| NATIONAL RESEARCH COUNCIL OF CANADA Patent applications |
| Patent application number | Title | Published |
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| 20120093819 | ANTIBODIES THAT SPECIFICALLY BLOCK THE BIOLOGICAL ACTIVITY OF A TUMOR ANTIGEN - Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorectal, breast, brain, and prostate cancer, as well as melanoma. The invention also relates to cells expressing the monoclonal antibodies and antigen binding fragments such as humanized and chimeric antibodies. Additionally, method of detecting and treating cancer using the antibodies and fragments are also disclosed. | 04-19-2012 |
| 20120071635 | METHODS AND COMPOSITIONS FOR MODULATING TUMOR CELL ACTIVITY - Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding the clusterin. | 03-22-2012 |
| 20120070541 | SYRUP AND SUGAR PREPARED FROM MAPLE SAP OR MAPLE SYRUP AND PROCESS FOR PREPARATION THEREOF - Natural maple saps and maple syrups are contacted with an immobilized isomaltulose-forming microorganism to convert at least 20% of the sucrose contained in the sap or syrup to isomaltulose. The microorganism may be immobilized on calcium alginate and prepared as a column through which sap or syrup flows. The resultant isomaltulose-containing solutions are concentrated to produce reduced or low glycemic index sugar syrups, semi-solid and solid sugar products. | 03-22-2012 |
| 20120041146 | PHENOL-FORMALDEHYDE POLYMER WITH CARBON NANOTUBES, A METHOD OF PRODUCING SAME, AND PRODUCTS DERIVED THEREFROM - The present invention provides methods to functionalize and solubilize WCNT with a phenolic polymer such as a lignin or a PF resin followed by in-situ integration of this functionalized CNT in the presence of formaldehyde and phenol and/or lignin to generate either CNT-reinforced phenol-formaldehyde polymer or CNT-reinforced lignin-phenol-formaldehyde polymer in either liquid or powder form suitable as an adhesive in the manufacture of a lignocellulosic composite material such as OSB and plywood. | 02-16-2012 |
| 20110318348 | INDUCTION OF MUCOSAL IMMUNE RESPONSES BY MUCOSAL DELIVERY PENTABODY COMPLEX (MDPC) - The subject invention provides, for example, a novel approach to specifically induce intranasal and/or oral mucosal as well as humoral antibody response by administrating a mucosal delivery pentabody complex (MDPC). The MDPC is a complex formed by mixing a target antigen and a mucosal delivery pentabody (MDP) that has a strong affinity to the target antigen. The MDP is a fusion protein of a single domain antibody (sdAb; which binds to the target antigen specifically) to a pentamerization domain (which can include the B-subunit of an AB5 toxin family, including the B subunit of cholera toxin (CT) or heat-labile toxin (LT)). The pentamerization domain can self-assemble into a pentamer, through which a pentameric single domain antibody, or a pentabody, is formed. | 12-29-2011 |
| 20110311813 | SELF-ASSEMBLED NANOSTRUCTURES - Nanostructures are formed from alkylated derivatives of aromatic acids of the formula: | 12-22-2011 |
| 20110306147 | Method of Multiple Spiking Isotope Dilution Mass Spectrometry - A comprehensive approach for interpretation of the multiple spiking isotope dilution results is described herein. It has now been found that a method of multiple spiking isotope dilution analysis for mass spectrometry is possible using an approach that permits precise and simultaneous characterization of m substances from a sample even if species inter-conversion (degradation and formation) has occurred prior to separation. Advantageously, initial and final amounts of involved analytes, conversion extent, conversion degree and rate constants from the results of a single quantitation experiment may be obtained with the present method. In a particularly advantageous embodiment, uncertainty in the characterization of the substances may be estimated more accurately by also estimating increase in the uncertainty due to interconversion of the analytes. | 12-15-2011 |
| 20110303122 | STERICALLY BULKY STABILIZERS - A sterically bulky stabilizer that includes an alkylated-benzimidazolone compound, where the sterically bulky stabilizer is associated non-covalently with a benzimidazolone pigment, and the presence of the sterically bulky stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 12-15-2011 |
| 20110282072 | SELF-ASSEMBLED NANOSTRUCTURES - An alkylated benzimidazolone compound of the formula: | 11-17-2011 |
