| MICROMASS UK LIMITED Patent applications |
| Patent application number | Title | Published |
|---|
| 20120136586 | Acquisition Method and Apparatus for Mass Spectrometer Data - A method and apparatus for acquiring data from a mass spectrometer and its transmission to a computer system including a data acquisition engine, a network interface and a throughput optimization module which includes a ring buffer and a protocol stack. A compression engine may be provided between the acquisition engine and the ring buffer. The ring buffer is configured as a number of segments containing portions of memory matching the size of data words from the acquisition engine. When a segment is full of data corresponding to the words, or is partially full and has received data containing an end of scan marker, the number of words in the segment is written into a header word in the segment and the data in that segment are moved to the protocol stack. Subsequent data is received by the next segment in the buffer. | 05-31-2012 |
| 20120130700 | METHOD AND SYSTEM OF ESTIMATING THE CROSS-SECTIONAL AREA OF A MOLECULE FOR USE IN THE PREDICTION OF ION MOBILITY - A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterisation of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs. | 05-24-2012 |
| 20120126110 | Method of Processing Mass Spectral Data - A method of processing mass spectral data is disclosed comprising digitizing a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time T | 05-24-2012 |
| 20120126108 | Dual Source Mass Spectrometry System - A dual source mass spectrometer system ( | 05-24-2012 |
| 20120122077 | Method to Detect and Sequence Post Translationally Modified Peptides - A method of detecting and sequencing post translationally modified peptides is disclosed wherein a negative ion precursor scan is performed. A negative ion high resolution MS scan is then performed and then MRM channels in positive ion mode are determined and monitored. A positive ion MS/MS scan is then performed. | 05-17-2012 |
| 20120119078 | Ion Population Control Device For A Mass Spectrometer - A mass spectrometer is disclosed wherein an ion beam attenuator is arranged upstream of an ion trap mass analyser. An ion tunnel ion trap comprising an upstream ion accumulation section and a downstream ion accumulation section is arranged upstream of the ion beam attenuator. Ions are released from the ion tunnel ion trap and the intensity of the ion beam which is transmitted to the ion trap analyser is controlled by the ion beam attenuator. The fill time during which ions are admitted into the ion trap mass analyser remains substantially constant and is substantially independent of the intensity of the ion beam. | 05-17-2012 |
| 20120116690 | METHOD AND SYSTEM OF ESTIMATING THE CROSS-SECTIONAL AREA OF A MOLECULE FOR USE IN THE PREDICTION OF ION MOBILITY - A method of estimating the cross-sectional area of a molecule for use in the prediction of ion mobility gives gas phase interaction radii determination and cross-sectional algorithm computation to provide separation and characterisation of structurally related isomers. More specifically, the invention provides a method of correlating the differences in the molecular structures with differences in anti-cancer activity of pre-determined anti-cancer drugs by utilizing a new algorithm for estimating the cross-sectional area of the molecules of such drugs. | 05-10-2012 |
| 20120112055 | Mass Spectrometer - A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound. | 05-10-2012 |
| 20120104246 | Dual Source Mass Spectrometry System - In or for a dual source mass spectrometer system ( | 05-03-2012 |
| 20120097844 | Dual Source Mass Spectrometry System - In or for a dual source mass spectrometry system ( | 04-26-2012 |
| 20120085901 | Time Of Flight Acquisition System - A Time of Flight Acquisition system is disclosed wherein a digitiser ( | 04-12-2012 |
| 20120056084 | Apparatus Comprising an Ion Mobility Spectrometer - A mass spectrometer is disclosed comprising a first chamber and a second chamber. The second chamber is located downstream of the first chamber and an inter-chamber aperture is provided between the two chambers. An ion guide is located in the first chamber and an ion mobility spectrometer is located in the second chamber. Helium gas is provided to the first chamber. As ions are accelerated towards the ion mobility spectrometer from a relatively low pressure region they pass initially into the first chamber. The helium gas provided in the first chamber minimises ion fragmentation and ion discrimination effects as ions are accelerated into a relatively high pressure region. The ions are then transmitted by the ion guide and are subsequently transmitted to the ion mobility spectrometer located in the second chamber. | 03-08-2012 |
