National University Corporation Kumamoto University Patent applications |
Patent application number | Title | Published |
20160068933 | FLAME-RETARDANT MAGNESIUM ALLOY AND METHOD OF MANUFACTURING SAME - A method of manufacturing a flame-retardant magnesium alloy having mechanical properties of a long period stacking ordered magnesium alloy and having an ignition temperature of 800° C. or more is provided. The method of manufacturing a flame-retardant magnesium alloy comprises a step of melting a flame-retardant magnesium alloy which contains a atomic % of Zn, b atomic % of Y, x atomic % of Ca and a residue of Mg, and a, b and x satisfy formulae 1 to 4 below. | 03-10-2016 |
20150160194 | METHOD FOR SCREENING FOR SUBSTANCE - The object of the present invention is to provide a method for screening a substance capable of promoting induction of induced pluripotent stem cells from cells derived from an individual affected by a disease for which it is impossible to produce induced pluripotent stem cells simply by introducing reprogramming genes. The present invention provides a method for screening a substance, which comprises culturing cells derived from an individual affected by a disease for which it is impossible to produce induced pluripotent stem cells simply by introducing reprogramming genes, the cells being transfected with reprogramming genes, in the presence of test substances, and selecting a test substance capable of promoting induction of induced pluripotent stem cells from the cells. | 06-11-2015 |
20150052625 | HUMANIZED MOUSE - The present invention provides embryonic stem cells obtainable from an embryo of an immunodeficient mouse which is deficient in both Rag2 and Jak3 genes by culture in the presence of a GSK3 inhibitor and an MEK inhibitor, as well as a transgenic mouse, which is created with the use of these embryonic stem cells. | 02-19-2015 |
20140311769 | COMPOSITE CONDUCTOR AND ELECTRIC WIRE USING THE SAME - A composite conductor | 10-23-2014 |
20140289878 | METHOD FOR PRODUCING MODEL ANIMAL, AND MODEL ANIMAL - A method for producing a model animal which has a desired lifetime, and in which a predetermined biological reaction can be induced, and a model animal are provided. The present invention produces a first individual in which a gene of interest is heterozygously deficient using a first ES cell from a non-human mammalian animal. Meanwhile, a fragment containing a homologous gene that has homology to the gene of interest is made, a second ES cell constituted so that a predetermined region on X chromosome of the animal can be substituted is used, and the fragment is introduced into the second ES cell to generate a substituted ES cell in which the predetermined region has been substituted with the fragment. A second individual is produced using the substituted ES cell. The first individual and the second individual are mated with each other to produce a model animal. | 09-25-2014 |
20140256043 | SMALL CHEMICAL COMPOUND WHICH PROMOTES INDUCTION OF DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS AND METHOD FOR INDUCING DIFFERENTIATION OF STEM CELLS INTO INSULIN-PRODUCING CELLS USING SAID SMALL CHEMICAL COMPOUND - A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of ES cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of ES cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells. Another purpose of the present invention is to provide the thus-induced insulin-producing cells. Provided are: an agent for promoting induction of the differentiation of stem cells derived from a mammal into insulin-producing cells, which contains a compound that is selected from the group consisting of dopamine metabolism inhibitors, serotonin metabolism inhibitors, acetylchotine, acetylcholine degrading enzyme inhibitors and acetylcholine receptor activators; and a method for inducing differentiation using the agent for promoting induction of differentiation. | 09-11-2014 |
20140255942 | METHOD FOR PRODUCING PLURIPOTENT CELL USING BACTERIUM HAVING FERMENTATION ABILITY - It is an object of the present invention to provide a method for producing pluripotent cells that are free of the risk of cellular canceration and that can be applied to regenerative medicine with a high degree of safety. The present invention provides a method for producing pluripotent cells from somatic cells comprising a step of bringing bacteria having fermentation ability or a component or secretory product thereof into contact with somatic cells. | 09-11-2014 |