| 20110277668 | STERICALLY BULKY STABILIZERS - A sterically bulky stabilizer that is associated non-covalently with a benzimidazolone pigment. The sterically bulky stabilizer compound includes an aromatic acid derivative, and the presence of the sterically bulky stabilizer limits an extent of particle growth and aggregation, to afford nanoscale pigment particles. | 11-17-2011 |
| 20110274617 | Antibody-Targeted Carrier For Contrast Agents - A nanoconjugate is formed from a self-assembled unilamellar vesicle (ULV), at least one contrast agent which may be a MRI contrast agent, a radioisotope or a fluorophore, and at least one antibody, which may be an IgG or an antibody fragment such as a single-domain antibody. The nanoconjugate be targetted with the antibody to receptors specific to certain disease states, and thus be used in diagnostic and imaging methods using the properties o contrast agent. | 11-10-2011 |
| 20110271874 | Nanosized Particles of Benzimidazolone Pigments - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is a substituted pyridine derivative; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 11-10-2011 |
| 20110269148 | Nanoaggregate Embedded Beads Conjugated To Single Domain Antibodies - A nanoaggregate embedded bead is formed from an inner core formed of comprising metallic nanoparticles and Raman active reporter molecules, an outer shell, and single-domain antibodies to target the bead to a specific target. The nanoaggregate embedded bead may be used in methods to detect analytes or pathogens in biological or environmental samples using Raman spectroscopy. | 11-03-2011 |
| 20110269039 | APPARATUS AND METHOD FOR CONTROLLING VARIABLE POWER CONDITIONS IN A FUEL CELL - A fuel cell comprises an anode having an inner face and an outer face fluidly communicable with a fuel; a cathode having an inner face ionically communicable with and physically separated from the anode inner face, and having an outer face fluidly communicable with an oxidant; and at least one movable guard movable over at least one of the anode outer face, cathode outer face, anode inner face, and cathode inner face. The guard has a structure sufficient to block at least part of one or more of the anode's communication with the fuel, the cathode's communication with the oxidant, and the ionic communication between the anode and cathode thereby reducing a maximum potential active area of the fuel cell to an effective active area of the fuel cell. | 11-03-2011 |
| 20110230430 | SAPONIN EXTRACT FROM SAPONARIA SPP. AND USES THEREOF - A saponin extract from | 09-22-2011 |
| 20110226962 | METHOD AND APPARATUS FOR DETECTING FLUORESCENCE EMITTED BY PARTICLE-BOUND FLUOROPHORES CONFINED BY PARTICLE TRAPS - A method of detecting a fluorescence signal emitted by fluorophores bound to particles confined in a particle trap, includes an objective lens having a focal plane, which is normally the focal plane for incident collimated light. The particle trap is typically located in the focal plane, and a beam of excitation light is directed via the objective lens onto the confined particles in the trap. The excitation light is in the form of a divergent beam coming to focus at a plane displaced from the focal plane. The divergent beam has a spot diameter at the focal plane determined by the divergence of the beam. The fluorescent light emitted by the fluorophores is detected with a confocal detector. | 09-22-2011 |
| 20110223107 | ANTIBODIES THAT SPECIFICALLY BLOCK THE BIOLOGICAL ACTIVITY OF A TUMOR ANTIGEN - Novel monoclonal antibodies that specifically bind to KAAG1 are described. In some embodiments, the antibodies block the biological activity of KAAG1 and are useful in composition in certain cancers, more particularly in cancers that have increased cell surface expression of KAAG1, such as ovarian, renal, lung, colorectal, breast, brain, and prostate cancer, as well as melanoma. The invention also relates to cells expressing the monoclonal antibodies and antigen binding fragments such as humanized and chimeric antibodies. Additionally, methods of detecting and treating cancer using the antibodies and fragments are also disclosed. | 09-15-2011 |
| 20110217244 | COMPOSITIONS AND METHODS FOR ENHANCING IMMUNE RESPONSE - The use of oxidatively transformed carotenoid or a component thereof to enhance the immune response in a subject for the treatment of infection or to enhance the immune response to an antigen in a subject being immunized. Also disclosed are pharmaceutical compositions and kits containing the oxidatively transformed carotenoid. | 09-08-2011 |