| 20120032074 | Mass Spectrometer Arranged To Perform MS/MS/MS - A mass spectrometer is disclosed comprising an ion trap and a fragmentation device. Ions are fragmented in the ion trap to form first generation fragment ions. The ion trap has a relatively high mass cut-off. The first generation fragment ions are then transferred to a fragmentation device which is arranged to have a substantially lower low mass cut-off. The first generation fragment ions are fragmented within the fragmentation device any may optionally be stored in an ion accumulation region prior to being passed to a mass analyser for subsequent mass analysis. | 02-09-2012 |
| 20120018631 | ION-MOBILITY ANALYSER - An ion-mobility analyser is disclosed comprising a plurality of axially segmented upper electrodes | 01-26-2012 |
| 20110303838 | Method Of Avoiding Space Charge Saturation Effects In An Ion Trap - A mass spectrometer is provided comprising a first ion trap ( | 12-15-2011 |
| 20110291001 | Ion Mobility Spectrometer - An ion mobility spectrometer is disclosed wherein ions are passed through an ion mobility spectrometer ( | 12-01-2011 |
| 20110284734 | Ion Mobility Spectrometer - An ion mobility spectrometer ( | 11-24-2011 |
| 20110266435 | Ion Guide Array - An ion guide array is disclosed comprising a first ion guide section ( | 11-03-2011 |
| 20110233396 | Mass Spectrometer - A mass analyser | 09-29-2011 |
| 20110215237 | Mass Analysis Using Alternating Fragmentation Modes - A method for the analysis of mixtures of components includes separating or partially separating different components of a mixture of a sample by means that causes the components to elute sequentially over a period of time, forming precursor ions from the components in the eluent, repeatedly switching, altering or varying an Electron Capture Dissociation fragmentation device back and forth between a hi-fragmentation mode and a low-fragmentation mode to alternately produce product ions from the precursor ions in the hi-fragmentation mode and to produce substantially fewer product ions in the low-fragmentation mode, and obtaining mass spectra during the period of time from the precursor and product ions received from the Electron Capture Dissociation fragmentation device. | 09-08-2011 |
| 20110210242 | Ion Source with Device for Oxidising a Sample - An ion source is disclosed wherein a sample is introduced into the sample chamber ( | 09-01-2011 |
| 20110189788 | Glow Discharge Ion Source - A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode ( | 08-04-2011 |
| 20110180706 | Atmospheric Pressure Solids Analysis Probe Assembly - An atmospheric pressure ion source probe assembly ( | 07-28-2011 |
| 20110180704 | Mass Spectrometer - An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio. | 07-28-2011 |
| 20110168882 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion guide ( | 07-14-2011 |
| 20110127416 | Mass Spectrometer - A mass spectrometer is disclosed comprising a sampling cone ( | 06-02-2011 |
| 20110114835 | Method Of Charge Reduction Of Electron Transfer Dissociation Product Ions - A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell | 05-19-2011 |
| 20110095176 | Mass Spectrometer - A method of searching for potentially unknown metabolites of pharmaceutical compounds is disclosed. The accurate mass of a pharmaceutical compound will generally be known and can be rendered in the form of an integer nominal mass or mass to charge ratio component and a decimal mass or mass to charge ratio component. Possible metabolites are searched for on the basis of having a decimal mass or mass to charge ratio component which is substantially very similar to the decimal mass or mass to charge ratio of the parent pharmaceutical compound. | 04-28-2011 |
| 20110095175 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a FAIMS device comprising two parallel electrodes ( | 04-28-2011 |
| 20110062323 | Electron Transfer Dissociation Device - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process. | 03-17-2011 |