20140179754 | FUSED TRICYCLIC ETHER CARBAMATES AND THEIR USE - Tricylic ether carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are describes. Methods of using the disclosed compounds for treating patients infected with HIV are also described. | 06-26-2014 |
20140148508 | C-3 SUBSTITUTED BICYCLOOCTANE BASED HIV PROTEASE INHIBITORS - C3-functionalized-cyclopentanyltetrahydrofuranyl carbamates that inhibit HIV proteolytic enzymes and processes for preparing the compounds are described. Compositions comprising the disclosed compound and methods of using the compounds and/or compositions for treating patients infected with HIV are also described. | 05-29-2014 |
20140086823 | CATALYST FOR DECOMPOSITION OF SULFUR TRIOXIDE AND HYDROGEN PRODUCTION PROCESS - A sulfur trioxide decomposition catalyst, in particular, a sulfur trioxide decomposition catalyst capable of lowering the temperature required when producing hydrogen by an S—I cycle process is disclosed. A sulfur trioxide decomposition catalyst that includes a composite oxide of tungsten, vanadium and at least one metal selected from the group consisting of transition metal and rare earth elements is provided. Also, a sulfur dioxide production process that includes decomposing sulfur trioxide into sulfur dioxide and oxygen by using the sulfur trioxide decomposition catalyst above is provided. Furthermore, a hydrogen production process, wherein the reaction of decomposing sulfur trioxide into sulfur dioxide and oxygen by an S—I cycle process is performed by the above-described sulfur dioxide production process is provided. | 03-27-2014 |
20130310544 | Screening Method for Substance Having Hemocyte Maturation Acceleration Action - An objective is to provide screening methods for substances having an activity of promoting maturation into hemocytes. It was revealed that in the maturation process of erythrocytes and platelets, RP S19 multimers are released to the outside of the cell and act on the C5a receptors of erythroblasts and megakaryocytes, thereby causing maturation of erythroblasts and megakaryocytes to erythrocytes and platelets. Based on such findings, the present invention provides methods of screening for substances having an activity of promoting maturation into hemocytes by targeting the RP S19 multimers and C5a receptors. The screening methods of the present invention can detect hemocyte maturation using an increase of the R4 RGS family as an indicator. Furthermore, the present invention provides agents for promoting hemocyte maturation, which comprise RP S19 multimers and a substance having an activity of promoting maturation into hemocytes as useful components. The present invention also provides methods for producing erythrocytes and platelets, which include the step of contacting RP S19 multimers and a substance having an activity of promoting maturation into hemocytes with erythroblasts or megakaryocytes. | 11-21-2013 |
20130197199 | ANTIBODY AGAINST HUMAN PROSTAGLANDIN E2 RECEPTOR EP4 - It is an object of the present invention to provide an antibody that binds to a human PGE | 08-01-2013 |
20130195818 | METHOD OF PRODUCING MYELOID BLOOD CELLS - An object of the present invention is to provide a method of producing a myeloid blood cell possessing a proliferative capability. According to the present invention, provided is a method of producing a myeloid blood cell possessing a proliferative capability, including forcedly expressing (A) a cMYC gene, and (B) at least one gene selected from the group consisting of a BMI1 gene, an EZH2 gene, an MDM2 gene, an MDM4 gene, and an HIF1A gene in a myeloid blood cell. | 08-01-2013 |
20130071905 | PLASMA IRRADIATION DEVICE FOR SUBSTANCE INTRODUCTION AND SUBSTANCE INTRODUCTION METHOD USING PLASMA IRRADIATION DEVICE - Disclosed is a liquid culture medium for substance introduction, which is capable of increasing the survival rate of cells after substance introduction as much as possible when the cells are irradiated with plasma for the purpose of introducing a target substance into each of the cells. Specifically disclosed is a liquid culture medium for substance introduction, which is used for the purpose of introducing a predetermined target substance into a cell and enables introduction of the target substance into the cell by having the cell in the liquid culture medium, which contains the target substance, irradiated with a plasma jet. The liquid culture medium contains a damage preventing component that prevents the cell from damage due to the plasma jet. | 03-21-2013 |