| 20110206905 | METHOD FOR FORMING A BLOCK COPOLYMER PATTERN - A method for forming a block copolymer pattern on a substrate, wherein the areal density of nanostructures in the pattern is increased by increasing the thickness of the block copolymer film that is applied to the substrate. | 08-25-2011 |
| 20110171686 | REVERSE CUMATE REPRESSOR MUTANT - Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from | 07-14-2011 |
| 20110165582 | MOLECULAR METHOD FOR DIAGNOSIS OF COLON CANCER - Methods for diagnosing or detecting cancerous colon tissue. A panel of 17 specific marker genes are provided. The overexpression of some of these marker genes compared to their expression in normal human colon tissue and the underexpression of the rest of these marker genes are indicative of cancerous colon tissue. By using these 17 marker genes as a diagnostic tool, smaller tissue samples, such as those obtained by core needle biopsies, from patient stool samples, or from blood samples can be used. | 07-07-2011 |
| 20110143997 | PHAGE RECEPTOR BINDING PROTEINS FOR ANTIBACTERIAL THERAPY AND OTHER NOVEL USES - The subject invention relates in part to novel uses of bacteriophage tail spike proteins (TSPs). Some preferred uses are therapeutic uses in animals, such as chickens, against pathogenic bacteria, such as Salmonella. Fragments of the TSPs can also be used according to the subject invention, particularly protein fragments comprising the phage receptor binding domains (PRBDs), which recognize their hosts and facilitate infection. The binding domains are specific to unique surface structures on bacteria and may be used for a variety of applications according to the subject invention. We have shown that by utilizing these PRBDs, it is possible to exploit the long-established evolutionary relationship between bacteria and their viruses (ie bacteriophages) that specifically infect them. The subject invention also relates in part to novel, synthetic forms of tail spike proteins. In some preferred embodiments, these are hexamers. | 06-16-2011 |
| 20110135932 | Production of Sulfur-Free Nanoparticles by Yeast - A method of producing sulfur-free nanoparticles involves growing yeast in a growth medium containing a source of an element in a bio-reducible oxidation state (e.g. Se(V1), and, precipitating nanoparticles containing the element in a lower oxidation state (e.g. Se(O)) than the oxidation state of the element in the source. The method advantageously can provide substantially spherical nanoparticles at high production efficiencies. | 06-09-2011 |
| 20110111454 | ENGINEERED VERSIONS OF CgtB (Beta-1,3 GALACTOSYLTRANSFERASE) ENZYMES, WITH ENHANCED ENZYMATIC PROPERTIES - CgtB proteins with enhanced beta 1,3-galactosaminyltransferase activity, nucleic acids that encode the CgtB proteins and methods for use of the CgtB proteins. | 05-12-2011 |
| 20110098999 | TEXT CATEGORIZATION BASED ON CO-CLASSIFICATION LEARNING FROM MULTILINGUAL CORPORA - The present document describes a method and a system for generating classifiers from multilingual corpora including subsets of content-equivalent documents written in different languages. When the documents are translations of each other, their classifications must be substantially the same. Embodiments of the invention utilize this similarity in order to enhance the accuracy of the classification in one language based on the classification results in the other language, and vice versa. A system in accordance with the present embodiments implements a method which comprises generating a first classifier from a first subset of the corpora in a first language; generating a second classifier from a second subset of the corpora in a second language; and re-training each of the classifiers on its respective subset based on the classification results of the other classifier, until a training cost between the classification results produced by subsequent iterations reaches a local minima. | 04-28-2011 |
| 20110098371 | Proton-Conducting Polymeric Poly(Arylene Ether)s with Pendant Phenyl Sulfonic Acids - Disclosed are sulfonated polymers of formula (I) or a salt thereof: wherein X is (a) or (b), R is hydrogen or an organic moiety, n is an integer from 10 to 10,000, p is 1 or 2, and m is 0 or 1 for a particular monomer unit such that the polymer has a degree of sulfonation of 0.50 or greater. Such polymers are useful in proton exchange membranes (PEMs) having high ion exchange capacity with higher proton conductivity than Nafion™, while having lower methanol permeability and lower water uptake than previously disclosed polymers. | 04-28-2011 |