| 20110057097 | Mass Spectrometer - A mass spectrometer is disclosed comprising a 2D or 3D ion trap. The 2D ion trap comprises a quadrupole rod set ion trap wherein a slot is provided in each of the rods | 03-10-2011 |
| 20110049358 | Linear Ion Trap - A linear ion trap ( | 03-03-2011 |
| 20110049357 | ION GUIDING DEVICE - An ion guiding device is disclosed comprising a first ion guide ( | 03-03-2011 |
| 20110049353 | Mass Spectrometer - A mass spectrometer is disclosed wherein a signal output from an ion detector is digitised using an Analogue to Digital Converter. A background or baseline level is dynamically subtracted from the digitised signal whilst the time of flight data is still being acquired. A threshold is also applied dynamically to the digitised signal in order to reduce electronic noise. | 03-03-2011 |
| 20110042565 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator | 02-24-2011 |
| 20110042563 | Mass Spectrometer | 02-24-2011 |
| 20110024618 | Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). A transient DC voltage wave is applied to the electrodes (2) in order to load reagent anions into the ion guide (2). Analyte cations are then subsequently transmitted through the ion-ion reaction cell by a subsequent transient DC voltage wave. Ion are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of a transient DC voltage wave. | 02-03-2011 |
| 20110024616 | Gas Electron Multiplier Detector - A mass spectrometer is disclosed comprising a Gas Electron Multiplier ion detector. The ion detector comprises three gas electron multiplier stages GEM | 02-03-2011 |
| 20100327157 | Mass Spectrometer - A mass spectrometer is disclosed comprising a time of flight mass analyser ( | 12-30-2010 |
| 20100301952 | Method For The Production Of High Amplitude RF Voltages With Control Of The Phase Angle Between Outputs - A method of producing high frequency high amplitude AC voltages with control of the phase angle between outputs from a plurality of generators having individual DC current controlled variable inductors which method comprises controlling the timing of the circuit to allow inputs at the same frequency to have their phase angle preserved. All the outputs are phase locked and synchronised to a common external timed signal and programmed to the same output frequency. | 12-02-2010 |
| 20100301208 | Mass Spectrometer - A fault detection system for protecting a mass spectrometer from the effects of temperature extremes. The system comprises an ion block, a thermal source for providing thermal energy to the ion source block, a temperature sensor providing a reading for the temperature of the ion source block, a temperature regulation means for controlling the thermal source in dependence of the reading and a control system for monitoring the temperature change produced by the energy source. | 12-02-2010 |
| 20100301207 | Mass Spectrometer - A detachable and replaceable ion source for a mass spectrometer. The ion source comprises a housing which defines an ion source chamber, an ion source mounting means complementary to mounting means on the mass spectrometer to detachably couple with the mass spectrometer. This allows movement of the housing to bring the ion source chamber into a position of use at the inlet of said mass spectrometer and to take the ion source chamber from said position of use into a retracted position. Sealing means is provided to create an air tight seal between the housing and the mass spectrometer when the ion source chamber is in its position of use. A release mechanism is provided which cooperates with the mass spectrometer to allow the said movement of said housing. | 12-02-2010 |
| 20100301206 | Mass Spectrometer - An ion-ion reaction cell is provided comprising a plurality of electrodes ( | 12-02-2010 |
| 20100301201 | Mass Spectrometer And Method Of Mass Spectrometry - The invention relates to a method of derivina improved data from a mass spectrometer. The method includes operating the mass spectrometer in a mode enabling quantitation; assigning a threshold value for the total ion current (TIC) above which at least MS and/or MSMS data is desired; and triggering the mass spectrometer out of the mode enabling quantitation into at least an MS and/or MSMS mode when said TIC rises above the threshold but triggering only at such time at or after a confirmed TIC maxima has been reached. | 12-02-2010 |