20130023574 | METHOD FOR GENERATING DATA SET FOR INTEGRATED PROTEOMICS, INTEGRATED PROTEOMICS METHOD USING DATA SET FOR INTEGRATED PROTEOMICS THAT IS GENERATED BY THE GENERATION METHOD, AND METHOD FOR IDENTIFYING CAUSATIVE SUBSTANCE USING SAME - Provided are a method for generating a data set for integrated proteomics analysis, whereby expression level variations of both of proteins and genes can be integrally united together and, moreover, highly accurate and appropriate analysis results can be obtained compared with the existing cases where the expression variation amount of proteins or genes is singly analyzed, an integrated proteomics analysis method, a method for identifying a protein causative of a disease or the like using these methods, and a method of using the same???. The aforesaid method for generating a data set for integrated proteomics analyses comprises: a protein identity number-assigning step for assigning common identity numbers to the expression variation amount data of individual proteins; a gene identity number-assigning step for assigning common identity numbers to the expression variation amount data of individual genes; a data-binding step for binding together the set of the expression variation amount data; a data-rejecting step for rejecting, among the individual expression variation amount data constituting the thus bound data set, data showing a p-value equal to or greater than a specific level; and a data-selecting step for selecting one data, from a set of data having the same common identity number assigned thereto, on the basis of a definite requirement to thereby generate the data set to be subjected to integrated proteomics analyses. Further, the data set for integrated proteomics analyses thus generated is subjected to GO analysis and network analysis to thereby identify a protein causative of a disease, a pathological condition or the like. Furthermore, the causative protein thus identified is usable, for example, a tumor marker or a clinical target. | 01-24-2013 |
20120325373 | METHOD FOR TREATMENT OF METAL SURFACE, AND SURFACE-MODIFIED METAL PRODUCT - Provided is a method of treating a metal surface, which can improve surface properties of a target metal, such as surface hardness and wear resistance in a simple manner and at low cost using very simple equipment alone, and which can prevent the deterioration of the metal to create high added value. The present invention is comprised of a method of treating a metal surface, characterized in that: heat-treating a target metal ( | 12-27-2012 |
20120225818 | PLASMA PROTEIN EFFECTIVE FOR SUPPRESSING COUGH - The activated Factor XI is provided as an antitussive for cough caused by the stimulation at the tracheal bifurcation such as chronic cough. A pharmaceutical composition for prevention, treatment and/or symptom amelioration of cough, comprising a polypeptide chain as an active ingredient and a pharmaceutically acceptable carrier, wherein the polypeptide chain consists of a full length amino acid sequence constituting activated Factor XI (hereinafter also referred to as “FXIa”), the amino acid sequence with one or several amino acids therein being deleted, substituted or added, or a partial sequence of either of the above amino acid sequences, or an amino acid sequence comprising as a part any of the above amino acid sequences. | 09-06-2012 |
20120195838 | ORAL COMPOSITION FOR DENTURE WEARERS - Provided is an oral composition for denture wearers, which includes an antimicrobial substance of biological origin, is biocompatible, and has an antimicrobial activity. Specifically, provided is an antimicrobial oral composition for denture wearers including a component of common rush origin. The oral composition for denture wearers is placed in the mouth, and hence the oral composition for denture wearers including a component of common rush origin, which may also be used as a food additive, is safe for a living body and useful. | 08-02-2012 |
20120157535 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR DYSMENORRHEA - Disclosed is a prophylactic and/or therapeutic agent for dysmenorrhea and/or associated symptoms thereof. Specifically disclosed is a prophylactic and/or therapeutic agent for dysmenorrhea and/or associated symptoms thereof, which comprises tranilast as an active ingredient thereof. | 06-21-2012 |
20120134890 | OZONE GENERATOR - An ozone generator is provided with a pulse generator ( | 05-31-2012 |
