| Mount Sinai School of Medicine Patent applications |
| Patent application number | Title | Published |
|---|
| 20120135882 | METHODS FOR DIAGNOSING CHRONIC KIDNEY DISEASE AND ASSESSING THE RISK OF DISEASE PROGRESSION - Methods and compositions for diagnosing chronic kidney disease and assessing the risk of disease progression, as well as methods of screening for molecular biomarkers useful for diagnosing the likelihood of disease progression, are provided. | 05-31-2012 |
| 20120130164 | MAGNETIC BASED DEVICE FOR RETRIEVING A MISPLACED ARTICLE - A device for locating and retrieving a misplaced foreign body that has metallic characteristics includes a shaft connected to a handle and a retrieval tool that is coupled to the shaft and moves between a deployed position and collapsed position. The tool has a magnetic element that generates a magnetic field, wherein the magnetic field extends over a greater area in the deployed position and is of sufficient strength to attract the foreign body such that it is held in contact with the tool. | 05-24-2012 |
| 20120115158 | METHOD TO DETERMINE EMBRYO AND OOCYTE QUALITY BASED ON CERAMIDASE - The present invention relates to a method of predicting the likelihood of embryo or oocyte survival. This method involves providing a sample of an embryo, an oocyte, or surrounding liquid or cells, and screening the sample for ceramidase expression or activity. The ceramidase expression or activity obtained through said screening is then correlated to a prediction of the likelihood of embryo or oocyte survival. Also disclosed is a kit. | 05-10-2012 |
| 20120082688 | In Vitro Generation of Myeloid Derived Suppressor Cells - The invention relates to methods of isolating, culturing, and differentiating myeloid derived suppressor cells (MD-SCs) from embryonic stem (ES) cells and hematopoietic stem cells (HSCs). In certain embodiments, the invention relates to methods and compositions for producing MDSCs from ES cells and HSCs using a combination of factors including macrophage colony-stimulating factor (M-CSF). | 04-05-2012 |
| 20120039841 | T-Helper Cell Type 17 Lineage-Specific Adjuvants, Compositions and Methods - The present invention relates to compositions and methods for the modulation of T | 02-16-2012 |
| 20120037165 | SPINAL SHIELD IMPLANT AND TREATMENT OF SPINAL METASTASES - A radiation shield for use in treating spinal metastatic disease is formed of a body that is configured to surround the spinal cord and includes a section that can be axially extended for increasing the surface area of the shield. | 02-16-2012 |
| 20120028912 | Methods of modulating bromodomains - The present invention features compounds useful for and methods for preventing or inhibiting the binding of bromodomains to acetyl-lysine residues of proteins and methods for treating HIV infection and HIV related disease. | 02-02-2012 |
| 20110275955 | TISSUE SAMPLING TOOL - A sampling tool for isolating and collecting a tissue biopsy includes a hollow sampling cylinder that includes a first end and an opposing second end. The first end being a sharpened, annular cutting edge and a central bore extending completely from the first end to the second end. An outer surface of the sampling cylinder includes a modified gripping surface. The sampling tool also includes a plunger having a first end and a second end. The plunger includes a shaft portion that terminates in the first end. The plunger has a handle portion at the second end that has greater dimensions than the shaft portion. The plunger includes an air evacuation feature in the form of an air evacuation channel that extends from one end of the plunger to the other end and is open at both ends. The sampling tool has particular utility in isolating and collecting cylindrical core placental biopsies of a standardized size that can be used for multiple downstream applications, including the sampling of other harvested solid, soft-tissue organs such as brain, liver, kidney, and spleen. | 11-10-2011 |
| 20110256101 | SERCA2 THERAPEUTIC COMPOSITIONS AND METHODS OF USE - The present invention provides methods for treating pulmonary hypertension in a subject by delivering a therapeutic adeno-associated virus (AAV)-SERCA2 composition to a subject in need thereof. | 10-20-2011 |
| 20110088695 | PROTECTIVE SHEATH FOR USE WITH VENTILATION BAG - In accordance with one embodiment of the present invention, a protective sheath for use with a manual ventilation bag that is associated with an anesthesia apparatus includes a sheath body that is intended to surround the manual ventilation bag. The sheath body has a plurality of removable overlying sheath layers, with each sheath layer being progressively longer in length from an innermost layer to an outermost layer with respect to the ventilation bag that is received within the sheath body. | 04-21-2011 |
