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National Institutes of Health (NIH), U. S. Dept. of Health and Human Resources (DHHS) U. S. Govt.

National Institutes of Health (NIH), U. S. Dept. of Health and Human Resources (DHHS) U. S. Govt. Patent applications
Patent application numberTitlePublished
20110245153Neutralizing Agents for Bacterial Toxins - Stabilized variable regions of the T cell receptor and methods of making the same using directed evolution through yeast display are provided. In one embodiment, the variable region is variable beta. In one embodiment, the stabilized T cell receptor variable regions have high affinity for a superantigen, such as TSST-1 or SEB. These T cell receptor variable regions are useful as therapeutics.10-06-2011