| National University Corporation Tokyo Medical and Dental University Patent applications |
| Patent application number | Title | Published |
|---|
| 20120118292 | Artificial Respirator and Operation Method Thereof - To provide a compact and low-power-consumption artificial respirator and an operation method therefore including a controller which alternately switches between a first state for feeding inspiratory air stored in the reservoir tank to a patient and a second state for releasing expired air of the patient. A pressurizing pump has a discharge function for reversing a reduction of pressure within the reservoir tank, which is caused due to the inspiration, within an expiration period of time. | 05-17-2012 |
| 20110275109 | Immunity Evaluation Method, Apparatus and Program - An immunity evaluation method, apparatus, and program are provided that can evaluate comprehensive immunity with high precision. An immunity evaluation method for evaluating immunity from collected blood includes measuring a number of specific T cells that are CD8 positive and CD28 positive or negative in the collected blood, and determining a T lymphocyte age based on a regression equation on the basis of a correlation between a specific parameter that is dependent on the number of the specific T cells and age, and the number of specific T cells thus measured. | 11-10-2011 |
| 20110244481 | COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES - Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogues modified at the 8-position of coelenterazine and coelenteramide analogues modified at the 2- or 3-position of coelenteramide. | 10-06-2011 |
| 20110242485 | FLUORESCENCE IMAGE ACQUISITION METHOD, FLUORESCENCE IMAGE ACQUISITION PROGRAM, AND FLUORESCENCE IMAGE ACQUISITION APPARATUS - A fluorescence image acquisition method including: irradiating an eyeground with a short-pulse beam of light for exciting a fluorescent dye; setting the time point of emission of the light as a reference, measuring the intensities of luminescence of the fluorescent dye at two different times which are predetermined periods of time after the reference, determining the ratio between the intensities of luminescence at the two different times, and detecting the intensity of luminescence of the fluorescent dye having marked a target by using the ratio; and generating a fluorescence image of the fluorescent dye having marked the target, based on the results of detection by the detecting step. | 10-06-2011 |
| 20110165173 | THERAPEUTIC AGENT AND DETECTION REAGENT FOR ARTERIOSCLEROTIC DISEASE WHICH TARGETS FOR SALUSIN - The present invention provides a prophylactic and therapeutic agent for arteriosclerotic diseases and a method or reagent for detecting arteriosclerotic diseases. Further, the present invention provides a therapeutic agent for an arteriosclerotic disease, comprising salusin-α as an active ingredient, a therapeutic agent for an arteriosclerotic disease, comprising an antagonist of salusin-β as an active ingredient, and a method for detecting an arteriosclerotic disease, comprising assaying salusin-α in a biological sample. | 07-07-2011 |
| 20110151485 | METHOD FOR SCREENING FOR ANTIANGIOGENIC AGENT, AND METHOD FOR SCREENING FOR ANTIANGIOGENIC SIGNAL GENE - Disclosed are a method for screening for an antiangiogenic agent and a method for screening for an antiangiogenic gene, both of which are achieved by detecting an antiangiogenic signal within a short time by a simple means. The method for screening for an antiangiogenic agent comprises: a candidate compound administration step of administering a candidate compound for the antiangiogenic agent to a vascular endothelial cell or a cultured cell derived from a vascular endothelial cell; a cell-maintaining step of maintaining the vascular endothelial cell or the cultured cell derived from the vascular endothelial cell to which the candidate compound has been administered; and a signal detection step of detecting the phosphorylation of a protein phosphorylated by the administration of endostatin. | 06-23-2011 |
| 20100329971 | NOVEL HYDROXY RADICAL GENERATION METHOD, AND ANTI-VIRAL MATERIAL UTILIZING HYDROXYL RADICAL GENERATED BY THE METHOD - Disclosed is a novel hydroxy radical generation method which relies on a novel scientific fact relating to the generation of a hydroxy radical and the inactivation of a virus. Also disclosed is an anti-viral material produced by utilizing the method. The anti-viral material comprises a metal oxide powder and a hydroxide which enable the generation of a hydroxy radical that can inactivate a virus. An virus can be inactivated by the action of the hydroxy radical generated from the anti-viral material. | 12-30-2010 |
| 20100304997 | METHOD FOR DETECTING ABNORMAL SPOTS OF NUCLEIC ACID MICROARRAY - A method carries out a nucleic acid analysis using a nucleic acid microarray. A probe nucleic acid including a probe sequence (a′) complementary to a target sequence (a) and a sequence (b′) which is different from the probe sequence (a′) is immobilized on the nucleic acid microarray. The method includes hybridizing the nucleic acid microarray and a labeled abnormality detecting nucleic acid (B) containing a sequence (b) which can be bound to the sequence (b′), obtaining a labeled amount value (Fc1) of the labeled abnormality detecting nucleic acid (B) from a spot (X1), and determining, based on the measured labeled amount value (Fc1), as to whether or not the spot (X1) is an abnormal spot unsuitable for detecting the target nucleic acid. | 12-02-2010 |
| 20100262237 | Biomaterial, Joint Prosthesis Using the Biomaterial and Method of Producing the Same - The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer. | 10-14-2010 |
