NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY Patent applications |
Patent application number | Title | Published |
20150284812 | METHOD FOR EVALUATING BOTH INDUCTION OF DRUG-METABOLIZING ENZYME AND CYTOTOXICITY, AND VECTOR AND CELL FOR USE IN SAID METHOD - It is an object of the present invention to evaluate the induction of a drug-metabolizing enzyme by a test substance more accurately than ever before, by simple operations, using a vector in which a reporter gene is connected downstream of the expression control region of a drug-metabolizing enzyme gene and a cell into which the aforementioned vector is introduced. The present invention provides a vector for producing a cell that is used for evaluation of the induction of a drug-metabolizing enzyme by a test substance and the cytotoxicity of the test substance, the vector comprising an expression control region of a fetus-specific gene, a first reporter gene, an expression control region of a drug-metabolizing enzyme gene, and a second reporter gene, wherein the first reporter gene is located downstream of the expression control region of the fetus-specific gene and the second reporter gene is located downstream of the expression control region of the drug-metabolizing enzyme gene. In addition, the present invention also provides a cell comprising the aforementioned vector and a method for evaluating induction of a drug-metabolizing enzyme by a test substance and cytotoxicity of the test substance using the vector. | 10-08-2015 |
20150096063 | MOUSE ARTIFICIAL CHROMOSOME VECTOR - Disclosed is a mouse artificial chromosome vector, comprising: a natural centromere derived from a mouse chromosome; a mouse-chromosome-derived long-arm fragment formed by deleting a long-arm distal region at a mouse chromosome long-arm site proximal to the centromere; and a telomere sequence, wherein the vector is stably retained in a cell and/or tissue of a mammal. In addition, disclosed are cells or non-human animals comprising the vector, and use of the cells or non-human animals. | 04-02-2015 |
20140363673 | THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE - The present invention provides a therapeutic and/or prophylactic agent for inflammatory bowel disease and an NF-kB activation inhibitor, each of which comprises chitin nanofibers or chitosan nanofibers. | 12-11-2014 |
20140336453 | PRESSURE SENSOR, ENDOSCOPE AND ENDOSCOPE DEVICE - There are provided a pressure sensor which can avoid an endoscope from causing intestinal perforation, an endoscope including the pressure sensor, and an endoscope device including the endoscope. There is provided a pressure sensor including a support unit and a pressure sensitive unit disposed on the ridge line of the front end of the support unit and configured to output a signal corresponding to an applied pressure. The pressure sensitive unit includes a first electrode disposed in a ring shape and multiple second electrodes opposed to the first electrode. The second electrodes are spaced in the circumferential direction of the first electrode. | 11-13-2014 |
20140241991 | CHIMERIC NON-HUMAN ANIMAL CARRYING HUMAN HEPATOCYTE - A chimeric non-human animal having an in vivo human hepatocyte population, wherein the effects of non-human animal cells on drug metabolism are suppressed or deleted is provided. A method for producing a chimeric non-human animal that lacks a drug-metabolizing system or has a suppressed drug-metabolizing system and is provided with a drug-metabolizing system driven by human hepatocytes, is provided. The method comprises transplanting human hepatocytes into a non-human animal characterized by (i) being immunodeficient, (ii) having liver damage, and (iii) lacking the functions of an endogenous Cyp3a gene. | 08-28-2014 |
20140112892 | SYNTHESIS AND ANALYSIS OF NOVEL COMPOUND CAPABLE OF INDUCING DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELL INTO HEPATOCYTE - The purpose is to select low-molecular-weight compounds which are effective in inducing differentiation of mesenchymal stem cell into hepatocyte and to develop a safe differentiation-inducing method having excellent efficiency of differentiating mesenchymal stem cell into hepatocyte. Provided are at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; a differentiation inducer comprising at least one compound selected from the group consisting of compounds represented by formulae (1) and (2), a salt thereof, or a solvate of them; and a differentiation inducer comprising a compound represented by formula (8), a salt thereof, or a solvate of them. | 04-24-2014 |
20130190389 | Method For Producing Novel Hipsc By Means Of Mirna Introduction - A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including a single-stranded or double-stranded polynucleotide containing the base sequence shown in SEQ ID NO:41 or a base sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 41, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided. | 07-25-2013 |
20130184335 | Method For Producing Novel Hipsc By Means Of Sirna Introduction - A novel compound to induce a pluripotent stem cell is provided. A novel anti-malignant-tumor substance is provided. A pluripotent stem cell-inducing agent, including one or more single-stranded or double-stranded polynucleotides selected from the group consisting of: a) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:1 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 1, b) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:2 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 2, c) a single-stranded or double-stranded polynucleotide containing a sequence of SEQ ID NO:3 or a sequence including deletion, substitution, or addition of 1 to 3 bases in SEQ ID No: 3, in which the pluripotent stem cell-inducing agent induces a cell to become a pluripotent stem cell is provided. | 07-18-2013 |