| 20110071443 | REHABILITATIVE TRAINING DEVICES FOR USE BY STROKE PATIENTS - According to one embodiment, a rehabilitative training device for use with a stroke patient includes a first component that is operatively coupled to a first body part (unaffected body part) of the patient and a second component that is operatively coupled to a second body part (affected body part) of the patient. The first component and second component are operatively coupled to one another such that motion of the first component as a result of movement of the first body part by the user causes the second component and second body part to move in a symmetrical motion. | 03-24-2011 |
| 20100316572 | USE OF FSH RECEPTOR LIGANDS FOR DIAGNOSIS AND THERAPY OF CANCER - The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed by tumor endothelial cells and circulating blood cells. | 12-16-2010 |
| 20100310451 | ALTERED N-CADHERIN PROCESSING IN TUMOR CELLS BY FURIN AND PROPROTEIN CONVERTASE 5A (PC5A) - The present invention relates to a method for diagnosis and/or prognosis of cancer and for monitoring the progression of cancer and/or the therapeutic efficacy of an anti-cancer treatment in a subject by determining the molecular form of cadherin at the cell surface of cancer cells in the subject. The invention also relates to a method for preventing, inhibiting or treating cancer or its metastasis in a subject by increasing the adhesive forms of cadherin and/or decreasing the non-adhesive forms of cadherin at the cell surface. The invention also relates to a method step of determining the expression level of furin and proprotein convertase 5A (PC5A). | 12-09-2010 |
| 20100249184 | INDUCTION AND/OR MAINTENANCE OF TUMOR DORMANCY BY DISRUPTION OF UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR-INTEGRIN INTERACTION - The present invention relates to a method of inducing cancer cells into dormancy and treating cancer in a subject. This method involves administering to a subject an effective amount of a compound that disrupts interaction between urokinase plasminogen activator receptor and integrin, thereby including cancer cells into dormancy and treating cancer in the subject. Also disclosed is a method of disrupting interaction between integrin and urokinase plasminogen activator receptor on cancer cells. The present invention also relates to a method of screening for compounds effective in inducing tumor dormancy and treating cancer in a subject. | 09-30-2010 |
| 20100077491 | Modulators of RNF5 and Uses Thereof - Provided herein are compositions and methods relating to the involvement of RNF5 in muscle wasting. | 03-25-2010 |
| 20090220515 | TREATMENT AND PREVENTION OF RENAL DISEASE - The present invention is directed to a method of treating or preventing renal disease in a subject. This method involves administering the subject an agent which inhibits FAT10 expression in the subject under conditions effective to prevent or treat renal disease. Also disclosed is a method of screening for agents effective in treating or preventing renal disease. | 09-03-2009 |
| 20090209482 | AZACYTIDINE ANALOGUES AND USES THEREOF - The present invention is directed toward compounds of Formula (I) as follows: | 08-20-2009 |
| 20090209477 | AZACYTIDINE ANALOGUES AND USES THEREOF - The present invention is directed toward compounds of Formula (I) as follows: | 08-20-2009 |
| 20080311133 | METHODS OF USING MULTIVALENT MHC CLASS II-PEPTIDE CHIMERAS - The present invention provides a multimeric complex of at least two chimeric molecules, wherein the chimeric molecules comprise an immunoglobulin constant region element and two MHC elements wherein each MHC element is associated with a peptide, and wherein the chimeric molecules are covalently linked through a carbohydrate residue of the immunoglobulin constant region element by a polyalkylene glycol linker. Methods of making and using the multimeric complexes are also provided. | 12-18-2008 |
| 20080249082 | Use of Memantine (Namenda) to Treat Autism, Compulsivity and Impulsivity - The present invention relates to the treatment of compulsive, impulsive and pervasive developmental disorders. More particularly, the methods described herein comprise administration of memantine to an individual suffering from such a disorder in an amount effective to relieve one or more symptoms of said disorder. In particularly preferred aspects, the invention is directed to the use of memantine for the treatment of autism | 10-09-2008 |
| 20080199450 | ACID CERAMIDASE AND CELL SURVIVAL - The present invention relates to methods of promoting the survival of cells by treating the cells with acid ceramidase. A kit for promoting ex vivo cell survival is also disclosed, as is a method of predicting in vitro fertilization outcome of a female subject. | 08-21-2008 |