| 20110093983 | ALGAL GLYCEROL-3 PHOSPHATE ACYLTRANSFERASE - The present disclosure relates to the isolation of, purification of, characterization of, and uses for a glycerol-3-phosphate acyltransferase (TpGPAT1), and genes encoding TpGPAT1, from algae. | 04-21-2011 |
| 20110091874 | ULTRASENSITIVE DETECTION OF TARGET USING TARGET-READY PARTICLES - The invention relates to methods and reagents for detecting minute amounts of targets having affinity for nucleic acid. The present invention more particularly relates to target detection using aggregates of cationic polymer chains and nucleic acid capture probes linked to particles, such as controllable mobility particles. | 04-21-2011 |
| 20110088124 | REDUCTION OF LYSO-PHOSPHATIDYLCHOLINE ACYLTRANSFERASE ACTIVITY - Reducing lyso-phosphatidylcholine acyltransferase (LPCAT) activity in a plant increases seed oil content and/or fatty acid levels in the plant. Increases in the level of unusual fatty acids 16:3, 18:3 and 20:1c11 are particularly pronounced. | 04-14-2011 |
| 20110084251 | ATOMISTIC QUANTUM DOT - A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed therefrom. | 04-14-2011 |
| 20110083586 | CONTROLLED RELEASE OF CHEMICAL ADMIXTURES - A method of controlling release of an admixture in a cement-based composition involves intercalating an admixture (e.g. an accelerator, a set retarder, a superplasticizer) for the cement-based composition into a layered double hydroxide or mixture thereof. A cement-based composition prepared in such a manner and containing a cement-based material (e.g. cement, mortar or concrete) has better workability, especially in respect of slump-loss characteristics. | 04-14-2011 |
| 20110068361 | HIGH PERFORMANCE LIGHT-EMITTING DEVICES - A light emitting device in the form of a layered structure has a passive bottom multilayer stack including a cathode layer, a cavity layer including a light emitting region, a passive top multilayer stack including a hole transport layer, and a transparent anode layer. The passive bottom and top multilayer stacks are devoid of a light emitting layer. A transparent substrate, through which light is emitted from the device, is located over the top multilayer stack. At least one functional additional layer group in the passive top multilayer stack controls the reflectance of the passive top multilayer stack and phase changes occurring upon reflection from the passive top multilayer stack in the cavity layer. | 03-24-2011 |
| 20110060045 | ANTI-DIABETIC CATARACT COMPOUNDS AND THEIR USES - The invention disclosed relates to the use of anti-glycation agents of formula (I), | 03-10-2011 |
| 20110052565 | NON-AGGREGATING HUMAN VH DOMAINS - The present invention relates to non-aggregating VH domains or libraries thereof. The V | 03-03-2011 |
| 20110033471 | METHODS AND COMPOSITIONS FOR MODULATING TUMOR CELL ACTIVITY - Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding the clusterin. | 02-10-2011 |
| 20110021610 | AROMATIC PRENYLTRANSFERASE FROM HOP - Nucleic acid molecules from hop ( | 01-27-2011 |
| 20110003084 | Process of Making Ceria-Based Electrolyte Coating - It has been surprisingly found that injecting ceria-based particles (mean size less than 200 nm) suspended in a combustible organic solvent into a plume having a maximum temperature between about 2,600° C. and 4,000° C. to impart a mean temperature to the particles from about 2,600° C. to about 3,800° C., and to accelerate the particles to a mean velocity between about 600 to 1000 m/s, produces a thin, uniform, dense, crack-free, nanocrystalline ceria-based coating, which may be applied on porous cermet or metal substrate, for example. The physical environment of a high-velocity oxy-fuel (HVOF) thermal spraying gun suitably ably deployed using standard fuels produces these conditions. The method of the present invention is particularly useful for the cost-effective fabrication of ceria-containing electrolytes for solid oxide fuel cells (SOFCs). | 01-06-2011 |
| 20110002854 | Use of Francisella Tularensis For Prevention and Treatment of Allergic Airway Disorders - A pharmaceutical composition for treating or preventing a Th | 01-06-2011 |