20120122214 | METHOD FOR PRODUCING CELL MEDICINE - It is an object of the present invention to provide a method for producing a cell medicine that is effective for diseases while causing a low risk to these diseases. The present invention provides a method for producing a phagocyte that expresses a foreign protein, which comprises: a step of introducing a protein expression vector into an induced pluripotent stem cell; and a step of inducing the induced pluripotent stem cell, into which the protein expression vector has been introduced, to differentiate into a phagocyte. | 05-17-2012 |
20120016158 | LOXOPROFEN DERIVATIVE AND PHARMACEUTICAL PREPARATION CONTAINING THE SAME - There is provided a novel loxoprofen derivative that has no side effect such as a gastrointestinal disorder and also has excellent anti-inflammatory and analgesic effects and is represented by the following formula (I) or (II): | 01-19-2012 |
20110304330 | PHASE DIFFERENCE ENHANCED IMAGING METHOD (PADRE), FUNCTIONAL IMAGE CREATING METHOD, PHASE DIFFERENCE ENHANCED IMAGING PROGRAM, PHASE DIFFERENCE ENHANCED IMAGING APPARATUS, FUNCTIONAL IMAGE CREATING APPARATUS, AND MAGNETIC RESONANCE IMAGING (MRI) APPARATUS - A functional image creating method and a functional image creating apparatus, each enabling rendering of an activated region, are provided. A phase difference image PDr(x) is created using a complex image σr(x) created from an MR signal in an inactive state and a complex image σ′r(x) obtained by filtering the complex image σr(x). A phase difference image PDa(x) is created using a complex image σa(x) created from an MR signal in an active state and a complex image σ′a(x) obtained by filtering the complex image σa(x). Function signal images diff | 12-15-2011 |
20110223294 | METHOD OF TREATING FOOD AND FOOD OBTAINED BY THIS METHOD - A method of treating food capable of easily softening or pulverizing food in a short time without losing nutrients is provided. A shock wave (SW) generated in a shock wave source is applied to food such as an apple or tea leaves to soften or pulverize the food. A large mechanical load is not necessary, so the food is easily softened or pulverized. Moreover, it is not necessary to heat the food, so the food is softened or pulverized in a short time without losing nutrients in the food due to heat during heating. | 09-15-2011 |
20100134776 | HIGH REPETITION PULSE POWER SOURCE AND EXPOSURE DEVICE WITH HIGH REPETITION POWER SOURCE - A pulse power source which can perform high repetition of pulse signals by enhancing the throughput of a pulse source is provided. The pulse power source includes: a charger; an initial-stage capacitor section which is provided with a capacitor charged by the charger; and a magnetic pulse compression circuit which performs magnetic pulse compression of a pulse current generated by discharging a charge from the capacitor at the initial-stage capacitor section and, thereafter, outputs the pulse current. An exposure device which includes the pulse power source is also provided. The pulse power source includes, between the initial-stage capacitor section and the magnetic pulse compression circuit, a transistor which controls timing of discharging a charge from the initial-stage capacitor section, an inductor which constitutes a resonance circuit together with the capacitor at the initial stage capacitor section, and a diode which rectifies the pulse current. The pulse power source further includes a means for preventing the generation of an electric current in the reverse direction in the pulse current. | 06-03-2010 |
20100130350 | OXYGEN STORAGE/RELEASE MATERIAL AND EXHAUST GAS PURIFYING CATALYST COMPRISING THE SAME - There is provided an oxygen storage/release material using a rare earth oxysulfate or oxysulfide, which has a high oxygen storage/release capacity even at lower temperatures. The oxygen storage/release material of the present invention comprises a compound consisting of Pr | 05-27-2010 |
20090272265 | Method for Separating and Enriching Isotope Material, Multistage Rotor, and Apparatus for Separating and Enriching Isotope Material - This invention provides a method for separating and enriching isotopes in an efficient and low-cost manner from a condensation-system (liquid or/and solid) material comprising two or more different isotopes by taking advantage of the sedimentation of atoms through an acceleration field by ultra-high speed rotation. A condensation-system (liquid or/and solid) material ( | 11-05-2009 |