Merck Patent applications |
Patent application number | Title | Published |
20140349968 | Compositions and Methods for Treating Cancer - The instant invention provides a method of treating a cancer selected from the group consisting of non-small cell lung cancer and breast cancer with an mTOR inhibitor and an αv62 3 integrin antagonist, wherein the mTOR inhibitor is ridaforolimus, everolimus, temsirolimus or a combination thereof. | 11-27-2014 |
20140187751 | PURIFICATION OF FUSION PROTEINS - The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing TNFR:Fc for human administration which comprises an optimized Protein A affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode. | 07-03-2014 |
20130302825 | USES OF MACROPHAGE MANNOSE RECEPTOR TO SCREEN COMPOUNDS AND USES OF THESE COMPOUNDS - Methods and associated compositions of matter (e.g., kits, cell lines, etc.) for screening compounds that bind to macrophase mannose receptor (MMR). Compounds identified by these methods and drug conjugates that includes these compounds are also encompassed as are their uses in the manufacture of medicaments. | 11-14-2013 |
20130228767 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES - The present invention relates to a mixture comprising a) a polymer which contains at least one L=X structural unit, b) a triplet emitter compound and c) a carbazole compound or a soluble neutral molecule. The invention furthermore relates to organic electroluminescent devices which contain the mixture according to the invention. | 09-05-2013 |
20120231497 | SELECTIVE ENZYMATIC HYDROLYSIS OF C-TERMINAL TERT-BUTYL ESTERS OF PEPTIDES - The present invention relates to a process for the selective enzymatic hydrolysis of C-terminal esters of peptide substrates in the synthesis of peptides, comprising hydrolysing C-terminal tert-butyl esters using the protease subtilisin. This process is useful in the production of protected or unprotected peptides. | 09-13-2012 |
20120213728 | GRANULOCYTE-COLONY STIMULATING FACTOR PRODUCED IN GLYCOENGINEERED PICHIA PASTORIS - Compositions comprising granulocyte-colony stimulating factor (GCSF) produced in a strain of | 08-23-2012 |
20120201835 | ANTIBODIES SPECIFIC FOR DKK-1 - Antibodies specific for Dkk-1, an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway, are described. The antibodies, which inhibit binding of Dkk-1 to LRP5, are useful in compositions for stimulating bone growth, in particular, compositions for treating bone disorders which result in a loss in bone, for example, osteoporosis. | 08-09-2012 |
20100261741 | Quinazolinone T-Type Calcium Channel Antagonists - The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved. | 10-14-2010 |