| 20100290037 | PRISM COUPLED SILICON ON INSULATOR SENSOR - Methods and devices related to a sensor element for use in the detection and monitoring of molecular interactions. The sensor element uses a silicon-on-insulator wafer optically coupled to a silicon prism. The wafer has a thin silicon film top layer, a silicon substrate layer, and a buried silicon dioxide layer sandwiched between the silicon film and substrate layers. The wafer is coupled to the prism on the wafer's substrate side while the interactions to be monitored are placed on the wafer's silicon film side. An incident beam is directed at the prism and the incident angle is adjusted until the beam optically couples to the silicon film's optical waveguide mode. When this occurs, a decrease in the intensity of the reflected beam can be detected. The molecular interactions affect the phase velocity or wave vector of the propagating mode. Similarly, instead of measuring the incident angle at which optical coupling occurs, the phase of the reflected beam may be measured. | 11-18-2010 |
| 20100225497 | Surface-Mounted Crack Detection - A cementitious compound provides a brittle undercoat for making a surface-mounted crack sensor on a surface. A low percent elongation and low tensile strength of the cementitious compound have proven valuable in ensuring that cracks in the underlying surface are transmitted through the undercoat so that a trace of conductive ink or paint on the undercoat more reliably detects the crack. | 09-09-2010 |
| 20100167349 | ORF11 FROM CAMPYLOBACTER JEJUNI IS A SIALATE-O-ACETYLTRANSFERASE - The invention relates to sialate-O-acetyltransferase (SOAT) polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides. | 07-01-2010 |
| 20100151354 | Membraneless Fuel Cell And Method Of Operating Same - A direct fuel cell comprises a cathode comprising electroactive catalyst material; and an anode assembly comprising an anode having a porous layer and electroactive catalyst material in the porous layer. The electrode characteristics of the anode assembly are selected so that fuel supplied to the anode is reacted within the anode so that cross-over from the anode to the cathode does not have more than a 10% negative effect on voltage or a 25 mV voltage loss when at peak power and steady state conditions. The anode and cathode each have a first major surface facing each other in non-electrical contact and without a microporous separator or ion exchange membrane therebetween. | 06-17-2010 |
| 20100110443 | PLANAR WAVEGUIDE WAVELENGTH DISPERSIVE DEVICES WITH MULTIPLE WAVEGUIDE INPUT APERTURE - A spectrometer has a multi-input aperture for admitting an input wavefront and an array of multiple waveguide structures terminating at the multi-input aperture. The input wavefront is incident on each of the waveguide structures, which provide a dispersive function for the input wavefront. Interferometers are formed by elements of the waveguide structures. The interferometers have different optical path length differences (OPDs). The interferometers provide a wavelength responsive output for spatially extended light sources. The output of the interferometers is detected with a detector array. The spectrometer has an improved etendue, and in some embodiments very high resolution. | 05-06-2010 |
| 20100104963 | NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is a substituted pyridine derivative; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 04-29-2010 |
| 20100087614 | NUCLEOPHILIC SUBSTITUTION OF CARBON NANOTUBES - Compounds are attached to carbon nanotubes (CNT) by a process which comprises: subjecting surface treated CNTs which have been treated to induce negatively charged surface groups thereon, to nucleophilic substitution reaction with a compound carrying a functional group capable of reacting with the negatively charged groups on the CNT surface, whereby the compound chemically bonds to the CNT. The surface CNT treatment may be reduction. The compounds which are bonded to the CNT may be epoxy resins, bonded directly or through a spacer group. Bi-functional CNTs, grafted to both epoxy resins and other polymers such as polystyrene, are also made by this process. | 04-08-2010 |
| 20100069604 | BLOCK FUNCTIONALIZATION METHODS - Epoxy resins are chemically attached to carbon nanotubes (CNTs), in a one-step process in which a reaction mixture comprising the epoxy polymer, the CNTs and a bridging agent which is a chemical compound capable of forming living polymers, e.g. styrene or MMA is formed and radical formation is initiated in the reaction mixture; the epoxy polymer or monomer grafts onto the CNTs through the intermediary block of the bridging agent. | 03-18-2010 |
| 20100063140 | WATER-SOLUBLE COMPOSITIONS OF BIOACTIVE LIPOPHILIC COMPOUNDS - Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: | 03-11-2010 |
| 20100037955 | NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated derivative of an aromatic acid; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 02-18-2010 |