20120272342 | MOUSE ARTIFICIAL CHROMOSOME VECTOR - Disclosed is a mouse artificial chromosome vector, comprising: a natural centromere derived from a mouse chromosome; a mouse-chromosome-derived long-arm fragment formed by deleting a long-arm distal region at a mouse chromosome long-arm site proximal to the centromere; and a telomere sequence, wherein the vector is stably retained in a cell and/or tissue of a mammal. In addition, disclosed are cells or non-human animals comprising the vector, and use of the cells or non-human animals. | 10-25-2012 |
20120219675 | APPARATUS AND METHOD FOR MANUFACTURING PET FOOD - A manufacturing apparatus and a manufacturing method of pet food are provided. The manufacturing apparatus comprises a material inlet through which a kneaded material is fed, the kneaded material being obtained through kneading a raw pet food material; an extrusion molding section configured to extrude the kneaded material through an extruding outlet; a cutter configured to cut the kneaded material extruded through the extruding outlet at desired intervals to form material grains; a reservoir disposed in a location to receive the material grains falling due to the cutting; an agitating section provided in the reservoir and configured to agitate the material grains; a heating section configured to heat the material grains while the material grains are agitated by the agitating section; and a drying section configured to dry the material grains within the reservoir after the heating. | 08-30-2012 |
20120216867 | FULLERENE DERIVATIVES - A fullerene derivative having two or more structures represented by the formula ( | 08-30-2012 |
20110193073 | FULLERENE DERIVATIVE, COMPOSITION AND ORGANIC PHOTOELECTRIC CONVERSION ELEMENT - The present invention provides a fullerene derivative represented by the following formula (1). | 08-11-2011 |
20110193072 | FULLERENE DERIVATIVE, COMPOSITION, AND ORGANIC PHOTOELECTRIC CONVERSION ELEMENT - The present invention provides a fullerene derivative represented by the following formula (1). | 08-11-2011 |
20110065197 | DIAGNOSTIC KIT FOR ALZHEIMER'S DISEASE, DIAGNOSTIC MARKER, AND DETECTION METHOD FOR INDICATOR OF PATHOLOGICAL STATE THEREOF - [Problems] The differential diagnosis of Alzheimer's disease as distinguished from other type of dementia and the diagnosis of Alzheimer's disease at such an early stage where neural cell death has not proceeded yet are important for the treatment of Alzheimer's disease. On the other hand, it is difficult to differentially diagnose Alzheimer's disease at an earlier stage by a diagnosis mainly made by questioning by a doctor or a diagnostic technique using phosphorylated tau or amyloid-β protein as an indicator. Thus, the development of a novel diagnostic technique has been demanded. | 03-17-2011 |
20110023138 | MAMMALIAN ARTIFICIAL CHROMOSOME VECTOR COMPRISING HUMAN CYTOCHROME P450 GENE (CLUSTER) AND NON-HUMAN MAMMALIAN ANIMAL RETAINING THE SAME - This invention relates to a mammalian artificial chromosome vector, which retains a human chromosome 7 fragment comprising human cytochrome P450 genes and is transmittable to progeny, wherein the human chromosome 7 fragment retains a region of approximately 1 Mb±500 Kb in size comprising at least a human CYP3A gene cluster, which region is located between chromosome markers AC004922 and AC073842, and to a non-human mammalian animal retaining the vector. | 01-27-2011 |
20110001093 | FULLERENE DERIVATIVE - Disclosed is an organic photoelectric converter having a layer containing a fullerene derivative represented by the formula (1) below. (In the formula (1), m represents an integer of 1-6; n represents an integer of 1-4; p represents an integer of 0-5; r represents an integer of 0-4; and Q represents a group represented by the formula (2) or (3) below. When there are a plurality of m's, they may be the same as or different from each other. In the formulae (2) and (3), R | 01-06-2011 |
20100298184 | SOLVENT COMPOSITION - A solvent composition includes a substance that is subject to oxidative alteration by an oxygen radical, and a compound that has a superoxide dismutase-mimetic activity that includes oxygen radical-removing capability. In the solvent composition of the invention, oxygen radicals can be removed by the compound having an superoxide dismutase-mimetic activity that includes oxygen radical-removing capability, and therefore the substance that is subject to oxidative alteration can be prevented from oxidizing. | 11-25-2010 |
20100248356 | hTERT GENE EXPRESSION REGULATORY GENE - Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated. | 09-30-2010 |
20100224829 | PHOSPHOR - Disclosed is a phosphor having high luminance, which is composed of M | 09-09-2010 |
20100184216 | hTERT GENE EXPRESSION REGULATORY GENE - Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated. | 07-22-2010 |
20100184208 | hTERT GENE EXPRESSION REGULATORY GENE - Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated. | 07-22-2010 |
20100010054 | THERAPEUTIC AGENT FOR AMYOTROPHIC LATERAL SCLEROSIS - A novel therapeutic agent for amyotrophic lateral sclerosis. A therapeutic agent for amyotrophic lateral sclerosis, including a compound having xanthine dehydrogenase inhibitory action and not acting as a substrate for the purine salvage pathway. | 01-14-2010 |
20090124794 | hTERT GENE EXPRESSION REGULATORY GENE - Disclosed is a novel substance capable of regulating the expression of a telomerase reverse transcriptase gene in a cell of a mammal. A gene capable of regulating the expression of hTERT, comprising a nucleotide sequence depicted in SEQ ID No: 1 or 2. The expression of a telomerase reverse transcriptase gene can be inhibited by inhibiting the expression of the gene. By utilizing this mechanism, the expression of a telomerase reverse transcriptase gene can be regulated. | 05-14-2009 |