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NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER

Osaka, JP

NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER Patent applications
Patent application numberTitlePublished
20120088896DRUG FOR INHIBITING LECTIN-LIKE OXIDIZED LDL RECEPTOR AND DRUG FOR PREVENTING ARTERIOSCLEROSIS - A compound having an excellent activity to inhibit a lectin-like oxidized LDL receptor has been identified.04-12-2012
20110144714BLOOD PRESSURE REGULATING SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION - A blood pressure regulating system uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising at least one blood pressure sensing means which senses blood pressure and outputs a input blood pressure signal, a calculating means which receives the input blood pressure signal, calculates a transfer function by computing a Fourier transform of a normal blood pressure signal and a normal sympathetic nerve activity from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a sympathetic nerve stimulation signal using a convolution integral between the input blood pressure signal and the impulse response, and outputs the sympathetic nerve stimulation signal, and a stimulating means which receives the sympathetic nerve stimulation signal, and stimulates the sympathetic nerve innervating vascular beds based on the sympathetic nerve stimulation signal such that blood pressure is regulated.06-16-2011
20110144710CARDIAC PACING SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION - The present invention provides a cardiac pacing system based on biological activities, comprising: a) at least one nerve activity sensing means which senses nerve activity of a cardiac sympathetic nerve and/or a vagal nerve, and outputs a plurality of input nerve activity signals; b) a calculating means which receives the input nerve activity signals, calculates a transfer function by computing a Fourier transform of normal nerve activity signals and a normal heart rate signal from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a plurality of pacing signals for control of a heart rate using a convolution integral between the input nerve activity signals and the impulse response, and outputs the pacing signals; and c) a pacing means which receives the pacing signals, and stimulates the heart based on the pacing signals such that heart rate is regulated.06-16-2011