| MedTrain Technologies, LLC Patent applications |
| Patent application number | Title | Published |
|---|
| 20100041128 | Microfluidic Device for Application of Shear Stress and Tensile Strain - The present invention provides a cell culture device for applying shear stress and strain on single cells. The device includes at least one channel, at least one cell culture chamber having at least one single-cell attachment surface, a flexible membrane, at least one vacuum channel, and an inlet and an outlet. The inventive single-cell culture assembly fluid flow for applying fluid induced stress and/or substrate induced stress to cultured cells. | 02-18-2010 |
| 20090275136 | Nuclear Targeting Sequence - The present provides nuclear localization signaling (NLS) sequences derived from titin, comprised of amino acids 181-220: SVGRATSTAE LLVQGEEEVP AKKTKTIVST AQISESRQTR and fragments thereof, such as amino acids 193-208: VQGEEEVP AKKTKTIV; amino acids 199-208: VPAKKTKTIV; and amino acids 200-206: PAKKTKT. The NLS sequences can be linked to agents, such as peptides, proteins or nucleotides, for transporting the agents into the nucleus of cells, and the NLS-agent complex can be further linked to antibodies or ligands for specific binding to cells. Also provided is a method for constructing cDNAs comprising combining a NLS sequence with a nucleic acid sequence for a target protein for expression and entry of the target protein into the nucleus of cells, which then can perform specific functions therein. | 11-05-2009 |
| 20090123993 | BIOREACTOR FOR DEVELOPMENT OF BLOOD VESSELS - The present invention provides a blood vessel bioreactor and accessory system to harvest, maintain, transport, and/or develop a native blood vessel or a tissue-engineered biosynthetic blood vessel construct in which regulated nutritive fluid flow as well as a pressure and shear stress regimen is supplied which nutritionally and mechanically conditions the native or tissue-engineered blood vessel construct to withstand an in vitro or in vivo environment. The present invention includes a blood vessel harvest and carriage cassette ( | 05-14-2009 |
