| Monash University Patent applications |
| Patent application number | Title | Published |
|---|
| 20120058500 | PLATELET AGGREGATION USING A MICROFLUIDICS DEVICE - A microfluidics device to provide real time monitoring of platelet aggregation of a biological sample obtained from a subject. The device comprises a channel configured for passage of the biological sample, the channel comprising a protrusion configured to induce an upstream region of shear acceleration coupled to a downstream region of shear deceleration and defining there-between a region of peak rate of shear, the downstream region of shear deceleration defining a zone of platelet aggregation. The device further comprises a platelet detection means for detecting aggregation of platelets in the zone of aggregation as a result of passage of the biological sample through the channel. Methods to assess real time platelet aggregation of a biological sample obtained from a subject are further described. | 03-08-2012 |
| 20120046244 | DUAL FUNCTIONING IONIC LIQUIDS AND SALTS THEREOF - Disclosed herein are ionic liquid compositions comprising active pharmaceutical, biological, and nutritional compounds, and methods of use. Further disclosed are compositions of matter including liquid ion pairs alone or in solution and their use; compositions of ionic liquids that are ‘solvated,’ for example, ‘hydrated’ and their uses. | 02-23-2012 |
| 20120009662 | METHOD OF FABRICATING MICROFLUIDIC SYSTEMS - A method of fabricating a microfluidic system having microfluidic channels on a surface of a hydrophilic substrate, the method including the steps of: hydrophobizing the substrate surface; locating a mask defining the substrate surface, the mask having open areas defining the periphery of the microfluidic channels; and applying an irradiation treatment to areas of the substrate surface exposed by the open areas of the mask, said exposed areas becoming hydrophilic to therefore form said microfluidic channels. | 01-12-2012 |
| 20110303271 | PHOTOVOLTAIC DEVICES - A photovoltaic device including cathode and anode electrodes ( | 12-15-2011 |
| 20110230571 | DIAGNOSTIC AND THERAPEUTIC PROTOCOLS - The present invention relates to methods for determining co-receptor usage of an HIV in a subject including the steps of: culturing a viral preparation derived from the subject's plasma with one or more cell lines which express surface CD4 and CCR5, surface CD4 and CXCR4, or surface CD4, CCR5 and CXCR4, wherein an anticoagulant is added to the viral preparation or to the culture; and screening for infection, wherein the presence or absence of infected cells is indicative of the co-receptors used by the HIV. | 09-22-2011 |
| 20110194120 | METHOD AND DEVICE FOR PHASE MEASUREMENT - The present invention relates to the field of phase measurement, particularly optical phase measurement. In one form, the invention relates to a method and device for measuring the phase between distinct signals by converting phase variations between the signals into amplitude variations. In one embodiment the invention provides a method of arranging the structure of a two-dimensional or three-dimensional crystal to measure the phase between signals, comprising the steps of (i) providing a respective waveguide for each signal and (ii) providing a micro-cavity array arranged to provide a resonance output in response to the phase of the signals. The invention has application to a wide range of apparatus and devices across many industries including communications, food technology, pharmacology, medicine and biology. | 08-11-2011 |
| 20110190270 | METHODS OF TREATING THROMBOEMBOLIC DISORDERS - The field of the invention relates to methods for dissolving a thrombus using inhibitors of platelet contractility. More particularly, the present invention relates to the use of an inhibitor of platelet contractility in combination with one or more thrombolytic agents and optionally one or more anticoagulants for inhibiting platelet contraction and consolidation in the developing thrombus. | 08-04-2011 |
| 20110148253 | PIEZOELECTRIC ACTUATOR FOR USE IN MICRO ENGINEERING APPLICATIONS - A piezoelectric actuator including a piezoelectric element and an elongate transducer mounted on the piezoelectric element. The transducer is formed from an elongate cylindrical member, and at least one helical slot is provided around the outer surface of the cylindrical member to enable coupling of resonance modes of the transducer when actuated by the piezoelectric element. | 06-23-2011 |
