clade neutralizing Abs were present. This approach results in more potent and broader neutralizing antibody levels, a result of “immunofocusing” the humoral immune response on neutralizing epitopes such as V3. | 11-13-2008 |
| 20080259508 | HIGH SPEED LOW POWER MAGNETIC DEVICES BASED ON CURRENT INDUCED SPIN-MOMENTUM TRANSFER - A high speed and low power method to control and switch the magnetization direction and/or helicity of a magnetic region in a magnetic device for memory cells using spin polarized electrical current. The magnetic device comprises a reference magnetic layer with a fixed magnetic helicity and/or magnetization direction and a free magnetic layer with a changeable magnetic helicity. The fixed magnetic layer and the free magnetic layer are preferably separated by a non-magnetic layer, and the reference layer includes an easy axis perpendicular to the reference layer. A current can be applied to the device to induce a torque that alters the magnetic state of the device so that it can act as a magnetic memory for writing information. The resistance, which depends on the magnetic state of the device, is measured to thereby read out the information stored in the device. | 10-23-2008 |
| 20080228457 | METHODS, COMPUTER-ACCESSIBLE MEDIUM, AND SYSTEMS FOR GENERATING A GENOME WIDE HAPLOTYPE SEQUENCE - Methods, computer-accessible medium, and systems for generating a genome wide probe map and/or a genome wide haplotype sequence are provided. In particular, a genome wide probe map can be generated by obtaining a plurality of detectable oligonucleotide probes hybridized to at least one double stranded nucleic acid molecule cleaved with at least one restriction enzyme, and detecting the location of the detectable oligonucleotide probes. For example, genome wide haplotype sequence can be generated by analyzing at least one genome wide restriction map in conjunction with at least one genome wide probe map to determine distances between restriction sites of the at least one genome wide restriction map and locations of detectable oligonucleotide probes of the at least one genome wide probe map and defining a consensus map indicating restriction sites based on each of the at least one genome wide restriction map and locations of detectable oligonucleotide probes based on each of the at least one genome wide probe map. | 09-18-2008 |
| 20080221315 | NUCLEIC ACID-BASED TRANSLATION SYSTEM AND METHOD FOR DECODING NUCLEIC ACID ENCRYPTED MESSAGE - A nucleic acid-based translation system where the components of a nucleic acid multicrossover molecule serve as message, translation device and part of the translated product. One continuous strand of a nucleic acid multicrossover molecule acts as a message, which nucleic acid crossover strands, functioning together as a translation device, translate into nucleic acid product strands. Organic molecules appended to the backbone of the nucleic acid product strands can also be polymerized to form a polymer sequence of appended organic molecules. | 09-11-2008 |
| 20080219993 | HUMAN RGR ONCOGENE AND TRUNCATED TRANSCRIPTS THEREOF DETECTED IN T CELL MALIGNANCIES, ANTIBODIES TO THE ENCODED POLYPEPTIDES AND METHODS OF USE - Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein. | 09-11-2008 |
| 20080215512 | SYSTEM, METHOD, AND COMPUTER-ACCESSIBLE MEDIUM FOR PROVIDING A MULTI-OBJECTIVE EVOLUTIONARY OPTIMIZATION OF AGENT-BASED MODELS - Agent-based models (ABMs)/multi-agent systems (MASs) are one of the most widely used modeling-simulation-analysis approaches for understanding the dynamical behavior of complex systems. These models can be often characterized by several parameters with nonlinear interactions which together determine the global system dynamics, usually measured by different conflicting criteria. One problem that can emerge is that of tuning the controllable system parameters at the local level, in order to reach some desirable global behavior. According to one exemplary embodiment t of the present invention, the tuning of an ABM for emergency response planning can be cast as a multi-objective optimization problem (MOOP). Further, the use of multi-objective evolutionary algorithms (MOEAs) and procedures for exploration and optimization of the resultant search space can be utilized. It is possible to employ conventional MOEAs, e.g., the Nondominated Sorting Genetic Algorithm II (NSGA-II) and the Pareto Archived Evolution Strategy (PAES), and their performance can be tested for different pairs of objectives for plan evaluation. In the experimental results, the approximate Pareto front of the non-dominated solutions is effectively obtained. Further, a conflict between the proposed objectives can be seen. Additional robustness analysis may be performed to assist policy-makers in selecting a plan according to higher-level information or criteria which is likely not present in the original problem description. | 09-04-2008 |
| 20080206264 | Constrained Hiv V3 Loop Peptides as Novel Immunogens and Receptor Antagonists - The present invention provides constrained peptides and other organic molecules, that mimic the three dimensional characteristics of the HIV-1 V3 loop peptide when bound by a highly potent human neutralizing monoclonal antibody specific for a V3 conformational epitope, which structure is determined by NMR. Methods for screening for, and designing such molecules are disclosed. These molecules are useful as immunogens for inducing broadly-neutralizing antibodies against HIV-1 as well as antagonists for inhibiting the binding of HIV-1 to the relevant co-receptors, and may therefore be used in method of preventing or treating HIV-1 infection and disease. | 08-28-2008 |