| 20100234282 | SYSTEM FOR DELIVERING NUCLEIC ACIDS FOR SUPPRESSING TARGET GENE EXPRESSION BY UTILIZING ENDOGENOUS CHYLOMICRON - The object of present invention is to provide a system that can deliver in vivo nucleic acids such as an siRNA for suppressing a target gene expression in vivo more safely and efficiently, and to provide an expression-suppressing agent and a pharmaceutical composition utilizing the system. An introduction substance into chylomiclon, particularly nucleic acids to which an alpha-tocopherol is bound for suppressing a target gene expression, can be delivered more safely and efficiently into hepatic cells in vivo by administering the nucleic aids under the condition where the production of chylomicron is induced in the body. Alternatively, alpha-tocopherol-bound nucleic acids are mixed with extracted chylomiclon, and then they are administered. Consequently, a target gene expression is suppressed, thereby a disease caused by an elevated expression of the target gene can be treated more safely and efficiently. | 09-16-2010 |
| 20100178692 | MODEL CELL CHIP, APPARATUS FOR EVALUATING DRUG EFFECT USING THE MODEL CELL CHIP AND METHOD OF EVALUATING DRUG EFFECT - The present invention provides an apparatus for evaluating a drug effect enabling on-chip evaluation of the effect of a drug while the drug is acting on hERG-expressing cells. The present invention also provides a myocardial toxicity test apparatus and method therefor enabling in vitro myocardial toxicity testing that has previously been performed in vivo. | 07-15-2010 |
| 20100114321 | HOMUNCULUS - The object of the present invention is to provide a homunculus of a glenohumeral joint in which the supraspinatus and the infraspinatus are correctly connected to the superior humerus. A homunculus | 05-06-2010 |
| 20100113878 | Endoscopic multi-purpose treatment hood and endoscope - On the periphery of a silicon tube | 05-06-2010 |
| 20100099702 | Therapeutic agent for neuropathic pain - Disclosed is a therapeutic agent for neuropathic pain having an excellent therapeutic effect on neuropathic pain which is a intractable disease. More specifically, disclosed are a therapeutic agent for neuropathic pain which comprises a peripheral benzodiazepine receptor antagonist (particularly PK 11195) as the active ingredient; a pharmaceutical composition for the treatment of neuropathic pain which comprises a peripheral benzodiazepine receptor antagonist as the active ingredient; a method for the treatment of neuropathic pain using a peripheral benzodiazepine receptor antagonist; and others. | 04-22-2010 |
| 20100062978 | METHOD FOR INHIBITING SIGNAL TRANSDUCTION, SIGNAL TRANSDUCTION INHIBITOR TO BE USED THEREIN AND USE THEREOF - An object of the present invention is to provide a method for inhibiting activation of signaling pathway mediated by erbB1 or erbB2 in human cell and a signaling inhibitor to be used therefor. The above-described activation of signaling pathway can be inhibited by a polypeptide comprising at least one of PTB domain or ERK2 binding domain of human FRS2β. The above-described polypeptide may be introduced directly into cell, or nucleic acid which encodes for the above-described polypeptide may be introduced into cell to allow expression of the polypeptide in the cell. Such polypeptide and nucleic acid can be used, for example, as a signaling inhibitor. In addition, since erbB1 and erbB2 are involved in development of cancer, the above-described signaling inhibitor is also useful, for example, as an anticancer drug. | 03-11-2010 |
| 20090158448 | DNA ENCODING POLYPEPTIDE CAPABLE OF MODULATING MUSCLE-SPECIFIC TYROSINE KINASE ACTIVITY - Disclosed are DNA encoding a polypeptide which can modulate the activity of a muscle-specific tyrosine kinase, and others. The DNA is selected from the following members (a) to (d): (a) DNA comprising a specific nucleotide sequence; (b) DNA comprising a nucleotide sequence capable of hybridizing with a specific nucleotide sequence under stringent conditions; (c) DNA comprising a nucleotide sequence encoding an amino acid sequence having the substitution, deletion and/or addition of one or several amino acid residues in a specific amino acid sequence; and (d) DNA comprising a nucleotide sequence having 90% or higher homology to a specific nucleotide sequence. | 06-18-2009 |
| 20090118625 | Method for Measuring Flow Rate and Head of Centrifugal Pump, Apparatus Thereof, and Apparatus for Evaluating Circulatory State of Pulsating Cardiovascular System - In centrifugal pumps | 05-07-2009 |
| 20080279918 | Liposome And Method For Injecting Substance To Cell Using This Liposome - It is intended to efficiently inject into a target cell, a substance charged within a liposome. The present inventors have found that connexin synthesized within a liposome is introduced as connexon having a gap junction function into the liposome membrane. Specifically, the liposome according to the present invention is a liposome in which connexon composed of connexin synthesized by an in-vitro protein synthesis system is incorporated in a state of having a gap junction function. | 11-13-2008 |
| 20080220089 | Medical agent for preventing or treating diseases resulting from one of inflammation and remodeling, and method for preventing or treating the diseases - An object of the present invention is to provide a medical agent that has an excellent effect on the diseases resulting from one of inflammation and remodeling and that can prevent or treat them in response to various mechanisms of onset and development of the diseases. Thus, the present invention relates to a medical agent for preventing or treating diseases resulting from one of inflammation and remodeling in blood vessel, including nanobubbles. | 09-11-2008 |