| 20110142790 | Polyol Based - Bioceramic Composites - Polyol-bioceramic composites are prepared by the reaction of a polyol and polycarboxylic acid in the presence of a bioceramic. Implantable medical devices fabricated at least in part with the crosslinked polyol-bioceramic composite materials are useful in a wide variety of applications. | 06-16-2011 |
| 20110117454 | ELECTRODE FOR ELECTROCHEMICAL CELLS - The invention relates to an electrode for oxygen reduction comprising a porous organic material and at least one inherently conducting polymer such as a charge transfer complex or a conductive polymer, optionally combined with a non-conducting polymer. A current conductor may be located intermediate the porous organic material and the inherently conductive polymer. The electrode is suitable for use with an ion-conducting membrane and fuel such as hydrogen, an alcohol or borohydride to form a fuel-cell. The electrode is also suitable for use with an anode, such as a reactive metal and an electrolyte to form a battery. | 05-19-2011 |
| 20110110933 | ECTOPIC PREGNANCY TREATMENT - The invention pertains to methods for treating ectopic pregnancy. More particularly, the present invention relates to methods for treating unruptured ectopic pregnancy using a non-surgical method comprising the administration of an EGFR inhibitor alone or in combination with an anti-metabolite e.g. methotrexate (MTX). The methodology is potentially applicable to treatment of unruptured ectopic pregnancies of all sizes. | 05-12-2011 |
| 20110086911 | NOVEL BISMUTH(III) NSAID COMPOUNDS AND METHODS FOR THEIR USE - The present invention relates to the field of non-specific anti inflammatory drugs (NSAIDs). In particular, the invention relates to bismuth(III) tris-carboxylate complexes having the formula [Bi(III)L | 04-14-2011 |
| 20110042225 | ELECTROCHEMICAL NANOCOMPOSITE BIOSENSOR SYSTEM - The present invention relates to an electrode useful in electrochemical nanobiosensors for determining the presence or concentration of analytes in aqueous samples. In particular, the electrode comprises a biocatalyst or other bioreceptor entrapped in a conducting polymeric film deposited on a conducting material and a non-conducting or conducting coating. In particular embodiments, the conducting polymeric layer also comprises metallic nanoparticles. Electrochemical nanobiosensors containing the electrode, methods of making the electrode or sensor and methods of detecting analytes are other aspects of the invention. | 02-24-2011 |
| 20110039915 | IMMUNOSTIMULATORY siRNA MOLECULES - The present invention relates to a double-stranded siRNA molecule that is capable of silencing gene expression as well as inducing an immune response. The molecule comprises a sense strand and an antisense strand, wherein the antisense strand comprises a first nucleotide sequence that is specifically complementary to mRNA transcribed from a target gene, and the sense strand comprises a second nucleotide sequence that is substantially or perfectly complementary to the antisense strand with the exception that the second nucleotide sequence comprises at least one immunostimulatory motif comprising two or more non-complementary nucleotides. Such a molecule may be utilized in a method of treating or preventing a disease or condition (such as a viral infection, a bacterial infection, or cancer) in a subject. | 02-17-2011 |
| 20100331521 | Controlled Polymerisation Process - The present invention relates to a controlled metathesis-driven polymerisation process which is particularly useful for the synthesis of biological polymers such as peptides and polymers. The invention also provides metathesisable supports, groups and linkers for use in the process. | 12-30-2010 |
| 20100276955 | TREATMENT OF RAILWAY WHEELS - A method of treating a steel railway wheels to form a required distribution of compressive residual stress in the rim. In general terms the wheel heated and then quenched from the plate towards the rim. The wheel is first heated to form austenite throughout the plate and rim portions. The wheel is then cooled to form bainite/martensite in the plate portion. The wheel is cooled to form bainite/martensite in an inner portion of the rim. The wheel is cooled to form bainite/martensite in an outer portion of the rim. | 11-04-2010 |
