| NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES Patent applications |
| Patent application number | Title | Published |
|---|
| 20120107854 | REAGENT FOR MEASUREMENT OF CHOLINESTERASE ACTIVITY - An N-alkylpiperidine methanethiol ester derivative represented by any one of the general formulae (1) to (4) or a salt thereof has been discovered. The N-alkylpiperidine methanethiol ester derivative or the salt thereof has specificity for acetylcholinesterase or butyrylcholinesterase and is useful as a reagent for measurement of cholinesterase activity by the Ellman method. | 05-03-2012 |
| 20110224534 | PET/MRI DEVICE, PET DEVICE, AND IMAGE RECONSTRUCTION SYSTEM - A PET/MRI device includes an MRI device that has a measurement port, a PET detector that can be inserted into the measurement port, and a mechanism that can slide the PET detector into and out of the MRI measurement port. Thereby, the PET/MRI device allows MRI measurement during PET measurement. | 09-15-2011 |
| 20110127435 | GAMMA RAY DETECTOR, RADIATION DIAGNOSTIC DEVICE, TOMOGRAPHY DEVICE, AND METHOD OF ANALYZING TOMOGRAPHY DEVICE - A gamma ray detector for detecting a gamma ray emitted from a target of measurement includes: an organic scintillator for detecting Compton electrons resulting from a gamma ray emitted from the target of measurement; an inorganic scintillator for detecting a Compton gamma ray; and photodetector modules for detecting light generation in the corresponding scintillators. Light generation signals from the organic and inorganic scintillators are synchronously measured, and a detection window of a gamma ray is generated. Thus, an inexpensive radiation diagnostic device of an ultra-high S/N ratio and low cost is provided. | 06-02-2011 |
| 20110121184 | DOI RADIATION DETECTOR - In a DOI radiation detector, scintillation crystals are arranged in three dimensions on a light receiving surface of a light receiving element, and a response of a crystal having detected a radiation ray can be identified on the light receiving surface. Thereby, a position at which the radiation ray is detected is determined in three dimensions. In this DOI radiation detector, regular triangular prism scintillation crystals are used, and response positions of the respective crystals are shifted for each set. This allows crystal identification without loss even with a structure such as a three-layer or six-layer structure hard to achieve by a quadrangular prism scintillation crystal. | 05-26-2011 |
| 20110101229 | DOI TYPE RADIATION DETECTOR - This aims to provide a DOI type radiation detector in which scintillation crystals arranged two-dimensionally on a light receiving surface to form rectangular section groups in extending directions of the light receiving surface of a light receiving element are stacked up to make a three-dimensional arrangement and responses of the crystals that have detected radiation are made possible to identify at response positions on the light receiving surface, so that a three-dimensional radiation detection position can be obtained. In the DOI type radiation detector, scintillation crystals are right triangle poles extending upwards from the light receiving surface and the response positions on the light receiving surface are characterized. With this structure, DOI identification of a plurality of layers can be carried out by simply performing an Anger calculation of a light receiving element signal. | 05-05-2011 |
| 20110092814 | COMBINED RADIATION THERAPY/PET APPARATUS - A combined radiation therapy/PET apparatus includes: an open PET device having multi-ring detector rings that are opposed to each other in the direction of the body axis so as to leave a gap therebetween; and a radiation therapy apparatus for performing radiation therapy through the gap. When imaging the condition of an affected area and a treatment beam for monitoring in radiation therapy of irradiating the affected area with X-rays, gamma rays, or particle beams, the apparatus covers a region of interest in the irradiation field of the radiation therapy with the field-of-view of the open PET device, thereby making possible the positioning of the irradiation field and treatment monitoring using PET images. | 04-21-2011 |