| 20100035172 | NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - A nanoscale pigment particle composition includes an organic benzimidazolone pigment, and a sterically bulky stabilizer compound, wherein the benzimidazolone pigment associates non-covalently with the sterically bulky stabilizer compound that is an alkylated-benzimidazolone compound; and the presence of the associated stabilizer limits the extent of particle growth and aggregation, to afford nanoscale pigment particles. | 02-11-2010 |
| 20100012844 | IDENTIFICATION OF IMMUNOGLOBULIN (Ig) DISORDERS USING FOURIER TRANSFORM INFRARED SPECTROSCOPY - A method and a corresponding system for obtaining a serum mid-infrared spectroscopic profile using Fourier-transform infrared spectroscopy (FTIR) are described. The method comprises acquiring FTIR spectra for dried sera and preprocessing the FTIR spectra of sera by differentiation and smoothing to enhance weak spectral features and to remove baseline variations. The preprocessed FTIR spectra are normalized to a common intensity range, the normalization being performed in a spectral sub-region defined by strongest infrared (IR) absorption for a protein to obtain the serum spectroscopic profile. The serum spectroscopic profiles provide a basis to diagnose immunoglobulin disorders or to quantify serum immunoglobulin levels. | 01-21-2010 |
| 20100004360 | METHODS OF MAKING NANOSIZED PARTICLES OF BENZIMIDAZOLONE PIGMENTS - Nanoscale particles of benzimidazolone pigments are made by providing one or more organic pigment precursor(s) to a benzimidazolone pigment, providing a solution or suspension of a sterically bulky stabilizer compound that associates non-covalently with a benzimidazolone moiety on one of the pigment precursors, wherein the sterically bulky stabilizer compound is selected from the group consisting of substituted pyridine derivatives, alkylated benzimidazolone compounds, alkylated derivatives of aromatic acids, and mixtures thereof, and carrying out a coupling reaction to form a benzimidazolone pigment composition, whereby one or more functional moieties on the benzimidazolone pigment is non-covalently associated with the sterically bulky stabilizer, so as to limit an extent of particle growth and aggregation and results in nanoscale pigment particles. | 01-07-2010 |
| 20090286288 | ALPHA-1, 4-GALACTOSYLTRANSFERASE (CgtD) FROM CAMPYLOBACTER JEJUNI - α-1,4-galactosyltransferase (CgtD) polypeptides, nucleic acids that encode the polypeptides, including a polypeptide from | 11-19-2009 |
| 20090246832 | PRODUCTION OF POLYSIALIC ACID CONTAINING GLYCOCONJUGATES USING A SELF-PRIMING POLYSIALYLTRANSFERASE - The invention relates to a fusion protein comprising a bifunctional sialytransferase and a poly-sialytransferase and methods to use the fusion proteins for production of poly-sialylated end products, e.g. oligosaccharides and glycoproteins. | 10-01-2009 |
| 20090236544 | UV REACTIVE SPRAY CHAMBER FOR ENHANCED SAMPLE INTRODUCTION EFFICIENCY - An analyte for atomic spectrometry detection is prepared by introducing an aerosol of the analyte into a chamber, and irradiating the aerosol with ultraviolet light in the presence of a low molecular weight organic acid or other suitable photoactivatable ligand donor species to create vapor containing the analyte. The vapor containing the analyte is extracted from the chamber and used for atomic spectrometry detection. | 09-24-2009 |
| 20090215116 | Identification of a beta-1,3-N-acetylgalactosaminyltransferase (CGTE) from campylobacter jejuni LIO87 - The invention relates to β-1,3-N-acetylgalactosaminyltransferase polypeptides, nucleic acids that encode the polypeptides, and methods of using the polypeptides. | 08-27-2009 |
| 20090215115 | SIALYLTRANSFERASES COMPRISING CONSERVED SEQUENCE MOTIFS - The present invention provides, e.g., sialyltransferase proteins comprising conserved sequence motifs, including α-2,3-sialyltransferase proteins from | 08-27-2009 |
| 20090211632 | PHOTOVOLTAIC DEVICE BASED ON CONFORMAL COATING OF COLUMNAR STRUCTURES - A photovoltaic device, comprises a first electrode, an electron donor layer in electrical contact with the first electrode, an electron acceptor layer in contact with the electron donor layer across an interface having a shape defined by a columnar structure grown by oblique angle deposition, and a second electrode in electrical contact with the electron acceptor layer. | 08-27-2009 |