| 20100301200 | Mass Spectrometer - An ion source, a mass spectrometer and a method of enhancing the performance of an ion source for use with a mass spectrometer. The ion source has a housing incorporating an ion source enclosure defining a chamber and an outer cover remote from the chamber. A fluid flow passageway is provided between the ion source enclosure and the outer cover. The method of the invention comprising supplying to the ion source housing a regulated flow of fluid through the fluid passageways so as to maintain the ion source enclosure within a predetermined temperature range of substantially between 60° c. and 80° c. and preferably at 70° c. | 12-02-2010 |
| 20100294923 | MASS SPECTROMETER - A collision or fragmentation cell ( | 11-25-2010 |
| 20100252730 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion trap ( | 10-07-2010 |
| 20100237237 | TANDEM ION TRAPPING ARRANGEMENT - A mass spectrometer is disclosed comprising a first storage ion trap ( | 09-23-2010 |
| 20100213361 | Mass Spectrometer - A mass spectrometer is disclosed wherein an ion signal is split into a first and second signal. The first and second signals are multiplied by different gains and are digitised. Arrival time and intensity pairs are calculated for both digitised signals and the resulting time and intensity pairs are combined to form a high dynamic range spectrum. The spectrum is then combined with other corresponding spectra to form a summed spectrum. | 08-26-2010 |
| 20100171055 | Liquid-Chromatography Apparatus Having Diffusion-Bonded Titanium Components - An HPLC apparatus includes a heat exchanger formed from diffusion-bonded first and second titanium substrates. At least two conduits for counterflow are defined between the first and second substrates. | 07-08-2010 |
| 20100148056 | Mass Spectrometer - A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap ( | 06-17-2010 |
| 20100108879 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion mobility spectrometer ( | 05-06-2010 |
| 20100108878 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first quadrupole rod set mass filter ( | 05-06-2010 |
| 20100096543 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed wherein the time period between successive orthogonal acceleration pulses is less than the time of flight of ions having the maximum mass to charge ratio of interest. As a result, some ions are subject to wrap-around and will appear in a subsequent mass spectrum. Mass spectra obtained at two different sampling rates may be compared and mass peaks relating to ions which have and have not been subject to wrap-around may be identified. | 04-22-2010 |
| 20100084547 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device. Broadband frequency-signals ( | 04-08-2010 |
| 20100072360 | Mass Spectrometer - A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell ( | 03-25-2010 |
| 20100065737 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a mass selective ion trap or mass analyser ( | 03-18-2010 |
| 20100065733 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator ( | 03-18-2010 |
| 20100044561 | APPARATUS COMPRISING AN ION MOBILITY SPECTROMETER - A mass spectrometer is disclosed comprising a first chamber ( | 02-25-2010 |
| 20100038530 | Mass Spectrometer - An ion guide or ion trap ( | 02-18-2010 |
| 20100032561 | Mass Spectrometer - A mass spectrometer is disclosed comprising a device ( | 02-11-2010 |
| 20100001180 | MASS SPECTROMETER - A Time of Flight mass analyser is disclosed comprising an ion detector comprising an Analogue to Digital Converter. Output signals from the ion detector are digitised and the arrival times and intensity values relating to ion arrival events are determined. If the determined arrival times from two signals fall within the same time window then the arrival times are added together in a weighted manner and the intensity values are combined. | 01-07-2010 |
| 20090321628 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a Time of Flight mass analyser comprising an ion detector comprising an Analogue to Digital Converter. Signals from the Analogue to Digital Converter are digitised and the arrival time and intensity of ions are determined. The arrival time T | 12-31-2009 |
| 20090314935 | Mass Spectrometer - A mass analyser ( | 12-24-2009 |
| 20090314934 | MASS SPECTROMETER - A multi-turn Time of Plight mass analyser is disclosed comprising a first electric sector ( | 12-24-2009 |
| 20090302210 | MASS SPECTROMETER - A mass spectrometer comprising a collision, fragmentation or reaction cell ( | 12-10-2009 |
| 20090302209 | MASS SPECTROMETER - An ion guide or mass analyser ( | 12-10-2009 |