| 20110084211 | DETECTOR-SHIFT TYPE COMBINED RADIATION THERAPY/PET APPARATUS - In beam monitoring for detecting annihilation radiations produced by radiation irradiation in radiation therapy for cancer which is performed by irradiating the affected area by X-rays, gamma rays, or particle beams, a detector-shift type combined radiation therapy/PET apparatus is provided with an open PET device that includes a plurality of shiftable multi-ring detector rings; and a radiation irradiation device that is capable of irradiation with a radiation beam through between the detector rings. The apparatus changes the positions of the detector rings, performs irradiation with the radiation beam through between the detector rings, and then performs radiation measurement. | 04-14-2011 |
| 20110031407 | OPEN-TYPE PET SCANNER - In an open-type PET scanner including a plurality of detector rings having multiple rings arrayed in the body axis direction, radiation measurement is performed while at least one detector ring is relatively moved with respect to a subject in the body axis direction, thereby dispersing simultaneous radiation in an open region to suppress a local reduction in sensitivity. The detector rings are optimized in constitution, moving direction and/or moving speed, thus making it possible to reduce the variation of distribution of sensitivity and expand a clearance in the open region and a field-of-view in the body axis direction. | 02-10-2011 |
| 20110024638 | PET SCANNER AND METHOD FOR DECIDING ARRANGEMENT OF DETECTORS - A PET scanner in which detector rings are arrayed in a multilayered manner so as to oppose each other in the body axis direction is provided. In the PET scanner, a predetermined number of detector units, each of which is made up of a predetermined number of detector rings, are arrayed so as to give each other a clearance, and a first ring set in which the clearance is less than or equal to a mean value of widths of two detector units forming each clearance and a second ring set constituted with a predetermined number of detector units are arrayed apart so as to give a clearance which is less than or equal to a mean value of the width of the first ring set and that of the second ring set, thereby imaging a field-of-view including the clearance and continuing in the body axis direction to an entire length of the first ring set and that of the second ring set. | 02-03-2011 |
| 20110024637 | OPEN-TYPE PET SCANNER - In an open-type PET scanner, detector rings arranged in a multilayered manner in an axial direction are at least partially opened and the thus opened part of the detector rings is at least partially included in a main focus region. Then, at least some of the detecting elements constituting the detector ring are disposed obliquely in the axial direction so that the main sensitivity direction thereof is turned closer to the main focus region, increasing the resolution in the main focus region. Thereby, it is possible to retain resolution in the body axis direction without using a high-resolution DOI detector and to reduce the price of the open-type PET scanner. | 02-03-2011 |
| 20110001049 | METHOD FOR DETECTING RADIATION, DEVICE THEREOF, AND POSITRON EMISSION TOMOGRAPHY SCANNER - A light receiver for detecting incident time is installed on the side of a radiation source of a scintillator (including a Cherenkov radiation emitter), and information (energy, incident time, an incident position, etc.) on radiation made incident into the scintillator is obtained by the output of the light receiver. It is, thereby, possible to identify an incident position and others of radiation into the scintillator at high accuracy. | 01-06-2011 |
| 20100308225 | BETA RAY DETECTOR AND BETA RAY RECONSTRUCTION METHOD - Provided are a beta ray detector and a beta ray reconstruction method capable of achieving consistently high detection efficiency of beta rays in a wider energy region compared to that of a conventional beta ray detector while enhancing energy resolution. The beta ray detector comprises an absorber scintillator | 12-09-2010 |
| 20100301221 | GAMMA RAY DETECTOR AND GAMMA RAY RECONSTRUCTION METHOD - Provided are a gamma ray detector and a gamma ray reconstruction method which can be used in SPECT and PET and which combine and reconstruct the information on “Compton-scattered” gamma rays, thereby remarkably increasing gamma ray detection sensitivity, decreasing the amount of a radioactive substance given to a subject, and remarkably reducing the concern about the amount of radiation exposure. The gamma ray detector comprises an absorber scintillator | 12-02-2010 |
