| NATIONWIDE CHILDREN'S HOSPITAL, INC. Patent applications |
| Patent application number | Title | Published |
|---|
| 20120128701 | COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS - Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system. | 05-24-2012 |
| 20120122935 | COMPOSITIONS AND METHODS FOR TREATING NECROTIZING ENTEROCOLITIS - The present invention relates to a method for treating or preventing necrotizing enterocolitis (NEC) in a human neonate in need thereof, comprising administering to the neonate a pharmaceutically effective amount of a composition comprising a poly(ADP-ribose) synthetase/polymerase (PARP) inhibitor. Also contemplated herein is an infant food or treatment composition comprising a PARP inhibitor in an amount that is 5 to 500 times greater than a daily recommended intake dosage for the PARP inhibitor. | 05-17-2012 |
| 20120027798 | ANTIBODY GENE TRANSFER AND RECOMBINANT AAV THEREFOR - The present invention relates generally to the use of recombinant adeno-associated viruses (rAAV) for gene delivery and more specifically to the use of rAAV to deliver antibody genes to target cells in mammals. Administration of rAAV encoding antibodies that neutralize the HIV-1 virus is exemplified. | 02-02-2012 |
| 20110301226 | COMPOSITIONS AND METHODS FOR TREATING HEPATIC NEOPLASIA - The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia. | 12-08-2011 |
| 20110293624 | Genes of an Otitis Media Isolate of NonTypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 12-01-2011 |
| 20110275566 | METHODS OF TREATING NECROTIZING ENTEROCOLITIS USING HEPARIN BINDING EPIDERMAL GROWTH FACTOR (HB-EGF) - Methods of treating, abating and reducing the risk for necrotizing enterocolitis (NEC) in an infant are disclosed. Preferred methods include administering an EGF receptor agonist, such as HB-EGF or EGF, within 24 hours following birth or following the onset of at least one symptom of NEC, in an amount effective to reduce the onset or seventy of NEC. | 11-10-2011 |
| 20110223174 | Nontypeable Haemophilus Influenzae Virulence Factors - The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of | 09-15-2011 |
| 20110201088 | Production of rAAV in Vero Cells Using Particular Adenovirus Helpers - The present invention relates to methods and materials for recombinant adeno-associated virus production. More particularly, in some embodiments the invention contemplates the use of an adenovirus known as Simian Adenovirus 13 (SAdV-13) and Vero cells for production of recombinant adeno-associated virus (rAAV). | 08-18-2011 |
| 20110150889 | HAEMOPHILUS INFLUENZAE TYPE IV PILI - The invention described herein relates to a | 06-23-2011 |
| 20110135646 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 06-09-2011 |
| 20110081357 | Chimeric Vaccine for Haemophilus Influenzae-Induced Disease - The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention. | 04-07-2011 |
| 20100310601 | Adeno-Associated Virus Materials and Methods - The present invention provides adeno-associated virus (AAV) materials and methods which are useful for DNA delivery to cells. More particularly, the invention provides recombinant AAV (rAAV) genomes, methods for packaging rAAV genomes, stable host cell lines producing rAAV and methods for delivering genes of interest to cells utilizing the rAAV. Particularly disclosed are rAAV useful in generating immunity to human immunodeficiency virus-1 and in therapeutic gene delivery for treatment of neurological disorders. | 12-09-2010 |
| 20100310569 | Genes of an Otitis Media Isolate of Nontypeable Haemophilus Influenzae - The invention relates to the polynucleotide sequence of a nontypeable stain of | 12-09-2010 |
| 20100261155 | METHODS AND COMPOSITIONS RELATING TO VIRAL FUSION PROTEINS - Provided herein are isolated paramyxovirus pre-triggered fusion proteins, or functional fragments thereof, which contain one or more CRAC domains in a location that is away from the transmembrane domain. Also provided herein is a computer model of the structure of the pre-triggered F protein. Compositions that directly or indirectly bind and interfere with the normal activity or binding of the pre-triggered F proteins, or the CRAC domains, are useful as antiviral agents in the treatment of paramyxovirus infections. Thus, disclosed herein are methods of screening for antiviral agents, using the isolated pre-triggered F protein, or functional fragments thereof. | 10-14-2010 |
| 20100260800 | AVV Vectors and Methods - The invention relates to Adeno-associated virus vectors. In particular, it relates to Adeno-associated virus vectors with modified capsid proteins and materials and methods for their preparation and use. | 10-14-2010 |
| 20100196382 | Nontypeable Haemophilus Influenzae Virulence Factors - The invention relates to a mutation within the sap operon of an avirulent clone of a nontypeable strain of | 08-05-2010 |
| 20100035973 | DISRUPTION OF PROGRAMMED DEATH 1 (PD-1) LIGAND TO ADJUVANT ADENO-ASSOCIATED VIRUS VECTOR VACCINES - The invention provides for methods of modulating an immune response against a therapeutic polypeptide or an antigenic polypeptide delivered via rAAV comprising administering a modulator of programmed death-1 (PD-1) signaling. | 02-11-2010 |
| 20090105188 | Compositions and Methods for Treating Necrotizing Enterocolitis - The present invention relates to a method for treating or preventing necrotizing enterocolitis (NEC) in a human neonate in need thereof, comprising administering to the neonate a pharmaceutically effective amount of a composition comprising a poly(ADP-ribose) synthetase/polymerase (PARP) inhibitor. Also contemplated herein is an infant food or treatment composition comprising a PARP inhibitor in an amount that is 5 to 500 times greater than a daily recommended intake dosage for the PARP inhibitor. | 04-23-2009 |
| 20080311110 | Chimeric Vaccine for Haemophilus Influenzae-Induced Disease - The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention. | 12-18-2008 |