| 20090294642 | Mass Spectrometer - A mass spectrometer is disclosed comprising a MALDI ion source coupled to an orthogonal acceleration Time of Flight mass analyser ( | 12-03-2009 |
| 20090272891 | Mass Spectrometer - A mass spectrometer is disclosed comprising an ion guide. The ion guide comprises a hollow tubular conductor ( | 11-05-2009 |
| 20090242749 | MASS SPECTROMETER - An Electrospray ionisation ion source is disclosed comprising a capillary tube ( | 10-01-2009 |
| 20090218487 | MASS-SPECTROMETER INTERFACE HOUSING - An apparatus for performing chemical analyses includes a mass spectrometry module and an interface module that processes sample materials for delivery to the mass spectrometry module. The interface module includes a vessel having an opening to access a vessel chamber, a door to block the opening, a sealing member disposed between the door and the vessel, and an interlock. The interlock is actuated by the sealing member if the door is in the closed position and the sealing member is properly disposed between the door and the vessel to seal the vessel. The sealing member alternatively includes an indicator portion that is visible to an operator if the door is in the closed position and the sealing member is properly disposed. | 09-03-2009 |
| 20090194688 | Mass Spectrometer - A mass spectrometer is disclosed comprising a quadrupole rod set ion guide or mass filter device ( | 08-06-2009 |
| 20090173880 | Mass Spectrometer - An ion guide ( | 07-09-2009 |
| 20090173877 | Mass Spectrometer - A mass spectrometer is disclosed comprising a first ion trap or ion guide ( | 07-09-2009 |
| 20090166525 | Mass Spectrometer - A method of chemical separation includes dispensing a sample from a sample pumping system, pumping a solvent from a solvent gradient pumping system to elute the dispensed sample through a separation column, identifying an analyte of interest in the eluting sample, and pumping a solvent from the sample pumping system for peak parking of the analyte in the separation column. | 07-02-2009 |
| 20090134321 | MASS SPECTROMETER - A mass spectrometer is disclosed comprising a mass selective ion trap ( | 05-28-2009 |
| 20090121123 | Mass Spectrometer - An ion guide or ion trap ( | 05-14-2009 |
| 20090114810 | MASS SPECTROMETER - An ion trap mass analyser ( | 05-07-2009 |
| 20090114808 | Mass spectrometer - A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output. | 05-07-2009 |
| 20090072136 | Mass Spectrometer - A mass analyser ( | 03-19-2009 |
| 20090057547 | MASS SPECTROMETER - A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Q | 03-05-2009 |
| 20090057546 | MASS SPECTROMETER | 03-05-2009 |
| 20090039245 | Mass Spectrometer - A Matrix Assisted Laser Desorption Ionisation ion source or ion imaging device is disclosed comprising a laser ( | 02-12-2009 |
| 20090014641 | Mass Spectrometer - A closed-loop ion guide ( | 01-15-2009 |
| 20090014639 | Mass Spectrometer - A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source ( | 01-15-2009 |
| 20090014637 | Mass Spectrometer - An ion guide or ion trap | 01-15-2009 |
| 20080318213 | Mass Spectrometer - A mass spectrometer and a method of spectrometry are disclosed wherein liquid chromatography mass spectral data are probabilistically clustered on the basis of mass to charge ratio and retention time. | 12-25-2008 |
| 20080302958 | Mass Spectrometer - An ion trap mass analyser ( | 12-11-2008 |
| 20080286764 | Method of mass spectrometry - A method of identifying molecules of biological origin is disclosed. The molecules are identified and the basis of the accurately determined mass to charge ratio of the molecules and at least a further physico-chemical property such as elution time or charge state. Further physico-chemical properties may be used. The experimentally determined accurate mass and physico-chemical properties can then be compared with a look-up table of information. The look-up table may generated or physico-chemical properties of data in a conventional database may be calculated. The ability to recognise and preferably identify the same molecules in two different samples may be used to determine whether a particular biological molecules has been expressed differently in an experimental sample relative to a control sample. | 11-20-2008 |
| 20080265152 | Mass Spectrometer - A mass spectrometer is disclosed comprising a High Pressure Liquid Chromatography system ( | 10-30-2008 |