| 20100274512 | METHOD, DEVICE AND PROGRAM FOR ESTIMATING PARTICLE EMITTED FROM RADIOISOTOPE SOURCE, METHOD FOR ESTIMATING RADIATION DETECTOR, METHOD AND DEVICE FOR CALIBRATING RADIATION DETECTOR, AND RADIOISOTOPE SOURCE - When an energy of a particle emitted from a radioisotope source is obtained by a detector, a histogram obtained from a relationship between a difference ΔE between an energy of a particle emitted outside the radioisotope source and an initial energy which the particle possesses at the time of generation and a count is treated as being asymmetric, and an energy distribution (L | 10-28-2010 |
| 20100237239 | Ion Beam Detector - In order to attain an object to realize an ion beam capable of (i) immediately determining energy of the ion beam to be generated, and (ii) measuring an ion beam in real time while carrying out laser irradiation, an ion beam detector ( | 09-23-2010 |
| 20100133445 | ION BEAM CONTROL APPARATUS AND METHOD - Provided are an ion beam control apparatus and a control method for controlling an ion beam energy expansion level and an ion beam size in a radial direction. An ion beam control apparatus Sa is provided with an ion beam generating unit | 06-03-2010 |
| 20100130376 | DNA CHIP FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIOTHERAPY, AND METHOD FOR PREDICTION OF OCCURRENCE OF LATE ADVERSE REACTION IN URINARY ORGAN AFTER RADIO THERAPY USING THE SAME - A DNA chip and a prediction method for predicting the occurrence of a late adverse reaction in a urinary organ after C-ion RT are provided. The DNA chip comprises a supporting means for supporting a DNA probe thereon, and a plurality of genetic markers supported on the supporting means. The prediction method comprises a first step of hybridizing a genetic marker with a labeled DNA prepared from a subject to be examined, a second step of identifying bases of both alleles of the labeled DNA hybridized with the genetic marker, and a third step of determining a genotype of the labeled DNA as a risk genotype if the combination of the identified bases corresponds to the specified combination, and predicting that the subject is predisposed to develop a late adverse reaction in a urinary organ after radiotherapy when the number of the risk genotypes is three or more and the subject is not predisposed to develop a late adverse reaction in a urinary organ after radiotherapy when the number of the risk genotypes is two or less. The method enables to predict whether or not a subject is affected with a late adverse reaction in a urinary organ after radiotherapy. | 05-27-2010 |
| 20100128956 | PET SCANNER AND IMAGE RECONSTRUCTION METHOD THEREOF - A plurality of detector rings in which detectors arranged densely or spatially in a ring shape or in a polygonal shape are arranged, with an open space kept in the body axis direction, coincidences are measured for some of or all of detector pairs connecting the detector rings apart from the open space to perform three-dimensional image reconstruction, thereby imaging the open space between the detector rings as a tomographic image. Therefore, the open space is secured, with the deteriorated quality of an image suppressed, thus making it possible to easily gain access to a patient under PET scanning from outside a gantry and also provide irradiation of particle beams for cancer treatment as well as X-ray CT scanning. | 05-27-2010 |
| 20100111838 | BRAIN-LOCALIZING POLYPEPTIDES COMPRISING A MULTIVALENT BINDING MOIETY AND IMPROVED METABOLIC STABILITY - Brain-localizing polypeptides carrying a reactive group for linking to a molecule that does not have brain-localizing activity were successfully produced by introducing at least two lysine residues into cyclized polypeptides having a brain-localizing motif sequence. These polypeptides have improved metabolic stability compared to conventional brain-localizing polypeptides, and can efficiently translocate desired molecules into the brain. | 05-06-2010 |
| 20100099976 | GAMMA- RAY DETECTOR AND PET APPARATUS USING THE SAME - A medium area (S) filled with liquid xenon ( | 04-22-2010 |
| 20100048512 | RADIATION PROTECTION DRUG CONTAINING TOCOPHEROL OR TOCOTRIENOL COMPOUND ESTER DERIVATIVE AS ACTIVE INGREDIENT - Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure. | 02-25-2010 |