| 20100274554 | SPEECH ANALYSIS SYSTEM - A speech analysis system, including a kurtosis module for processing a coded sound signal to generate kurtosis measure data; a wavelet module for processing the coded sound signal to generate wavelet coefficients; and a classification module for processing the wavelet coefficients and the kurtosis measure data to generate label data representing a classification for the coded sound signal. The sound signal is classified as environmental noise, silence, speech from a single speaker, speech from multiple speakers, speech from a single speaker plus environmental noise, or speech from multiple speakers plus environmental noise. Speech is further classified as voiced or unvoiced. | 10-28-2010 |
| 20100266552 | TREATMENT OF CHRONIC LUNG DISEASE - A method of cellular therapy for a lung disease or condition in a subject is disclosed, wherein the method involves the administration of multipotent epithelial stem cells derived from amnion tissue (AECs). In a particular application, the method is used for the treatment of lung diseases and conditions such as chronic lung diseases including chronic obstructive pulmonary disease (COPD), acute lung conditions such as acute respiratory distress syndrome (ARDS), and ventilator associated lung injury (VALI). | 10-21-2010 |
| 20100261978 | NEURAL RESPONSE SYSTEM - A neural response system, including a plurality of filters for each receiving and filtering a plurality of tilt response signals obtained from a person; a segmenter for segmenting the filtered response signals into time segments; and a neural event extractor for performing a neural event extraction process on each of the time segments to obtain and generate biomarker data representing a plurality of biomarkers for each segment. | 10-14-2010 |
| 20100221746 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE - The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one activin antagonist, and optionally a pharmaceutically acceptable carrier, adjuvant and/or diluent. The invention also relates to methods of treatment of disease associated with fibrosis in a vertebrate, as well as methods for diagnosing such conditions, and kits therefor. | 09-02-2010 |
| 20100201228 | METHOD OF COATING - The present invention provides a method of depositing a metallic layer on to a surface of a piezoelectric substrate, which method comprises the application of cold spraying to deposit the metallic layer or layers. | 08-12-2010 |
| 20100191665 | SERVICE VALUE CALCULATION METHOD, SYSTEM, AND PROGRAM - A service value calculation system includes: crisis problem inspection means which detects a crisis or a problem of a service object; and virtual damage amount calculation means which calculates a virtual damage amount generated if a detected crisis or problem is not solved when a service is not applied and calculates the service value. | 07-29-2010 |
| 20100068214 | Identification of Candidate Vaccine Antigens from Dichelobacter Nodosus - This invention relates to a prophylactic and/or therapeutic treatment of footrot, and in particular to a vaccine effective in prophylactic and/or therapeutic treatment of footrot. Specific polypeptides of | 03-18-2010 |
| 20100063788 | METHOD OF MODELLING THE INTERACTION BETWEEN DEFORMABLE OBJECTS - The present invention provides methods for determining a collision between a first deformable object and a second deformable object in a virtual reality simulation, the method including the steps of providing a first test capable of determining the proximity of the first object to the second object, providing a second test capable of determining the proximity of the first object to the second object, wherein the second test is more comprehensive than the first test, and wherein the second test is capable of being implemented once the first test returns a positive result. Since the more comprehensive test is implemented only when a collision is likely or imminent (as determined by the first test), the processor executing the simulation is not unduly burdened, and can devote resources to other tasks required by the simulation program. | 03-11-2010 |
| 20100036089 | Methods for the Synthesis of Dicarba Bridges in Organic Compounds - The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis. | 02-11-2010 |
| 20100022749 | Contoxin Analogues and Methods for Synthesizing Same - According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides. | 01-28-2010 |
