20140031412 | METHOD OF TREATMENT - The present disclosure teaches the treatment of a blood pathology, such as a blood pathology associated with impaired hemoglobin synthesis including the treatment of β-thalassemia or a related hemoglobinopathy. An RNA molecule such as a short interfering RNA or a hairpin RNA which targets an mRNA species encoding α-globin is administered to a subject to reduce the amount of α-globin produced to non-zero levels and ameliorate the effects of an α- and β-globin chain imbalance. | 01-30-2014 |