| 20100046818 | IMAGE RECONSTRUCTION METHOD FOR TOMOGRAPHY SCANNER, FAILURE DIAGNOSIS METHOD, TOMOGRAPHY SCANNER AND MANAGEMENT PROGRAM FOR SYSTEM MATRIX - In a case where an error is included in measurement data corresponding to one or a plurality of detecting elements in a tomography scanner, a system matrix to be calculated or referenced on image reconstruction calculation is corrected in accordance with the error. Thus, even when an error such as a defect or a fault occurs in a detector, influence of the error is eliminated, thereby reducing an artifact generated in an image. At that time, positional information of the detecting elements including the error and information on the degree of the error are stored in a storage device and referenced inside image reconstruction software, thus making it possible to correct the system matrix in accordance with the error. | 02-25-2010 |
| 20100032574 | RADIATION DETECTING METHOD UTILIZING ENERGY INFORMATION AND POSITIONAL INFORMATION AND EQUIPMENT THEREOF - Upon detection of radiation by using a (three-dimensional) detector capable of distinguishing a detection position in a depth direction and energy, an energy window for distinguishing between a signal and noise is changed depending on the detection position in the depth direction, thus making it possible to obtain scattering components inside the detector. Alternatively, a weight is given to a detection event depending on the detection position in the depth direction and energy information to obtain scattering components inside the detector. Thereby, scattering components inside the detector can be obtained to increase the sensitivity of the detector. In this case, different detecting elements can be used depending on the detection position in the depth direction. | 02-11-2010 |
| 20100028871 | Light-inducible and rhythmically expressed genes and method for screening substances that affect an internal clock system - A method for screening a substance that affect an internal clock system in an organism, comprising the detection of the expression level of a gene exhibiting a light-inducible and rhythmic expression in a circadian manner, which is typically expressed in the suprachiasmatic nucleus of mammalian, such as for example, Dusp4, Snk, Slc39a6 or Nnat. | 02-04-2010 |
| 20090311753 | Method for amplifying genomic DNA - A method for amplifying genomic DNA is provided. The method comprises the steps of: (1) incubating a cell-containing agarose solution at a pH of 9 to 12 and a temperature of 45 to 80° C. to produce a genomic DNA-dispersed agarose solution wherein 0.002 to 1 copies/5 microliter of single-stranded genomic DNA is dispersed; (2) solidifying the genomic DNA-dispersed agarose solution to produce a genomic DNA-dispersed agarose gel and neutralizing a pH of the gel; and (3) adding a DNA polymerase with strand displacement activity, primer and dNTP to the genomic DNA-dispersed agarose gel and incubating the gel at a temperature of 0 to 60° C. to amplify the genomic DNA. | 12-17-2009 |
| 20090294669 | SURFACE CONTAMINATION EXAMINING DEVICE AND METHOD - A surface contamination examining device includes a radiation detector | 12-03-2009 |
| 20090271143 | RADIATION MEASURING DEVICE AND DATA PROCESSING METHOD - A radiation measuring device capable of identifying the incident direction of a radiation ray and energy (segmentation) The directivity characteristics of a plurality of detectors are different from each other. A plurality of energy segmentations are set respectively for a plurality of spectra corresponding to a plurality of detectors, and actual measurement ratio information (a plurality of actual measurement counting ratios) expressing the mutual ratio between integrated counting values for each energy segmentation is computed. The actual measurement ratio information is checked against a plurality of response functions, and, when the compatibility relation between specific actual measurement ratio information and specific theoretical ratio information is found, the incident direction of a radiation ray and an energy segmentation are identified based on that relation. | 10-29-2009 |