| 20090210959 | METHOD FOR PRODUCTION OF SAPONARIA FROM MICROSPORES | 08-20-2009 |
| 20090187388 | METHOD AND SYSTEM FOR LOCATING LANDMARKS ON 3D MODELS - A plurality of landmarks are automatically located on a 3-dimensional polygonal mesh of connected vertices. A probabilistic graph is generated for the plurality of landmarks pre-identified on each of a first set of 3-dimensional models. The graph represents local surface characteristics for each landmark and relational positions between neighboring pairs of landmarks. Local surface characteristics are determined for each vertex of the mesh. For each landmark, a set of the vertices is identified that satisfies a criteria based on a surface difference between the vertex local surface characteristics and the landmark local surface characteristics. A relational position for each pair of vertices from the sets of vertices corresponding to the neighboring pairs is determined based on the graph. One of the vertices is determined for each of the plurality of landmarks to minimize the surface difference and the relational difference for the landmark. | 07-23-2009 |
| 20090176275 | EXPRESSION SYSTEM, COMPONENTS THEREOF AND METHODS OF USE - Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from | 07-09-2009 |
| 20090121125 | Blind Extraction of Pure Component Mass Spectra from Overlapping Mass Spectrometric Peaks - A method of obtaining pure component mass spectra or pure peak elution profiles from mass spectra of a mixture of components involves estimating number of components in the mixture, filtering noise, and extracting individual component mass spectra or pure peak elution profiles using blind entropy minimization with direct optimization (e.g. downhill simplex minimization). The method may be applied to deconvolution of pure GC/MS spectra of overlapping or partially overlapping isotopologues or other compounds, separation of overlapping or partially overlapping compounds in proteomics or metabolomics mass spectrometry applications, peptide sequencing using high voltage fragmentation followed by deconvolution of the obtained mixture mass spectra, deconvolution of MALDI mass spectra in the separation of multiple components present in a single solution, and specific compound monitoring in security and/or environmentally sensitive areas. | 05-14-2009 |
| 20090020710 | SEMICONDUCTOR NANOCRYSTALS FOR TIME DOMAIN OPTICAL IMAGING - A method of performing high repetition rate laser time domain imaging employs as fluoroprobes semiconductor nanocrystals having a fluorescence lifetime less than the laser pulse separation, typically less than 5 ns. The nanocrystals of the invention have a core/shell structure and may be surface treated to increase radiative decay. CdSe/Zns nanocrystals are particularly suitable. | 01-22-2009 |
| 20080317780 | VIRAL VACCINE AND METHOD FOR PREPARATION THEREOF - The invention relates to a viral vaccine, especially a retroviral vaccine, and methods of forming such a vaccine. The vaccine is formed from a whole-killed virus suspension in a cell lysate or culture medium, wherein the virus is killed by exposure to a chloramine compound at a level adequate to inactivate zinc finger proteins. The chloramine compound may be taurine chloramine, adenosine chloramine, phenylalanine chloramine, and alanine chloramine. The vaccine may be used as a prophylactic or therapeutic vaccine and may be developed from a subject's own strains of virus so as to be considered an autologous vaccine. | 12-25-2008 |
| 20080314122 | MONITORING OF LEAKAGE IN WASTEWATER FORCE MAINS AND OTHER PIPES CARRYING FLUID UNDER PRESSURE - A method of detecting leakage in a force main involves placing at least two spaced sensors on the force main. Liquid is pumped through the pipe by means of a pump. The pump is shut down for an interval of time, and during the period following pump shutdown while negative pressure is present in the pipe, signals are generated at the sensors due to noise or vibration resulting from fluid being drawn into the pipe. The position of a leak in the pipe is determined by correlating the leak noise signals generated while the pipe is under negative pressure. Alternatively, the invention can be applied to a pressurized pipe, in which case conditions of negative pressure can be deliberatively created for a period to draw in fluid from the outside. | 12-25-2008 |
| 20080311618 | Expression System, Components Thereof and Methods of Use - Recently, the development of inducible expression systems has involved exploitation of the p-cym operon from | 12-18-2008 |