| 20090220239 | METHODS AND APPARATUS FOR OPTICAL TRANSMISSION OF DIGITAL SIGNALS - A method of communicating digital information over a dispersive optical channel includes encoding the digital information into a plurality of data blocks, each of which includes a number of bits of the information. A time-varying electrical signal is generated which corresponds with each of said data blocks. The time-varying electrical signal is applied to an optical transmitter ( | 09-03-2009 |
| 20090206171 | CONCENTRATION AND DISPERSION OF SMALL PARTICLES IN SMALL FLUID VOLUMES USING ACOUSTIC ENERGY - A method of manipulating particles suspended within a fluid droplet using a microfluidic system including a piezo-electric substrate ( | 08-20-2009 |
| 20090169213 | METHODS AND APPARATUS FOR OPTICAL TRANSMISSION OF DIGITAL SIGNALS | 07-02-2009 |
| 20090076742 | ESTIMATION OF WHEEL RAIL INTERACTION FORCES - A method of estimating contact forces between the wheels of a railway wagon and a rail track, for use in determining information such as the likelihood of derailment. Accelerations of the body of the wagon are measured using motion sensors located at suitable points on the body. Forces on the side frames of the wagon are calculated based on the accelerations of the body and predetermined parameters of the body. Forces on the wheels of the wagon are calculated based on the accelerations of the body and predetermined parameters of the body. The contact forces between the wheels and the rails are then calculated based on the forces calculated for the side frames and the wheels. The calculations are carried out using an inverse model of the wagon system. Equipment which implements the method is also described. | 03-19-2009 |
| 20080317763 | Regulation of Metalloprotease Cleavage of Cell Surface Proteins - Elucidation of the crystal structure of an ADAM10 substrate-recognition and proteinase-positioning module comprising the protein cysteine-rich and disintegrin domains, and detailed functional analysis revealed that an acidic pocket within the cysteine-rich domain forms a substrate-recognition site. The binding of this pocket to receptor/ligand complexes facilitates effective ligand cleavage, which is prevented when critical residues within the pocket are changed. This provides use of the surface pocket within the extracellular domain of ADAM10, and the corresponding structure in related proteases such as ADAM17, as a target for structure-based computational and high-throughput screens for small-molecule substrate-specific inhibitors or monoclonal antibodies that inhibit ADAM protease cleavage of ephrins and other ADAM10 or ADAM17 substrates. These inhibitors will be useful in therapeutic intervention of tumour development, invasion and metastasis and other diseases which involve the activity of the ADAM10 and ADAM17 proteases, such as inflammation, cardio-vascular disease, arthritis and other auto-immune diseases. | 12-25-2008 |
| 20080293917 | Peptide Purification By Means Of Metal Ion Affinity Chromatography - A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S. | 11-27-2008 |
| 20080286272 | EphA3 Antibodies for the Treatment of Solid Tumors - The invention provides methods and compositions comprising anti-EphA3 antibodies for the treatment of solid tumors. | 11-20-2008 |
| 20080279812 | Disease Prevention and Vaccination Prior to Thymic Reactivation - The present disclosure provides methods for preventing or treating illness, improving responsiveness to immunization, and improving the efficacy of gene therapy in a patient by disrupting sex steroid signalling in the patient, wherein the bone marrow and other immune cell functionality is improved without, prior to, or concurrently with, thymic regeneration. In some embodiments, sex steroid signalling is interrupted or ablated in the patient by the administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines, anti-androgens, anti-estrogens, selective estrogen receptor modulators (SERMs), selective androgen receptor modulators (SARMs), selective progesterone response modulators (SPRMs), ERDs, aromatase inhibitors, or various combinations thereof. | 11-13-2008 |
| 20080199495 | Stimulation of thymus for vaccination development - The present disclosure provides methods for enhancing the response of a patient's immune system to vaccination. This is accomplished by reactivating the thymus. Optionally, hematopoietic stem cells, autologous, syngeneic, allogeneic or xenogeneic, are delivered to increase the speed of regeneration of the patient's immune system. In one embodiment the hematopoietic stem cells are CD34 | 08-21-2008 |