| 20090261760 | H-MODE DRIFT-TUBE LINAC AND DESIGN METHOD THEREFOR - A linearity of a voltage change to a tuner insertion amount is verified for at least one of a plurality of tuners. Based on the voltage change linearity, individual voltage change data corresponding to respective insertion amounts are calculated for each of the plurality of tuners through a proportional calculation. A combination of auto-tuners and a combination of respective insertion amounts of the auto-tuners are determined using the individual voltage change data, and an adequacy of the determined combinations is verified through a direct three-dimensional electromagnetic field calculation. The combinations are determined on a condition that, when the individual voltage change data of nominated tuners are added together, respective voltage changes attributed to the nominated tuners are cancelled out to allow an entire voltage distribution to have substantially no change. | 10-22-2009 |
| 20090252296 | MULTI-COLOR X-RAY GENERATOR - A multi-color X-ray generator includes an electron beam generator | 10-08-2009 |
| 20090234162 | Radioactive Halogen-Labeled Phenyloxyaniline Derivatives - A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R | 09-17-2009 |
| 20090159804 | Positron emission tomography scanner and radiation detector - A positron emission tomography (PET) scanner is provided which uses information on the time-of-flight difference (TOF) between annihilation radiations for image reconstruction. The scanner has detection time correction information (memory) corresponding to information on coordinates in a radiation detection element (e.g., scintillator crystal), in the depth and lateral directions, at which an interaction has occurred between an annihilation radiation and the crystal. Reference is made to the detection time correction information, thereby providing information on time-of-flight difference with improved accuracy. As such, an improved signal to noise ratio and spatial resolution are provided for image reconstruction using time-of-flight (TOF) difference. | 06-25-2009 |
| 20090069592 | METHOD FOR SYNTHESIZING RADIOACTIVE LIGAND HAVING 18F-LABELED FLUOROBENZENE RING - A phenyl tin compound is synthesized by using a derivative having various functional groups and a bromo- or iodo-benzene ring as a labeling material of a radioactive ligand. On the other hand, a novel hydroxytosyl iodobenzene compound having an electron-donating group is obtained by oxidizing iodobenzene having one or more electron-donating groups and reacting it with tosylic acid. Then, a diphenyliodonium salt which is a labeling precursor is synthesized by reacting the resulting compound with various phenyl tin compounds. Finally, a | 03-12-2009 |
| 20090067570 | Computed tomography method and apparatus for a dynamic image of a moving site - When a repeatedly periodically moving site of a to-be-examined subject in a gantry is subjected to computed tomography and is reconstructed, the gantry is rotated in synchronization with the movement of the periodically moving site, and a dynamic image showing a transient phenomenon is obtained in which the periodic movement of the moving site has been stopped. As a result, the flow of a contrast agent or the like can be observed in a state of stopping the movement of an internal organ that moves repeatedly periodically. | 03-12-2009 |
| 20090052625 | DEVICE FOR SWITCHING/GENERATING X-RAYS FOR DIAGNOSIS AND CURING - There is disclosed a device including: an electron beam generation device | 02-26-2009 |
| 20090051937 | Device and method for measuring profiles of electron beam and laser beam - A device for measuring profiles of an electron beam and a laser beam is provided with a profile measuring device | 02-26-2009 |
| 20090022379 | Method for Quantifying Organ Motion, Apparatus Therefor, Method for Estimating Organ Position, Apparatus Therefor, Method for Irradiating Radiation, Apparatus Therefor, and Apparatus for Detecting Abnormal Organ - A plurality of CT images of an organ ( | 01-22-2009 |
| 20090011423 | GENES FOR PROGNOSIS OF CANCER - To provide a novel method for determining the risk of lymph node metastasis of breast cancer uses as an index the difference in the expression levels of marker genes between metastatic breast cancer tissue (or cell) and non-metastatic breast cancer tissue (or cell). The method involves ( | 01-08-2009 |
| 20080272305 | Radiation Detected Value Forecasting Method and Forecast Responsive Radiation Detector - In a radiation detector, a response is approximated as a primary delay system, and when a time constant T indicating the characteristic of the response is known, a final response value N | 11-06-2008 |