| 20080254188 | FORMULATIONS OF LIPOPHILIC BIOACTIVE MOLECULES - This invention provides aqueous and non-aqueous clear formulations including at least one lipophilic bioactive molecules and an amphiphilic solubilizing agent. Exemplary aqueous formulations include a water-soluble reducing agent, which diminishes or prevents chemical degradation of the lipophilic bioactive molecule. The invention also provides methods of using the formulations of the invention. For example, the invention provides beverages including the formulations of the invention. The invention further provides methods of making the formulations and beverages. | 10-16-2008 |
| 20080248094 | VACCINE ADJUVANT PROPERTIES OF LIPSOMES FORMED AT ELEVATED TEMPERATURES FROM THE POLAR CHLOROFORM EXTRACTABLE LIPIDS FROM MYCOBACTERIUM BOVIS - The invention relates to a liposome comprising a chloroform soluble and extractable total polar lipid of Mycobacterium spp, particularly a chloroform soluble extractable total polar lipid of Mycobacterium bovis BCG. The chloroform soluble and extractable polar lipid may comprise at least one of phosphatidylinositol (PI), phosphatidylinositol mannoside (PIM | 10-09-2008 |
| 20080242754 | LOW LOSS FOAM COMPOSITION AND CABLE HAVING LOW LOSS FOAM LAYER - The invention relates to a low loss foam composition and cable, such as a coaxial cable. The foam composition is formed by heating an olefinic polymer, such as a high density polyethylene, medium density polyethylene, low density polyethylene, linear low density polyethylene, polypropylene, or a combination thereof, into a molten state composition, optionally with a nucleating agent. The molten mixture is extruded under pressure through a die with a blowing agent comprising an atmospheric gas, such as carbon dioxide, nitrogen or air, and a co-blowing agent selected from hydrofluorocarbons, hydrochlorofluorocarbons, or perfluoro compounds, such as HFC-134a. The cable is formed by extruding the foam composition onto a signal carrying conductor and sheathing the foam-coated signal carrying conductor in an appropriate conducting shield. | 10-02-2008 |
| 20080237576 | Voltage Controlled Computing Element for Quantum Computer - A computing element for use in a quantum computer has at least three coupled quantum dots, and at least one gate for applying an electric field to manipulate the state of said qubit. | 10-02-2008 |
| 20080220028 | ARCHAEAL POLAR LIPID AGGREGATES FOR ADMINISTRATION TO ANIMALS - The invention provides non-replicating compositions, and methods for the delivery of these compositions containing pharmaceuticals, biologically relevant molecules, and/or antigens to the host, by administration via a mucosal route such as the intranasal. This invention provides non-replicating vaccine compositions and methods for the delivery of antigens in these vaccine compositions comprising an antigen and a self-adjuvanting carrier, useful for inducing antigen-specific mucosal and systemic immune responses in the host upon immunization via a mucosal route such as intranasal. The vaccine compositions comprise multivalent cations in association with a plurality of spherical archaeal polar lipid aggregates containing aqueous compartments, the AMVAD structure, formed by the interaction of archaeosomes and antigen(s) with multivalent cations such as Ca | 09-11-2008 |
| 20080207801 | Compatibilization of Polymer Clay Nanocomposites - A polymer nanocomposite contains layered clay dispersed in a polymer matrix together with compatibilizers for the clay and polymer matrix. The compatibilizers are a combination of two or more graft polymers. One graft polymer has high functionality and short chain length and another graft polymer has low functionality and long chain length. Such polymer nanocomposites have improved dispersion and better strength and modulus, while maintaining good toughness and impact strength. The polymer nanocomposites are particularly useful in applications where good mechanical performance and light-weight are of importance. | 08-28-2008 |
| 20080200339 | Synthesis and Biological Activity of Bicyclic Aba Analogs - Bicyclic abscisic acid (ABA) analogs of Formula (I) and (II) and the process for their production are disclosed. The bicyclic ABA analogs include the structural elements and functional groups of the parent molecule that are required for activity, and have an aromatic ring fused to the ring replacing the vinyl methyl group of absicisie acid. Methods for using the bicyclic ABA analogs to inhibit cell growth and seed germination are also disclosed. | 08-21-2008 |
